Journal
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
Volume 39, Issue 1, Pages 78-85Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/147323001103900110
Keywords
LUNG CANCER; SMOKING; BIOMARKER; MRNA; AKR1B10
Funding
- Korean Health and Welfare, Republic of Korea [A050162]
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This prospective study explored the relationship between expression of AKR1B10 mRNA and various clinical parameters in non-small-cell lung cancer (NSCLC) in terms of its validation as a marker for NSCLC. Tumour tissue samples were collected from 229 patients with NSCLC. Tissue samples from adjacent nonmalignant lung tissue (> 5 cm from the tumour) of 89 of these patients and samples from 20 patients with benign lung disease were used as controls. Quantitative reverse transcription-polymerase chain reaction showed significantly higher levels of AKR1B10 mRNA expression in NSCLC tumour tissue than in adjacent non-malignant lung tissue and benign lung tissue. Statistically significant factors for AKR1B10 mRNA over-expression were found to be male gender, smoking, squamous cell carcinoma and moderate or poor cell differentiation. It is concluded that AKR1B10 seems to have potential as a prognostic marker for NSCLC and warrants further investigation.
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