Journal
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
Volume 38, Issue 4, Pages 1507-1512Publisher
FIELD HOUSE PUBLISHING LLP
DOI: 10.1177/147323001003800434
Keywords
NARROW-BAND ULTRAVIOLET B (NB-UVB); PHOTOTHERAPY; PSORIASIS VULGARIS; SOLUBLE CELL ADHESION MOLECULES; PSORIASIS AREA AND SEVERITY INDEX (PASI)
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This study investigated the effect of narrow-band ultraviolet B (NB-UVB) phototherapy on serum levels of the soluble cell adhesion molecules sE-selectin, sP-selectin, sL-selectin and soluble intercellular adhesion molecule-1 (sICAM-1) in 58 patients with psoriasis vulgaris. Psoriasis Area and Severity Index (PASI) scores significantly decreased after treatment, confirming the efficacy of NB-UVB phototherapy. Serum levels of sE-selectin also decreased significantly after treatment, and levels of sICAM-1 showed a significant correlation with PASI score and with levels of sE-selectin. The efficacy of NB-UVB phototherapy in improving psoriatic lesions may be a function of decreased serum levels of E-selectin. These findings emphasize the complex roles of soluble cell adhesion molecules in the immunopathogenesis of psoriasis.
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