Biomarkers: refining diagnosis and expediting drug development - reality, aspiration and the role of open innovation

Omalizumab in Severe Allergic Asthma Inadequately Controlled With Standard Therapy

(2013) Nicola A. Hanania et al.   ANNALS OF INTERNAL MEDICINE

Circulating p53-Responsive MicroRNAs as Predictive Biomarkers in Heart Failure After Acute Myocardial Infarction

(2013) Sarah Evans et al.   CIRCULATION RESEARCH

Identifying novel biomarkers for cardiovascular disease risk prediction

(2013) Y. Ge et al.   JOURNAL OF INTERNAL MEDICINE

Analysis of Circulating Tumor DNA to Monitor Metastatic Breast Cancer

(2013) Sarah-Jane Dawson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical Judgment Versus Biomarker Prostate Cancer Gene 3: Which Is Best When Determining the Need for Repeat Prostate Biopsy?

(2013) Bertrand Tombal et al.   UROLOGY

Quality of life and chronic heart failure therapy guided by natriuretic peptides: Results from the ProBNP Outpatient Tailored Chronic Heart Failure Therapy (PROTECT) study

(2012) Anju Bhardwaj et al.   AMERICAN HEART JOURNAL

Prognostic value of a cell cycle progression signature for prostate cancer death in a conservatively managed needle biopsy cohort

(2012) J Cuzick et al.   BRITISH JOURNAL OF CANCER

Clinical Pharmacogenetics Implementation Consortium Guidelines for HLA-B Genotype and Abacavir Dosing

(2012) M A Martin et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The determination and interpretation of the therapeutic index in drug development

(2012) Patrick Y. Muller et al.   NATURE REVIEWS DRUG DISCOVERY

Next-generation sequencing in the clinic: are we ready?

(2012) Leslie G. Biesecker et al.   NATURE REVIEWS GENETICS

Tumor markers in prostate cancer I: Blood-based markers

(2011) Shahrokh F. Shariat et al.   ACTA ONCOLOGICA

Evaluation of GSTP1 and APC methylation as indicators for repeat biopsy in a high-risk cohort of men with negative initial prostate biopsies

(2011) Bruce J. Trock et al.   BJU INTERNATIONAL

Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C9 and VKORC1 Genotypes and Warfarin Dosing

(2011) J A Johnson et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Pharmacoeconomic evaluation of warfarin pharmacogenomics

(2011) Joyce HS You   EXPERT OPINION ON PHARMACOTHERAPY

Treatment of HER2-positive breast cancer: current status and future perspectives

(2011) Carlos L. Arteaga et al.   Nature Reviews Clinical Oncology

Glycogen Storage Diseases: A Brief Review and Update on Clinical Features, Genetic Abnormalities, Pathologic Features, and Treatment

(2011) John Hicks et al.   ULTRASTRUCTURAL PATHOLOGY

PK–PD modeling of protein drugs: implications in assay development

(2011) Lorin K Roskos et al.   Bioanalysis

The Alzheimer's Disease Neuroimaging Initiative: Progress report and future plans

(2010) Michael W. Weiner et al.   Alzheimers & Dementia

The role of metabolites and metabolomics in clinically applicable biomarkers of disease

(2010) Mamas Mamas et al.   ARCHIVES OF TOXICOLOGY

MicroRNAs and Heart Failure Diagnosis

(2010) David W. Markham et al.   CIRCULATION RESEARCH

Antipsychotic Occupancy of Dopamine Receptors in Schizophrenia

(2010) Magdalena Nord et al.   CNS Neuroscience & Therapeutics

Towards a knowledge-based Human Protein Atlas

(2010) Mathias Uhlen et al.   NATURE BIOTECHNOLOGY

Messy biology and the origins of evolutionary innovations

(2010) Dan S Tawfik   Nature Chemical Biology

A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury

(2010) Jonathan B Singer et al.   NATURE GENETICS

Effect of VX-770 in Persons with Cystic Fibrosis and the G551D-CFTRMutation

(2010) Frank J. Accurso et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pharmacogenomic biomarkers: new tools in current and future drug therapy

(2010) Sarah C. Sim et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects

(2009) Leslie M. Shaw et al.   ANNALS OF NEUROLOGY

Genetic basis for idiosyncratic reactions to antiepileptic drugs

(2009) Diego Franciotta et al.   CURRENT OPINION IN NEUROLOGY

Total and phosphorylated tau protein as biological markers of Alzheimer’s disease

(2009) Harald Hampel et al.   EXPERIMENTAL GERONTOLOGY

MammaPrint™ 70-gene signature: another milestone in personalized medical care for breast cancer patients

(2009) Elzbieta A Slodkowska et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Protein microarrays: high-throughput tools for proteomics

(2009) Oda Stoevesandt et al.   Expert Review of Proteomics

How-to guide on biomarkers: biomarker definitions, validation and applications with examples from cardiovascular disease

(2009) V O Puntmann   POSTGRADUATE MEDICAL JOURNAL

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

(2009) L. A. Hindorff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetics of Cystic Fibrosis

(2009) Sherstin Lommatzsch et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

HLA-B*5701 Screening for Hypersensitivity to Abacavir

(2008) Simon Mallal et al.   NEW ENGLAND JOURNAL OF MEDICINE

New serological biomarkers of inflammatory bowel disease

(2008) Xuhang Li et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Strategic Approach to Fit-for-Purpose Biomarkers in Drug Development

(2007) John A. Wagner   Annual Review of Pharmacology and Toxicology

EAU Guidelines on Prostate Cancer

(2007) Axel Heidenreich et al.   EUROPEAN UROLOGY