Article
Nutrition & Dietetics
Xin Shu, Jiaqi Wu, Tao Zhang, Xiaoyu Ma, Zuoqin Du, Jin Xu, Jingcan You, Liqun Wang, Ni Chen, Mao Luo, Jianbo Wu
Summary: The study suggests that PCSK9 expression in adipose tissue may mediate statin-induced adipocyte insulin resistance. PCSK9 deficiency could protect against statin-induced impairments in insulin signaling.
Review
Immunology
Zheng Zhou, Bao Sun, Dongsheng Yu, Chunsheng Zhu
Summary: Type 2 diabetes mellitus, a common metabolic disease, is associated with gut microbiota dysbiosis. Remodeling the gut microbiota may be a potential strategy for treating T2DM and its complications.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Endocrinology & Metabolism
Linda A. Jahn, Lee M. Hartline, Amanda J. Kleiner, William B. Horton, Farhad Hasan, Alvin Wai Kit Tan, Zhenqi Liu, Eugene J. Barrett
Summary: This study compared the metabolic and microvascular responses to insulin in healthy adults and adults with T1DM. It found that T1DM patients had decreased microvascular response to insulin, impaired metabolic insulin sensitivity, and higher vascular stiffness during hyperinsulinemia.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Medicine, General & Internal
Shiyu Zhou, Licong Su, Ruqi Xu, Yanqin Li, Ruixuan Chen, Yue Cao, Peiyan Gao, Xiaodong Zhang, Fan Luo, Qi Gao, Shengli An, Wenyi Cai, Lilong Lin, Hong Xu, Bicheng Liu, Jianping Weng, Chen Chunbo, Huafeng Liu, Qiongqiong Yang, Hua Li, Yaozhong Kong, Guisen Li, Qijun Wan, Yan Zha, Ying Hu, Gang Xu, Yongjun Shi, Yilun Zhou, Guobin Su, Ying Tang, Mengchun Gong, Xin Xu, Sheng Nie
Summary: Based on the analysis of the China Renal Data System database, this study found that statin therapy can reduce the risk of kidney disease development in patients with type 2 diabetes mellitus, particularly in those with intensive control of low-density lipoprotein cholesterol. This suggests that statin initiation may be an effective approach for preventing kidney disease in these patients.
CANADIAN MEDICAL ASSOCIATION JOURNAL
(2023)
Article
Endocrinology & Metabolism
Weiming Wang, Na Li, Xiaoyi Wang, Xu Zhang, Menghan Tu, Lixia Lin, Qian Li, Huaqi Zhang, Jin Liu, Xuefeng Yang, Liping Hao, Nianhong Yang
Summary: This study investigated the association between remnant cholesterol (RC) and gestational diabetes mellitus (GDM) risk. The results showed that elevated RC levels were associated with an increased risk of GDM, independent of traditional risk factors.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Pharmacology & Pharmacy
Laura Alvarez-Jimenez, Felix Morales-Palomo, Alfonso Moreno-Cabanas, Juan F. Ortega, Ricardo Mora-Rodriguez
Summary: This study provides an update on the diabetogenic effect of statins by analyzing randomized-controlled trials. The results show that statin therapy increases glycated hemoglobin levels and insulin resistance regardless of the glycemic control status. The diabetogenic effect is not influenced by the type or dosage of statin prescribed.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Hematology
Thomas W. King, Blake J. Cochran, Kerry-Anne Rye
Summary: ApoA-I, the main component of HDL, has multiple cardioprotective and antidiabetic functions. This review summarizes the current knowledge of apoA-I's antidiabetic effects, the mechanism behind these effects, and the potential of small peptides that mimic apoA-I to be used as innovative treatments for diabetes.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Xinmei Huang, Bingbing Zha, Manna Zhang, Yue Li, Yueyue Wu, Rui Zhang, Li Sheng, Jiong Xu, Zhiyan Yu, Cuijun Gao, Zaoping Chen, Heyuan Ding, Ling Ma, Yanquan Zhang, Shufei Zang, Tie-Ning Zhang, Jun Liu
Summary: The study found that decreased monocyte count throughout pregnancy was closely associated with the development of gestational diabetes mellitus (GDM), macrosomia, and the chronic inflammatory state of GDM. First-trimester monocyte count performed better as a risk factor and diagnostic predictor of GDM and macrosomia compared to second and third trimester counts.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Letter
Endocrinology & Metabolism
Bo Zhou, Ying-Qi Jin, Lian-Ping He
Summary: Skeletal muscle is a large insulin-sensitive tissue in the body, and its loss of mass is associated with mitochondrial dysfunction, often seen in diabetes. Insufficient insulin or insulin resistance is only manifested as reduced skeletal muscle mass. Diabetes is caused by a lack of insulin or insulin resistance, but insulin resistance is not unique to diabetes and also exists in many other diseases.
WORLD JOURNAL OF DIABETES
(2022)
Article
Endocrinology & Metabolism
Yumin Ma, Yingying Luo, Siqian Gong, Xianghai Zhou, Yufeng Li, Wei Liu, Simin Zhang, Xiaoling Cai, Qian Ren, Lingli Zhou, Xiuying Zhang, Yanai Wang, Xiuting Huang, Xueying Gao, Mengdie Hu, Xueyao Han, Linong Ji
Summary: The low-frequency variant of GCK gene, rs13306393, was found to be associated with type 2 diabetes and prediabetes in the Chinese population. This variant increased the risk of developing diabetes and prediabetes by reducing insulin sensitivity rather than affecting beta-cell function, which should be considered in future clinical use of GCK activators.
Article
Endocrinology & Metabolism
Yang Niu, Qingya Tang, Xuan Zhao, Xuelin Zhao, Xiaomeng Mao, Jinye Sheng, Wei Cai, Yi Feng
Summary: This study aimed to evaluate the role of serum uric acid (SUA) in mediating insulin resistance in obese children and adolescents. The results showed that SUA partially mediated the link between BMI, fasting insulin levels, and insulin resistance in this population.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Agriculture, Multidisciplinary
Shujuan Zheng, Kunlun Huang, Tao Tong
Summary: Oleuropein is a dietary bioactive compound that shows potential in ameliorating diabetes and its complications. Its beneficial effects include modulation of insulin secretion, repair of islet morphology, activation of hepatic AMP-activated protein kinase signaling, improvement of glucose tolerance and insulin resistance. Oleuropein can also alleviate diabetes complications such as diabetic nephropathy, cardiovascular complications, retinopathy, wound healing, neuropathy, and testicular dysfunction by reversing cell apoptosis, regenerating tissues, restoring histological organization, and decreasing oxidative stress. It is a promising compound for the management of diabetes and its complications and can be used as a nutraceutical in combating these diseases.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Abnoos Mokhtari Ardekani, Saman Mohammadzadehsaliani, Hamid Behrouj, Heresh Moridi, Mohammad Nabi Moradi, Hassan Ghasemi
Summary: This study investigated the association of the rs17669 variant of miR-122 with miR-122 circulating level, risk of T2DM development, and biochemical parameters. The results showed no significant association between the rs17669 variant and miR-122 expression and biochemical parameters, but miR-122 expression was significantly higher in T2DM patients compared to controls. Furthermore, miR-122 dysregulation was found to be involved in T2DM development through inducing dyslipidemia, hyperglycemia, and insulin resistance.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Multidisciplinary Sciences
Richard R. Rodrigues, Manoj Gurung, Zhipeng Li, Manuel Garcia-Jaramillo, Renee Greer, Christopher Gaulke, Franziska Bauchinger, Hyekyoung You, Jacob W. Pederson, Stephany Vasquez-Perez, Kimberly D. White, Briana Frink, Benjamin Philmus, Donald B. Jump, Giorgio Trinchieri, David Berry, Thomas J. Sharpton, Amiran Dzutsev, Andrey Morgun, Natalia Shulzhenko
Summary: The Western diet is a major contributor to diabetes, with gut microbiota playing a crucial role in mediating its effects. Utilizing network analysis, the study identifies two species of Lactobacilli decreased by the Western diet, which improve glucose metabolism and restore hepatic mitochondria function in mice.
NATURE COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
Chan Liu, Xiao-Rong Zhou, Mu-Yao Ye, Xiang-Qing Xu, Yu-Wei Zhang, Hong Liu, Xian-Zhe Huang
Summary: Objective Hyperuricemia (HUA) is strongly associated with abnormal glucose metabolism and insulin resistance (IR). This study found that plasma RBP4 levels were significantly higher in both HUA patients and HUA rat models compared to control groups. Additionally, RBP4 may be involved in HUA-induced IR by inhibiting IRS/PI3K/Akt phosphorylation, leading to improved insulin sensitivity.
FRONTIERS IN ENDOCRINOLOGY
(2021)
