Pathogenic immune mechanisms at the neuromuscular synapse: the role of specific antibody-binding epitopes in myasthenia gravis

Complement associated pathogenic mechanisms in myasthenia gravis

(2013) Erdem Tüzün et al.   AUTOIMMUNITY REVIEWS

Antibodies to active zone protein ERC1 in Lambert–Eaton myasthenic syndrome

(2013) Maartje G. Huijbers et al.   HUMAN IMMUNOLOGY

Muscle-specific kinase myasthenia gravis IgG4 autoantibodies cause severe neuromuscular junction dysfunction in mice

(2012) Rinse Klooster et al.   BRAIN

Passive and active immunization models of MuSK-Ab positive myasthenia: Electrophysiological evidence for pre and postsynaptic defects

(2012) Stuart Viegas et al.   EXPERIMENTAL NEUROLOGY

Structural basis of agrin-LRP4-MuSK signaling

(2012) Y. Zong et al.   GENES & DEVELOPMENT

Divalent and monovalent autoantibodies cause dysfunction of MuSK by distinct mechanisms in a rabbit model of myasthenia gravis

(2012) Shuuichi Mori et al.   JOURNAL OF NEUROIMMUNOLOGY

Antibodies against Wnt receptor of muscle-specific tyrosine kinase in myasthenia gravis

(2012) Masaharu Takamori et al.   JOURNAL OF NEUROIMMUNOLOGY

Antibodies against the main immunogenic region of the acetylcholine receptor correlate with disease severity in myasthenia gravis

(2012) Tomoko Masuda et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Biglycan Is an Extracellular MuSK Binding Protein Important for Synapse Stability

(2012) A. R. Amenta et al.   JOURNAL OF NEUROSCIENCE

Lrp4 is a retrograde signal for presynaptic differentiation at neuromuscular synapses

(2012) Norihiro Yumoto et al.   NATURE

Long-lasting treatment effect of rituximab in MuSK myasthenia

(2012) J. Diaz-Manera et al.   NEUROLOGY

Antibodies against Muscle-Specific Kinase Impair Both Presynaptic and Postsynaptic Functions in a Murine Model of Myasthenia Gravis

(2011) Shuuichi Mori et al.   AMERICAN JOURNAL OF PATHOLOGY

Autoantibodies to Lipoprotein-Related Protein 4 in Patients With Double-Seronegative Myasthenia Gravis

(2011) John S. Tzartos   ARCHIVES OF NEUROLOGY

Myasthenogenicity of the main immunogenic region and endogenous muscle nicotinic acetylcholine receptors

(2011) Jie Luo et al.   AUTOIMMUNITY

Agrin Binds to the N-terminal Region of Lrp4 Protein and Stimulates Association between Lrp4 and the First Immunoglobulin-like Domain in Muscle-specific Kinase (MuSK)

(2011) Wei Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clinical Dutch-English Lambert-Eaton Myasthenic Syndrome (LEMS) Tumor Association Prediction Score Accurately Predicts Small-Cell Lung Cancer in the LEMS

(2011) Maarten J. Titulaer et al.   JOURNAL OF CLINICAL ONCOLOGY

Anti-LRP4 autoantibodies in AChR- and MuSK-antibody-negative myasthenia gravis

(2011) Alexandra Pevzner et al.   JOURNAL OF NEUROLOGY

Anti-MuSK autoantibodies block binding of collagen Q to MuSK

(2011) Y. Kawakami et al.   NEUROLOGY

Autoantibodies to low-density lipoprotein receptor-related protein 4 in myasthenia gravis

(2010) Osamu Higuchi et al.   ANNALS OF NEUROLOGY

Recent approaches to the development of antigen-specific immunotherapies for myasthenia gravis

(2010) George Lagoumintzis et al.   AUTOIMMUNITY

A systematic review of population based epidemiological studies in Myasthenia Gravis

(2010) Aisling S Carr et al.   BMC Neurology

To build a synapse: signaling pathways in neuromuscular junction assembly

(2010) H. Wu et al.   DEVELOPMENT

Anti-Heat Shock Protein 70 antibody levels are increased in myasthenia gravis and Guillain-Barré syndrome

(2010) Geir Helgeland et al.   JOURNAL OF NEUROIMMUNOLOGY

Patient autoantibodies deplete postsynaptic muscle-specific kinase leading to disassembly of the ACh receptor scaffold and myasthenia gravis in mice

(2010) R. N. Cole et al.   JOURNAL OF PHYSIOLOGY-LONDON

Autoimmunity to SOX2, clinical phenotype and survival in patients with small-cell lung cancer

(2010) Paul Maddison et al.   LUNG CANCER

Pre- and postsynaptic neuromuscular junction abnormalities in musk myasthenia

(2010) Erik H. Niks et al.   MUSCLE & NERVE

Specific immunotherapy of experimental myasthenia gravis by a novel mechanism

(2009) Jie Luo et al.   ANNALS OF NEUROLOGY

Immunoglobulin G4: an odd antibody

(2009) R. C. Aalberse et al.   CLINICAL AND EXPERIMENTAL ALLERGY

SOX Antibodies in Small-Cell Lung Cancer and Lambert-Eaton Myasthenic Syndrome: Frequency and Relation With Survival

(2009) Maarten J. Titulaer et al.   JOURNAL OF CLINICAL ONCOLOGY

Crystal Structure of the Frizzled-Like Cysteine-Rich Domain of the Receptor Tyrosine Kinase MuSK

(2009) Amy L. Stiegler et al.   JOURNAL OF MOLECULAR BIOLOGY

Antigenic Structure of the Human Muscle Nicotinic Acetylcholine Receptor Main Immunogenic Region

(2009) Jie Luo et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Main Immunogenic Region Structure Promotes Binding of Conformation-Dependent Myasthenia Gravis Autoantibodies, Nicotinic Acetylcholine Receptor Conformation Maturation, and Agonist Sensitivity

(2009) J. Luo et al.   JOURNAL OF NEUROSCIENCE

HLA class II allele analysis in MuSK-positive myasthenia gravis suggests a role for DQ5

(2009) E. Bartoccioni et al.   NEUROLOGY

Anti-MuSK patient antibodies disrupt the mouse neuromuscular junction

(2008) Rebecca N. Cole et al.   ANNALS OF NEUROLOGY

Antigen-specific Apheresis of Pathogenic Autoantibodies from Myasthenia Gravis Sera

(2008) Socrates J. Tzartos et al.   Annals of the New York Academy of Sciences

Response to Therapy in Myasthenia Gravis with Anti-MuSK Antibodies

(2008) Amelia Evoli et al.   Annals of the New York Academy of Sciences

Lambert-Eaton Myasthenic Syndrome

(2008) Maarten J. Titulaer et al.   Annals of the New York Academy of Sciences

Lrp4 Is a Receptor for Agrin and Forms a Complex with MuSK

(2008) Natalie Kim et al.   CELL

Clinical fluctuations in MuSK myasthenia gravis are related to antigen-specific IgG4 instead of IgG1

(2008) E.H. Niks et al.   JOURNAL OF NEUROIMMUNOLOGY

Lambert–Eaton myasthenic syndrome: Search for alternative autoimmune targets and possible compensatory mechanisms based on presynaptic calcium homeostasis

(2008) Masaharu Takamori   JOURNAL OF NEUROIMMUNOLOGY

Lambert–Eaton myasthenic syndrome differential reactivity of tumor versus non-tumor patients to subunits of the voltage-gated calcium channel

(2008) H PELLKOFER et al.   JOURNAL OF NEUROIMMUNOLOGY

The Lambert–Eaton myasthenic syndrome 1988–2008: A clinical picture in 97 patients

(2008) M.J. Titulaer et al.   JOURNAL OF NEUROIMMUNOLOGY

LRP4 Serves as a Coreceptor of Agrin

(2008) Bin Zhang et al.   NEURON