☆ 4.7 Article

Kinetic studies to investigate lipoprotein metabolism

JOURNAL OF INTERNAL MEDICINE (2012)

Journal

JOURNAL OF INTERNAL MEDICINE

Volume 271, Issue 2, Pages 166-173

Publisher

WILEY

DOI: 10.1111/j.1365-2796.2011.02497.x

Keywords

kinetics; lipoproteins; metabolism; stable isotopes; very low-density lipoproteins

Categories

Medicine, General & Internal

Funding

Novo Nordisk Fonden [NNF11OC1014864] Funding Source: researchfish

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Abstract

To develop novel strategies for the prevention and treatment of dyslipidaemia, it is essential to understand the pathophysiology of dyslipoproteinaemia in humans. Lipoprotein metabolism is a complex system in which abnormal concentrations of various lipoprotein particles can result from alterations in their rates of production, conversion and/or catabolism. Traditional methods that measure plasma lipoprotein concentrations only provide static estimates of lipoprotein metabolism and hence limited mechanistic information. By contrast, the use of tracers labelled with stable isotopes and mathematical modelling provides a powerful tool for probing lipid and lipoprotein kinetics in vivo and furthering understanding of the pathogenesis of dyslipoproteinaemia.

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JOURNAL OF INTERNAL MEDICINE (2022)

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Review Cardiac & Cardiovascular Systems

Metabolism of triglyceride-rich lipoproteins in health and dyslipidaemia

Jan Boren, Marja-Riitta Taskinen, Elias Bjornson, Chris J. Packard

Summary: Accumulating evidence suggests the causal role of triglyceride-rich lipoproteins and their cholesterol-enriched remnants in atherogenesis. Genetic and kinetic studies have revealed the key proteins involved in the regulation of triglyceride transport and the complexity of triglyceride-rich lipoprotein metabolism. Ongoing investigations aim to understand the consequences of dysregulation caused by diet or genetic variation. The identification of molecular control mechanisms has laid the foundation for precision-medicine approaches to therapy, with novel pharmacological agents targeting specific molecular targets.

NATURE REVIEWS CARDIOLOGY (2022)

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Article Endocrinology & Metabolism

Role of endogenous incretins in the regulation of postprandial lipoprotein metabolism

Marja-Riitta Taskinen, Niina Matikainen, Elias Bjornson, Sanni Soderlund, Mari Ainola, Antti Hakkarainen, Nina Lundbom, Carina Sihlbom, Annika Thorsell, Linda Andersson, Martin Adiels, Bolette Hartmann, Carolyn F. Deacon, Jens J. Holst, Chris J. Packard, Jan Boren

Summary: This study aimed to investigate the impact of physiological levels of incretins on chylomicron and VLDL production and clearance rates. The results showed that physiological levels of incretins do not have a significant regulatory effect on lipid metabolism.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2022)

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Article Medicine, Research & Experimental

Postprandial metabolism of apolipoproteins B48, B100, C-III, and E in humans with APOC3 loss-of-function mutations

Marja-Riitta Taskinen, Elias Bjornson, Niina Matikainen, Sanni Soderlund, Joel Ramo, Mari-Mia Ainola, Antti Hakkarainen, Carina Sihlbom, Annika Thorsell, Linda Andersson, Per-Olof Bergh, Marcus Henricsson, Stefano Romeo, Martin Adiels, Samuli Ripatti, Markku Laakso, Chris J. Packard, Jan Boren

Summary: This study investigates the impact of apoC-III on lipoprotein metabolism in individuals with a loss-of-function mutation in the APOC3 gene. The results demonstrate that lowering apoC-III levels significantly affects the metabolism of lipoproteins and remnants, potentially having important implications for cardiovascular disease prevention.

JCI INSIGHT (2022)

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Article Multidisciplinary Sciences

Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study

Helena A. K. Lapatto, Minna Kuusela, Aino Heikkinen, Maheswary Muniandy, Birgitta W. van der Kolk, Swetha Gopalakrishnan, Noora Pollanen, Martin Sandvik, Mark S. Schmidt, Sini Heinonen, Sina Saari, Juho Kuula, Antti Hakkarainen, Janne Tampio, Tuure Saarinen, Marja-Riitta Taskinen, Nina Lundbom, Per-Henrik Groop, Marja Tiirola, Pekka Katajisto, Marko Lehtonen, Charles Brenner, Jaakko Kaprio, Satu Pekkala, Miina Ollikainen, Kirsi H. Pietilainen, Eija Pirinen

Summary: Nicotinamide riboside (NR), a precursor of nicotinamide adenine dinucleotide (NAD(+)), has shown promise in improving obesity-associated mitochondrial dysfunction and metabolic syndrome. However, short-term clinical trials have not yielded positive results. This study aimed to investigate the long-term effects of NR supplementation on mitochondrial biogenesis and metabolic health in humans. The results showed that NR improved NAD(+) metabolism, muscle mitochondrial number, myoblast differentiation, gut microbiota composition, and epigenetic control of gene expression. However, it did not improve adiposity or metabolic health.

SCIENCE ADVANCES (2023)

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Article Endocrinology & Metabolism

Contribution of intestinal triglyceride-rich lipoproteins to residual atherosclerotic cardiovascular disease risk in individuals with type 2 diabetes on statin therapy

Marja-Riitta Taskinen, Niina Matikainen, Elias Bjornson, Sanni Soderlund, Jussi Inkeri, Antti Hakkarainen, Helka Parviainen, Carina Sihlbom, Annika Thorsell, Linda Andersson, Martin Adiels, Chris J. Packard, Jan Boren

Summary: This study investigated the hypothesis that individuals with type 2 diabetes on statin therapy may have significant abnormalities in the metabolism of intestinally derived lipoproteins. The findings suggest that in these individuals, there are increased production and longer circulation time of ApoB-48-containing lipoproteins, which may contribute to residual cardiovascular disease risk.

DIABETOLOGIA (2023)

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Article Cardiac & Cardiovascular Systems

Triglyceride-rich lipoprotein remnants, low-density lipoproteins, and risk of coronary heart disease: a UK Biobank study

Elias Bjornson, Martin Adiels, Marja-Riitta Taskinen, Stephen Burgess, Aidin Rawshani, Jan Boren, Chris J. Packard

Summary: In this study, the association between triglyceride-rich lipoproteins (TRL) and coronary heart disease (CHD) was investigated using population data from the UK Biobank. The results suggest that TRL/remnant cholesterol has a stronger and independent association with CHD compared to LDL cholesterol. Moreover, different genetic clusters impact TRL/remnants and LDL differentially, with TRL/remnants exhibiting a higher atherogenicity per particle than LDL.

EUROPEAN HEART JOURNAL (2023)

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