Article
Biochemistry & Molecular Biology
Zhiwen Qi, Guliang Yang, Tao Deng, Jianmin Wang, Hao Zhou, Sergey A. Popov, Elvira E. Shults, Chengzhang Wang
Summary: This study investigated the design and cellular activity of six UA PROTAC hydrochloride compounds, with one compound showing remarkable in vitro antitumor activity. The compound induced significant degradation of MDM2 protein and promoted the expression of P21 and PUMA proteins, leading to inhibition of proliferation and promotion of apoptosis in A549 cells. This work demonstrated proof of designing the efficient target protein degradation by UA PROTACs with the POE linkers.
BIOORGANIC CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Aleksandr Popov, Emma Kozlovskaya, Tatyana Rutckova, Olga Styshova, Aleksey Vakhrushev, Elena Kupera, Ludmila Tekutyeva
Summary: Recent research has shown that matrix metalloproteinase-generated functional proteins (MKs) can be a valuable source of nutrition and therapy, reducing the risk of serious diseases such as cancer. MKs have antitumor properties and can be used in combination therapy without toxic side effects. This review summarizes the data on the antitumor activity of MKs from various sources and discusses their potential and challenges in therapeutic use.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Kelsey A. Hauser, Julia C. Singer, Muhammad Riadul H. Hossainey, Tyler E. Moore, Emily S. Wendel, Amulya Yaparla, Namarta Kalia, Leon Grayfer
Summary: Tadpoles exhibit stronger intestinal type I and III IFN responses to FV3 infections compared to adult frogs, likely mediated by myeloid cells. Healthy (uninfected) adult frogs already have myeloid cells with similar cytology in their intestines, possibly contributing to their resistance to FV3. Understanding the differences in tadpole and adult frog responses to ranaviral infections is essential for comprehending susceptibility and resistance to these pathogens.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tanjilur Rahman, Ayan Das, Mehedy Hasan Abir, Iqbal Hossain Nafiz, Aar Rafi Mahmud, Md. Rifat Sarker, Talha Bin Emran, Mohammad Mahmudul Hassan
Summary: Cytokines are protein molecules that play important roles in the immune system. They can be used as therapeutics for treating malignant diseases through the administration of recombinant or purified cytokines, or by inhibiting the harmful effects of endogenous and overexpressed cytokines. Cytokine receptor antagonists can also serve as anti-inflammatory agents by altering the treatment of inflammation disorders. This article highlights the research on the use of cytokines as therapeutics and vaccine adjuvants, their role in immunotolerance, and their limitations.
Review
Chemistry, Medicinal
Zufa Sabeel, Youfeng Liang, Mingxuan Hao, Lu Ying, Rui Guo, Ruolan Chen, Xiaoning Li, Changyuan Yu, Zhao Yang
Summary: Angelica species have been traditionally used for their medicinal properties. Recent studies have suggested their potential use as anticancer agents, making them an area of interest for further research. Active compounds in the Angelica genus exhibit anticancer properties through various mechanisms, and specific species have the potential as anticancer agents by targeting cellular pathways, generating reactive oxygen species, and inducing apoptotic cell death. Further research into the properties of the Angelica genus is needed for developing new treatments for cancer.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Wenhua Yang, Hao Luan, Chuqi Tang, Xuanchen Li, Shuaijinyi Li, Hexia Ding, Xiaobin Yu, Nils Arneborg, Guohua Yang, Jianli Zhou
Summary: In this study, the application of acylated blueberry pomace anthocyanins in food and nutraceuticals was expanded. Enzymatic acylation reaction was carried out with cyanidin-3-O-glucoside (C3G) and Novozyme 435 as the biocatalyst. The acylated blueberry pomace anthocyanins showed improved lipophilicity, thermostability, photostability, and significantly inhibited tumor cells while being less toxic to normal cells.
PROCESS BIOCHEMISTRY
(2023)
Editorial Material
Oncology
Kung-Chi Kao, Alison Jaccard, Ping-Chih Ho
Summary: Hu and colleagues demonstrate that the combination of IFN alpha administration and anti-PD-1 therapy can enhance the antitumor response of CD8(+) T-cells in hepatocellular carcinoma, suggesting a novel therapeutic strategy.
Article
Engineering, Chemical
Kenta Komatsu, Tomokatsu Hayakawa, Hiroshi Fudouzi
Summary: In this study, a sandwich structure was formed by bonding two fcc structure colloidal crystal films together using hot pressing, and a clear defect mode was observed. The effect of the thickness of the defect layer in the sandwich structure on the optical properties was investigated.
ADVANCED POWDER TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Mihaela Cudalbeanu, David Peitinho, Francisco Silva, Rosa Marques, Teresa Pinheiro, Ana C. Ferreira, Fernanda Marques, Antonio Paulo, Catarina F. Soeiro, Silvia Andreia Sousa, Jorge Humberto Leitao, Aurel Tabacaru, Sorin Marius Avramescu, Rodica Mihaela Dinica, Maria Paula Cabral Campello
Summary: Gold nanoparticles were prepared using root extracts from Danube Delta Nymphaea alba, showing antibacterial and anticancer activities, with the smallest nanoparticles exhibiting enhanced activities.
Article
Multidisciplinary Sciences
Shane T. Killarney, Rachel Washart, Ryan S. Soderquist, Jacob P. Hoj, Jamie Lebhar, Kevin H. Lin, Kris C. Wood
Summary: During apoptosis, the release of mitochondrial RNA into the cytosol can be prevented by casp3/7, which inhibits inflammatory signaling. Inhibition of casp3/7 promotes a cytosolic mtRNA-driven Type I interferon response, increasing the immunogenicity of chemotherapy-induced apoptosis.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Medicinal
Laura Grau, Richard Soucek, M. Dolors Pujol
Summary: Resveratrol, a natural compound with antioxidant properties, has potential as both a chemopreventive and cancer chemotherapeutic agent. Due to its poor bioavailability, the study of new derivatives is important. In this study, (E)-stilbenes derived from resveratrol and cyclic analogues with benzofuran or indole nucleus were synthesized and evaluated for their impact on tumor growth. Some compounds showed higher cytotoxicity than (E)-resveratrol, with one derivative demonstrating eight times greater cytotoxic activity against colon cancer cells. Certain cyclic derivatives also exhibited strong inhibition of cell growth.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Huan Hu, Yaxiu Feng, Ming-Liang He
Summary: Zika virus (ZIKV) infection causes neurological disorders and elicits a wide range of immune response. Type I interferons (IFNs) and its signaling cascade play a crucial role in innate immunity against ZIKV infection, but ZIKV can antagonize them. Toll-like receptors 3 (TLR3), TLR7/8 and RIG-I-like receptor 1 (RIG-1) recognize the ZIKV genome and induce the expression of Type I IFNs and interferon-stimulated genes (ISGs). ISGs exert antiviral activity at different stages of the ZIKV life cycle. The NS proteins of ZIKV directly interact with factors in the pathways to evade innate immunity, while structural proteins and antibody-binding of BDCA2 or inflammasome activation enhance ZIKV replication. In this review, recent findings about the interaction between ZIKV infection and type I IFNs pathways are summarized, and potential strategies for antiviral drug development are suggested.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Chemistry, Inorganic & Nuclear
Chunyan Jia, Glen B. Deacon, Yingjie Zhang, Chuanzhu Gao
Summary: This article summarizes the main problems of platinum-based anticancer drugs, introduces Pt-IV drugs and their characteristics, and focuses on the combination therapy with nanocarriers, looking forward to the application prospects of Pt-IV drugs and nanotechnology in the field of cancer chemotherapy.
COORDINATION CHEMISTRY REVIEWS
(2021)
Review
Biotechnology & Applied Microbiology
Shilpa Maddheshiya, Seema Nara
Summary: This article introduces the application of nanozymes and their significance in oxidative therapy. Composite nanozymes, as a multifunctional platform combining various nanomaterials, have great potential in antibacterial, antibiofilm, and antitumor therapies.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Editorial Material
Immunology
Shicheng Su, Erwei Song
Summary: Immune checkpoint blocking therapies may not always be effective and have risks, but it is now easier and more accurate to identify non-responders and patients at risk.
