Article
Multidisciplinary Sciences
Mario R. Calderon, Megumi Mori, Grant Kauwe, Jill Farnsworth, Suzana Ulian-Benitez, Elie Maksoud, Jordan Shore, A. Pejmun Haghighi
Summary: This study reveals that Delta/Notch signaling in subperineurial glia plays an essential role in controlling the expression of matrix metalloproteinase 1 (Mmp1), which is crucial for the extracellular matrix (ECM). In the absence of this signaling, enhanced Mmp1 activity disrupts septate junctions and glial ensheathment, leading to compromised neurotransmitter release.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Medicine, General & Internal
Steven T. Proulx, Britta Engelhardt
Summary: The central nervous system maintains a unique relationship with the immune system through brain barriers, allowing for immune surveillance and protection of neural tissue without activating immune responses unless direct injury occurs.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Cell Biology
Diana M. Morales-Prieto, Jose M. Murrieta-Coxca, Milan Stojiljkovic, Celia Diezel, Priska E. Streicher, Julian A. Henao-Restrepo, Franziska Roestel, Julia Lindner, Otto W. Witte, Sebastian Weis, Christian Schmeer, Manja Marz
Summary: Extracellular vesicles, specifically small EVs, are involved in neuroinflammation and neurodegenerative diseases. Aging brains show increased neuroinflammation and glial activation, which can be influenced by EVs. Our study demonstrates that sEVs from aged mice can cross the blood-brain barrier and induce glial cell activation in young animals.
Article
Biochemistry & Molecular Biology
Lisa Epping, Christina B. Schroeter, Christopher Nelke, Stefanie Bock, Lukas Gola, Nadine Ritter, Alexander M. Herrmann, Saskia Rauber, Antonia Henes, Beatrice Wasser, Juncal Fernandez-Orth, Winfried Neuhaus, Stefan Bittner, Thomas Budde, Michael Platten, Stjepana Kovac, Guiscard Seebohm, Tobias Ruck, Manuela Cerina, Sven G. Meuth
Summary: This study found that glycine can act as a ligand for NMDAR on endothelial cells, playing an important regulatory role in BBB integrity.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Neurosciences
Jiru Zhou, Peiwen Guo, Mingxu Duan, Junhan Li, Xufang Ru, Lin Li, Zongduo Guo, John H. Zhang, Hua Feng, Yujie Chen, Xiaochuan Sun
Summary: Stressed astrocytes may serve as a secondary barrier to protect against brain injury after subarachnoid hemorrhage (SAH), and strategies for maintaining this barrier may be beneficial in alleviating early brain injury.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Neurosciences
Amirah-Iman Hicks, Simona Kobrinsky, Suijian Zhou, Jieyi Yang, Masha Prager-Khoutorsky
Summary: The subfornical organ (SFO) is a sensory circumventricular organ located along the anterodorsal wall of the third ventricle. SFO lacks a complete blood-brain barrier (BBB), and thus peripherally-circulating factors can penetrate the SFO parenchyma. The anatomical organization of the rat SFO reveals unique populations of non-neuronal cells, different types of vasculature, and distinct neuronal responses to stimuli like angiotensin II or hypertonic NaCl.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Medicine, Research & Experimental
Subhajit Dasgupta, Mausumi Bandyopadhyay
Summary: SARS-COV-2 infection causes severe respiratory illness and the virus Spike epitopes may lead to brain inflammation based on clinical observations.
MEDICAL HYPOTHESES
(2021)
Review
Biochemistry & Molecular Biology
Michele Cerasuolo, Michele Papa, Anna Maria Colangelo, Maria Rosaria Rizzo
Summary: Alzheimer's disease is a progressive and degenerative disease that is the most common type of dementia worldwide. The amyloidogenic hypothesis, which involves amyloid beta (A beta) and tau proteins, has been the main pathogenetic hypothesis in recent decades. Amyloid deposition, vascular damage, blood-brain barrier dysfunction, and cellular dysfunction are all important mechanisms in the pathogenesis of Alzheimer's disease. Understanding the complex interactions between A beta, tau, and elements of the blood-brain barrier and neurovascular unit is crucial for developing therapies to predict and slow down the progression of the disease.
Review
Physiology
Omid Razi, Bakhtyar Tartibian, Ismail Laher, Karuppasamy Govindasamy, Nastaran Zamani, Silvia Rocha-Rodrigues, Katsuhiko Suzuki, Hassane Zouhal
Summary: Multiple sclerosis (MS) and COVID-19 infection are related, both causing neuroinflammation and plaque formation. Conditions related to MS that make patients more susceptible to viral infection include inflammatory status, blood-brain barrier permeability, function of CNS cells, and plaque formation. Both MS and COVID-19 infection are also associated with psychoneurological and mood disorders. Moderate exercise training can improve the health of patients with MS.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Gabriela Soledad Chileski, Enrique Nicolas Garcia, Javier Walter Lertora, Norma Mussart, David Roque Hernandez, Luciana Andrea Cholich
Summary: The study investigated the effects of Senna occidentalis seeds on pig livers and brains, finding that ingestion led to a range of symptoms and biochemical changes. Experimental pigs showed signs of poisoning and damage to astrocytes, which could be useful for studying hepatoencephalopathy.
Review
Immunology
Brandon C. Smith, Rachel A. Tinkey, Benjamin C. Shaw, Jessica L. Williams
Summary: The blood-brain barrier is a barrier with selective permeability that separates the periphery from the central nervous system. The neurovascular unit, consisting of multiple cells, regulates the permeability of the blood-brain barrier. Understanding the contributions of each member of the neurovascular unit can lead to novel methods for delivering neurotherapies to the central nervous system.
IMMUNOLOGICAL REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Ivan Kushkevych, Mykola Bychkov, Solomiia Bychkova, Mario Gajdacs, Romana Merza, Monika Vitezova
Summary: Autophagy allows prolonged survival in tumor cells with defects in apoptosis, and NAADP may affect the release of Ca2+ from organelles. The activity of ATPases in colorectal cancer tissues is higher, and NAADP has different effects on ion transport in cancer and control samples, showing promising possibilities for the treatment of colorectal cancer.
Article
Chemistry, Analytical
Surya P. Aryal, Mengfan Xia, Ebubechi Adindu, Caroline Davis, Pavel Ortinski, Christopher Richards
Summary: This study developed an endoplasmic reticulum-targeted calcium indicator, ER-GCaMP6f, which enables the measurement of signaling in close proximity to the endoplasmic reticulum in astrocytes. By utilizing microscopy techniques, the researchers demonstrated the localization of the indicator in astrocyte cell soma and processes, and detected calcium fluctuations in small astrocytic processes that were not observable with existing indicators. ER-GCaMP6f also identified dynamics in calcium signaling of endoplasmic reticulum resident receptors that were missed by other indicators.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
America Vera-Montecinos, Jordi Galiano-Landeira, Monica Roldan, Francisco Vidal-Domenech, Enrique Claro, Belen Ramos
Summary: METTL7A is mainly located in the endoplasmic reticulum and lipid droplets, with limited cellular expression in the brain. Reduced protein levels of METTL7A have been found in schizophrenia. Our study shows that METTL7A is highly expressed in Bergmann glia and has contacts with Purkinje neurons. The localization of METTL7A may play a role in maintaining cerebellar homeostasis and modulating cerebellar circuits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Behavioral Sciences
Cameron R. R. Love, Sumit Gautam, Chamala Lama, Nhu Hoa Le, Brigitte Dauwalder
Summary: The blood brain barrier (BBB) protects the brain from harmful molecules and controls selective uptake. Understanding how BBB cells regulate neuronal function is important. In Drosophila, signaling in the BBB is necessary for normal male courtship behavior and involves male-specific molecules. Researchers have found that the dopamine receptor D2R is expressed in the BBB and is required for normal mating behavior in adult males. These findings identify a specific glial function for the DR2 receptor and dopamine signaling in complex behavior regulation.
GENES BRAIN AND BEHAVIOR
(2023)
Article
Biophysics
Haruo Homareda, Masahiro Otsu, Sachiko Yamamoto, Makoto Ushimaru, Sayaka Ito, Toshiyuki Fukutomi, Taeho Jo, Yoshinobu Eishi, Yukichi Hara
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
(2017)
Article
Cell Biology
Kiyono Osanai, Yoichi Kobayashi, Masahiro Otsu, Tomoko Izawa, Keiji Sakai, Mitsutoshi Iwashita
Article
Neurosciences
Ghazala Begum, Masahiro Otsu, Usman Ahmed, Zubair Ahmed, Adam Stevens, Daniel Fulton
Article
Biochemistry & Molecular Biology
Kuniko Akama, Ryosuke Tatsuno, Masahiro Otsu, Tomoe Horikoshi, Takashi Nakayama, Megumi Nakamura, Tosifusa Toda, Nobuo Inoue
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
(2008)
Article
Biochemistry & Molecular Biology
Kuniko Akama, Tomoe Horikoshi, Takashi Nakayama, Masahiro Otsu, Noriaki Imaizumi, Megumi Nakamura, Tosifusa Toda, Michiko Inuma, Hisashi Hirano, Yasushi Kondo, Yutaka Suzuki, Nobuo Inoue
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
(2011)
Article
Biochemistry & Molecular Biology
Kuniko Akama, Tomoe Horikoshi, Takashi Nakayama, Masahiro Otsu, Noriaki Imaizumi, Megumi Nakamura, Tosifusa Toda, Michiko Inuma, Hisashi Hirano, Yasushi Kondo, Yutaka Suzuki, Nobuo Inoue
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
(2013)
Article
Neurosciences
Masahiro Otsu, Tomoaki Sai, Takashi Nakayama, Koji Murakami, Nobuo Inoue
NEUROSCIENCE RESEARCH
(2011)
Article
Neurosciences
Mayu Isono, Masahiro Otsu, Teruaki Konishi, Kana Matsubara, Toshiaki Tanabe, Takashi Nakayama, Nobuo Inoue
NEUROSCIENCE RESEARCH
(2012)
Article
Neurosciences
Hiroyuki Omori, Masahiro Otsu, Asami Suzuki, Takashi Nakayama, Kuniko Akama, Masaru Watanabe, Nobuo Inoue
NEUROSCIENCE RESEARCH
(2014)
Article
Multidisciplinary Sciences
Hiroyuki Omori, Masahiro Otsu, Haruo Nogami, Masayoshi Shibata
Summary: Cells have a regulatory mechanism called heat shock (HS) response, which is sensitive to both exogenous and endogenous factors, leading to both positive and negative effects on cells. The response of neural stem cells to heat shock is unclear, but studies have shown that extending the pre-culture period significantly affects the heat shock response and cell survival.
Article
Neurosciences
Takashi Nakayama, Tomoaki Sai, Masahiro Otsu, Tomoko Momoki-Soga, Nobuo Inoue
