Article
Neurosciences
Alina Vulpe, Karen Menuz
Summary: Insects perceive most odors through two large families of olfactory receptors, the Odorant Receptors (ORs) and Ionotropic Receptors (IRs). Different tuning receptors and their co-receptors are expressed in various sensilla, with some evidence suggesting possible functional overlap between different co-receptors. The high conservation and co-expression of these co-receptors in chemosensory neurons suggest a potential partnership in other insects as well.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Sara Bolivar, Esther Udina
Summary: Specificity in regeneration after peripheral nerve injuries is crucial for functional recovery. This study found that cutaneous mechanoreceptors regenerated faster than other neuron populations, followed by motoneurons and then proprioceptors. Additionally, all neuron types initially preferred to regenerate into the cutaneous branch, but in the long term, they mainly regenerated through their original branch. Furthermore, motoneurons had more collateral branches than proprioceptors, and myelinated neurons extended more regenerative sprouts in the cutaneous branch.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Food Science & Technology
Dabin Kim, Young Hun Jin, Jae-Hyung Mah
Summary: This study aimed to select Bacillus strains capable of degrading biogenic amines (BAs) from Cheonggukjang and investigate their effects on BA reduction during Cheonggukjang fermentation, with and without the presence of Enterococcus faecium, a prolific tyramine-producing species. Three BA-degrading and low BA-producing strains (B. licheniformis CH7P22, B. haynesii CH7P24, and B. velezensis CH7P28) were selected from a total of 327 isolated strains. B. licheniformis CH7P22 exhibited the largest reduction in tyramine and spermine contents during fermentation.
Article
Multidisciplinary Sciences
Cristina C. Clement, Angelo D'Alessandro, Sangeetha Thangaswamy, Samantha Chalmers, Raquel Furtado, Sheila Spada, Giada Mondanelli, Federica Ianni, Sarah Gehrke, Marco Gargaro, Giorgia Manni, Luisa Carlota Lopez Cara, Peter Runge, Wanxia Li Tsai, Sinem Karaman, Jorge Arasa, Ruben Fernandez-Rodriguez, Amanda Beck, Antonio Macchiarulo, Massimo Gadina, Cornelia Halin, Francesca Fallarino, Mihaela Skobe, Marc Veldhoen, Simone Moretti, Silvia Formenti, Sandra Demaria, Rajesh K. Soni, Roberta Galarini, Roccaldo Sardella, Gregoire Lauvau, Chaim Putterman, Kari Alitalo, Ursula Grohmann, Laura Santambrogio
Summary: 3-hydroxy-L-kynurenamine (3-HKA) is a metabolite deriving from a lateral pathway of tryptophan catabolism. The authors identify 3-HKA as a biogenic amine with anti-inflammatory properties, showing its protective effects against psoriasis and nephrotoxic nephritis in mice.
NATURE COMMUNICATIONS
(2021)
Article
Microbiology
Junsu Lee, Young Hun Jin, Alixander Mattay Pawluk, Jae-Hyung Mah
Summary: This study successfully identified lactic acid bacteria capable of degrading biogenic amines from kimchi and demonstrated their effectiveness in reducing amine content during Baechu kimchi fermentation. Among the strains, Levilactobacillus brevis PK08 showed the highest reduction in tyramine content, potentially improving the safety of kimchi fermentation.
Article
Biochemistry & Molecular Biology
Kishore K. Joshi, Tarmie L. Matlack, Stephanie Pyonteck, Mehul Vora, Ralph Menzel, Christopher Rongo
Summary: Metazoans utilize protein homeostasis pathways to respond to adverse conditions, with the nervous system playing a role in regulating proteostasis in different tissues. This study reveals that Caenorhabditis elegans uses biogenic amine neurotransmitters to modulate UPS proteostasis in epithelia by promoting eicosanoid production through P450 monooxygenases, ultimately maintaining protein turnover.
Review
Neurosciences
Lucas B. R. Orssatto, Anthony J. Blazevich, Gabriel S. Trajano
Summary: This article describes that nervous system deterioration is a primary driver of age-related motor impairment. Modulation of persistent inward currents (PICs) is crucial for motor neurones' capacities. Impaired intrinsic motor neurone properties can reduce the PIC contribution to motor neurone firing in older adults. Resistance training has emerged as a promising intervention to counteract age-associated PIC impairments.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Food Science & Technology
Lina Sun, Wenrui Guo, Yujia Zhai, Lihua Zhao, Ting Liu, Le Yang, Ye Jin, Yan Duan
Summary: This study screened three strains from different regions of Inner Mongolia that have the ability to degrade biogenic amines (BAs) in meat products. These strains can degrade various BAs, especially tryptamine and phenethylamine. They can be used as starter cultures in meat products due to their good fermentation capacity and strong ability to reduce BAs.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Neurosciences
Fabio Miazzi, Kalpana Jain, Sabine Kaltofen, Jan E. Bello, Bill S. Hansson, Dieter Wicher
Summary: This article presents different preparations to study odor information processing in the olfactory system of fruit flies, including in vivo imaging and embedding in silica hydrogel. The results show that the odor response dynamics under different conditions are qualitatively similar.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Polymer Science
Daniele Gomes Mueller, Eliezer Quadro Oreste, Monika Grazielle Heinemann, Daiane Dias, Felipe Kessler
Summary: This article discusses the importance of food transportation and distribution and how sensors can be used to improve food quality control. It also explores the relevance of amine determinations and their impact on human health, as well as the use of polymeric materials in sensor construction.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Neurosciences
Claire McGregor, Manning Sabatier, Arthur English
Summary: The expression of p75(NTR) surrounding regenerating axons contributes to poor regeneration after peripheral nerve injury, while inhibition of p75(NTR) may be a therapeutic target for treatments of peripheral nerve injuries.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Food Science & Technology
Yunhe Zhang, Zezhong Li, Yongjin Hu, Jiashun Gong
Summary: This study identifies biogenic amine oxidase-producing strains, such as Enterococcus faecium and Enterococcus faecalis, that can significantly reduce the production of biogenic amines in Sanchuan ham during fermentation. The use of mixed starter cultures shows a more remarkable effect in decreasing the accumulation of biogenic amines compared to single starter cultures, indicating the potential for improving the safety and health of Sanchuan ham and other fermented meat products.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2022)
Article
Ecology
Kalpana Jain, Regina Stieber, Sabine Kaltofen, Bill S. Hansson, Dieter Wicher
Summary: We generated a genetically modified fly line expressing Orco proteins fused with GFP at the N-terminus. The highest fluorescence intensity was observed in homozygous flies in the dendritic areas of olfactory sensory neurons. However, the fusion of GFP did not affect the olfactory capability of homozygous flies compared to wild-type flies, as determined by single sensillum recording.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2023)
Article
Neurosciences
Altamash S. Hassan, Melissa E. Fajardo, Mark Cummings, Laura Miller McPherson, Francesco Negro, Julius P. A. Dewald, C. J. Heckman, Gregory E. P. Pearcey
Summary: Ageing is a natural process that causes changes in the neuromuscular system, leading to a reduced quality of life. Persistent inward currents play a crucial role in the neural control of human movement, influenced by monoamines from the brainstem. Estimates of persistent inward currents are reduced in older adults compared to younger individuals, suggesting a potential mechanism for reduced firing rates in the older population.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Biology
Arnault H. Caillet, Andrew T. M. Phillips, Dario Farina, Luca Modenese
Summary: The study focuses on deriving mathematical relationships between MN electrophysiological and anatomical properties by reprocessing data from 40 experimental studies in adult cat, rat, and mouse MN preparations. The validated mathematical framework provides a convenient tool for neuroscientists and experimenters. By using this framework, modelers can build profiles of inter-consistent MN-specific properties to scale pools of MN models, enhancing the accuracy and interpretability of simulations.
Article
Cell Biology
Sudeshna Dutta, Franziska Rieche, Nina Eckl, Carsten Duch, Doris Kretzschmar
DISEASE MODELS & MECHANISMS
(2016)
Article
Neurosciences
Alison A. Williams, Robin White, Ashley Siniard, Jason Corneveaux, Matt Huentelman, Carsten Duch
NEUROBIOLOGY OF DISEASE
(2016)
Article
Multidisciplinary Sciences
Alison A. Williams, Vera J. Mehler, Christina Mueller, Fernando Vonhoff, Robin White, Carsten Duch
Article
Neurosciences
Dimitrios Kadas, Aylin Klein, Niklas Krick, Jason W. Worrell, Stefanie Ryglewski, Carsten Duch
JOURNAL OF NEUROSCIENCE
(2017)
Article
Neurosciences
Stefanie Ryglewski, Fernando Vonhoff, Kathryn Scheckel, Carsten Duch
Article
Cell Biology
Alexandros Gaitanidis, Agapi Dimitriadou, Harold Dowse, Subhabrata Sanyal, Carsten Duch, Christos Consoulas
Article
Multidisciplinary Sciences
Natalie Schuetzler, Chantal Girwert, Isabell Huegli, Giriram Mohana, Jean-Yves Roignant, Stefanie Ryglewski, Carsten Duch
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Genetics & Heredity
Jan Werner, Jashar Arian, Ida Bernhardt, Stefanie Ryglewski, Carsten Duch
JOURNAL OF NEUROGENETICS
(2020)
Article
Neurosciences
Robert Court, Shigehiro Namiki, J. Douglas Armstrong, Jana Borner, Gwyneth Card, Marta Costa, Michael Dickinson, Carsten Duch, Wyatt Korff, Richard Mann, David Merritt, Rod K. Murphey, Andrew M. Seeds, Troy Shirangi, Julie H. Simpson, James W. Truman, John C. Tuthill, Darren W. Williams, David Shepherd
Article
Multidisciplinary Sciences
Niklas Krick, Stefanie Ryglewski, Aylin Pichler, Arthur Bikbaev, Torsten Goetz, Oliver Kobler, Martin Heine, Ulrich Thomas, Carsten Duch
Summary: The study reveals the presence of two different voltage-gated calcium channels at the presynaptic terminals of glutamatergic neuromuscular synapses in fruit flies, showing spatial and functional separation in regulating neurotransmitter release and recycling. The Cav2 channel is required for neurotransmitter release, while the Cav1 channel mainly contributes to calcium influx and fine-tuning short-term plasticity. The findings suggest a conserved functional triad of Cav2, Cav1, and PMCA for separate control of synaptic vesicle release and recycling rates in presynaptic terminals.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Ferdi Ridvan Kiral, Suchetana B. Dutta, Gerit Arne Linneweber, Selina Hilgert, Caroline Poppa, Carsten Duch, Max von Kleist, Bassem A. Hassan, P. Robin Hiesinger
Summary: Genetic determinism is limited in affecting the variability of synapse numbers and partners, as shown by studying brain wiring and behavior in Drosophila with non-genetic perturbations like developmental temperature. Lower temperatures and slower development unexpectedly lead to increased axo-dendritic branching, synapse numbers, and non-canonical synaptic partnerships, while maintaining a robust ratio of canonical synapses. The findings suggest that genetically encoded relative and scalable synapse formation helps develop functional, but not identical, brains and behaviors.
Article
Multidisciplinary Sciences
Silvan Huerkey, Nelson Niemeyer, Jan-Hendrik Schleimer, Stefanie Ryglewski, Susanne Schreiber, Carsten Duch
Summary: This study identifies a miniaturized circuit solution for the central-pattern-generating (CPG) neural network underlying insect asynchronous flight. The network consists of motoneurons interconnected by electrical synapses that produce network activity splayed out in time instead of synchronized across neurons. This mechanism translates unpatterned premotor input into stereotyped neuronal firing with fixed sequences of cell activation, ensuring stable wingbeat power and is conserved across multiple species.
Article
Neurosciences
Dimitrios Kadas, Carsten Duch, Christos Consoulas
Article
Neurosciences
Bettina Stocker, Christina Bochow, Christine Damrau, Thomas Mathejczyk, Heike Wolfenberg, Julien Colomb, Claudia Weber, Niraja Ramesh, Carsten Duch, Natalia M. Biserova, Stephan Sigrist, Hans-Joachim Pflueger
FRONTIERS IN SYSTEMS NEUROSCIENCE
(2018)
Article
Neurosciences
Stefanie Ryglewski, Carsten Duch, Benjamin Altenhein
FRONTIERS IN SYSTEMS NEUROSCIENCE
(2017)