Review
Medicine, Research & Experimental
Xinyuan Wang, Yizhi Xiao, Wencheng Song, Lanxiang Ye, Chen Yang, Yuzhen Xing, Zhenglin Yuan
Summary: This article discusses the significance and effects of pulp treatment, focusing on the applications of several common calcium silicate-based bioceramics in endodontic treatment and comparing their efficacy in human trials.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Materials Science, Ceramics
Carolyn Primus, James L. Gutmann, Franklin R. Tay, Anna B. Fuks
Summary: Calcium silicate cements and calcium aluminate cements are considered excellent materials in dentistry, promoting biomineralization and aiding in the repair of teeth.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2022)
Article
Engineering, Biomedical
Chen Qin, Hongjian Zhang, Lei Chen, Meng Zhang, Jingge Ma, Hui Zhuang, Zhiguang Huan, Yin Xiao, Chengtie Wu
Summary: To achieve regeneration of highly vascularized and innervated tissues, a pre-angiogenic cell-laden scaffold with durable angiogenic functions is prepared. The scaffold supports long-term cell survival and growth, and exhibits durable angiogenic capability both in vitro and in vivo. The pre-angiogenic scaffolds can induce the neurogenetic differentiation and osteogenic differentiation, and may represent the future direction of biomaterials for complex tissue/organ regeneration.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Fupo He, Chao Qiu, Teliang Lu, Xuetao Shi, Jiandong Ye
Summary: In this study, tricalcium phosphate (TCP) bioceramics were modified by gallium doping in conjunction with incorporation of calcium silicate (CS). The results showed that the incorporation of CS promoted the transition and densification process of the bioceramics, and reduced the inhibition effect of gallium on osteoblast activities while maintaining its effect on restraining osteoclast activities.
BIOMEDICAL MATERIALS
(2022)
Review
Chemistry, Physical
Linh B. Truong, David Medina Cruz, Ebrahim Mostafavi, Catherine P. O'Connell, Thomas J. Webster
Summary: Bioceramic scaffolds functionalized with photothermal materials offer a dual approach to osteosarcoma treatments, killing cancer cells while promoting healthy bone tissue regeneration. The use of 3D printing for bioceramic scaffold production provides a sustainable, highly reproducible, and scalable method.
Article
Materials Science, Ceramics
Michal Hicak, L'ubomir Medvecky, Miroslav Hnatko, Radoslava Stulajterova, Maria Giretova, Monika Tatarkova, Zoltan Lences, Pavol Sajgalik
Summary: The addition of highly porous silicon nitride/alpha-tricalcium phosphate microgranules improved the tetracalcium phosphate/monetite biocement, serving as a potential carrier for drug release. By adjusting the amount of drug-infiltrated ceramic granules, the total drug release time can be modified.
INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY
(2022)
Article
Materials Science, Ceramics
Se Woong Lee, Okmin Park, Seungmin Kang, Hyung Tay Rho, Sang-il Kim
Summary: Mineral trioxide aggregate (MTA) is a bioactive endodontic material with biocompatibility, high strength, and good sealing ability, widely used in root canal therapy. This study investigated the physicochemical properties of MTA depending on the ratio of tricalcium silicate (C3S) and dicalcium silicate (C2S), and found that MTA with higher C2S content has lower solubility and better flowability.
JOURNAL OF THE KOREAN CERAMIC SOCIETY
(2023)
Review
Biology
Mauro Schmitz Estivalet, Lucas Peixoto de Araujo, Felipe Immich, Adriana Fernandes da Silva, Nadia de Souza Ferreira, Wellington Luiz de Oliveira da Rosa, Evandro Piva
Summary: This study aimed to synthesize and map key concepts related to the bioactivity analysis of bioceramic-based root canal sealers through in vitro and in vivo studies. The results showed that common methods in vitro included mineralization potential, formation of carbonated apatite on the surface, and gene expression, while in vivo studies mainly utilized staining techniques and immunohistochemical tests to detect mineralization.
Article
Materials Science, Multidisciplinary
Daniil Golubchikov, Tatiana V. Safronova, Elizaveta Nemygina, Tatiana B. Shatalova, Irina N. Tikhomirova, Ilya V. Roslyakov, Dinara Khayrutdinova, Vadim Platonov, Olga Boytsova, Maksim Kaimonov, Denis A. Firsov, Konstantin A. Lyssenko
Summary: Synthesis from mixed-anionic aqueous solutions is a novel approach to obtain active powders for bioceramics production. The phase compositions of the powders include brushite, calcium silicate hydrate, and an amorphous phase containing hydrated quasi-amorphous calcium phosphate and calcium silicate. The ceramic samples obtained from the powders exhibit different densities and contain biocompatible and bioresorbable phases.
Review
Chemistry, Physical
Khalid S. Almulhim, Mariam Raza Syed, Norah Alqahtani, Marwah Alamoudi, Maria Khan, Syed Zubairuddin Ahmed, Abdul Samad Khan
Summary: This review article introduces the application of bioceramics in dental restorations. Despite their similar chemical composition to human hard tissues and excellent bioactive and biological properties, concern has been raised regarding the mechanical properties of bioceramics. Dental materials must be biocompatible, long-lasting, mechanically strong enough, wear-resistant, easily manipulated, and implanted.
Article
Pharmacology & Pharmacy
Yayoi Kawano, Shiyang Chen, Takehisa Hanawa
Summary: The study focused on enhancing the solubility of ibuprofen by adsorbing it onto spherical porous calcium silicate. Both evaporation and sealed heating methods were effective in amorphizing ibuprofen and improving its solubility, with the sealed heating method showing a higher dissolution rate compared to the evaporation method.
Article
Dentistry, Oral Surgery & Medicine
Sang Won Kwak, Jina Koo, Minju Song, Il Ho Jang, Gianluca Gambarini, Hyeon-Cheol Kim
Summary: The aim of this study was to compare the physicochemical properties and biocompatibility between various calcium silicate-based bioceramic sealers (CSBSs) and the epoxy resin-based sealer AH Plus (AHP). The physical properties of CSBSs, including flow, setting time, radiopacity, dimensional stability, and pH, were evaluated according to the ISO 6876 standards. The biocompatibility of CSBSs was found to be higher than that of AHP, as assessed through cytotoxicity and cell attachment assays.
JOURNAL OF ENDODONTICS
(2023)
Article
Engineering, Biomedical
Claire Guillet, Ulrik Birgersson, Thomas Engstrand, Jonas aberg, Viviana R. Lopes, Andreas Thor, Hakan Engqvist, Franck Forterre
Summary: This study explores bone neoformation beyond the skeletal envelope using a collagen pouch filled with calcium phosphate granules placed over the frontal bone in sheep. The results show colonization of the implant by newly formed bone and fibrous connective tissue. The use of a collagen sleeve as a container for calcium phosphate granules allows for good neoformation and bridging bone formation between the test article and recipient bone. This method opens new perspectives for bone augmentation and treatment of cranio-maxillofacial defects and malformations.
BIOMEDICAL MATERIALS
(2023)
Article
Materials Science, Ceramics
Nayarit A. Mata, Patricia Ros-Tarraga, Pablo Velasquez, Angel Murciano, Piedad N. De Aza
Summary: The sol-gel process combined with the polymer sponge replicate technique was used to obtain materials with different phases. The versatile sol-gel process allowed for the coating of the core material with additional phases, resulting in multilayer scaffolds. The accelerated bioactivity and properties of the multiphase and multilayer scaffolds demonstrate their potential in tissue engineering.
BOLETIN DE LA SOCIEDAD ESPANOLA DE CERAMICA Y VIDRIO
(2022)
Review
Engineering, Biomedical
Matheus C. Tronco, Julia B. Cassel, Luis A. dos Santos
Summary: This review paper focuses on the synthesis and properties of alpha-tricalcium phosphate (alpha TCP), a promising material for bone repair and substitution. It discusses the complexity of alpha TCP synthesis, the impact of synthesis parameters on material properties, and provides guidance for selecting the most suitable process for each application.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Xiao-Fan Hu, Lin Wang, Geng Xiang, Wei Lei, Ya-Fei Feng
ACTA BIOMATERIALIA
(2018)
Article
Multidisciplinary Sciences
Faqi Wang, Lin Wang, Yafei Feng, Xiaojiang Yang, Zhensheng Ma, Lei Shi, Xiangyu Ma, Jian Wang, Tiancheng Ma, Zhao Yang, Xinxin Wen, Yang Zhang, Wei Lei
SCIENTIFIC REPORTS
(2018)
Article
Materials Science, Biomaterials
Xiao-Fan Hu, Ya-Fei Feng, Geng Xiang, Wei Lei, Lin Wang
JOURNAL OF MATERIALS CHEMISTRY B
(2018)
Article
Cell Biology
Libin Xu, Yu Zhang, Zhenguo Zhao, Zhengju Chen, Zheng Wang, Songfeng Xu, Xinxin Zhang, Ting Liu, Shengji Yu
Article
Endocrinology & Metabolism
Xinxin Zhang, Xiying Yu, Zhenguo Zhao, Zhennan Yuan, Peiqing Ma, Zhibin Ye, Liping Guo, Songfeng Xu, Libin Xu, Ting Liu, Huanmei Liu, Shengji Yu
Article
Medicine, Research & Experimental
Songfeng Xu, Ting Liu, Xinxin Zhang, Huanmei Liu, Zhenguo Zhao, Libin Xu, Shengji Yu
Summary: The study retrospectively evaluated the efficacy of fluoroscopy-guided percutaneous vertebroplasty (PVP) for osteoblastic spinal metastases pain relief. The results showed that PVP is effective in reducing pain, improving quality of life, with main complications being bone cement leakage and incomplete pain relief in some cases.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Engineering, Biomedical
SongFeng Xu, Hang Zhang, Xiang Li, XinXin Zhang, HuanMei Liu, Yinze Xiong, RuiNing Gao, ShengJi Yu
Summary: The porous beta-TCP ceramic printed by a digital light processing system exhibits good biocompatibility and osteogenicity, showing high potential for special applications in bone repair. The study demonstrates excellent mechanical properties and cell culture performance of the porous ceramic.
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE
(2021)
Article
Orthopedics
Shuguang Zhang, Changyou Jing, Huanmei Liu, Zhenguo Zhao, Xinxin Zhang, Ting Liu, Songfeng Xu, Libin Xu, Shengji Yu
Summary: The study found that the most important clinical variables affecting the survival of Epithelioid Sarcoma (ES) patients were R0 resection margin and tumor size. R0 resection margin was the only prognostic factor for influencing the LRFS and DMFS.
JOURNAL OF ORTHOPAEDIC SURGERY
(2021)
Article
Oncology
Shuguang Zhang, Xinxin Zhang, Zhenguo Zhao, Libin Xu, Songfeng Xu, Ting Liu, Shengji Yu
Summary: The study aims to investigate the factors affecting the survival rate in patients with undifferentiated pleomorphic sarcoma (UPS), and found some prognostic markers related to the survival rate through a retrospective analysis.
TRANSLATIONAL CANCER RESEARCH
(2022)
Article
Engineering, Biomedical
Zimei Wu, Qiaodan Hou, Tingting Chen, Xingzhu Jiang, Lulu Wang, Jing Xu, Lin Wang
Summary: This study demonstrated the therapeutic potential of ROS-reactive PMS/PC in treating bone fragility and fracture risk in long-standing diabetes mellitus cases. The PMS/PC system released PC to eliminate excessive ROS, achieving dynamic ROS regulation and maintaining ROS homeostasis. Furthermore, PMS/PC promoted angiogenesis-osteogenesis coupling to enhance bone formation and prevent vascular oxidative stress.
Article
Cell Biology
Laihua Fu, Songfeng Xu, Yang Zhou, Jingyang Huang, Jin Qiu, Pengzhou Huang
Summary: LncRNA DICER1-AS1 is highly expressed in osteosarcoma and affects the cell cycle. It binds with CDC5L, inhibiting its nuclear transfer and suppressing cell proliferation while inducing apoptosis. DICER1-AS1 may serve as a novel target for osteosarcoma treatment.
CONNECTIVE TISSUE RESEARCH
(2023)
Review
Oncology
Songfeng Xu, Shihjye Tan, Ling Guo
Summary: Patient-derived sarcoma organoids (PDSOs) are a new and promising tool for treating sarcomas, providing personalized treatment decisions and helping to discover new biomarkers and treatment options. By mimicking the complexity of a patient's tumor, PDSOs improve patient outcomes and revolutionize sarcoma management.
Article
Materials Science, Biomaterials
Zijie Wang, Tingting Chen, Zimei Wu, Xingzhu Jiang, Qiaodan Hou, Sikai Miao, Ruihao Xia, Lin Wang
Summary: This study investigates the effects of melatonin on the titanium-bone interface in diabetic conditions. The results show that the nanofiber coating created using PLGA@MT-Ti promotes osteogenesis and osteointegration by activating the BMP-4/WNT pathway and attenuating ROS overproduction. This provides a novel strategy for biomaterial modification and biofunctionalization under diabetic conditions.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Meeting Abstract
Cell & Tissue Engineering
L. Wang
TISSUE ENGINEERING PART A
(2017)
