Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 104, Issue 5, Pages 583-591Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2010.01.011
Keywords
Antitumor activity; Benzoxazole; Transition metal complexes; DNA intercalation
Funding
- NSFC [20771048, 20931003, 20621091]
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A new ligand 2((2-((benzo[d]oxazol-2-yl)methoxy)phenoxy)methyl)benzoxazole (L) and its four transition metal complexes M(NO3)(2)L (M = Cu, Co, Ni, Zn), have been synthesized and investigated. The single crystal structures of the complexes show that all of them have similar molecular structure and the ligand exhibits good coplanarity after coordination with the metal ions. Further investigation of DNA binding indicates that both the ligand L and the complexes can bond to DNA by intercalation mode, and the latter possesses much stronger binding affinity. Antitumor activity of these compounds tested on the four cancer cell lines, follows the order: Cu-L > Ni-L approximate to Co-L > Zn-L approximate to L, which are thought to be related with their DNA-binding affinity. (C) 2010 Elsevier Inc. All rights reserved.
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