Article
Engineering, Environmental
Xu Chai, Huaqi Dong, Zenggao Zhang, Zhaoyang Qi, Jie Chen, Zhixian Huang, Changshen Ye, Ting Qiu
Summary: A novel Zr-based metal-organic framework (UiO-66-DMP) was synthesized as an excellent adsorbent for mercury removal. UiO-66-DMP exhibited high specific surface area and multiple adsorption sites, achieving high selectivity and the highest reported Hg(II) adsorption capacity to date.
JOURNAL OF WATER PROCESS ENGINEERING
(2022)
Article
Materials Science, Multidisciplinary
M. Gonzalez-Ildelfonso, J. Escobar, E. Gordillo-Cruz, P. del Angel, V. A. Suarez-Toriello, J. A. De los Reyes
Summary: In this study, researchers successfully achieved deep removal of refractory dibenzothiophene using catalysts supported on Al2O3 with noble metal modification. Calcined catalysts showed better catalytic activity, while Ru-doped catalysts were detrimental to catalytic activity when not calcined before activation.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Chemistry, Physical
Benedicto A. V. Lima, Jaldyr de J. G. Varela Jr, Javier Ellena, Alzir A. Batista, Alberico B. F. da Silva, Rodrigo S. Correa
Summary: Reactions of cis-[RuCl2(P-P)(bipy)] precursors with the SpymMe2 ligand yielded complexes of the [Ru(SpymMe2)(P-P)(bipy)]PF6 type. The structures of the complexes were characterized and analyzed using various techniques, including spectroscopy, electrochemical analysis, elemental analysis, and single-crystal X-ray diffraction. Theoretical studies were also conducted using the DFT/B3LYP method, which helped to explain the stability and properties of the complexes compared to the precursors. The results showed the importance of coordination and ligand positioning in determining the stability and properties of the complexes.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Namik Ozdemir, Funda Dogan Karabekmez, Emine Ozge Karaca, Nevin Gurbuz, Ismail Ozdemir
Summary: A new N-coordinated benzimidazole ruthenium(II) complex was successfully synthesized and fully characterized using FT-IR, 1H and 13C NMR spectroscopy. The molecular structure was confirmed through X-ray crystallography. Theoretical structure and spectroscopic data were obtained using density functional theory and compared with experimental results. The complex exhibited activity in the N-alkylation of aromatic amines with arylmethyl alcohols under neat conditions in the presence of KOBut. (c) 2023 Elsevier B.V. All rights reserved.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
Malgorzata Fabijanska, Maria M. Kasprzak, Justyn Ochocki
Summary: The study found that ruthenium compounds can partially or completely overcome the resistance to platinum drugs by activating apoptosis pathways and inducing loss of mitochondrial membrane potential, while platinum compounds have cytostatic effects requiring longer exposure time. Additionally, cisplatin-resistant cells have higher glutathione levels compared to sensitive cells, indicating mechanisms to evade apoptosis caused by DNA damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Piotr Swiatek, Teresa Glomb, Agnieszka Dobosz, Tomasz Gebarowski, Kamil Wojtkowiak, Aneta Jezierska, Jaroslaw J. Panek, Malgorzata Swiatek, Malgorzata Strzelecka
Summary: Chronic inflammation plays a significant role in major human diseases, with prostaglandin E-2 and COX activator being implicated in tumor growth. Existing anti-inflammatory drugs have limitations, thus the development of new compounds with potential anticancer activity and safety is necessary.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Monica Martinez-Estevez, Soledad Garcia-Fontan, Saray Argibay-Otero, Inmaculada Prieto, Ezequiel M. Vazquez-Lopez
Summary: In this study, the reaction between [Ru2Cl2(mu-Cl)(2)(eta(6)-p-cymene)(2)] and two thiosemicarbazones was investigated. The resulting cationic complexes were isolated and characterized. The study revealed the presence of two isomers in the triflate salts and only one isomer in the chloride. X-ray crystallography confirmed this finding. The coordination of the thiosemicarbazone ligand to the ruthenium center was also demonstrated.
Article
Chemistry, Inorganic & Nuclear
Pragti, Sreshtha Nayek, Satyam Singh, Avinash Sonawane, Ivo Grabchev, Rakesh Ganguly, Suman Mukhopadhyay
Summary: In this study, three Ru(II) arene complexes with a bidentate benzimidazole-based ligand were synthesized and their antitumor activity was studied by varying the co-ligand X. The synthesized compounds showed good interactions with serum albumin proteins, had good drug stability and lipophilic character. They were found to bind with DNA and could induce apoptosis in cancer cells, as well as upregulate cleaved caspase-3 expression and downregulate BCLXL expression. These findings provide a new direction for the investigation of antitumor ruthenium-based metallodrugs using benzimidazole-based ligands.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Zhen-Fang Zeng, Qiu-Ping Huang, Jie-Hui Cai, Guang-Jin Zheng, Li-Jin Qin, Qiu-Chan Huang, You-Huan Wei
Summary: A novel copper (II) complex was successfully synthesized and characterized for its binding properties with CT-DNA and HSA. The complex exhibited intercalative bindings with CT-DNA and HSA, resulting in fluorescence quenching. In vitro assays showed the complex's superior anti-proliferative effects on various cancer cell lines compared to cisplatin, with dose- and time-dependent induction of apoptosis/necrosis and cell cycle arrest at G0/G1 phase in HepG2 cells.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Fortuna Ponte, Stefano Scoditti, Pierraffaele Barretta, Gloria Mazzone
Summary: A combined quantum-mechanical and classical molecular dynamics study was conducted on a Ru-(II) complex with potential dual anticancer action. The complex demonstrated the ability to function as a single oxygen generator and intercalating agent. Computational results suggested that the complex could generate O-1(2) for photodynamic therapy and establish reversible electrostatic interactions with DNA bases.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Stephen Mensah, Joseph D. Rosenthal, Mamta Dagar, Tyson Brown, Jonathan J. Mills, Christopher G. Hamaker, Gregory M. Ferrence, Michael I. Webb
Summary: The evolution of high virulence bacterial strains has led to the development of novel therapeutic agents. Metal-based therapeutics, with their structural variability and unique modes of action, show great promise. This study focused on the preparation and evaluation of ruthenium(ii)-arene complexes containing Schiff base ligands with an attached ferrocene, and identified a complex with prominent activity against clinically relevant bacterial strains.
DALTON TRANSACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Gregory F. Grawe, Katia M. Oliveira, Celisnolia M. Leite, Tamires D. de Oliveira, Analu R. Costa, Carlos A. F. Moraes, Joao Honorato, Marcia R. Cominetti, Eduardo E. Castellano, Rodrigo S. Correa, Sergio P. Machado, Alzir A. Batista
Summary: This study reports on three new ruthenium(II) complexes and their cytotoxicity against lung and breast cancer cell lines. The results show that these complexes have potential as anticancer agents, with better selectivity than cisplatin. The complexes also exhibit interactions with DNA and human serum albumin, indicating their promising therapeutic effects.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Keerthika Kumarasamy, Tamiloli Devendhiran, Shibu Marthandam Asokan, Ramasamy Mahendran, Mei-Ching Lin, Wei-Jyun Chien, Selva Kumar Ramasamy, Chih-Yang Huang
Summary: A new half-sandwich benzimidazole-based Ru(II) complex has been successfully synthesized and fully characterized. Cell experiments showed that the complex exhibited significant cytotoxicity against human hepatoma, breast cancer, and non-small cell lung cancer cell lines, which was associated with increased mitochondrial reactive oxygen species accumulation.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Urszula K. Komarnicka, Sandra Koziel, Agnieszka Skorska-Stania, Agnieszka Kyziol, Francesco Tisato
Summary: In this study, new complexes based on ruthenium(II) and iridium(III) with phosphine ligands and phenyl rings with/without methoxy motifs were synthesized and characterized. The complexes showed high catalytic efficiency in the oxidation of NADH to NAD(+) and exhibited potential applications in biological and medical fields. Furthermore, they demonstrated redox activity and significant cytotoxicity against various cancer cell lines.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Raphael T. Ryan, Dmytro Havrylyuk, Kimberly C. Stevens, L. Henry Moore, Sean Parkin, Jessica S. Blackburn, David K. Heidary, John P. Selegue, Edith C. Glazer
Summary: The beta-diketone scaffold, a commonly used synthetic intermediate, showed promising structure-dependent cytotoxicity in constructing Ru(II) complexes, suggesting the potential for future drug development.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Engineering, Biomedical
Cesar Augusto Roque-Borda, Mauro de Mesquita Souza Saraiva, Wagner Dias Macedo Junior, Jose Carlos Estanislao Marquez Montesinos, Andreia Bagliotti Meneguin, Anna Beatriz Toledo Borges, Edson Crusca Junior, Saulo Santesso Garrido, Adriana Maria de Almeida, Reinaldo Marchetto, Marlus Chorilli, Angelo Berchieri Junior, Silvio Rainho Teixeira, Fernando Rogerio Pavan, Eduardo Festozo Vicente
Summary: The incorrect use of conventional drugs for intestinal infections has led to the spread of bacterial resistance. Antimicrobial peptide Ctx(Ile21)-Ha has shown effective antimicrobial activity against multidrug-resistant bacteria. However, direct oral application is not feasible due to gastrointestinal degradation. In this study, alginate microparticles loaded with Ctx(Ile21)-Ha peptide were designed to protect it and release it in the intestine, providing a potential solution for combating intestinal pathogens.
Article
Biochemistry & Molecular Biology
Carlos Y. Fernandez, Natalia Alvarez, Analu Rocha, Javier Ellena, Antonio J. Costa-Filho, Alzir A. Batista, Gianella Facchin
Summary: A series of new copper complexes were synthesized and characterized for their potential as antitumor drugs. The experimental results showed that these complexes exhibited good cytotoxicity in solid state and solution, making them potential candidates for the treatment of aggressive tumors with no curative pharmacological treatment.
Article
Chemistry, Inorganic & Nuclear
Henrique Vieira Reis Silva, Guilherme Alvaro Ferreira da Silva, Bruno Zavan, Rafael Pereira Machado, Joao Honorato de Araujo-Neto, Javier Alcides Ellena, Marisa Ionta, Marilia Imaculada Fraza, Antonio Carlos Doriguetto
Summary: A series of new ruthenium complexes were synthesized and characterized. These complexes interacted with DNA and human serum albumin and exhibited cytotoxicity against various cancer cells. One of the complexes showed higher toxicity against melanoma cells, inhibited clonogenic capacity, induced cell cycle arrest, and triggered apoptosis through the production of reactive oxygen species.
Article
Chemistry, Physical
Rafael R. Domeneguetti, Vanessa Y. Sakai, Gustavo F. Perotti, Isabel C. Silva, Agnieszka Tercjak, Hernane S. Barud, Fernando Pavan, Vera R. L. Constantino, Sidney J. Ribeiro
Summary: The effect of different concentrations of Laponite on the structure and properties of bacterial cellulose (BC) membranes was investigated. It was found that an appropriate amount of Laponite can improve the transparency and properties of BC membranes. This opens up new possibilities for the application of nanocomposites in the fields of medical, pharmaceutical, and cosmetics.
APPLIED CLAY SCIENCE
(2023)
Article
Chemistry, Medicinal
Guilherme F. S. Fernandes, Karyn F. Manieri, Andressa F. Bonjorno, Debora L. Campos, Camila M. Ribeiro, Fernanda M. Demarqui, Daniel A. G. Ruiz, Nailton M. Nascimento-Junior, William A. Denny, Andrew M. Thompson, Fernando R. Pavan, Jean L. Dos Santos
Summary: New carbamate derivatives showed potent antimicrobial activity against multidrug-resistant strains of M. tuberculosis with minimal toxicity to host cells and other microorganisms. Molecular docking studies indicated that these compounds may interact with the nitroreductase in a similar manner to pretomanid. These findings highlight the potential of imidazo[2,1-b][1,3]oxazine derivatives in treating multidrug-resistant tuberculosis.
Article
Biochemistry & Molecular Biology
Renan C. F. Leitao, Francisco Silva, Gabriel H. Ribeiro, Isabel C. Santos, Joana F. Guerreiro, Filipa Mendes, Alzir A. Batista, Fernando R. Pavan, Pedro Ivo da S. Maia, Antonio Paulo, Victor M. Deflon
Summary: Gallium and indium octahedral complexes with isoniazid derivative ligands were successfully synthesized. The complexes showed moderate affinity with human serum albumin through hydrophobic interactions. The complexes with H2L2 exhibited higher cytotoxicity against MCF-7 cells, as well as stronger accumulation in MCF-7 and PC-3 cells compared to the non-halogenated complexes. The ligands and metal complexes also demonstrated potent growth inhibitory effects against Mycobacterium tuberculosis.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Wilton R. Lustri, Silmara C. Lazarini, Nayara Ap Simei Aquaroni, Flavia A. Resende, Nadia A. Aleixo, Douglas H. Pereira, Bruna Cardinali Lustri, Cristiano Gallina Moreira, Camila M. Ribeiro, Fernando R. Pavan, Douglas H. Nakahata, Adriano M. Goncalves, Nailton M. Nascimento-Junior, Pedro P. Corbi
Summary: This article describes the in vitro antibacterial activity and beta-lactamase inhibition of a novel silver(I) complex with the sulfonamide probenecid (Ag-PROB). The Ag-PROB complex showed significant growth inhibitory activity against various bacteria, including multi-drug resistant uropathogenic E. coli and ESBL-producing bacteria. Molecular docking results suggested the potential molecular mechanism of ESBL inhibition by Ag-PROB. These findings highlight the potential of Ag-PROB as a promising antibacterial agent.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Raphael Tristao Cruvinel Silva, Micaela Guidotti-Takeuchi, Jessica Laura Miranda Peixoto, Fernanda Manaia Demarqui, Ananda Paula Mori, Carolyne Ferreira Dumont, Gabriella Rayane Aparecida Ferreira, Gabriele de Menezes Pereira, Daise Aparecida Rossi, Pedro Paulo Corbi, Fernando Rogerio Pavan, Celso de Oliveira Rezende Junior, Roberta Torres de Melo, Wendell Guerra
Summary: This work presents the synthesis, characterization, and antimicrobial activity of four palladium(II) complexes. The complexes showed high antimicrobial activity against Mycobacterium tuberculosis H37Rv strain and Campylobacter jejuni. Complex 2 exhibited the highest activity with a minimum inhibitory concentration (MIC) of 3.28 mu g/mL against M. tuberculosis. Complex 1 significantly reduced the bacterial population and biomass intensity of C. jejuni.
Article
Biochemistry & Molecular Biology
Joyce C. Oliveira, Renato L. de Carvalho, Hugo G. S. Sampaio, Joao Honorato, Javier A. Ellena, Felipe T. Martins, Joao V. M. Pereira, Pedro M. S. Costa, Claudia Pessoa, Rafaela S. Ferreira, Maria H. Araujo, Claus Jacob, Eufranio N. da Silva Junior
Summary: Our research group successfully combined two redox centres (ortho-quinone/para-quinone or quinone/selenium-containing triazole) through a copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction, leading to significant anticancer activity. We synthesized 15 new quinone-based derivatives and evaluated their efficacy in nine cancer cell lines and the fibroblast line L929. Our study confirmed the effectiveness of A-ring functionalized para-quinones coupled with ortho-quinones in obtaining diverse two redox centre compounds with potential applications against cancer.
Review
Microbiology
Giulia Polinario, Laura Maria Duran Gleriani Primo, Maiara Alane Baraldi Cerquetani Rosa, Freddy Humberto Marin Dett, Paula Aboud Barbugli, Cesar Augusto Roque-Borda, Fernando Rogerio Pavan
Summary: Tuberculosis and lung cancer are closely related diseases with similar symptoms. Patients with active pulmonary tuberculosis are more likely to develop lung cancer. Therefore, it is crucial to monitor patients after recovery and explore combined therapies to treat both diseases, as well as address the issue of drug resistance.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Crystallography
Paulo Nunes, Pedro Henrique de Oliveira Santiago, Cecilia Carolina Pinheiro da Silva, Javier Ellena
Summary: Drug repurposing offers advantages over traditional drug development, particularly with the emergence of the global COVID-19 pandemic. Known drugs like acyclovir have shown efficacy against COVID-19. However, acyclovir's low permeability and limited water solubility pose challenges. This study presents two new salts of acyclovir aimed at improving its pharmacokinetic properties.
Article
Pharmacology & Pharmacy
Natalia Alvarez, Analu Rocha, Victoria Collazo, Javier Ellena, Antonio J. J. Costa-Filho, Alzir A. A. Batista, Gianella Facchin
Summary: Coordination complexes can serve as anticancer agents by enhancing ligand uptake by cancer cells. In this study, the complex Cu-dipicolinate was used as a neutral scaffold to form ternary complexes with diimines, which exhibited strong cytotoxicity towards human cancer cells and high DNA binding affinity.
Article
Chemistry, Multidisciplinary
Marianna C. Silva, Gracielle Cunha, Pollyana Firmino, Loide O. Sallum, Antonio Menezes, Jocely Dutra, Joao de Araujo-Neto, Alzir A. Batista, Javier Ellena, Hamilton B. Napolitano
Summary: The Cerrado biome, as the largest tropical savanna, has a lack of scientific discussion and evidence about the medicinal use of its plants. This study successfully extracted, purified, and characterized 3-O-methylquercetin from Strychnos pseudoquina, and tested its anti-proliferative activity and selectivity against different tumor cell lines. The structural differences of 3-O-methylquercetin were found to influence its activity and selectivity.
Article
Chemistry, Inorganic & Nuclear
Marilia I. F. Barbosa, Rodrigo S. Correa, Adriana P. M. Guedes, Alex M. Graca, Francyelli M. Andrade, Celisnolia M. Leite, Elisangela P. Silveira-Lacerda, Javier Ellena, Henrique V. Reis, Antonio C. Doriguetto, Alzir A. Batista
Summary: Herein, we report on the synthesis and characterization of ruthenium compounds with different amino acids as ligands. The complexes were characterized using various techniques and the structures of two compounds were determined using X-ray diffraction. In vitro evaluation showed that these compounds exhibited cytotoxic activities against triple-negative breast cancer cells and inhibited their migration. Therefore, these compounds may be promising drug candidates for the treatment of triple-negative breast cancer.
Article
Chemistry, Inorganic & Nuclear
Carlos Y. Fernandez, Analu Rocha, Mohammad Azam, Natalia Alvarez, Kim Min, Alzir A. Batista, Antonio J. Costa-Filho, Javier Ellena, Gianella Facchin
Summary: In this study, three copper(II) carboxylate complexes were synthesized and characterized. The complexes showed DNA binding capability and exhibited cytotoxic activity against cisplatin-resistant cancer cells.
Article
Biochemistry & Molecular Biology
Michael Ramek, Jasmina Sabolovic
Summary: This paper investigates the geometries, energy landscapes, and magnetic parameters of copper(II) amino acid compounds using density functional theory calculations. The results show that certain conformers with histaminate-like and glycine-like modes have low Gibbs free energies and high metal-binding affinities. The predicted conformations reproduce the experimental electron paramagnetic resonance parameters.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Wei Tian, Wen Zhong, Zengyan Yang, Ling Chen, Shijie Lin, Yanping Li, Yuxing Wang, Peilin Yang, Xing Long
Summary: A series of novel dibutyltin complexes based on salen-like ligands were synthesized and characterized. Complex S03 showed excellent in vitro anticancer activity and induced cancer cell death through multiple mechanisms. This study reveals new mechanisms of organotin complexes and provides new insights into the development of organotin metal complexes as anticancer drugs.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Natalie C. Korkola, Martin J. Stillman
Summary: Many proteins require a metal cofactor for their function, and these metals play a role in protein folding. The study found that the metallation rates of different metal binding pathways are influenced by pH, with the less cooperative pathway being more affected by low pH conditions. Specific mixtures of structures are formed in the initial steps of metallation, and unfolding the disordered apo-MT structure hinders the formation of these preliminary structures. The compact conformation of the native apo-MT allows for rapid formation of metal-thiolate structures with high affinity, providing protection from oxidation.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Boxuan Yang, Xitong Song, Binju Wang
Summary: The diiron active site plays a crucial role in catalytic transformations in both biological and chemical systems. Recent advancements in the field include the synthesis of biomimetic diiron catalysts inspired by the active structure of soluble methane monooxygenase (sMMO), which have been successfully applied to the dehydrogenation of indolines.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Christina N. Banti, Angeliki A. Piperoudi, Catherine P. Raptopoulou, Vassilis Psycharis, Constantinos M. Athanassopoulos, Sotiris K. Hadjikakou
Summary: Two copper(I) polymorphs with mitochondria-targeting properties were successfully prepared via metal ion conjugation. These compounds showed promising activities in DNA binding, enzyme inhibition, and cancer cell inhibition. The molecular mechanisms of action were investigated.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
