Article
Chemistry, Inorganic & Nuclear
Jan Hormann, Olga Verbitsky, Xiaoyu Zhou, Beatrice Battistella, Margarete van der Meer, Biprajit Sarkar, Cunyuan Zhao, Nora Kulak
Summary: We synthesized and characterized Cu(ii) complexes CuL1-CuL6 with cyclen-based ligands. The ligands L-1-L-6 comprise different donor sets including S and O atoms. The substitution of N donor atoms with hard donor O atoms leads to efficient oxidative nucleases, but dissociation of the complex upon reduction. We are showing that the rational combination of O and S atoms next to two nitrogen donors within the macrocycle leads to the stabilization of both redox states, resulting in the highest oxidative DNA cleavage activity within this family of cyclen-based Cu(ii) complexes.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Himadri Priya Gogoi, Anmol Singh, Pranjit Barman, Diganta Choudhury
Summary: A series of Cu(II), Zn(II), and Cd(II) complexes coordinated with a new Schiff base ligand (L1) were synthesized and characterized. The ligand exhibited strong DNA binding ability, while the Cd(II) complex showed better antibacterial properties.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Fayezeh Samari, Bahram Hemmateenejad, Santiago Aparicio, Mehdi Rashidi, Mojtaba Shamsipur, Sayed Mostafa Hosseini
Summary: The binding interaction between two organoplatinum complexes and calf thymus DNA (CT-DNA) was investigated using various biophysical techniques. The results showed that the complexes exhibited a tight intercalative interaction with CT-DNA, which was confirmed by both experimental and computational studies. These findings suggest that these organoplatinum complexes have potential for cancer therapeutic applications.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Multidisciplinary
Hanan B. Howsaui, Abeer A. Sharfalddin, Magda H. Abdellattif, Amal S. Basaleh, Mostafa A. Hussien
Summary: Novel anti-cancer transition metal complexes were successfully synthesized and characterized using Schiff base derived from 2-aminopyrazine and salicylaldehyde. The complexes exhibited different structures and properties under different metal ions, showing promising anti-cancer activity. The Cu(II) complex showed practical results with HOP-62 cell lines, while the Zn(II) and Co(II) complexes demonstrated non-toxicity at doses up to 370 mg/kg based on LD50 values.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Applied
Emel Karakilic, Zuhal Alim, Mustafa Emirik, Arif Baran
Summary: Two novel metallophthalocyanines were synthesized and characterized for their solubility and properties, including UV-Vis, FT-IR, and NMR. The compounds exhibited strong inhibitory effects on human erythrocyte carbonic anhydrase isoforms, supported by molecular docking studies. The binding interaction of metallophthalocyanines with enzymes was analyzed in detail.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Hossein Farhangian, Ali Nemati Kharat
Summary: A novel method using water as a green solvent was introduced to synthesize two new water soluble Pd complexes. The synthesized complexes were characterized and their interaction with DNA was studied using various spectroscopic techniques. The theoretical study indicated their potential as anti-cancer drugs. Cytotoxic screening showed higher anticancer activity of the complexes against the A2780CP cancer cell line compared to cisplatin.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
Zahra Shabaninejad, Maryam Nikkhah, S. Masoud Nabavizadeh
Summary: The DNA binding capacity and cytotoxic effects of two cycloplatinated complexes (C1 and C2) were evaluated. Both complexes exhibited high DNA binding affinity and were able to quench the fluorescence of ethidium bromide. They also induced DNA viscosity increase, confirming their intercalative interactions with DNA. C2 showed the highest cytotoxicity, particularly on a cisplatin resistant-cell line, and induced apoptosis comparable or higher than cisplatin in all cell lines.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
P. K. Anuja, Priyankar Paira
Summary: The synthesized Ru(ii)-arene complexes showed higher cytoselectivity and potency in cancer cells, with RuL3 complex exhibiting the highest cytoselectivity and DNA intercalative nature, making it suitable for imaging applications.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Ebube E. Oyeka, Ilknur Babahan, Bernard Eboma, Kenechukwu J. Ifeanyieze, Obinna C. Okpareke, Esin P. Coban, Ali Ozmen, Burak Coban, Mehran Aksel, Namik Ozdemir, Tatiana Groutso, Jude Ayogu, Ufuk Yildiz, Mehmet Dincer Bilgin, H. Halil Biyik, Briana R. Schrage, Christopher J. Ziegler, Jonnie N. Asegbeloyin
Summary: The study found that the presence of a morpholine substituent and metal complexation affect the activities of acylthioureas. Metal complexes bind more strongly to DNA compared to ligands, and some compounds have the potential to be developed into novel antimicrobial and anticancer agents.
INORGANICA CHIMICA ACTA
(2021)
Article
Chemistry, Applied
K. Rajeshwari, P. V. Anantha Lakshmi, J. Archana, M. Sumakanth
Summary: Three new water soluble ternary metal complexes were synthesized, characterized, and pharmacodynamically evaluated in this study. Spectral analysis and DNA binding studies revealed their geometry, stability, and potential applications. These complexes showed significant antihyperglycemic activity, with complex 1 exhibiting the highest effect compared to pure drug.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Noha Nabil, Omima M. Adly, Magdy Shebl, Ali Taha, Fatma Samy
Summary: A series of novel octahedral chromone complexes were successfully synthesized. The structures of the complexes were confirmed by various characterization techniques. The synthesized complexes exhibited antimicrobial activity, which correlated well with the molecular docking results.
Review
Chemistry, Physical
Nitesh Kumar, Raj Kaushal, Pamita Awasthi
Summary: Transition metal complexes are widely used therapeutic agents due to their small size, various coordination numbers, geometries, physiologically relevant redox potentials, as well as kinetic and thermodynamic stability. These complexes proved to be potential cytotoxic agents by acting on DNA which stops the replication of DNA and ultimately results in cell death.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Pharmacology & Pharmacy
Burcu Saygideger Demir, Simay Ince, Mustafa Kemal Yilmaz, Aycan Sezan, Ezgi Derinoz, Tugba Taskin-Tok, Yasemin Saygideger
Summary: This study investigates the DNA-binding ability of Pd(II) and Pt(II) complexes of four phosphorus Schiff base ligands and four hydrazonoic-phosphines through in silico analyses and experimental validation. The synthesized Pd(II) complexes with the best DNA-binding potential are further characterized. The antitumor properties of these complexes are demonstrated in vitro in different cancer cells, and the mechanisms of cell death are elucidated.
Article
Chemistry, Applied
Indu Bala, Kiran Singh, Ramesh Kataria, Meena Sindhu
Summary: In this study, a series of metal complexes based on Ni(II), Cu(II), and Zn(II) were synthesized and characterized using various techniques. The results revealed their molecular geometry, intermolecular interactions, chemical reactivity, photophysical properties, and biological activity. The metal complexes showed strong antibacterial and antifungal efficacy, possibly through interactions with proteins.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Abdellatif A. Helaly, Ashraf A. El-Bindary, Shadia A. Elsayed
Summary: Azo dye ligand and its metal chelates were synthesized and characterized. Their binding affinity with DNA, anticancer and antimicrobial activities, as well as their interactions with COVID-19 and prostate cancer receptors, were investigated.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Environmental Sciences
Samavia Batool, Athar Ali Shah, Ahmad Farid Abu Bakar, Mohd Jamil Maah, Nor Kartini Abu Bakar
Summary: The Fe-0-B-RtP and Fe-0-B-Che nanocomposites exhibited good performance in removing OCPs from water, combining advantages of adsorption and dechlorination. Fe-0-B-RtP showed higher removal efficiency after repeated use compared to Fe-0-B-Che.
Article
Chemistry, Inorganic & Nuclear
Cheang Wei Chan, Chin Yoong Yong, How Mun Chang, Pei Ying Ng, Fabian Davamani, Ebenezer Chitra, Vannajan Sanghiran Lee, Kong Wai Tan, Mohd Jamil Maah, Chew Hee Ng
Summary: Copper complexes show promising anticancer properties with increased cytotoxicity towards metastatic breast cancer cells, surpassing the effectiveness of cisplatin. They also demonstrate potential in overcoming drug resistance.
Article
Chemistry, Physical
Jing Wei Lai, Mohd Jamil Maah, Rozie Sarip, Yvonne Ai Lian Lim, Khaw Loke Tim, Chew Hee Ng
Summary: The use of copper in medicine has a long history and copper-containing compounds have multiple applications. In this study, the researchers investigated the mechanisms and structure-activity relationship of a series of copper(II) complexes towards Plasmodium falciparum (Pf). The results showed that these complexes exhibited significant anti-malarial activity.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Physical
Wei Chuen Chan, Min Phin Ng, Chun Hoe Tan, Chee Wei Ang, Kae Shin Sim, Sheena Yin Xin Tiong, Nur Amira Solehah Pungut, Chew Hee Ng, Kong Wai Tan
Summary: A new probe RTPP was developed for the detection of Cu2+ and Al3+, showing color and fluorescence enhancement. The probe exhibited high affinity towards Al3+/Cu2+ with a limit of detection down to at least 10-7 M. The system was successfully used for the colorimetric determination of Cu2+ in water samples and integrated with a smartphone application for on-site qualitative and quantitative analysis. Additionally, RTPP was also used as a sensor for detecting acidic pH change in HCT 116 human colorectal carcinoma cell line.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Lloyd Ling, Ahmed Faris Aldoghachi, Zhi Xiong Chong, Wan Yong Ho, Swee Keong Yeap, Ren Jie Chin, Eugene Zhen Xiang Soo, Jen Feng Khor, Yoke Leng Yong, Joan Lucille Ling, Naing Soe Yan, Alan Han Kiat Ong
Summary: miRNAs in liquid biopsies are considered potential alternatives or complements to breast cancer biomarkers, with the potential to play a significant role in BC management. The utilization of artificial intelligence and machine learning platforms on the big data of miRNAs can help in a more comprehensive assessment of cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Ahmed Faris Aldoghachi, Zhi Xiong Chong, Swee Keong Yeap, Soon Keng Cheong, Wan Yong Ho, Alan Han Kiat Ong
Summary: Cancer recurrence, drug resistance, and metastasis are common challenges in cancer management. The use of stem cells in cancer therapy is gaining popularity as it offers unique tumor-homing activities and anti-cancer properties. This review focuses on the interactions between different stem cell types (including mesenchymal stroma/stem cells, induced pluripotent stem cells, induced pluripotent stem cell-derived mesenchymal stromal cells, and cancer stem cells) and cancer, particularly in terms of paracrine signaling activities, exosomal miRNA interactions, and their therapeutic potential in delivering anti-cancer agents. Furthermore, the role of exosomal miRNA released by cancer stem cells in cancer recurrence and metastasis is discussed, providing insights into their potential use as non-cell-based cancer therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Infectious Diseases
Jing Wei Lai, Mohd Jamil Maah, Kong Wai Tan, Rozie Sarip, Yvonne Ai Lian Lim, Rakesh Ganguly, Loke Tim Khaw, Chew Hee Ng
Summary: The study synthesized copper(II) and zinc(II) complexes and evaluated their anti-malarial potency against drug-sensitive and artemisinin-resistant strains of Plasmodium falciparum. The dinuclear copper(II) complex showed high potency against both strains, overcoming total drug resistance of the artemisinin-resistant strain. The zinc(II) complexes were effective against the drug-sensitive strain but encountered total resistance against the artemisinin-resistant strain. Mechanistic studies showed induction of reactive oxygen species, malarial proteasome inhibition, loss of mitochondrial membrane potential, and morphological features indicative of apoptosis.
Article
Chemistry, Physical
Thales Souza Freire, Ignez Caracelli, Julio Zukerman-Schpector, Ran Friedman
Summary: Gilteritinib is effective in treatment of acute myeloid leukaemia (AML) by inhibiting the FLT3/ITD mutated protein. However, tumour cells develop resistance to gilteritinib due to mutations in the drug target. We used a computer-aided approach to understand the resistance mechanism and found that the mutations F691L and D698N lead to higher activation energy barrier, making mutant enzymes more active. This suggests that tyrosine kinases contribute to resistance against type 1 and type 2 kinase inhibitors.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Wee Li Mah, Xiu Jun Tan, Kar Bee Choo, Shiaw Xian Lee, Kong Wai Tan, Keng Yoon Yeong, Sui Mae Lee, Yuen Lin Cheow
Summary: This study synthesized a series of pyridine-functionalized (benz)imidazolium salts and found that some of the compounds exhibited good antimicrobial and anticancer properties. The use of microwave irradiation significantly reduced the reaction time.
Article
Chemistry, Multidisciplinary
Nur Husnina Nasaruddin, Shahrul Nizam Ahmad, Siti Syaida Sirat, Kong Wai Tan, Nurul Aili Zakaria, Siti Sarra Mohamad Nazam, Nor Mas Mira Abd Rahman, Nor Saadah Mohd Yusof, Hadariah Bahron
Summary: A Schiff base with two methyl substituents, named H2AD1Me, was synthesized and characterized. Complexes [Pd(AD1Me)] and [Ni(AD1Me)] were formed by coordinating the Schiff base with Pd(II) and Ni(II) respectively. The crystal structures of the metal complexes were analyzed, and the involvement of the azomethine nitrogen in the complexation was confirmed by various spectroscopic techniques. The compounds showed no significant antibacterial activity against three bacterial strains.
Article
Chemistry, Physical
Nur Amira Solehah Pungut, Chun Hoe Tan, Hazwani Mat Saad, Kae Shin Sim, Sheena Yin Xin Tiong, Chee Wei Ang, Chun Hau Gan, Kien Voon Kong, Kong Wai Tan
Summary: A new fluorescent sensor, RT4, was synthesized via a one-step reaction between trans-4-(diethylamino)cinnamaldehyde and rhodamine B hydrazide. FT-IR, 1H NMR, 13C NMR, and single crystal X-ray crystallography were used for the characterization of RT4. In aqueous acetonitrile (1:1, v/v pH 7.5), RT4 showed highly selective and sensitive colorimetric and fluorometric responses towards Cu2+ and Fe3+ ions. The calculated limit of detections (LOD) for RT4 with Cu2+ and Fe3+ were 0.20 and 0.18 mu M at lambda abs/em = 555 and 585 nm, respectively. Test strips for colorimetric detection of Cu2+ and Fe3+ were successfully prepared as an on-site test kit. Furthermore, RT4 exhibited low cytotoxicity in human colorectal carcinoma HCT 116 after 24 h in the MTT assay, and it could also serve as a biological fluorescence probe for the detection of Fe3+ in HCT 116 cells according to the fluorescence microscopy experiment.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Article
Polymer Science
Ummie Umaiera Mohd. Johan, Raja Noor Zaliha Raja Abd Rahman, Nor Hafizah Ahmad Kamarudin, Wahhida Latip, Mohd Shukuri Mohamad Ali
Summary: This study successfully immobilized the hyperthermostable carboxylesterase from Anoxybacillus geothermalis D9, improving its stability and reusability. The immobilized enzyme demonstrated broad thermal stability and pH tolerance, as well as improved stability towards various organic solvents. Through immobilization, the enzyme can be reused for up to seven cycles. This study highlights the improvement of operational stability and properties of the immobilized enzyme for practical applications.
Article
Chemistry, Physical
Wahhida Latip, Nur Ezzati Rosli, Mohd Shukuri Mohamad Ali, Nor Hafizah Ahmad Kamarudin, Raja Noor Zaliha Raja Abd Rahman
Summary: In this study, ALDH was successfully immobilized onto Seplite LX120 via physical adsorption and showed improved stability in high temperature and broad pH range. The immobilized ALDH also exhibited good long-term storage stability and reusability. The improved enzyme stability of immobilized ALDH is of great significance for future applications.
Article
Chemistry, Physical
Samah Hashim Albayati, Malihe Masomian, Siti Nor Hasmah Ishak, Adam Thean Chor Leow, Mohd Shukuri Mohamad Ali, Fairolniza Mohd Shariff, Noor Dina Muhd Noor, Raja Noor Zaliha Raja Abd Rahman
Summary: The regioselectivity of lipases allows for the construction of novel molecule units and modifications of fats. Geobacillus zalihae T1 lipase hydrolyzes the sn-1,3 acylglycerol chain. Through mutagenesis, the novel lipase mutant 3M switches the regioselectivity to sn-3. This mutant also alters pH, selectivity, and maintains catalytic efficiency.
Article
Chemistry, Inorganic & Nuclear
Wei Chuen Chan, Min Phin Ng, Chee Wei Ang, Kae Shin Sim, Kong Wai Tan
Summary: A new Schiff base sensor R4P was created by directly combining rhodamine B hydrazide with 4-propoxybenzaldehyde. The structure of this sensor was fully revealed by spectroscopic methods and a single crystal suitable for X-ray diffraction analysis was obtained. The sensor R4P exhibited orange fluorescence enhancement in the presence of Al3+ and a color change to pink when Cu2+ was present. Spectroscopic techniques, including UV, fluorescence, MS, and NMR spectroscopy, were used to study the recognition performance and complexation process of the sensor.
INORGANICA CHIMICA ACTA
(2023)
Article
Biochemistry & Molecular Biology
Michael Ramek, Jasmina Sabolovic
Summary: This paper investigates the geometries, energy landscapes, and magnetic parameters of copper(II) amino acid compounds using density functional theory calculations. The results show that certain conformers with histaminate-like and glycine-like modes have low Gibbs free energies and high metal-binding affinities. The predicted conformations reproduce the experimental electron paramagnetic resonance parameters.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Wei Tian, Wen Zhong, Zengyan Yang, Ling Chen, Shijie Lin, Yanping Li, Yuxing Wang, Peilin Yang, Xing Long
Summary: A series of novel dibutyltin complexes based on salen-like ligands were synthesized and characterized. Complex S03 showed excellent in vitro anticancer activity and induced cancer cell death through multiple mechanisms. This study reveals new mechanisms of organotin complexes and provides new insights into the development of organotin metal complexes as anticancer drugs.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Natalie C. Korkola, Martin J. Stillman
Summary: Many proteins require a metal cofactor for their function, and these metals play a role in protein folding. The study found that the metallation rates of different metal binding pathways are influenced by pH, with the less cooperative pathway being more affected by low pH conditions. Specific mixtures of structures are formed in the initial steps of metallation, and unfolding the disordered apo-MT structure hinders the formation of these preliminary structures. The compact conformation of the native apo-MT allows for rapid formation of metal-thiolate structures with high affinity, providing protection from oxidation.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Boxuan Yang, Xitong Song, Binju Wang
Summary: The diiron active site plays a crucial role in catalytic transformations in both biological and chemical systems. Recent advancements in the field include the synthesis of biomimetic diiron catalysts inspired by the active structure of soluble methane monooxygenase (sMMO), which have been successfully applied to the dehydrogenation of indolines.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Christina N. Banti, Angeliki A. Piperoudi, Catherine P. Raptopoulou, Vassilis Psycharis, Constantinos M. Athanassopoulos, Sotiris K. Hadjikakou
Summary: Two copper(I) polymorphs with mitochondria-targeting properties were successfully prepared via metal ion conjugation. These compounds showed promising activities in DNA binding, enzyme inhibition, and cancer cell inhibition. The molecular mechanisms of action were investigated.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)