Article
Oncology
Qin-Zhi Xiao, Li-Jun Zhu, Zi-Yi Fu, Xi-Rong Guo, Xia Chi
Summary: Obesity is associated with inflammation in adipose tissue, where dysregulation of miR-424 has been linked to metabolic syndromes. The study found that miR-424 expression was increased in adipose tissue of obese children but decreased during adipogenesis in cultured adipocytes. TNF-alpha was shown to downregulate miR-424 expression by binding to its promoter, and bioinformatics analysis revealed target genes involved in adipogenesis pathways like Wnt signaling.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Multidisciplinary Sciences
Cristina Martos-Rus, Goni Katz-Greenberg, Zhao Lin, Eurico Serrano, Diana Whitaker-Menezes, Marina Domingo-Vidal, Megan Roche, Kavitha Ramaswamy, Douglas C. Hooper, Bonita Falkner, Maria P. Martinez Cantarin
Summary: This study reveals that inflammation in adipose tissue contributes to unfavorable metabolic outcomes in uremic patients. The interaction between uremic activated macrophages and adipose tissue exacerbates inflammation in uremia, highlighting the important role of IL-6 in macrophage infiltration in uremia.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Nuria Oliveras-Canellas, Jessica Latorre, Elena Santos-Gonzalez, Aina Lluch, Francisco Ortega, Jordi Mayneris-Perxachs, Jose-Manuel Fernandez-Real, Jose Maria Moreno-Navarrete
Summary: This study investigates the impact of inflammation on iron homeostasis during human adipocyte differentiation and in adipose tissue. The results show that inflammation inhibits adipogenesis and leads to intracellular iron accumulation. Importers of iron, as well as markers of intracellular iron accumulation, were upregulated, while iron exporter-related genes were downregulated in response to inflammation. The findings suggest that induction of adipocyte inflammation disrupts iron homeostasis and results in adipocyte iron overload.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Irina Lousa, Flavio Reis, Alice Santos-Silva, Luis Belo
Summary: Chronic kidney disease is a global public health problem with high morbidity and mortality. Inflammation and inflammatory mediators, such as tumor necrosis factor-related biomarkers, play a role in the development and progression of CKD. Tumor necrosis factor receptors 1 and 2 have been associated with changes in kidney function and injury, and could potentially serve as biomarkers for CKD prognosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Xinming Wang, Chunlan Yang, Heinrich Korner, Chaoliang Ge
Summary: Tumor Necrosis Factor was initially thought to be deadly to cancer cells and tumors, but recent research reveals it primarily functions as a proinflammatory cytokine. Despite this, the search continues for a cytokine that can serve as a one-stop treatment for solid tumors and lymphomas.
Article
Cell Biology
Simona Cataldi, Marianna Aprile, Daniela Melillo, Ines Mucel, Sophie Giorgetti-Peraldi, Mireille Cormont, Paola Italiani, Matthias Blueher, Jean-Francois Tanti, Alfredo Ciccodicola, Valerio Costa
Summary: In this study, it was found that inflammatory factors secreted by metabolically-activated macrophages can modulate the expression and splicing of PPARG, leading to impaired adipocyte differentiation and exacerbating the defective PPAR gamma activity in hypertrophic adipose tissue.
Article
Agriculture, Dairy & Animal Science
Minghe Fan, Xiliang Du, Xiying Chen, Hongxu Bai, Juan J. Loor, Taiyu Shen, Yusheng Liang, Xudong Sun, Qiushi Xu, Yuxiang Song, Zhe Wang, Guowen Liu, Liangyu Yang, Xinwei Li, Xiaobing Li, Wenwen Gao
Summary: The study revealed that cows with clinical ketosis had lower abundance of CIDEC in subcutaneous WAT, and TNF-alpha increased the ratio of p-LIPE to LIPE and p-RELA to RELA, as well as the protein abundance of PNPLA2 and p-NFKBIA, while decreasing the secretion of anti-inflammatory cytokine IL-10.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Wendy A. Goodman, Shrikanth C. Basavarajappa, Angela R. Liu, Franklin D. Staback Rodriguez, Tailor Mathes, Parameswaran Ramakrishnan
Summary: Studies have shown that Sam68 is an important inflammatory driver in experimental colitis, reducing the expression of proinflammatory genes and suggesting that targeting Sam68 may hold promise for treating UC patients.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jin-Nam Kim, Sung Nim Han, Hye-Kyeong Kim
Summary: Black soybean anthocyanin extract (BSAn) alleviates obesity-induced oxidative stress and inflammation, improves lipid metabolic function in hypertrophied 3T3-L1 adipocytes and RAW264.7 macrophages coculture, and enhances insulin sensitivity.
Article
Food Science & Technology
Pei-Ying Huang, Chia-Chien Hsieh
Summary: This study investigated the mechanism of lunasin in regulating immune functions of RAW264.7 macrophages under obesity-related conditions. The findings showed that lunasin protected the vitality of macrophages, suppressed leptin secretion, and reduced inflammation markers in LPS-stimulated co-culture. However, it had opposing effects in adipocyte-conditioned medium and co-culture without LPS. Additionally, lunasin enhanced phagocytosis in both LPS and adipocyte-conditioned medium challenges.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Marco Rossato, Francesca Favaretto, Marnie Granzotto, Marika Crescenzi, Alessandra Boscaro, Angelo Di Vincenzo, Federico Capone, Edoardo Dalla Nora, Eva Zabeo, Roberto Vettor
Summary: Research shows that human adipocytes express various P2X and P2Y receptors, which can be functionally activated by extracellular ATP to regulate calcium levels and IL-6 secretion. Additionally, adipocytes are capable of spontaneously releasing ATP and modulating IL-6 secretion.
Article
Biology
Ashley A. Able, Allison J. Richard, Jacqueline M. Stephens
Summary: The enzymes G9a and GLP play important roles in metabolic diseases and fat cell function. By decreasing their levels in fat cells, the study found that the loss of both enzymes enhanced the effects of TNFa, a proinflammatory protein, on fat breakdown and gene expression. Additionally, the study showed that G9a and GLP form a complex with NF-?B, providing new insights into their role in systemic metabolic health.
Article
Biochemistry & Molecular Biology
Sadia Afrin, Malak El Sabah, Ahmed Manzoor, Mariko Miyashita-Ishiwata, Lauren Reschke, Mostafa A. Borahay
Summary: The aim of this study was to determine the cellular and molecular mechanisms by which adipocytes contribute to the initiation and promotion of uterine leiomyoma tumors. The results showed that adipocytes promote inflammation, fibrosis, and angiogenesis in leiomyoma cells by upregulating associated factors and transferring free fatty acids. Adipocyte-leiomyoma cell interaction increases the phosphorylation of NF-.B and enhances cell proliferation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Cell Biology
Miryam Mueller, Claire Saunders, Anke Senftleben, Johannes P. W. Heidbuechel, Birgit Halwachs, Julia Bolik, Nina Hedemann, Christian Roeder, Dirk Bauerschlag, Stefan Rose-John, Dirk Schmidt-Arras
Summary: Tspan8 subfamily members regulate the substrate selectivity of ADAM17 through different strategies, especially by recruiting ADAM17 into Tspan-enriched micro-domains to promote ADAM17-mediated TNF alpha release. This finding reveals the mechanism of Tspan8's involvement in tumorigenesis.
Article
Biochemistry & Molecular Biology
Felix Clemens Richter, Matthias Friedrich, Nadja Kampschulte, Klara Piletic, Ghada Alsaleh, Ramona Zummach, Julia Hecker, Mathilde Pohin, Nicholas Ilott, Irina Guschina, Sarah Karin Wideman, Errin Johnson, Mariana Borsa, Paula Hahn, Christophe Morriseau, Bruce D. Hammock, Henk Simon Schipper, Claire M. Edwards, Rudolf Zechner, Britta Siegmund, Carl Weidinger, Nils Helge Schebb, Fiona Powrie, Anna Katharina Simon
Summary: Lipids play a major role in inflammatory diseases through altering inflammatory cell functions. Autophagy, a lysosomal degradation pathway, is found to regulate lipid availability, which affects inflammation. Loss of autophagy gene Atg7 in adipocytes exacerbates intestinal inflammation by causing an imbalance of oxylipins, reducing IL-10 secretion, and exacerbating intestinal inflammation through the cytochrome P450-EPHX pathway.
Article
Geriatrics & Gerontology
Olivier Le Bacquer, Jerome Salles, Fabiana Piscitelli, Phelipe Sanchez, Vincent Martin, Christophe Montaurier, Vincenzo Di Marzo, Stephane Walrand
Summary: Sarcopenia in old rats is characterized by a significant decrease in muscle mass and function, associated with alterations in endocannabinoid levels in plasma, skeletal muscle, and adipose tissue. The findings suggest that changes in endocannabinoid tone are linked to sarcopenia, and OEA levels in plasma may be a potential biomarker for skeletal muscle function and loss of locomotor activity.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Pharmacology & Pharmacy
Melissa Simard, Volatiana Rakotoarivelo, Vincenzo Di Marzo, Nicolas Flamand
Summary: The CB2 receptor is expressed in a wide range of leukocytes and its activation has potential therapeutic effects for inflammatory and autoimmune diseases. Current research focuses on identifying immune cells expressing CB2 receptors and studying the consequences of receptor activation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Antonio Inserra, Giada Giorgini, Sebastien Lacroix, Antonella Bertazzo, Jocelyn Choo, Athanasios Markopolous, Emily Grant, Armita Abolghasemi, Danilo De Gregorio, Nicolas Flamand, Geraint Rogers, Stefano Comai, Cristoforo Silvestri, Gabriella Gobbi, Vincenzo Di Marzo
Summary: This study found that repeated administration of lysergic acid diethylamide (LSD) induces prosocial effects in mice and affects the composition of the hippocampal endocannabinoidome and gut microbiota.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ester Pagano, Barbara Romano, Donatella Cicia, Fabio A. Iannotti, Tommaso Venneri, Giuseppe Lucariello, Maria Francesca Nani, Fabio Cattaneo, Paola De Cicco, Maria D'Armiento, Marcello De Luca, Ruggiero Lionetti, Stefania Lama, Paola Stiuso, Pietro Zoppoli, Geppino Falco, Silvia Marchiano, Stefano Fiorucci, Raffaele Capasso, Vincenzo Di Marzo, Francesca Borrelli, Angelo A. Izzo
Summary: TRPM8 is overexpressed in colorectal cancer and its high expression is associated with lower survival rate of patients and hyperactivation of related signaling pathways. TRPM8 may serve as a prognostic marker and potential drug target for colorectal cancer.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Obstetrics & Gynecology
Camille Dugas, Laurence Laberee, Julie Perron, Gabrielle St-Arnaud, Veronique Richard, Veronique Perreault, Nadine Leblanc, Isabelle Marc, Vincenzo Di Marzo, Alain Doyen, Alain Veilleux, Julie Robitaille
Summary: This study compared the macronutrient and energy content of human milk between women with and without GDM. The results showed that protein, lactose, and energy content were similar between the two groups, but the concentration of TG was higher in women with GDM. Maternal age and fasting glucose level were associated with the composition of human milk, and TG in human milk was associated with infant growth in children without GDM.
BREASTFEEDING MEDICINE
(2023)
Article
Medicine, Research & Experimental
Hilal Kalkan, Ester Pagano, Debora Paris, Elisabetta Panza, Mariarosaria Cuozzo, Claudia Moriello, Fabiana Piscitelli, Armita Abolghasemi, Elisabetta Gazzerro, Cristoforo Silvestri, Raffaele Capasso, Andrea Motta, Roberto Russo, Vincenzo Di Marzo, Fabio Arturo Iannotti
Summary: This study found that there are changes in the gut microbiota composition, short-chain fatty acids (SCFAs) levels, and related metabolites in the mdx mouse model of Duchenne muscular dystrophy (DMD) compared to healthy controls. Supplementation with sodium butyrate (NaB) in mdx mice showed similar benefits as deflazacort (DFZ) in terms of muscle strength, autophagy, and inflammation. In LPS-stimulated C2C12 myoblasts, NaB reduced inflammation, promoted autophagy, and prevented dysregulation of microRNAs targeting the endocannabinoid CB1 receptor gene through the activation of GPR109A and PPAR gamma receptors. This suggests a potential disease-modifying approach for DMD and other muscular dystrophies.
EMBO MOLECULAR MEDICINE
(2023)
Article
Immunology
Fredy Alexander Guevara Agudelo, Nadine Leblanc, Isabelle Bourdeau-Julien, Gabrielle St-Arnaud, Sebastien Lacroix, Cyril Martin, Nicolas Flamand, Alain Veilleux, Vincenzo Di Marzo, Frederic Raymond
Summary: Dietary micronutrients, such as selenium, influence the gut microbiome and endocannabinoidome, which are associated with metabolic health and chronic low-grade inflammation. This study reveals that variations in selenium levels affect gut microbiota, circulating endocannabinoid mediators, and gene expression related to immune and antioxidant responses in the intestine, particularly in response to high-fat diets. These findings contribute to the development of new nutritional strategies for improving metabolic health.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Francesco Suriano, Claudia Manca, Nicolas Flamand, Matthias Van Hul, Nathalie M. Delzenne, Cristoforo Silvestri, Patrice D. Cani, Vincenzo Di Marzo
Summary: This study characterized the profile of endocannabinoidome and oxylipins in the intestines of obese and diabetic mice, and found correlations between these mediators and intestinal inflammation and gut microbiota composition. The results suggest that the altered eCBome and oxylipin signaling may contribute to obesity and diabetes-induced gut dysbiosis and inflammation.
Article
Biochemistry & Molecular Biology
Aniello Schiano Moriello, Fiorentina Roviezzo, Fabio Arturo Iannotti, Giuseppina Rea, Marco Allara, Rosa Camerlingo, Roberta Verde, Vincenzo Di Marzo, Stefania Petrosino
Summary: ARDS is a serious lung disorder caused by SARS-CoV-2 infection. This study evaluated the protective effects of PEA-um and its congener PEA-OXA in acute lung injury models. The results showed that both PEA-OXA and PEA can counteract the inflammatory response and EMT induced by poly-(I:C) or TGF-beta. PEA-OXA was found to be superior to PEA in exerting protective effects, making it a promising candidate in the management of acute lung injury.
Article
Biochemistry & Molecular Biology
Martina Di Bartolomeo, Tibor Stark, Serena Di Martino, Fabio Arturo Iannotti, Jana Ruda-Kucerova, Giovanni Luca Romano, Martin Kuchar, Samuele Laudani, Petr Palivec, Fabiana Piscitelli, Carsten T. Wotjak, Claudio Bucolo, Filippo Drago, Vincenzo Di Marzo, Claudio D'Addario, Vincenzo Micale
Summary: Adolescent exposure to cannabinoids, such as THC, may increase the risk of psychosis in individuals exposed to perinatal insult. In this study, the researchers examined the effects of peripubertal THC exposure on rats that were also exposed to prenatal methylazoxymethanol acetate (MAM) or perinatal THC (pTHC). They found that the rats exposed to MAM or pTHC exhibited adult phenotypes relevant to schizophrenia, including social withdrawal and cognitive impairment. The researchers also observed changes in gene expression and DNA methylation, suggesting potential molecular mechanisms underlying these effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Hayatte-Dounia Mir, Giada Giorgini, Vincenzo Di Marzo
Summary: This review article focuses on the expanded endocannabinoid system (eCBome) and the gut microbiome, which are increasingly attracting attention as sources of chemical signals regulating food intake, energy metabolism, and body weight. The article describes the mechanisms through which these two systems, in interactions with other signaling systems, intervene in eating disorders, based on studies in experimental models or patients. Furthermore, the article discusses the possibility of the involvement of the eCBome-gut microbiome axis in eating disorders, considering the emerging multi-faceted cross-talk mechanisms between these complex systems.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Cell Biology
Hilal Kalkan, Elisabetta Panza, Ester Pagano, Giuseppe Ercolano, Claudia Moriello, Fabiana Piscitelli, Monika Sztretye, Raffaele Capasso, Vincenzo Di Marzo, Fabio Arturo Iannotti
Summary: In this study, the researchers investigated the role of the endocannabinoid system in simvastatin-induced muscle toxicity. They found that the expression of endocannabinoids and specific miRNAs targeting the endocannabinoid CB1 gene increased in myoblasts exposed to simvastatin. Moreover, they discovered that the dysregulation of the CB1 receptor and its downstream signaling pathways contributed to statin-induced myopathy.
CELL DEATH & DISEASE
(2023)
Article
Microbiology
Thomas Deschenes, Fred Wilfried Elom Tohoundjona, Pier-Luc Plante, Vincenzo Di Marzo, Frederic Raymond
Summary: This study compared the performance of machine learning approaches according to different types of data representations derived from shotgun metagenomics. Gene-based approaches provided similar or improved classification performances compared to taxonomic and functional profiles. Feature selection based on biological function also improved classification performance for some pathologies. This study proposes new approaches to represent microbiome data for machine learning.
Article
Biology
Nicola Forte, Charlene Roussel, Brenda Marfella, Anna Lauritano, Rosaria Villano, Elvira De Leonibus, Emanuela Salviati, Tina Khalilzadehsabet, Giada Giorgini, Cristoforo Silvestri, Fabiana Piscitelli, Maria Pina Mollica, Vincenzo Di Marzo, Luigia Cristino
Summary: N-oleoylglycine and N-oleoylalanine reduce the rewarding properties of palatable food, dopamine neuron firing, and the obesogenic effect of a high-fat diet by activating PPAR alpha. Olive oil-rich diets can also decrease weight gain by increasing oleoylglycine levels and enhancing gut microbial diversity.
COMMUNICATIONS BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Tangui Barre, Vincenzo Di Marzo, Fabienne Marcellin, Patrizia Burra, Patrizia Carrieri
Summary: Obesity and nonalcoholic fatty liver disease (NAFLD) are global epidemics. The endocannabinoid system is seen as a key target for treating NAFLD. Although clinical trials are lacking, research suggests potential benefits of phytocannabinoids in treating liver steatosis. Cannabis plant should be considered a major prospect for NAFLD treatment. Overcoming scientific and non-scientific barriers is necessary for further research.
CANNABIS AND CANNABINOID RESEARCH
(2023)