Mogamulizumab, an Anti-CCR4 Antibody, Targets Human T-Lymphotropic Virus Type 1–infected CD8+and CD4+T Cells to Treat Associated Myelopathy

HTLV-1 induces a Th1-like state in CD4+CCR4+ T cells

(2014) Natsumi Araya et al.   JOURNAL OF CLINICAL INVESTIGATION

Tax-Inducible Production of CC Chemokine Ligand 22 by Human T Cell Leukemia Virus Type 1 (HTLV-1)-Infected T Cells Promotes Preferential Transmission of HTLV-1 to CCR4-Expressing CD4+ T Cells

(2014) K. Hieshima et al.   JOURNAL OF IMMUNOLOGY

Positive feedback loop via astrocytes causes chronic inflammation in virus-associated myelopathy

(2013) Hitoshi Ando et al.   BRAIN

Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking antitumor immune responses in humans

(2013) D. Sugiyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of Effector Memory CD8+ T Cells in the Synovial Fluid of Rheumatoid Arthritis

(2012) Bon-A Cho et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Defucosylated Anti-CCR4 Monoclonal Antibody (KW-0761) for Relapsed Adult T-Cell Leukemia-Lymphoma: A Multicenter Phase II Study

(2012) Takashi Ishida et al.   JOURNAL OF CLINICAL ONCOLOGY

Double control systems for human T-cell leukemia virus type 1 by innate and acquired immunity

(2011) Mari Kannagi et al.   CANCER SCIENCE

Susceptibility of Primary HTLV-1 Isolates from Patients with HTLV-1-Associated Myelopathy to Reverse Transcriptase Inhibitors

(2011) Beatrice Macchi et al.   Viruses-Basel

Human T-cell leukemia virus type I (HTLV-1) proviral load and disease progression in asymptomatic HTLV-1 carriers: a nationwide prospective study in Japan

(2010) M. Iwanaga et al.   BLOOD

Immunopathogenesis of lymphoma: Focus on CCR4

(2010) Takashi Ishida et al.   CANCER SCIENCE

Defucosylated Humanized Anti-CCR4 Monoclonal Antibody KW-0761 as a Novel Immunotherapeutic Agent for Adult T-cell Leukemia/Lymphoma

(2010) T. Ishii et al.   CLINICAL CANCER RESEARCH

Human memory CCR4+CD8+ T cell subset has the ability to produce multiple cytokines

(2009) T. Kondo et al.   INTERNATIONAL IMMUNOLOGY

Abnormally High Levels of Virus-Infected IFN-γ+CCR4+CD4+CD25+ T Cells in a Retrovirus-Associated Neuroinflammatory Disorder

(2009) Yoshihisa Yamano et al.   PLoS One

Impaired Tax-specific T-cell responses with insufficient control of HTLV-1 in a subgroup of individuals at asymptomatic and smoldering stages

(2008) Yukiko Shimizu et al.   CANCER SCIENCE

Increased IL-4+ CD8+ T cells in peripheral blood and autoreactive CD8+ T cell lines of patients with inflammatory arthritis

(2008) H. J. Baek et al.   RHEUMATOLOGY

High frequency of CD4+FoxP3+ cells in HTLV-1 infection: inverse correlation with HTLV-1-specific CTL response

(2007) F. Toulza et al.   BLOOD