Study of Genotypic and Phenotypic HIV-1 Dynamics of Integrase Mutations During Raltegravir Treatment: A Refined Analysis by Ultra-Deep 454 Pyrosequencing

High frequency of integrase Q148R minority variants in HIV-infected patients naive of integrase inhibitors

(2010) Charlotte Charpentier et al.   AIDS

Low level of the K103N HIV-1 above a threshold is associated with virological failure in treatment-naive individuals undergoing efavirenz-containing therapy

(2010) Derrick D Goodman et al.   AIDS

HIV-1 Integrase Sequence Variability in Antiretroviral Naïve Patients and in Triple-Class Experienced Patients Subsequently Treated with Raltegravir

(2010) Vici Varghese et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Secondary Integrase Resistance Mutations Found in HIV-1 Minority Quasispecies in Integrase Therapy-Naive Patients Have Little or No Effect on Susceptibility to Integrase Inhibitors

(2010) F. Ceccherini-Silberstein et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Analysis of Low-Frequency Mutations Associated with Drug Resistance to Raltegravir before Antiretroviral Treatment

(2010) Jia Liu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Dynamic escape of pre-existing raltegravir-resistant HIV-1 from raltegravir selection pressure

(2010) Francisco M. Codoñer et al.   ANTIVIRAL RESEARCH

HIV type-1 drug resistance in treatment-naive patients monitored using minority species assays: a systematic review and meta-analysis

(2010) Andrew J Buckton et al.   ANTIVIRAL THERAPY

Evolution patterns of raltegravir-resistant mutations after integrase inhibitor interruption

(2010) F. Canducci et al.   CLINICAL MICROBIOLOGY AND INFECTION

Low-frequency HIV-1 drug resistance mutations can be clinically significant but must be interpreted with caution

(2010) J. A. Johnson et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Prevalence and Clinical Significance of HIV Drug Resistance Mutations by Ultra-Deep Sequencing in Antiretroviral-Naïve Subjects in the CASTLE Study

(2010) Max Lataillade et al.   PLoS One

HIV-1 V3 envelope deep sequencing for clinical plasma specimens failing in phenotypic tropism assays

(2010) Ina Vandenbroucke et al.   AIDS Research and Therapy

Dynamic patterns of human immunodeficiency virus type 1 integrase gene evolution in patients failing raltegravir-based salvage therapies

(2009) Filippo Canducci et al.   AIDS

Natural Polymorphisms of Human Immunodeficiency Virus Type 1 Integrase and Inherent Susceptibilities to a Panel of Integrase Inhibitors

(2009) A. Low et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Strand transfer inhibitors of HIV-1 integrase: Bringing IN a new era of antiretroviral therapy

(2009) Damian J. McColl et al.   ANTIVIRAL RESEARCH

Low-Frequency K103N Strengthens the Impact of Transmitted Drug Resistance on Virologic Responses to First-Line Efavirenz or Nevirapine-Based Highly Active Antiretroviral Therapy

(2009) Anna Maria Geretti et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Minority Variants Associated with Transmitted and Acquired HIV-1 Nonnucleoside Reverse Transcriptase Inhibitor Resistance: Implications for the Use of Second-Generation Nonnucleoside Reverse Transcriptase Inhibitors

(2009) Vici Varghese et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Evolution of raltegravir resistance during therapy

(2009) N. Sichtig et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Low-Abundance Drug-Resistant Viral Variants in Chronically HIV-Infected, Antiretroviral Treatment–Naive Patients Significantly Impact Treatment Outcomes

(2009) Birgitte B. Simen et al.   JOURNAL OF INFECTIOUS DISEASES

Early emergence of raltegravir resistance mutations in patients receiving HAART salvage regimens

(2009) Fausto Baldanti et al.   JOURNAL OF MEDICAL VIROLOGY

A combined genotypic and phenotypic human immunodeficiency virus type 1 recombinant virus assay for the reverse transcriptase and integrase genes

(2009) Kurt Van Baelen et al.   JOURNAL OF VIROLOGICAL METHODS

Loss of Raltegravir Susceptibility by Human Immunodeficiency Virus Type 1 Is Conferred via Multiple Nonoverlapping Genetic Pathways

(2009) S. Fransen et al.   JOURNAL OF VIROLOGY

Clade-specific HIV-1 integrase polymorphisms do not reduce raltegravir and elvitegravir phenotypic susceptibility

(2008) Kurt Van Baelen et al.   AIDS

Emerging Pharmacology: Inhibitors of Human Immunodeficiency Virus Integration

(2008) Daria Hazuda et al.   Annual Review of Pharmacology and Toxicology

Mutations Associated with Failure of Raltegravir Treatment Affect Integrase Sensitivity to the Inhibitor In Vitro

(2008) I. Malet et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antiretroviral Drug Resistance Testing in Adult HIV‐1 Infection: 2008 Recommendations of an International AIDS Society–USA Panel

(2008) Martin S. Hirsch et al.   CLINICAL INFECTIOUS DISEASES

Minority Quasispecies of Drug‐Resistant HIV‐1 That Lead to Early Therapy Failure in Treatment‐Naive and ‐Adherent Patients

(2008) Karin J. Metzner et al.   CLINICAL INFECTIOUS DISEASES

Preexisting Resistance to Nonnucleoside Reverse‐Transcriptase Inhibitors Predicts Virologic Failure of an Efavirenz‐Based Regimen in Treatment‐Naive HIV‐1–Infected Subjects

(2008) Daniel R. Kuritzkes et al.   JOURNAL OF INFECTIOUS DISEASES

Analysis of Natural Sequence Variation and Covariation in Human Immunodeficiency Virus Type 1 Integrase

(2008) R. E. Myers et al.   JOURNAL OF VIROLOGY

Raltegravir with Optimized Background Therapy for Resistant HIV-1 Infection

(2008) Roy T. Steigbigel et al.   NEW ENGLAND JOURNAL OF MEDICINE