Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 206, Issue 10, Pages 1568-1576Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jis544
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Funding
- Roche Pharmaceuticals
- National Institutes of Health [R01 15999-01]
- Australian Government Department of Health and Ageing
- NHMRC
- VicHealth
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Studies examining the effect of coinfection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) on the HCV-specific immune response in acute HCV infection are limited. This study directly compared acute HCV-specific T-cell responses and cytokine profiles between 20 HIV/HCV-coinfected and 20 HCV-monoinfected subjects, enrolled in the Australian Trial in Acute Hepatitis C (ATAHC), using HCV peptide enzyme-linked immunospot (ELISPOT) and multiplex in vitro cytokine production assays. HIV/HCV coinfection had a detrimental effect on the HCV-specific cytokine production in acute HCV infection, particularly on HCV-specific interferon gamma (IFN-gamma) production (magnitude P = .004; breadth P = .046), which correlated with peripheral CD4(+) T-cell counts (rho = 0.605; P = .005) but not with detectable HIV viremia (rho = 0.152; P = .534).
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