Correction
Immunology
Nadia Caccamo, Gabriella Pietra, Lucy C. Sullivan, Andrew G. Brooks, Teresa Prezzemolo, Marco P. La Manna, Diana Di Liberto, Simone A. Joosten, Krista E. van Meijgaarden, Paola Di Carlo, Lucina Titone, Lorenzo Moretta, Maria C. Mingari, Tom H. M. Ottenhoff, Francesco Dieli
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Review
Immunology
Thiago M. Steiner, William R. Heath, Irina Caminschi
Summary: This review summarizes the mounting evidence that conventional dendritic cells (cDC) can also present native antigen to B cells besides priming T cells, supporting the view that both cDC1 and cDC2 are capable of initiating humoral responses provided antigen is captured by relevant surface receptors attuned to this process. Such understanding is fundamental for the development of innovative humoral vaccination approaches.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Maximilien Evrard, Erica Wynne-Jones, Changwei Peng, Yu Kato, Susan N. Christo, Raissa Fonseca, Simone L. Park, Thomas N. Burn, Maleika Osman, Sapna Devi, Jerold Chun, Scott N. Mueller, George Kannourakis, Stuart P. Berzins, Daniel G. Pellicci, William R. Heath, Stephen C. Jameson, Laura K. Mackay
Summary: The migratory receptor S1PR5 plays a critical role in T cell infiltration and emigration from peripheral organs, and is specifically downregulated in tissue-resident memory T (TRM) cells. The induction of S1pr5 relies on the transcription factors T-bet and ZEB2, and local TGF-beta signaling is necessary for the coordinated downregulation of Tbx21, Zeb2, and S1pr5. S1PR5-mediated control of tissue residency is conserved across innate and adaptive immune compartments.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Microbiology
Mikha Gabriela, Kathryn M. Matthews, Cas Boshoven, Betty Kouskousis, Thorey K. Jonsdottir, Hayley E. Bullen, Joyanta Modak, David L. Steer, Brad E. Sleebs, Brendan S. Crabb, Tania F. de Koning-Ward, Paul R. Gilson
Summary: The malaria parasite Plasmodium falciparum exports a large number of proteins into host erythrocytes, modifying the physiology of the host cells. This study has identified a subcomplex consisting of EXP2 and PTEX150 that facilitates the docking of HSP101. It has also demonstrated that HSP101 can interact with specific cargo proteins in the parasite's ER and guide them to the parasitophorous vacuole membrane. These findings provide insights into the mechanism of how exported proteins are targeted to PTEX.
Review
Immunology
Rebecca C. S. Edgar, Natalie A. Counihan, Sheena McGowan, Tania F. de Koning-Ward
Summary: Plasmodium falciparum malaria remains a global health problem due to the parasite's resistance to all antimalarials. Current therapeutics target the parasite's digestive vacuole, and studying this organelle is essential for understanding its function and developing new treatments.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Virology
Melkamu B. Tessema, Rubaiyea Farrukee, Christopher E. Andoniou, Mariapia A. Degli-Esposti, Clare Oates, James B. Barnes, Linda M. Wakim, Andrew G. Brooks, Sarah L. Londrigan, Patrick C. Reading
Summary: This study is the first to report the antiviral activity of mouse Mx1 against alphaherpesviruses, demonstrating that mMx1 can effectively inhibit the growth of HSV-1 by blocking viral genome replication and late gene expression. Additionally, the functional endogenous mMx1 is shown to limit the pathogenesis of HSV-1 in a mouse infection model.
JOURNAL OF VIROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hayley E. Bullen, Paul R. Sanders, Madeline G. Dans, Thorey K. Jonsdottir, David T. Riglar, Oliver Looker, Catherine S. Palmer, Betty Kouskousis, Sarah C. Charnaud, Tony Triglia, Mikha Gabriela, Molly Parkyn Schneider, Jo-Anne Chan, Tania F. de Koning-Ward, Jake Baum, James W. Kazura, James G. Beeson, Alan F. Cowman, Paul R. Gilson, Brendan S. Crabb
Summary: Infection with Plasmodium falciparum parasites leads to a significant number of deaths each year. Understanding the proteins involved in parasite invasion and growth within human erythrocytes is important for developing new therapeutic strategies. One of these proteins, P113, has been found to play a role in both invasion and intracellular processes. Through our investigation, we discovered that P113 interacts with the protein export machinery and various proteins associated with the parasite vacuole. Furthermore, disrupting P113 affects the architecture of the vacuole membrane. This research provides insights into the function of P113 and its potential as a target for malaria treatment.
MOLECULAR MICROBIOLOGY
(2022)
Article
Immunology
Lara S. U. Schwab, Rubaiyea Farrukee, Jean Francois Eleouet, Marie Anne Rameix-Welti, Sarah L. Londrigan, Andrew G. Brooks, Aeron C. Hurt, Christoph Coch, Thomas Zillinger, Gunther Hartmann, Patrick C. Reading
Summary: This study demonstrates that pretreatment of human, mouse, or ferret airway cell lines, as well as intravenous injection of mice and ferrets, with a synthetic retinoic acid-inducible gene I agonist resulted in reduced susceptibility to subsequent respiratory syncytial virus infection.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Parasitology
Sarah A. Knowler, Anya Shindler, Jennifer L. Wood, Asha Lakkavaram, Colleen J. Thomas, Tania F. de Koning-Ward, Elisa L. Hill-Yardin, Teresa G. Carvalho, Ashley E. Franks
Summary: Cerebral malaria is the most severe form of malaria and can have long-term neurological consequences. Research has shown the importance of the gut microbiome in brain health, but little is known about its role in malaria. In this study, mice infected with Plasmodium berghei ANKA parasites showed significant differences in bacterial communities compared to non-infected mice. The findings suggest that the gut microbiome is affected by the infection and could be a target for intervention strategies to reduce the severity of cerebral malaria.
PARASITOLOGY RESEARCH
(2023)
Article
Immunology
Ana Maria Valencia-Hernandez, Thomas Zillinger, Zhengyu Ge, Peck S. Tan, Anton Cozijnsen, Geoffrey I. McFadden, Mireille H. Lahoud, Irina Caminschi, Winfried Barchet, William R. Heath, Daniel Fernandez-Ruiz
Summary: Tissue resident memory T cells (TRM cells) play a crucial role in tissue surveillance and rapid response to infection. This study explores the potential of various adjuvants targeting different pathogen recognition receptors to induce CD8' TRM formation. CpG oligodeoxynucleotides (ODN) were found to be the most efficient inducers of liver TRM cells among all tested adjuvants. Additionally, combining CpG ODN with cationic liposome DOTAP further enhances their potency. This study provides valuable insights for the development of liver TRM-based vaccines.
Article
Immunology
Angelo Ferreira Chora, Sofia Marques, Joana Lisboa Goncalves, Priscila Lima, Daniel Gomes da Costa, Daniel Fernandez-Ruiz, Maria Ines Marreiros, Pedro Ruivo, Tania Carvalho, Ruy M. Ribeiro, Karine Serre, William R. Heath, Bruno Silva-Santos, Ann T. Tate, Maria M. Mota
Summary: During malaria infection, Plasmodium replicates in the liver and later infects red blood cells. It has been commonly believed that liver infection does not affect disease pathology as clinical manifestations only occur during the blood stage. However, a study using a mouse model uncoupling liver and blood stages of infection revealed that signals from both stages determine mortality outcomes. This finding was mediated by the activation of Vy4+ y8 T cells during the liver stage, which subsequently influenced cytokine profiles during the blood stage. The study also suggested that IL-17 produced by y8 T cells played a role in protecting mice from lethal cerebral malaria.
Editorial Material
Immunology
Philippa M. Saunders, Andrew G. Brooks, Jamie Rossjohn
Summary: Presentation of signal peptides by HLA-E to natural killer cells prevents cell lysis by interacting with the inhibitory CD94-NKG2A receptor. A study now shows an unexpected level of sophistication and heterogeneity in this receptor-ligand interaction.
Article
Biochemistry & Molecular Biology
Saeed Maymand, Asha L. Lakkavaram, Wasan Naser, Parisa Rasighaemi, Daniel Dlugolenski, Clifford Liongue, John Stambas, Tania F. de Koning-Ward, Alister C. Ward
Summary: This study reveals the regulatory role of CISH in both basal and EPO-induced erythropoiesis in vivo.
Article
Immunology
Mbaya Ntita, Shin-Ichi Inoue, Jiun-Yu Jian, Ganchimeg Bayarsaikhan, Kazumi Kimura, Daisuke Kimura, Mana Miyakoda, Eriko Nozaki, Takuya Sakurai, Daniel Fernandez-Ruiz, William R. Heath, Katsuyuki Yui
Summary: The differences in Plasmodium-specific CD4(+) T-cell responses between PbA- and Pcc-infected mice were associated with the difference in type I interferon production during the early phase of the infection. In PbA-infected mice, there was a higher response to type I interferon and a lower proportion of Th1 cells compared to Pcc-infected mice.
INTERNATIONAL IMMUNOLOGY
(2022)