Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 199, Issue 3, Pages 427-431Publisher
OXFORD UNIV PRESS INC
DOI: 10.1086/596049
Keywords
-
Categories
Funding
- MRC [MC_U122886351, G106/1219] Funding Source: UKRI
- Medical Research Council [G106/1219, MC_U122886351] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0508-10244] Funding Source: researchfish
- Medical Research Council [G106/1219, MC_U122886351] Funding Source: Medline
Ask authors/readers for more resources
Phylogenetic reconstructions of transmission events from individuals with acute human immunodeficiency virus (HIV) infection are conducted to illustrate this group's heightened infectivity. Varied definitions of acute infection and assumptions about observed phylogenetic clusters may produce misleading results. We conducted a phylogenetic analysis of HIV pol sequences from 165 European patients with estimated infection dates and calculated the difference between dates within clusters. Nine phylogenetic clusters were observed. Comparison of dates within clusters revealed that only 2 could have been generated during acute infection. Previous analyses may have incorrectly assigned transmission events to the acutely HIV infected when they were more likely to have occurred during chronic infection.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available