Article
Medicine, General & Internal
Pan Ma, Ruixiang Liu, Wenrui Gu, Qing Dai, Yu Gan, Jing Cen, Shenglan Shang, Fang Liu, Yongchuan Chen
Summary: This study used machine learning to predict teicoplanin trough concentrations and explained the prediction model using the SHAP method. The results showed that teicoplanin administration and renal function were the most important factors in predicting teicoplanin trough concentrations.
FRONTIERS IN MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Sasa Hu, Taotao Wang, Haisheng You, Siying Chen, Tao Zhang, Yalin Dong
Summary: This study aimed to explore the C-min values of teicoplanin in ARC patients using HD teicoplanin and provide reference for individualized medication. The results showed no significant difference in C-min values between the ARC and non-ARC groups on the third day of HD, but the ARC group had significantly lower C-min values during LD. During the dose maintenance period, the ARC group receiving HD had significantly lower C-min values than the non-ARC group and significantly higher C-min values than during LD. There was no significant difference in the incidence rates of nephrotoxicity and hepatotoxicity between these groups.
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
(2022)
Article
Oncology
Takayuki Takahashi, Hideyuki Terazono, Takayuki Suetsugu, Hideki Sugawara, Junko Arima, Mina Nitta, Toru Tanabe, Kayu Okutsu, Ryuji Ikeda, Keiko Mizuno, Hiromasa Inoue, Yasuo Takeda
Summary: Afatinib, a second-generation EGFR-tyrosine kinase inhibitor, is used to treat NSCLC with EGFR mutation. Monitoring its trough plasma concentration can help predict adverse effects and support effective therapy. Higher plasma concentrations of afatinib are associated with adverse events, indicating a need for potential dose reduction to maintain quality of life.
Article
Infectious Diseases
Takashi Ueda, Yoshio Takesue, Kazuhiko Nakajima, Kaoru Ichiki, Kaori Ishikawa, Kumiko Yamada, Toshie Tsuchida, Naruhito Otani, Takeshi Ide, Kenta Takeda, Shinichi Nishi, Yoshiko Takahashi, Mika Ishihara, Shingo Takubo, Hiroki Ikeuchi, Motoi Uchino, Takeshi Kimura
Summary: The study investigated the efficacy of an enhanced teicoplanin regimen for treating methicillin-resistant Staphylococcus aureus infection in patients undergoing CVVHDF with a low flow rate in Japan.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Yi-Chang Zhao, Yang Zou, Jing-Jing Hou, Chen-Lin Xiao, Bi-Kui Zhang, Jia-Kai Li, Da-Xiong Xiang, Indy Sandaradura, Miao Yan
Summary: The study aimed to explore optimized maintenance dose of voriconazole in children and factors affecting trough concentration. The probability of achieving target concentration increased after adjustment, with maintenance doses varying based on age and weight.
Article
Pharmacology & Pharmacy
Huaijun Zhu, Min Wang, Xiaofu Xiong, Yao Du, Danying Li, Zhou Wang, Weihong Ge, Yizhun Zhu
Summary: Inter- and intrapatient variability of tacrolimus exposure is a vital prognostic risk factor for the clinical outcome of liver transplantation. This study aimed to identify potential plasma metabolites associated with the dose-adjusted trough concentration of tacrolimus in liver transplant recipients using a global metabolomic approach. The results showed that microbiota-derived uremic retention solutes, bile acids, steroid hormones, and medium- and long-chain acylcarnitines were the main metabolites associated with the dose-adjusted trough concentration of tacrolimus.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Yanxia Huang, Le He, Yunxin Deng, Renjing Zhang, Mei Meng, Jiao Liu, Dechang Chen
Summary: The study suggests that using a loading dose of vancomycin can help achieve the target serum concentration earlier, reducing the risk of vancomycin treatment failure and decreasing 28-day mortality.
CHINESE MEDICAL JOURNAL
(2022)
Review
Pharmacology & Pharmacy
Yuki Hanai, Yoshiko Takahashi, Takashi Niwa, Toshihiko Mayumi, Yukihiro Hamada, Toshimi Kimura, Kazuaki Matsumoto, Satoshi Fujii, Yoshio Takesue
Summary: Teicoplanin therapy with a target C-min of 15-30 µg/ml is associated with better clinical responses for MRSA infections without increasing the risk of adverse effects, as shown in this study.
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
(2021)
Review
Pharmacology & Pharmacy
Marsilla Muth, Francis Williams Ojara, Charlotte Kloft, Markus Joerger
Summary: Classical taxanes like paclitaxel and docetaxel, as well as newer options like cabazitaxel and nanoparticle-bound nab-paclitaxel, are widely used in cancer treatment. However, there is still debate surrounding the optimal dosing strategy and pharmacological individualization. The value of personalized dosing for taxanes like cabazitaxel and nab-paclitaxel remains largely unexplored.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Infectious Diseases
Stefan Hatzl, Lisa Kriegl, Florian Posch, Gernot Schilcher, Philipp Eller, Alexander Reisinger, Yvonne Grinschgl, Tina Muhr, Andreas Meinitzer, Martin Hoenigl, Robert Krause
Summary: Increasing the first loading dose of isavuconazole in critically ill patients with ECMO can result in higher plasma concentrations during the initial 24 hours of treatment. However, regardless of the loading dose regimen, all patient groups reached similar plasma concentrations in the subsequent treatment period.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Infectious Diseases
Yuki Nakano, Yoko Inokuchi, Tadashi Hayama, Toshinori Hirai, Mamoru Nishiyama, Yoshiko Sueyasu, Kenjo Yokoo
Summary: This study aimed to determine the effective concentration of GS-441524, a key drug for treating COVID-19 pneumonia. The research found that there is a correlation between the concentration of GS-441524 and the improvement of COVID-19 pneumonia symptoms, and a concentration above 70 ng/mL can effectively predict efficacy. Decreased estimated glomerular filtration rate and BMI over 25 kg/m 2 were found to affect the probability of achieving effective concentration.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Biochemistry & Molecular Biology
Yiyoung Kwon, Eun-Sil Kim, Yoon-Zi Kim, Yon-Ho Choe, Mi-Jin Kim
Summary: This study aims to measure the concentration of cytokines produced during the inflammation process to investigate if there are any differences in response to treatment of pediatric Crohn's disease and to determine if the initial tumor necrosis factor-alpha (TNF-alpha) level affected the trough concentration of infliximab (IFX).
Article
Pharmacology & Pharmacy
Anaelle Chavant, Xavier Fonrose, Elodie Gautier-Veyret, Marie Noelle Hilleret, Matthieu Roustit, Francoise Stanke-Labesque
Summary: The study revealed that inflammation contributes to the variability of tacrolimus blood trough concentration and is associated with an increased risk of overexposure. It is suggested that inflammation should be considered for the correct interpretation of tacrolimus blood concentration.
Article
Energy & Fuels
Jifeng Song, Haiyu Wang, Kunhao Liu, Lianglin Zou, Kai Wang, Ying Su, Qian Wang, Zubing Zou
Summary: In this study, the convolution operation model is used to traverse and combine the flux patterns under multiple types of optical errors. By comparing the actual measured flux distribution profiles with the ideal values, the Gaussian slope error, gravity deformation error, and alignment error of the concentrator are identified.
Article
Engineering, Civil
M. Azadeh, M. M. Tavakol
Summary: The study investigated wind loads and flow field structure around an array of parabolic trough collectors using Delayed Detached Eddy Simulation method, with numerical solutions for various pitch angles showing the first PTC in the array experiencing the maximum mean pressure and the second row having the minimum mean drag coefficient, except for the stow mode.Comparisons of flow patterns around the collectors revealed high vorticity concentration in front of the collectors for specific pitch angles.
JOURNAL OF WIND ENGINEERING AND INDUSTRIAL AERODYNAMICS
(2021)
Article
Gastroenterology & Hepatology
Ryuichi Kuwahara, Motoi Uchino, Hiroki Ikeuchi, Toshihiro Bando, Hirofumi Sasaki, Michiko Yasuhara, Kei Kimura, Yoshiko Goto, Yuki Horio, Tomohiro Minagawa, Masataka Ikeda, Takashi Ueda, Yoshio Takesue
Summary: This study aimed to investigate the efficacy of changing surgical instruments to prevent incisional surgical site infection during lower GI surgery. The results showed that changing surgical instruments did not decrease the rate of incisional surgical site infection in patients undergoing lower GI surgery in either all wound classes or clean-contaminated conditions.
DISEASES OF THE COLON & RECTUM
(2022)
Review
Infectious Diseases
Yuki Hanai, Yoshiko Takahashi, Takashi Niwa, Toshihiko Mayumi, Yukihiro Hamada, Toshimi Kimura, Kazuaki Matsumoto, Satoshi Fujii, Yoshio Takesue
Summary: This study updates the guidelines for therapeutic drug monitoring (TDM) of teicoplanin and provides evidence-based recommendations for target trough concentration (C-min) in patients with MRSA infections. The study suggests different target C-min values and dosage regimens based on the severity of the infections, and also provides recommendations for specific subpopulations.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Takashi Ueda, Yoshio Takesue, Kazuhiko Nakajima, Kaoru Ichiki, Kaori Ishikawa, Kumiko Yamada, Toshie Tsuchida, Naruhito Otani, Takeshi Ide, Kenta Takeda, Shinichi Nishi, Yoshiko Takahashi, Mika Ishihara, Shingo Takubo, Hiroki Ikeuchi, Motoi Uchino, Takeshi Kimura
Summary: The study investigated the efficacy of an enhanced teicoplanin regimen for treating methicillin-resistant Staphylococcus aureus infection in patients undergoing CVVHDF with a low flow rate in Japan.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2022)
Article
Surgery
Hiroji Shinkawa, Shoji Kubo, Hiroshige Mikamo, Naoyuki Matsuda, Kenji Omura, Kohji Okamoto, Satoshi Ono, Hideaki Obara, Minako Kobayashi, Junichi Sasaki, Junzo Shimizu, Susumu Sueyoshi, Junichi Yoshida, Manabu Watanabe, Yoshio Takesue
Summary: This survey examined the use of bile replacement (BR) in patients with external biliary drainage, focusing on the indication and implementation protocol of BR for infection control. The results showed variations in the implementation of BR among institutions, indicating the need for appropriate indication and protocols for infection control.
Article
Infectious Diseases
Takashi Ueda, Yoshio Takesue, Kazuhiko Nakajima, Kaoru Ichiki, Kaori Ishikawa, Kumiko Yamada, Toshie Tsuchida, Naruhito Otani, Yoshiko Takahashi, Mika Ishihara, Shingo Takubo, Hiroki Ikeuchi, Motoi Uchino, Toshimi Kimura, Kazuaki Matsumoto, Kazutaka Oda, Takeshi Kimura
Summary: AUC-guided vancomycin treatment can reduce nephrotoxicity, and obtaining two samples for AUC estimation is preferable. Significant associations were found between AUC cutoff values and early treatment response as well as nephrotoxicity rate, particularly in patients receiving vancomycin every 12 hours.
Review
Pharmacology & Pharmacy
Kazuaki Matsumoto, Kazutaka Oda, Kensuke Shoji, Yuki Hanai, Yoshiko Takahashi, Satoshi Fujii, Yukihiro Hamada, Toshimi Kimura, Toshihiko Mayumi, Takashi Ueda, Kazuhiko Nakajima, Yoshio Takesue
Summary: This study provides guidelines for individualized dosing of vancomycin based on therapeutic drug monitoring. It suggests that AUC-guided dosing is more effective in reducing the risk of acute kidney injury compared to trough-guided dosing.
Article
Ophthalmology
Takaaki Sugisawa, Hiroto Ishikawa, Kazutaka Uchida, Yoshio Takesue, Junya Mori, Takamasa Kinoshita, Shohei Morikawa, Fumiki Okamoto, Tomoko Sawada, Masahito Ohji, Takayuki Kanda, Masaru Takeuchi, Akiko Miki, Sentaro Kusuhara, Tetsuo Ueda, Nahoko Ogata, Masahiko Sugimoto, Mineo Kondo, Shigeo Yoshida, Tadahiko Ogata, Kazuhiro Kimura, Yoshinori Mitamura, Tatsuya Jujo, Hitoshi Takagi, Hiroto Terasaki, Taiji Sakamoto, Yuki Komuku, Fumi Gomi
Summary: This retrospective observational study investigated potential predictive factors for visual prognosis in Japanese patients with endogenous endophthalmitis. The study found that pressure injuries, severe clinical symptoms, pathogen identification, and poor baseline visual acuity were risk factors for visual impairment at 12 weeks after treatment initiation. Staphylococcus aureus and fungus were associated with a better visual impairment outcome.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Review
Pharmacology & Pharmacy
Masaru Samura, Keisuke Takada, Naoki Hirose, Takenori Kurata, Fumio Nagumo, Masaki Uchida, Junki Inoue, Koji Tanikawa, Yuki Enoki, Kazuaki Taguchi, Kazuaki Matsumoto, Takashi Ueda, Shigeru Fujimura, Hiroshige Mikamo, Yoshio Takesue, Kotaro Mitsutake
Summary: This study compared the efficacy of standard and high doses of daptomycin for different types of infections. The results showed that the treatment success rate was significantly lower in the standard-dose group compared to the high-dose group in patients with complicated bacteraemia/infective endocarditis. However, using the standard dose did not decrease the success rate for the treatment of osteomyelitis and foreign body/prosthetic infection. Therefore, higher doses of daptomycin are recommended for patients with complicated bacteraemia/infective endocarditis.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Yoshio Takesue, Yuki Hanai, Kazutaka Oda, Yukihiro Hamada, Takashi Ueda, Toshihiko Mayumi, Kazuaki Matsumoto, Satoshi Fujii, Yoshiko Takahashi, Yoshitsugu Miyazaki, Toshimi Kimura
Summary: Increased adverse effects of Voriconazole, an antifungal drug, are observed in Asians due to the high rate of poor metabolizers. This therapeutic drug monitoring (TDM) guideline provides recommendations according to ethnic group.
CLINICAL THERAPEUTICS
(2022)
Article
Ophthalmology
Ayano Yoshimura, Hiroto Ishikawa, Kazutaka Uchida, Yoshio Takesue, Junya Mori, Takamasa Kinoshita, Shohei Morikawa, Fumiki Okamoto, Tomoko Sawada, Masahito Ohji, Takayuki Kanda, Masaru Takeuchi, Akiko Miki, Sentaro Kusuhara, Tetsuo Ueda, Nahoko Ogata, Masahiko Sugimoto, Mineo Kondo, Shigeo Yoshida, Tadahiko Ogata, Kazuhiro Kimura, Yoshinori Mitamura, Tatsuya Jujo, Hitoshi Takagi, Hiroto Terasaki, Taiji Sakamoto, Takaaki Sugisawa, Yuki Komuku-Yamamoto, Fumi Gomi
Summary: This study investigated the potential risk factors for visual prognosis in Japanese patients with exogenous endophthalmitis. Risk factors for legal blindness at 12 weeks after treatment initiation were evaluated based on patient characteristics, initial BCVA, causative events, pathogens, ocular symptoms, duration from symptom onset to initial treatment, and selected treatments. The results showed that 23.1% of eyes developed legal blindness. The six risk factors for legal blindness were presence of eye pain, pathogen identification, poor BCVA at the initial visit, longer duration from symptom onset to initial treatment, type of causative event, and type of causative pathogen.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Multidisciplinary Sciences
Hideki Ogura, Jin Gohda, Xiuyuan Lu, Mizuki Yamamoto, Yoshio Takesue, Aoi Son, Sadayuki Doi, Kazuyuki Matsushita, Fumitaka Isobe, Yoshihiro Fukuda, Tai-Ping Huang, Takamasa Ueno, Naomi Mambo, Hiromoto Murakami, Yasushi Kawaguchi, Jun-ichiro Inoue, Kunihiro Shirai, Sho Yamasaki, Jun-Ichi Hirata, Satoshi Ishido
Summary: This study explores the characteristics of virus-specific CTLs related to the severity of COVID-19. Through the establishment of a cellular screening method, the researchers found that the SARS-CoV-2 M protein is a frequent target of CD8(+) T cells, and identified M198-206 as an immunoprevalent epitope in convalescent COVID-19 patients. Further single cell RNA sequencing revealed an exhausted phenotype with less differentiated status in cells from the severe group compared to cells from the moderate group.
NATURE COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Takashi Ueda, Yoshio Takesue, Kazuhiko Nakajima, Kaoru Ichiki, Kaori Ishikawa, Kumiko Yamada, Toshie Tsuchida, Naruhito Otani, Yoshiko Takahashi, Mika Ishihara, Shingo Takubo, Kosuke Iijima, Hiroki Ikeuchi, Motoi Uchino, Takeshi Kimura
Summary: This study investigated the correlation between antibiotic diversity and antimicrobial resistance (AMR) in Gram-negative organisms. The findings suggest that antibiotic heterogeneity is negatively associated with the development of antibiotic resistance in Pseudomonas aeruginosa and Klebsiella pneumoniae.
Article
Multidisciplinary Sciences
Mika Morosawa, Takashi Ueda, Kazuhiko Nakajima, Tomoko Inoue, Masanobu Toyama, Hitoshi Ogasiwa, Miki Doi, Yasuhiro Nozaki, Yasushi Murakami, Makoto Ishii, Yoshio Takesue
Summary: This study aimed to compare the amount and diversity of antibiotic use and antimicrobial susceptibility of nosocomial isolates between a community hospital (CH) and a tertiary care hospital (TCH) in Japan. The study found that the TCH had a higher antibiotic use rate than the CH, but there was no significant difference in antimicrobial susceptibility. This suggests that increased antibiotic use in the TCH does not lead to increased resistance, possibly due to diversified antibiotic use. Therefore, assessing antibiotic use according to facility type is an effective method for evaluating antimicrobial stewardship programs.
Article
Infectious Diseases
Yasushi Murakami, Hitoshi Ogashiwa, Yasuhiro Nozaki, Takashi Ueda, Kazuhiko Nakajima, Mika Morosawa, Miki Doi, Miyuki Makino, Yoshio Takesue
Summary: Extending isolation for hospitalized COVID-19 patients is necessary. Utilizing Ct values to determine the end of isolation can shorten hospital stay, reduce testing frequency, and minimize the risk of nosocomial transmission.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2023)
Review
Immunology
Naruhito Otani, Masayuki Shima, Takashi Ueda, Kazuhiko Nakajima, Yoshio Takesue, Takuma Yamamoto, Toshiomi Okuno
Summary: Rubella is caused by a virus and poses a risk to newborns if pregnant women are infected. Japan has implemented routine immunization, but recent outbreaks indicate a potential failure in the introduction of rubella vaccination. In Japan, only junior high school girls initially received routine rubella immunization, leading to a high rate of susceptibility among unvaccinated males.
Article
Infectious Diseases
Hitoshi Yonezawa, Shingo Tanaka, Makito Tanaka, Ryo Kobayashi, Satoshi Takahashi
Summary: The aim of this study was to identify the risk factors for false positives in high-sensitivity HBsAg quantitative tests and reduce the need for neutralization tests. The results showed that younger age, female sex, lower HBsAg values, and reagent improvement were independent risk factors for false positives. The false-positive rate was highest in the range of 0.005-0.049 IU/mL.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2024)
Article
Infectious Diseases
Nobuaki Kobayashi, Katsushi Tanaka, Suguru Muraoka, Kohei Somekawa, Ayami Kaneko, Sousuke Kubo, Hiromi Matsumoto, Hiroaki Fujii, Keisuke Watanabe, Nobuyuki Horita, Yu Hara, Takeshi Kaneko
Summary: This study identified age, a negative T-SPOT.TB result, elevated CRP levels, and a high NLR as significant independent risk factors for death in hospitalized TB patients. These findings underscore the importance of these parameters in the risk stratification and management of hospitalized TB patients.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2024)
Article
Infectious Diseases
Naokuni Hishiya, Kenji Uno, Akiyo Nakano, Mitsuru Konishi, Seiya Higashi, Shuhei Eguchi, Tadashi Ariyoshi, Asami Matsumoto, Kentaro Oka, Motomichi Takahashi, Yuki Suzuki, Saori Horiuchi, Nobuyasu Hirai, Yoshihiko Ogawa, Taku Ogawa, Ryuichi Nakano, Keiichi Mikasa, Kei Kasahara, Hisakazu Yano
Summary: This study revealed intestinal dysbiosis near a CD4 count of 350 in HIV-infected patients undergoing cART. These findings contribute to the understanding of intestinal damage and systemic inflammation in HIV infection.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2024)