Article
Biotechnology & Applied Microbiology
Salim Ghandour, Konstantinos Pazarlis, Susanne Lewin, Per Isaksson, Peter Forsth, Cecilia Persson
Summary: This study developed a biomechanical model to study the effectiveness of Percutaneous Cement Discoplasty (PCD) in treating degenerative disc disease. The model showed that PCD treatment restored spinal segment stiffness after injury, and it accurately represented the clinical vacuum phenomena. The model can be used to test more complex loading scenarios, new materials, and surgical techniques in the future.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Orthopedics
Peter Endre Eltes, Laszlo Kiss, Ferenc Bereczki, Zsolt Szoverfi, Chloe Techens, Gabor Jakab, Benjamin Hajnal, Peter Pal Varga, Aron Lazary
Summary: The developed method aims to measure geometrical changes in surgically treated segments accurately and reproducibly. The volume and surface area of injected PMMA can predict the extent of indirect spinal canal decompression and have a significant impact on the clinical benefit achieved with the PCD procedure.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2021)
Editorial Material
Clinical Neurology
Carlos Sola, Gaston Camino Willhuber, Gonzalo Kido, Matias Pereira Duarte, Mariana Bendersky, Maximiliano Mereles, Matias Petracchi, Marcelo Gruenberg
Summary: This article introduces a percutaneous technique for treating advanced degenerative disk disease in elderly patients, providing a detailed technical description based on experience, presenting postoperative imaging results, and offering indications and recommendations for the application of this alternative minimally invasive strategy.
EUROPEAN SPINE JOURNAL
(2021)
Review
Clinical Neurology
Federico Fusini, Massimo Girardo, Alessandro Aprato, Alessandro Masse, Alberto Lorenzi, Domenico Messina, Gabriele Colo
Summary: Percutaneous cement discoplasty shows promising clinical results in providing pain relief for elderly patients, but the current literature quality is poor, and further research is needed to confirm its clinical efficacy and correct indications.
WORLD NEUROSURGERY
(2022)
Article
Orthopedics
Shuang Li, Baoshan Xu, Yancheng Liu, Jingyu Zhang, Guijun Xu, Pengfei Shao, Xiaoye Li, Yongcheng Hu, Xinlong Ma
Summary: Comparative analysis of the biomechanical properties of percutaneous cement discoplasty (PCD) in the spinal column revealed that fusion of bone cement and endplate can increase the stability of implants and reduce the risk of subsidence and dislocation.
ORTHOPAEDIC SURGERY
(2022)
Review
Surgery
Chloe Techens, Peter Endre Eltes, Aron Lazary, Luca Cristofolini
Summary: Percutaneous Cement Discoplasty (PCD) is a minimally invasive technique developed to treat lumbar disc degeneration disease, significantly improving clinical status of patients for up to two years. The surgery impacts spine alignment and increases disc height.
FRONTIERS IN SURGERY
(2022)
Article
Engineering, Biomedical
Susanne Lewin, Peter Forsth, Cecilia Persson
Summary: This study explores the potential of low-modulus PMMA bone cement in discoplasty and compares it with standard PMMA cement using a computational model. The results show that low-modulus PMMA cement has advantages in reducing spinal range of motion and alleviating stress.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
Article
Surgery
Jiajun Huang, Weike Zeng, Ming Li, Ziying Cheng, Junshen Huang, Changchun Liang, Yuxi Li, Lin Huang
Summary: Percutaneous cement discoplasty (PCD) can enhance the stability of the lumbar spine in flexion-extension and lateral bending, providing effective treatment for low back pain. Fractures and sliding of bone cement after PCD may lead to nerve compression.
FRONTIERS IN SURGERY
(2022)
Article
Clinical Neurology
Gaston Camino-Willhuber, Gilles Norotte, Nicolas Bronsard, Gonzalo Kido, Matias Pereira-Duarte, Martin Estefan, Mariana Bendersky, Sergio Terrasa, Julio Bassani, Matias Petracchi, Marcelo Gruenberg, Carlos Sola
Summary: Percutaneous cement discoplasty (PCD) resulted in significant improvement in pain and function in patients with advanced degeneration, with a relatively low rate of complications at 2 years of follow-up.
WORLD NEUROSURGERY
(2021)
Article
Orthopedics
Hongwei Jia, Bin Xu, Xiangbei Qi
Summary: This study investigated the indirect decompression effect of cement with different doses on nerve roots and the biomechanical changes on the spine during percutaneous cement discoplasty (PCD) using finite element analysis (FEA). The results showed that the injection of bone cement reduced the stress on the nerve roots, and the greater the amount of cement, the lesser the nerve root stress.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Clinical Neurology
Mahmoud Alkharsawi, Mootaz Shousha, Heinrich Boehm, Mohamed Alhashash
Summary: This retrospective cohort study evaluated the treatment results of pseudoarthrosis by cement injection in failed fusion in posterior lumbar interbody fusion in patients above 65 years. The study found that cement discoplasty offers a less invasive surgical solution for elderly patients with symptomatic lumbar pseudarthrosis, and can effectively improve symptoms.
EUROPEAN SPINE JOURNAL
(2022)
Article
Clinical Neurology
Vimal S. Gunasekaran, Dustin Hejdak, Benjamin Meyer, Andrew Klein, Kevin Koch
Summary: This study investigated the use of MRI-derived metrics as predictors of lumbar foraminal stenosis grade, revealing significant correlations between perineural fat volume and stenosis grades for all lumbar vertebral levels. The segmented volumes of perineural fat were found to predict the severity of clinically scored foraminal stenosis, suggesting the potential for further development of automated segmentation methods for more reproducible diagnosis and assessment.
EUROPEAN SPINE JOURNAL
(2021)
Article
Clinical Neurology
Toshio Nakamae, Kiyotaka Yamada, Takeshi Hiramatsu, Satoshi Ujigo, Naosuke Kamei, Kazuyoshi Nakanishi, Kjell Olmarker, Nobuo Adachi, Yoshinori Fujimoto
Summary: The study evaluated the clinical and radiologic results of PIPI for foraminal stenosis with radiculopathy in elderly patients with DLS. The results showed significant improvement in radiculopathy pain and function, as well as an increase in foraminal height and decrease in bone marrow edema extent after PIPI. This minimally invasive procedure is effective for treating not only low back pain but also radiculopathy in elderly patients with DLS.
WORLD NEUROSURGERY
(2022)
Article
Neurosciences
Edmond Jonathan Gandham, Nalli Ramanathan Uvaraj, Jin Hwa Eum
Summary: Minimally invasive spine surgery (MISS) is a technique that reduces local tissue injury while achieving the same results as traditional open surgery. Clinical outcomes have shown good results using endoscopic treatment for degenerative lumbar disc disease. This article presents a successful case of treating lumbar foraminal stenosis in an elderly patient using unilateral biportal endoscopic spine surgery (UBESS).
Article
Multidisciplinary Sciences
J. Hutchins, K. Lagerstrand, E. Stavlid, P-A Svensson, K. Rennerfelt, H. Hebelka, H. Brisby
Summary: This study aimed to test the feasibility of a new compression device and evaluate the image quality and foraminal properties during a Spurling test under MRI acquisition. The results showed that using this novel device for individualized provocation test could obtain satisfactory image quality and reveal changes in cervical lordosis and foraminal cross distance, which may help detect changes in foraminal properties.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Adam Biczo, Julia Szita, Iain McCall, Peter Pal Varga, Aron Lazary
EUROPEAN SPINE JOURNAL
(2020)
Article
Infectious Diseases
Aron Lazary, Istvan Klemencsics, Zsolt Szoverfi, Laszlo Kiss, Adam Biczo, Julia Szita, Peter Pal Varga
Summary: The study found that regardless of the presence of SSI, there was significant improvement in all PROMs, but patients with SSI may experience poorer subjective treatment outcomes in terms of GTO.
SURGICAL INFECTIONS
(2021)
Article
Rehabilitation
Julia Szita, Laszlo Kiss, Adam Biczo, Katalin Feher, Peter P. Varga, Aron Lazary
Summary: The STarT Back Tool is developed to identify modifiable prognostic factors for non-specific low back pain and classify patients into low, medium, and high risk of chronicity. The Hungarian version of the STarT Back Tool showed good reliability and validity in identifying risk groups of chronicity for low back pain patients. It can also be used to predict global treatment outcome in patients receiving group physical therapy.
DISABILITY AND REHABILITATION
(2022)
Editorial Material
Clinical Neurology
Aron Lazary
EUROPEAN SPINE JOURNAL
(2021)
Article
Engineering, Biomedical
Chloe Techens, Marco Palanca, Peter Endre Eltes, Aron Lazary, Luca Cristofolini
MEDICAL ENGINEERING & PHYSICS
(2020)
Article
Clinical Neurology
Annemarie L. Versteeg, Arjun Sahgal, Laurence D. Rhines, Daniel M. Sciubba, James M. Schuster, Michael H. Weber, Aron Lazary, Stefano Boriani, Chetan Bettegowda, Michael G. Fehlings, Michelle J. Clarke, Paul M. Arnold, Ziya L. Gokaslan, Charles G. Fisher
Summary: Surgery in patients with potentially unstable spinal metastases showed significant and sustained improvements in pain and HRQOL up to 1-year post-surgery, while treatment with radiotherapy alone resulted in short-term pain relief but no significant changes in HRQOL. Different clinical profiles were observed in patients treated with surgery or radiotherapy alone within the SINS potentially unstable group.
Article
Surgery
Peter Endre Eltes, Marton Bartos, Benjamin Hajnal, Agoston Jakab Pokorni, Laszlo Kiss, Damien Lacroix, Peter Pal Varga, Aron Lazary
Summary: A new method utilizing CT scan, 3D reconstruction, FEA analysis, CAD design, and 3D printing technology was proposed to assist surgeons in performing optimal surgical technique for revision surgery of non-union at the lumbosacral level, specifically addressing complications such as broken screws. Results showed that the modified bicortical convergent insertion technique is stiffer compared to monocortical divergent placement, indicating the potential for improved surgical outcomes.
FRONTIERS IN SURGERY
(2021)
Article
Clinical Neurology
Charlotte Dandurand, Charles G. Fisher, Laurence D. Rhines, Stefano Boriani, Raphaele Charest-Morin, Alessandro Gasbarrini, Alessandro Luzzati, Jeremy J. Reynolds, Feng Wei, Ziya L. Gokaslan, Chetan Bettegowda, Daniel M. Sciubba, Aron Lazary, Norio Kawahara, Michelle J. Clarke, Y. Raja Rampersaud, Alexander C. Disch, Dean Chou, John H. Shin, Francis J. Hornicek, IIya Laufer, Arjun Sahgal, Nicolas Dea
Summary: In high-volume cancer centers around the world, planned surgical margins can be achieved in approximately 75% of cases. The morbidity of the proposed intervention must be balanced with the expected success rate in order to optimize patient management and surgical decision-making.
NEUROSURGICAL FOCUS
(2021)
Article
Orthopedics
Peter Endre Eltes, Laszlo Kiss, Ferenc Bereczki, Zsolt Szoverfi, Chloe Techens, Gabor Jakab, Benjamin Hajnal, Peter Pal Varga, Aron Lazary
Summary: The developed method aims to measure geometrical changes in surgically treated segments accurately and reproducibly. The volume and surface area of injected PMMA can predict the extent of indirect spinal canal decompression and have a significant impact on the clinical benefit achieved with the PCD procedure.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2021)
Article
Clinical Neurology
Markian A. Pahuta, Felicity Fisk, Anne L. Versteeg, Charles G. Fisher, Arjun Sahgal, Ziya L. Gokaslan, Jeremy J. Reynolds, Ilya Laufer, Aron Lazary, Laurence D. Rhines, Stefano Boriani, Chetan Bettegowda, Nicolas Dea
Summary: This study aimed to develop a technique for calculating utilities from the Spine Oncology Study Group Outcomes Questionnaire v2.0 and provide a simple way to convert the questionnaire to utilities. The regression model demonstrated good predictive performance and revealed differences in the importance of individual items among participants.
Article
Clinical Neurology
Anne L. Versteeg, Arjun Sahgal, Ilya Laufer, Laurence D. Rhines, Daniel M. Sciubba, James M. Schuster, Michael H. Weber, Aron Lazary, Stefano Boriani, Chetan Bettegowda, Michael G. Fehlings, Michelle J. Clarke, Paul M. Arnold, Ziya L. Gokaslan, Charles G. Fisher
Summary: This international multicenter study aimed to investigate the association between the Spinal Instability Neoplastic Score (SINS) and patient-reported outcomes (PROs). The results showed a significant correlation between SINS and baseline PROs as well as changes in PROs post-treatment, with mechanical pain showing the highest correlation with PROs.
GLOBAL SPINE JOURNAL
(2023)
Article
Surgery
Jennifer Fayad, Mate Turbucz, Benjamin Hajnal, Ferenc Bereczki, Marton Bartos, Andras Bank, Aron Lazary, Peter Endre Eltes
Summary: This case report presented a 71-year-old female patient with severe spinal deformities due to repetitive surgeries over 39 years. By using patient-specific virtual geometry and 3D printed models, the surgical team successfully corrected the deformities, reduced complications, and improved surgical outcomes.
FRONTIERS IN SURGERY
(2021)
Article
Clinical Neurology
Anne L. Versteeg, Lior M. Elkaim, Arjun Sahgal, Laurence D. Rhines, Daniel M. Sciubba, James M. Schuster, Michael G. Fehlings, Aron Lazary, Michelle J. Clarke, Paul M. Arnold, Chetan Bettegowda, Stefano Boriani, Ziya L. Gokaslan, Charles G. Fisher, Michael H. Weber
Summary: This study investigated the effect of corticosteroids on preoperative neurological function in patients with metastatic epidural spinal cord compression (MESCC), finding that 50% of patients experienced stabilization or improvement of preoperative neurological function after steroid use.
Article
Multidisciplinary Sciences
Arpad Bozsodi, Beata Scholtz, Gergo Papp, Zoltan Sapi, Adam Biczo, Peter Pal Varga, Aron Lazary
Summary: Using RNA sequencing and bioinformatics analysis, we identified significantly dysregulated miRNAs and their target genes in sacral chordoma. We predicted regulatory networks and pathways that are affected by aberrant miRNA expression, which might play a role in the self-renewal of chordoma stem cells and provide potential targets for anti-chordoma therapies.
Article
Clinical Neurology
Michael R. Bond, Anne L. Versteeg, Arjun Sahgal, Laurence D. Rhines, Daniel M. Sciubba, James M. Schuster, Michael H. Weber, Michael G. Fehlings, Aron Lazary, Michelle J. Clarke, Stefano Boriani, Chetan Bettegowda, Paul M. Arnold, Ziya L. Gokaslan, Charles G. Fisher
GLOBAL SPINE JOURNAL
(2020)