Journal
JOURNAL OF INFECTION
Volume 62, Issue 2, Pages 119-129Publisher
W B SAUNDERS CO LTD
DOI: 10.1016/j.jinf.2010.10.002
Keywords
Innate immunity; Inflammasome; Infection; IL-1 beta
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Funding
- Southeast Regional Center of Excellence for Emerging Infections and Biodefense (SERCEB)
- NIH [R56 AI089756]
- Center for Comparative Biology of Vulnerable Populations (CCBVP)
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The innate immune system serves to generate immediate host defenses against pathogens. Advance in the mechanism of innate immunity has provided new insights into host-pathogen microbial interactions. The cytosolic multi-protein complex called the inflammasome, which regulates the caspase-1 dependent processing of inflammatory cytokines IL-1 beta and IL-18, is critical for the innate defense against pathogens. We summarize the current knowledge regarding the regulatory functions of the inflammasome in the pathogenesis of infections by various microbes (e.g., bacteria, fungi, viruses, and protozoa), and discuss its potential application in a clinical setting. Understanding of the unique role of the inflammasome signaling pathway in initiating and regulating inflammation is pivotal for the development of innovative approaches to optimize management of these infections. (C) 2010 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
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