Article
Multidisciplinary Sciences
Yong Chan Kim, Heun Choi, Young Ah Kim, Yoon Soo Park, Young Hee Seo, Hyukmin Lee, Kyungwon Lee
Summary: Understanding the risk factors and microbiological features in recurrent E. coli BSI can aid clinicians in their management planning. Data from 2017 to 2018 were collected to assess antimicrobial resistance rates and molecular epidemiology. Risk factors for recurrence included vascular catheterization, ESBL phenotype, and high SOFA score. The highest proportion of ST131 and ESBL genotype was observed in early onset recurrent BSI. Whole genome sequencing revealed the presence of various virulence factors, resistant genes, and plasmid types in all types of BSI. This knowledge is important for clinicians in managing recurrent E. coli BSI.
Article
Immunology
Andrew Bock, Blake M. Hanson, Felicia Ruffin, Joshua B. Parsons, Lawrence P. Park, Batu Sharma-Kuinkel, Michael Mohnasky, Cesar A. Arias, Vance G. Fowler, Joshua T. Thaden
Summary: Recurrent gram-negative bacterial bloodstream infections (GNB-BSI) are mainly caused by relapse, and pulsed-field gel electrophoresis accurately differentiates relapse from reinfection. Having a cardiac device is a risk factor for relapse.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Stephanie Shulder, Pranita D. Tamma, Suiyini Fiawoo, Kathryn Dzintars, Daniel Escobar, Daniel J. Livorsi, Anurag N. Malani, Danica Palacio, Emily S. Spivak, Matty Zimmerman, Jacqueline T. Bork
Summary: A 24-site observational cohort study showed that infectious diseases consultation (IDC) reduced the risk of 30-day mortality by 40% in hospitalized patients with Gram-negative bacteremia (GN-BSI).
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Oncology
Ahmed A. Mohamed, Alanna M. Chamberlain, Kathleen J. Yost, Gregory Jenkins, Lila J. Finney Rutten, Mark L. Wieland, Jane W. Njeru
Summary: This study examines the cancer incidence among Somali immigrant populations in Olmsted County, Minnesota and compares it with non-Somali populations. The study found a higher incidence and relative risk of liver malignancies among Somalis, but lower relative risk and incidence of breast, cervical, and melanoma malignancies. Adjusted for age and sex, liver cancer was the most common cancer in Somali men, while breast cancer was the most common malignancy in women.
Article
Infectious Diseases
Camille Bouchand, Anais Andreo, Florence Le Gallou, Stephane Corvec, Celine Bourigault, Didier Lepelletier
Summary: The retrospective study conducted from 2005 to 2019 showed a significant increase in the incidence density of E-ESBL infections over a 17-year period in the university hospital. Patients with E-ESBL bacteremia had a higher mortality rate, highlighting the importance of continued efforts to control the spread of these multidrug-resistant bacteria in the institution.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2022)
Article
Immunology
Keiju S. K. Kontula, Kirsi Skogberg, Jukka Ollgren, Asko Jarvinen, Outi Lyytikainen
Summary: This study evaluated the incidence, outcomes, and causative agents of bloodstream infections in Finland from 2004 to 2018. The incidence of BSI increased annually, especially among those aged 80 years and older. While the 1-month case-fatality rate decreased, the 1-month all-cause mortality rate rose due to an increase in BSIs caused by multidrug-resistant microbes such as extended-spectrum beta-lactamase-producing E. coli. Additional efforts are needed to address the rising trend of community-acquired BSIs and antimicrobial drug-resistant pathogens.
EMERGING INFECTIOUS DISEASES
(2021)
Review
Infectious Diseases
Jessica Waters, Andrew F. F. Shorr
Summary: Newer antibiotics have been developed and proven effective in treating various types of multidrug-resistant infections, but there is limited information on their efficacy specifically for bloodstream infections.
Article
Oncology
Justin C. Tossey, Zeinab El Boghdadly, Erica E. Reed, Jennifer Dela-Pena, Kelci Coe, Sherry N. Williams, Lynn C. Wardlow
Summary: This study compared the outcomes of cancer patients transitioning from IV to PO therapy with those continuing IV treatment. The PO therapy group had lower treatment failure rates, shorter hospital stays, and fewer complications.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Infectious Diseases
Michael H. Wilke, Birgit Preisendoerfer, Anna Seiffert, Maria Kleppisch, Caroline Schweizer, Stephan Rauchensteiner
Summary: Infections with carbapenem-resistant gram-negative bacteria are becoming a growing threat in Germany, with an increase in mortality. Using different data sources allows for a more realistic understanding of the situation.
Article
Infectious Diseases
Fan Zhang, Hao Wang, Liyu Liu, Teng Su, Bing Ji
Summary: A machine learning model was developed in this study to predict gram-positive and gram-negative bacteremia based on routine laboratory parameters.
BMC INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Atsushi Uda, Katsumi Shigemura, Koichi Kitagawa, Kayo Osawa, Kenichiro Onuma, Yonmin Yan, Tatsuya Nishioka, Masato Fujisawa, Ikuko Yano, Takayuki Miyara
Summary: The incidence of bacteremia caused by highly resistant Enterococcus faecium is increasing in Japan, with unclear risk factors for infection and mortality. Patients with E. faecium had higher antibiotic costs and were more commonly associated with prior use of specific antibiotics. Bacteremia of unknown source and acute kidney injury were associated with higher risks of mortality in enterococcal bacteremia patients.
Article
Microbiology
Olga Tsachouridou, Dimitrios Pilalas, Sideris Nanoudis, Athanasios Antoniou, Isidora Bakaimi, Theofilos Chrysanthidis, Konstantinos Markakis, Angeliki Kassomenaki, Paraskevi Mantzana, Efthymia Protonotariou, Lemonia Skoura, Symeon Metallidis
Summary: In endemic regions, mortality rates for multidrug-resistant bloodstream infections remain high, and high procalcitonin is the only predictor for death, while the use of rapid diagnostic tests did not improve mortality rates.
Article
Infectious Diseases
Haein Kim, Hyeonji Seo, Hyemin Chung, Sunghee Park, Heungsup Sung, Mi-Na Kim, Seongman Bae, Jiwon Jung, Min Jae Kim, Sung-Han Kim, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Yong Pil Chong
Summary: The value of follow-up blood culture (FUBC) in the management of Gram-negative bacteremia (GNB) is controversial. This study evaluated bedside risk predictors and found that hemodialysis, fever on the day of FUBCs, intravascular device, no use of in vitro active antibiotic within 24 h, non-fermenting bacteria, and multidrug resistance were independent risk factors for positive FUBCs in GNB. The yield of FUBCs increased as the number of bedside risk predictors increased, and positive FUBCs were significantly associated with 30-day mortality.
Article
Infectious Diseases
Marios Karvouniaris, Garyphallia Poulakou, Konstantinos Tsiakos, Maria Chatzimichail, Panagiotis Papamichalis, Anna Katsiaflaka, Katerina Oikonomou, Antonios Katsioulis, Eleni Palli, Apostolos Komnos
Summary: Intensive care unit patients may be infected by difficult-to-treat-resistant Gram-negative microorganisms. Colistin, as a last resort antibiotic, may not improve survival after the emergence of colistin-resistant isolates. The severity of infection is the independent predictor of mortality.
Article
Medicine, General & Internal
Lisa Vaughan, Wendy M. White, Yvonne S. Butler Tobah, Andrea Kattah, Santosh Parashuram, Madugodarlalalage D. Gunaratne, Jane V. Vermunt, Michelle Mielke, Natasa M. Milic, Sonja Suvakov, Suzette Bielinski, Alanna M. Chamberlain, Vesna D. Garovic
Summary: This article introduces the purpose, participants, findings to date, and future plans of the Olmsted County HDP cohort study. By constructing per-pregnancy and per-woman cohorts, it was found that the incidence rates of HDP were double when assessed on a per-woman basis compared to per-pregnancy basis. Moreover, women with a history of HDP were found to have higher rates of specific diseases at early ages, and a history of HDP was associated with accelerated aging through accumulation of multimorbidity.
Article
Infectious Diseases
Sarah E. Battle, Matthew Shuping, Sarah Withers, Julie A. Justo, P. Brandon Bookstaver, Majdi N. Al-Hasan
Summary: The quick Pitt bacteremia score (qPitt) is a useful tool for predicting mortality in patients with Staphylococcus aureus bloodstream infection (SAB), demonstrating good discrimination ability.
JOURNAL OF INFECTION
(2022)
Article
Pharmacology & Pharmacy
Kayla Antosz, Majdi N. Al-Hasan, Z. Kevin Lu, Benjamin Tabor, Julie Ann Justo, Alexander Milgrom, Joseph Kohn, P. Brandon Bookstaver
Summary: This study evaluates the economic and clinical utility of long-acting lipoglycopeptides (LaLGPs) in patients requiring prolonged antibiotic treatment. Results suggest that LaLGPs may be a beneficial treatment option for patients with deep-seated infections and socioeconomic factors.
Article
Immunology
Mariam Younas, Julie Royer, Hana R. Winders, Sharon B. Weissman, P. Brandon Bookstaver, Julie Ann Justo, Katie S. Waites, Linda Bell, Majdi N. Al-Hasan
Summary: This population-based retrospective cohort study found that increased influenza vaccination coverage was temporally associated with a decrease in ambulatory antibiotic use in children. After adjusting for yearly vaccine effectiveness, the antibiotic prescription rate decreased by 3/1000 person-months for each 1% increase in influenza vaccination coverage between 2012 and 2017 in South Carolina (P < 0.001).
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Emergency Medicine
Massimo Sartelli, Francesco M. Labricciosa, Federico Coccolini, Raul Coimbra, Fikri M. Abu-Zidan, Luca Ansaloni, Majdi N. Al-Hasan, Shamshul Ansari, Philip S. Barie, Miguel Angel Cainzos, Marco Ceresoli, Massimo Chiarugi, Jeffrey A. Claridge, Enrico Cicuttin, Evan Patchen Dellinger, Donald E. Fry, Xavier Guirao, Timothy Craig Hardcastle, Andreas Hecker, Ari K. Leppaniemi, Andrey Litvin, Sanjay Marwah, Emilio Maseda, John E. Mazuski, Ziad Ahmed Memish, Andrew W. Kirkpatrick, Leonardo Pagani, Mauro Podda, Huseyin Kemal Rasa, Boris E. Sakakushev, Robert G. Sawyer, Fabio Tumietto, Yonghong Xiao, Wedad Faraj Aboubreeg, Harissou Adamou, Lali Akhmeteli, Emrah Akin, Maria Grazia Alberio, Felipe Alconchel, Ibrahim Amadou Magagi, Ana Belen Arauz, Giulio Argenio, Boyko C. Atanasov, Semra Demirli Atici, Selmy Sabry Awad, Efstratia Baili, Lovenish Bains, Miklosh Bala, Oussama Baraket, Suman Baral, Vladislav A. Belskii, Moussa Benboubker, Offir Ben-Ishay, Pierpaolo Bordoni, Abdalia Boumediene, Giuseppe Brisinda, Laura Cavazzuti, Sujith J. Chandy, Maria Michela Chiarello, Nicola Cillara, Guglielmo Clarizia, Maria-Elena Cocuz, Iuliu Gabriel Cocuz, Luigi Conti, Raffaella Coppola, Yunfeng Cui, Jacek Czepiel, Fabrizio D'Acapito, Dimitrios Damaskos, Koray Das, Belinda De Simone, Samir Delibegovic, Zaza Demetrashvili, Dzemail S. Detanac, Sameer Dhingra, Stefano Di Bella, Evgeni N. Dimitrov, Agron Dogjani, Mario D'Oria, Irina Magdalena Dumitru, Mutasim M. Elmangory, Octavian Enciu, Massimo Fantoni, Daniela Filipescu, Francesco Fleres, Domitilla Foghetti, Pietro Fransvea, Mahir Gachabayov, Rita Galeiras, Gianni Gattuso, Wagih M. Ghannam, Valeria Ghisetti, Giorgio Giraudo, Kebebe Bekele Gonfa, Emre Gonullu, Yousif Tag Elsir Y. Hamad, Matthias Hecker, Arda Isik, Nizar Ismail, Azzain Ismail, Sumita Agarwal Jain, Souha S. Kanj, Garima Kapoor, Ilias Karaiskos, Alfie J. Kavalakat, Jakub Kenig, Faryal Khamis, Vladimir Khokha, Ronald Kiguba, Jae Il Kim, Yoshiro Kobe, Kenneth Yuh Yen Kok, Bojan M. Kovacevic, Igor Andreevich Kryvoruchko, Akira Kuriyama, Aitor Landaluce-Olavarria, Konstantinos Lasithiotakis, Varut Lohsiriwat, Eftychios Lostoridis, Davide Luppi, Gustavo Miguel Machain Vega, Marc Maegele, Athanasios Marinis, Gennaro Martines, Aleix Martinez-Perez, Damien Massalou, Cristian Mesina, Gokhan Metan, Maria Guadalupe Miranda-Novales, Shyam Kumar Mishra, Mohaned Ibrahim Hussein Mohamed, Ali Yasen Y. Mohamedahmed, Ismael Mora-Guzman, Francesk Mulita, Ana-Maria Musina, Pradeep H. Navsaria, Ionut Negoi, Gabriela Elisa Nita, Donal B. O'Connor, Carlos Alberto Ordonez, Desire Pantalone, Arpad Panyko, Aristeidis Papadopoulos, Nikolaos Pararas, Francesco Pata, Tapan Patel, Gianluca Pellino, Teresa Perra, Gennaro Perrone, Antonio Pesce, Tadeja Pintar, Georgi Ivanov Popivanov, Alberto Porcu, Martha Alexa Quiodettis, Razrim Rahim, Ashrarur Rahman Mitul, Martin Reichert, Miran Rems, Glendee Yolande Reynolds Campbell, Nuno Rocha-Pereira, Gabriel Rodrigues, Gustavo Eduardo Roncancio Villamil, Stefano Rossi, Ibrahima Sall, Hossein Samadi Kafil, Diego Sasia, Jeremiah Seni, Charalampos Seretis, Mario Serradilla-Martin, Vishal G. Shelat, Boonying Siribumrungwong, Mihail Slavchev, Leonardo Solaini, Boun Kim Tan, Antonio Tarasconi, Dario Tartaglia, Elena Adelina Toma, Gia Tomadze, Adriana Toro, Marcos Roberto Tovani-Palone, Harry van Goor, Alin Vasilescu, Andras Vereczkei, Massimiliano Veroux, Sergio Alberto Weckmann, Lukas Werner Widmer, AliIbrahim Yahya, Sanoop K. Zachariah, Andee Dzulkarnaen Zakaria, Nadezhda Zubareva, Wietse P. Zuidema, Isidoro Di Carlo, Francesco Cortese, Gian Luca Baiocchi, Ronald Maier, Fausto Catena
Summary: This study investigated the organizational characteristics of acute care facilities worldwide in preventing and managing infections in surgery, and assessed participants' perception regarding infection prevention and control measures. The results showed that patient involvement in IPC implementation is still not well-considered, and the COVID-19 pandemic has played a significant role in increasing awareness among HCWs of IPC programs.
WORLD JOURNAL OF EMERGENCY SURGERY
(2022)
Editorial Material
Infectious Diseases
Pamela Bailey, Majdi N. Al-Hasan
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Review
Pharmacology & Pharmacy
Kayla Antosz, Sarah Battle, Jack Chang, Marc H. Scheetz, Majdi Al-Hasan, P. Brandon Bookstaver
Summary: Infections of the central nervous system (CNS) are challenging to treat. The use of antistaphylococcal penicillins presents challenges, such as frequent dosing administration and adverse events. This review suggests that dose optimized cefazolin is a safe and effective alternative for CNS infections due to methicillin-susceptible Staphylococcus aureus.
Editorial Material
Immunology
Sarah E. Battle, Majdi N. Al-Hasan
TRANSPLANT INFECTIOUS DISEASE
(2022)
Article
Infectious Diseases
Yuwei Vivian Tsai, Caroline Derrick, Ismaeel Yunusa, Sharon Weissman, Majdi N. Al-Hasan, Julie Ann Justo, Paul Brandon Bookstaver
Summary: Nontuberculous mycobacterial (NTM) infections pose treatment challenges and limited data exists on treatment outcomes in U.S. adults. This retrospective study analyzed a cohort of NTM-infected adults and found Mycobacterium avium intracellulare complex and Mycobacterium abscessus to be the most prevalent isolates. Only 35% of patients received treatment, with a favorable outcome observed in 61.4% of cases. Multiple changes in antimicrobial therapy were associated with unfavorable outcomes, highlighting the importance of interdisciplinary collaboration to improve treatment outcomes in NTM infections.
Article
Infectious Diseases
Brian J. Haimerl, Rodrigo Encinas, Julie Ann Justo, Joseph Kohn, P. Brandon Bookstaver, Hana Rac Winders, Majdi N. Al-Hasan
Summary: This study investigated the impact of using the ESBL prediction score on the time to appropriate antimicrobial therapy for bloodstream infection (BSI). The results showed that the implementation of the score significantly reduced the time to initiate appropriate antimicrobial therapy.
Article
Immunology
Eric Senneville, Zaina Albalawi, Suzanne A. van Asten, Zulfiqarali G. Abbas, Geneve Allison, Javier Aragon-Sanchez, John M. Embil, Lawrence A. Lavery, Majdi Alhasan, Orhan Oz, Ilker Uckay, Vilma Urbancic-Rovan, Zhang-Rong Xu, Edgar J. G. Peters
Summary: The International Working Group on the Diabetic Foot has published evidence-based guidelines on the management and prevention of diabetes-related foot diseases since 1999. This updated guideline uses the GRADE framework and provides recommendations for healthcare professionals involved in diabetes-related foot care. The recommendations cover various aspects of foot infections in diabetes patients, including diagnosis, treatment, and adjunctive therapies. The guideline aims to improve patient care, reduce amputations, and lessen the burden of diabetes-related foot disease.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Endocrinology & Metabolism
Eric Senneville, Zaina Albalawi, Suzanne A. van Asten, Zulfiqarali G. Abbas, Geneve Allison, Javier Aragon-Sanchez, John M. Embil, Lawrence A. Lavery, Majdi Alhasan, Orhan Oz, Ilker Uckay, Vilma Urbancic-Rovan, Zhang-Rong Xu, Edgar J. G. Peters
Summary: The accurate diagnosis of diabetic foot infections is crucial for the management and prognosis of patients. Clinical signs and symptoms as well as the classification system can help predict the need for hospitalization, amputation, and mortality. Serum inflammatory markers provide supportive, but not definitive, evidence of soft tissue infection. Tissue culture yields more accurate microbiological information compared to superficial samples. Advanced imaging methods such as MRI and nuclear imaging can assist in diagnosing and localizing infection.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Endocrinology & Metabolism
Eric Senneville, Zaina Albalawi, Suzanne A. van Asten, Zulfiqarali G. Abbas, Geneve Allison, Javier Aragon-Sanchez, John M. Embil, Lawrence A. Lavery, Majdi Alhasan, Orhan Oz, Ilker Uckay, Vilma Urbancic-Rovan, Zhang-Rong Xu, Edgar J. G. Peters
Summary: The International Working Group on the Diabetic Foot (IWGDF) has published evidence-based guidelines on the management and prevention of diabetes-related foot diseases since 1999. This guideline is an update of the 2019 IWGDF guideline on the diagnosis and management of foot infections in persons with diabetes mellitus, developed using the GRADE framework. The recommendations cover various aspects of diagnosing and treating foot infections in diabetic patients, aimed at improving patient care, reducing amputations, and alleviating the burden of diabetes-related foot disease.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Review
Endocrinology & Metabolism
Edgar J. G. Peters, Zaina Albalawi, Suzanne A. van Asten, Zulfiqarali G. Abbas, Geneve Allison, Javier Aragon-Sanchez, John M. Embil, Lawrence A. Lavery, Majdi Alhasan, Orhan Oz, Ilker Uckay, Vilma Urbancic-Rovan, Zhang-Rong Xu, Eric Senneville
Summary: The optimal approaches to managing diabetic foot infections are still challenging, as existing studies on different treatment strategies generally produce comparable results and lack high-quality data. Recent research shows that treatment methods yield similar results for skin and soft tissue infections as well as osteomyelitis in patients with diabetes, with a few exceptions. Antibiotic therapy can be shortened to 10 days post-surgical debridement for moderate or severe infections, while for osteomyelitis, the treatment duration can be reduced to 3 weeks post-surgical debridement. There is insufficient high-quality evidence for the effectiveness of various adjunctive therapies. Further well-designed trials are needed to support treatment recommendations.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Microbiology
Lynn E. Broermann, Majdi N. Al-Hasan, Sarah Withers, Kristina L. Benbow, Taylor Ramsey, Meghan Mctavish, Hana R. Winders
Summary: This retrospective cohort study compares the effectiveness of partial oral antibiotic regimens to standard intravenous therapy in uncomplicated bloodstream infections caused by Streptococcus species. The study found that partial oral therapy does not have a higher risk of treatment failure and may result in shorter hospital stays compared to standard intravenous therapy.
Article
Infectious Diseases
Jordan Jones, Kamla Sanasi-Bhola, Majdi N. N. Al-Hasan, Layne Reihart, Julie Ann Justo, P. Brandon Bookstaver
Summary: Prompt treatment of candidemia is crucial, especially in immunocompromised patients. However, there may be discordance among different diagnostic methods, leading to delayed therapy. This case emphasizes the importance of understanding and interpreting rapid diagnostic technologies, shared decision-making in antimicrobial management, and the responsibility of antimicrobial stewardship teams.
THERAPEUTIC ADVANCES IN INFECTIOUS DISEASE
(2022)