Article
Medicine, General & Internal
Ali Goudarzi, Roham Sarmadian, Parsa Yousefichaijan, Abolfazl Gilani
Summary: This article reports a case of meningitis in a 5-year-old immunocompetent boy. The cerebrospinal fluid tested positive for streptococcus viridans.
CLINICAL CASE REPORTS
(2023)
Article
Infectious Diseases
Juan A. Quintero-Martinez, Joya-Rita Hindy, Said El Zein, Holenarasipur R. Vikram, Wendelyn Bosch, Daniel C. DeSimone, Larry M. Baddour
Summary: This study investigated the Viridans group streptococcal (VGS) isolates in patients with MVP endocarditis. The predominant species identified was S. mitis, and further evaluation of VGS species is recommended for risk profiling of infective endocarditis based on species identification.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Mohammed A. Almatrafi, Alhanouf Almuflihi, Rawan Jarwann, Shroq Alghraibi, Enais Ashgar, Nouf Alsahaf, Abdullah J. Aburziza
Summary: This article presents a case of a 14-month-old girl with fevers and irritability for 2 weeks, diagnosed with meningitis with abundant growth of VGS in the cerebrospinal fluid. After two weeks of ceftriaxone treatment, the patient showed marked clinical improvement.
AMERICAN JOURNAL OF CASE REPORTS
(2021)
Article
Infectious Diseases
Michael R. Yeaman, Liana C. Chan, Nagendra N. Mishra, Arnold S. Bayer
Summary: S. mitis-oralis strains exhibit rapid, high-level and durable resistance to daptomycin, with resistant cells showing significantly higher accumulation of daptomycin than susceptible cells. Both daptomycin and cationic host defense peptides induce cell membrane hyper-polarization in susceptible cells, leading to greater temporal killing compared to resistant cells. However, differences in cell membrane permeabilization, lipid turnover, and regulated cell death did not differentiate between susceptible and resistant phenotypes in this strain pair.
Article
Immunology
Niko Vahasarja, Bodil Lund, Anders Ternhag, Bengt Gotrick, Lars Olaison, Margareta Hultin, Anna Warnqvist, Carina Kruger Weiner, Aron Naimi-Akbar
Summary: A cohort study in Sweden suggests that there has been no increase in the incidence of oral streptococcal infective endocarditis among high-risk individuals since the recommended cessation of antibiotic prophylaxis in dentistry for the prevention of endocarditis in October 2012.
CLINICAL INFECTIOUS DISEASES
(2022)
Review
Biochemistry & Molecular Biology
Mustapha Abdeljalil Brai, Nadji Hannachi, Nabila El Gueddari, Jean-Pierre Baudoin, Abderrhamane Dahmani, Hubert Lepidi, Gilbert Habib, Laurence Camoin-Jau
Summary: The incidence of infective endocarditis (IE) has increased in the past decade, with changes in the causative bacteria. The role of bacterial interaction with human platelets in the pathogenesis of IE is crucial but not yet fully understood. This review explores the involvement of platelets in endocarditis, their role in vegetation formation depending on bacterial species, and investigates platelet therapy advancements and future research avenues to understand the mechanistic enigma of bacteria-platelet interaction for preventive and curative medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Niko Vahasarja, Bodil Lund, Anders Ternhag, Bengt Gotrick, Lars Olaison, Margareta Hultin, Carina Kruger Weiner, Aron Naimi-Akbar
Summary: The study did not find evidence to support the association between IDPs and VGS-IE in high-risk individuals, suggesting the need for larger studies to clarify the lack of association.
Article
Infectious Diseases
Takeaki Wajima, Atsuya Hagimoto, Emi Tanaka, Yoshiaki Kawamura, Hidemasa Nakaminami
Summary: This study identified TP1632 as a multidrug-resistant alpha-haemolytic streptococcus isolated from a patient with bacteraemia, showing characteristics of a novel species and the potential for horizontal transfer of antimicrobial resistance among streptococci.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Article
Microbiology
Celine Plainvert, Erika Matuschek, Nicolas Dmytruk, Marine Gaillard, Amandine Frigo, Yassine Ballaa, Eddy Biesaga, Gunnar Kahlmeter, Claire Poyart, Asmaa Tazi
Summary: NBHS are opportunistic pathogens frequently causing severe and difficult-to-treat infections such as endocarditis. This study highlights their importance and resistance to antibiotics, especially beta-lactam agents. A multicenter study conducted in France described the clinical and microbiological epidemiology of invasive NBHS infections, emphasizing the need for accurate species identification and antimicrobial susceptibility testing for effective treatment.
MICROBIOLOGY SPECTRUM
(2023)
Article
Infectious Diseases
Fen Pan, Na Zhao, Wantong Zhao, Chun Wang, Yan Sun, Haomin Zhang, Juanxiu Qin, Qian Liu, Hong Zhang
Summary: This study demonstrated that the two MALDI-TOF MS systems could differentiate most VGS isolates, but with different identification performances. The Bruker Biotyper system tends to produce more misidentifications compared to the VITEK MS system.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Immunology
Francesc Escrihuela-Vidal, Damaris Berbel, Nuria Fernandez-Hidalgo, Laura Escola-Verge, Patricia Munoz, Maria Olmedo, Miguel Angel Goenaga, Josune Goikoetxea, Mara Carmen Farinas, Arstides De Alarcon, Jose M. Miro, Guillermo Ojeda, Antonio Plata, Guillermo Cuervo, Jordi Carratala, GAMES Investigators
Summary: In a retrospective analysis, it was found that cephalosporin monotherapy was not associated with higher in-hospital mortality when the isolate showed intermediate susceptibility to penicillin. Therefore, for endocarditis caused by penicillin-intermediate streptococci, the use of cephalosporin monotherapy can avoid nephrotoxicity without affecting patient outcomes.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Ana M. Quintero, Diego A. Cruz Vidal, Brett G. Klamer, Monica Ardura, Sophonie J. Oyeniran
Summary: Implementation of LVX prophylaxis among high-risk children with underlying malignancy led to reduced rates of fluoroquinolone susceptible VGS bloodstream isolates over time, without significant differences in clinical outcomes when compared to subjects with LVX susceptible BSI isolates.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2023)
Review
Cardiac & Cardiovascular Systems
Walter R. Wilson, Michael Gewitz, Peter B. Lockhart, Ann F. Bolger, Daniel C. DeSimone, Dhruv S. Kazi, David J. Couper, Andrea Beaton, Catherine Kilmartin, Jose M. Miro, Craig Sable, Mary Anne Jackson, Larry M. Baddour
Summary: After reviewing the available evidence, no changes are recommended to the 2007 guidelines for preventing Viridans Group Streptococcal Infective Endocarditis. It is still advised to use antibiotic prophylaxis for high-risk patients, emphasizing the importance of oral health in disease prevention. Further randomized controlled studies are needed to refine recommendations.
Article
Infectious Diseases
Adrian Tellez, Juan Ambrosioni, Marta Hernandez-Meneses, Jaume Llopis, Marco Ripa, Stephen T. Chambers, David Holland, Manel Almela, Nuria Fernandez-Hidalgo, Benito Almirante, Emilio Bouza, Jacob Strahilevitz, Margaret M. Hannan, John Harkness, Zeina A. Kanafani, Tahaniyat Lalani, Selwyn Lang, Nigel Raymond, Kerry Read, Tatiana Vinogradova, Christopher W. Woods, Dannah Wray, Asuncion Moreno, Vivian H. Chu, Jose M. Miro
Summary: This study describes the clinical characteristics and outcome of Abiotrophia and Granulicatella infective endocarditis compared to Viridans group streptococci infective endocarditis. Patients with ABI/GRA-IE were younger and had similar clinical features and rates of surgery, but had a better prognosis compared to VGS-IE.
JOURNAL OF INFECTION
(2022)
Article
Dentistry, Oral Surgery & Medicine
Therese Thoresen, Stina Jordal, Stein-Atle Lie, Friederike Wunsche, Martha Rolland Jacobsen, Bodil Lund
Summary: This study suggests that the association between the origin of infectious endocarditis-causing bacteria and oral infection screening findings may be uncertain, indicating that the benefits of screening and eliminating oral infections in hospitalized patients with endocarditis may be overestimated.