Identification and characterization of the spiruchostatin biosynthetic gene cluster enable yield improvement by overexpressing a transcriptional activator

Combination of a novel HDAC inhibitor OBP-801/YM753 and a PI3K inhibitor LY294002 synergistically induces apoptosis in human endometrial carcinoma cells due to increase of Bim with accumulation of ROS

(2013) Takashi Yoshioka et al.   GYNECOLOGIC ONCOLOGY

Spiruchostatin A Inhibits Proliferation and Differentiation of Fibroblasts from Patients with Pulmonary Fibrosis

(2012) Elizabeth R. Davies et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Discovery and activity profiling of thailandepsins A through F, potent histone deacetylase inhibitors, from Burkholderia thailandensis E264

(2012) Cheng Wang et al.   MedChemComm

Thailandepsin A

(2011) Cheng Wang et al.   ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE

Romidepsin (Istodax, NSC 630176, FR901228, FK228, depsipeptide): a natural product recently approved for cutaneous T-cell lymphoma

(2011) Karen M VanderMolen et al.   JOURNAL OF ANTIBIOTICS

Thailandepsins: Bacterial Products with Potent Histone Deacetylase Inhibitory Activities and Broad-Spectrum Antiproliferative Activities

(2011) Cheng Wang et al.   JOURNAL OF NATURAL PRODUCTS

New Insights into the Genetic Organization of the FK228 Biosynthetic Gene Cluster inChromobacterium violaceumNo. 968

(2010) Vishwakanth Y. Potharla et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Reconstitution of the FK228 Biosynthetic Pathway Reveals Cross Talk between Modular Polyketide Synthases and Fatty Acid Synthase

(2010) Shane R. Wesener et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Improvement of secondary metabolite production in Streptomyces by manipulating pathway regulation

(2010) Yihua Chen et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

An FAD-Dependent Pyridine Nucleotide-Disulfide Oxidoreductase Is Involved in Disulfide Bond Formation in FK228 Anticancer Depsipeptide

(2009) Cheng Wang et al.   CHEMISTRY & BIOLOGY

The Genome Sequencer FLX™ System—Longer reads, more applications, straight forward bioinformatics and more complete data sets

(2008) Marcus Droege et al.   JOURNAL OF BIOTECHNOLOGY