A flexible pentacene thin film transistors as disposable DNA hybridization sensor

We fabricated a disposable DNA hybridization sensor using pentacene thin film transistors (TFTs) on flexible substrate. The analytes, 100-mer ss-DNA (poly A and poly T) or 100 bp ds-DNA were immobilized directly on the surface of the pentacene layer, thereby producing a dramatic change in the electrical properties of the devices. The electrical characteristics of devices were studied as a function of DNA immobilization conditions, DNA concentrations and between ss- and ds-DNA. Based on these results, we propose a disposable label-free sensor for DNA hybridization through direct measurement of electrical properties by the immobilization of DNA on flexible pentacene TFTs. (C) 2012 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.