Article
Immunology
Negisa Seyed Toutounchi, Saskia Braber, Belinda Van't Land, Suzan Thijssen, Johan Garssen, Aletta D. Kraneveld, Gert Folkerts, Astrid Hogenkamp
Summary: The study found that perinatal exposure to DON can negatively impact immune development in offspring, leading to enhanced allergic immune response to food allergens in female offspring and decreased immune response to influenza vaccine in male offspring. This suggests that maternal exposure to DON during pregnancy and lactation may have lasting effects on the immune system of offspring.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Environmental Sciences
Xiaoke Wang, Zixuan Zhao, Xin Wang, Wenxuan Hu, Chao Luo, Xiuyu Chu, Muzhou Qian, Rui Wang, Shali Yu, Qiyun Wu, Juan Tang, Xinyuan Zhao
Summary: This study reveals that exposure to high doses of polystyrene nanoplastics (PSNPs) through inhalation during pregnancy can lead to the development of non-alcoholic fatty liver disease in both dam and offspring. This highlights the potential health risks of airborne plastic particles.
Article
Chemistry, Multidisciplinary
Miroslava Lehotska Mikusova, Milena Busova, Jana Tulinska, Vlasta Masanova, Aurelia Liskova, Iveta Uhnakova, Maria Dusinska, Zora Krivosikova, Eva Rollerova, Radka Alacova, Ladislava Wsolova, Mira Horvathova, Michaela Szabova, Norbert Lukan, Zbynek Vecera, Pavel Coufalik, Kamil Krumal, Lukas Alexa, Vojtech Thon, Pavel Piler, Marcela Buchtova, Lucie Vrlikova, Pavel Moravec, Dusan Galanda, Pavel Mikuska
Summary: This study investigated the potential adverse effects of inhaling titanium dioxide nanoparticles (TiO2 NPs) using a whole-body inhalation chamber model. The results showed that TiO2 NPs had a dose-dependent effect on the innate immune system, stimulating phagocytic activity of monocytes at low doses and suppressing monocyte secretory function (IL-18) at high doses. The adaptive immune system in exposed mice showed a decrease in T-cell percentage, a reduction in T-helper cells, and a dose-dependent decrease in lymphocyte cytokine production, indicating possible immunosuppression. The increase in glutathione (GSH) concentration and GSH/GSSG ratio in whole blood demonstrated stimulated antioxidant defense against TiO2 NP-induced oxidative stress.
Article
Toxicology
Colleen T. O'Dell, Lisbeth A. Boule, Jacques Robert, Steve N. Georas, Sophia Eliseeva, B. Paige Lawrence
Summary: Exposure to a mixture of UOG-associated chemicals can have negative impacts on the immune system, leading to alterations in T-cell subsets. These impacts vary between different disease models and genders, suggesting that direct exposure to these chemicals may disrupt the adult immune system.
JOURNAL OF IMMUNOTOXICOLOGY
(2021)
Article
Environmental Sciences
Kirtan Kaur, Corina Lesseur, Lixian Chen, Syam S. Andra, Srinivasan Narasimhan, Divya Pulivarthi, Vishal Midya, Yula Ma, Erona Ibroci, Frederieke Gigase, Molly Lieber, Whitney Lieb, Teresa Janevic, Lotje D. De Witte, Veerle Bergink, Anna-Sophie Rommel, Jia Chen
Summary: Investigated the relationship between maternal plasma PFAS concentrations and SARS-CoV-2 antibody levels in a NYC-based pregnancy cohort. Found that all detected PFAS were negatively correlated with antibody levels, with several reaching statistical significance. Results suggest that PFAS may act as immunosuppressants during pregnancy.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Lu Peng, Jing Liu, Erqun Song, Yang Song
Summary: This study evaluated the immunotoxic effects of PCB29-pQ, an active quinone-type metabolite of PCBs. The results showed that exposure to PCB29-pQ led to reduced body weight and increased organ index of the spleen and lungs in mice, along with changes in their morphology and structure. Additionally, there was a significant decrease in certain types of lymphocyte subsets in the spleen, indicating immune dysfunction. Furthermore, PCB29-pQ induced apoptosis and an imbalance of Th1/Th2 cytokines. These findings provide new insights into the immunotoxicity mechanism of PCBs.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Stefania Papatheodorou, Weiyu Yao, Carolina L. Z. Vieira, Longxiang Li, Blair J. Wylie, Joel Schwartz, Petros Koutrakis
Summary: The study found that higher levels of residential radon exposure are associated with increased risk of hypertensive disorders of pregnancy (HDP), especially in women under 20. There was no effect modification by maternal race or education, highlighting the importance of identifying modifiable risk factors in addressing the burden of HDP.
ENVIRONMENT INTERNATIONAL
(2021)
Review
Immunology
Valentin P. Shichkin, Oleg V. Kurchenko, Elena N. Okhotnikova, Valentyna V. Chopyak, Domenico V. Delfino
Summary: This review analyzes the mechanisms and factors associated with IgE-associated allergic diseases caused by food allergens and discusses the clinical symptoms and current treatment approaches for food allergies. The review also emphasizes the use of enterosorbents in the complex therapy of food allergies and related manifestations, such as skin and respiratory symptoms associated with gastroenterological disorders. It summarizes the experience of using enterosorbents for detoxification purposes in post-Soviet countries, with a special focus on the enterosorbent White Coal (Carbowhite) based on silicon dioxide produced by the Ukrainian company OmniFarma.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Environmental Sciences
Ka Roach, Jr. Roberts
Summary: Allergic disease is a significant global public health crisis, with metals playing a major role as allergens. However, there is a lack of comprehensive review on the various disease variants of metal allergy in the current scientific literature. This review aims to provide an up-to-date reference document for researchers and clinicians, while also identifying knowledge gaps related to metal allergy.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS
(2022)
Article
Toxicology
Kristal A. Rychlik, Emily J. Illingworth, Ian F. Sanchez, Sarah E. Attreed, Prithvi Sinha, Kevin M. Casin, Nicole Taube, Jeff Loube, Rokeya Tasneen, Raihan Kabir, Eric Nuermberger, Wayne Mitzner, Mark J. Kohr, Fenna C. M. Sille
Summary: This study aimed to characterize the long-term impact of mid-pregnancy arsenic exposure on the lung, heart, and immune system. The results suggest that prenatal arsenic exposure can affect lung and immune cell function, potentially increasing the risk of respiratory diseases.
TOXICOLOGY LETTERS
(2023)
Review
Food Science & Technology
Tabussam Tufail, Yusra Rasheed, Huma Bader Ul Ain, Muhammad Umair Arshad, Muzzamal Hussain, Muhammad Nadeem Akhtar, Shamaail A. Saewan
Summary: Food allergy is a reaction of the immune system that occurs after consuming specific foods. Pregnant women are more prone to allergic reactions, and these reactions may have long-term effects. The severity of allergic reactions is linked to the type of allergen. Food allergies are more common in pregnant women, with one in every five pregnant women being affected. The specific causes and evidence of food allergies during pregnancy still need to be explored. Pregnant women should maintain a balanced diet and avoid known allergenic foods to minimize risks and complications. This review aims to expand knowledge on food allergies during pregnancy, their impact on babies, and help pregnant women cope with the complications caused by these allergies. It also aims to identify specific foods that may trigger allergies in pregnant women and their effects on babies.
FOOD SCIENCE & NUTRITION
(2023)
Article
Environmental Sciences
Shahid Ali Rajput, Aftab Shaukat, Imran Rashid Rajput, Asghar Ali Kamboh, Zahid Iqbal, Muhammad Saeed, Rana Waseem Akhtar, Syed Aftab Hussain Shah, Muhammad Asif Raza, Ahmad El Askary, Mohamed M. Abdel-Daim, Zuhair M. Mohammedsaleh, Rabab M. Aljarai, Muna O. Alamoudi, Mashael Alhumaidi Alotaibi
Summary: Rb1 significantly increased the average daily gain and daily feed intake of mice, alleviated DON-induced immune injury, reduced oxidative stress levels, and regulated the apoptosis pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Nanoscience & Nanotechnology
Chun Zhang, Changzhou Shi, Pengzhao Chang, Shuang Bian, Bangbang Li, Jingjing Li, Pingfu Hou
Summary: This study systematically evaluated the toxicity of MRI nano-contrast agent Gd-MCNs and compared it with Gd-DTPA. The results showed that Gd-MCNs had good biocompatibility and acceptable in vivo biosafety. Additionally, Gd-MCNs displayed better contrast enhancement of tumors compared to Gd-DTPA.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Environmental Sciences
Paula Pierozan, Liselott Kaellsten, Eleftheria Theodoropoulou, Radwa Almamoun, Oskar Karlsson
Summary: Increased exposure to manmade chemicals may lead to an increase in immune-related diseases and immune system dysfunction. Specifically, phthalates, which are suspected to disrupt the endocrine system, may influence the immune system. This study found that exposure to dibutyl phthalate (DBP) resulted in decreased total leukocyte count and T helper (Th) cell population, as well as increased non-classical monocyte population.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Food Science & Technology
Hanieh Malmir, Bagher Larijani, Ahmad Esmaillzadeh
Summary: This meta-analysis found that maternal fish consumption during pregnancy is associated with a lower risk of wheeze, eczema, and food allergy in children. However, there is no significant association between maternal fish consumption and the risk of offspring's asthma, allergic rhinitis, and inhalant allergy.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)