Article
Cell Biology
Romain Larrue, Sandy Fellah, Nihad Boukrout, Corentin De Sousa, Julie Lemaire, Carolane Leboeuf, Marine Goujon, Michael Perrais, Bernard Mari, Christelle Cauffiez, Nicolas Pottier, Cynthia van der Hauwaert
Summary: Non-small cell lung cancer is characterized by poor prognosis due to low diagnosis efficiency and drug resistance. Targeting a specific small RNA (miR-92a-3p) may be an effective strategy to overcome chemotherapy resistance in cancer cells.
CELL DEATH & DISEASE
(2023)
Article
Hematology
Ying Wang, Chunrui Li, Jieyun Xia, Ping Li, Jiang Cao, Bin Pan, Xu Tan, Hujun Li, Kunming Qi, Xiangmin Wang, Ming Shi, Guangjun Jing, Zhiling Yan, Hai Cheng, Feng Zhu, Haiying Sun, Wei Sang, Depeng Li, Xi Zhang, Zhenyu Li, Junnian Zheng, Aibin Liang, Jianfeng Zhou, Kailin Xu
Summary: The study revealed a significant and lasting humoral immune deficiency, especially for IgA, in patients with relapsed/refractory MM who received anti-BCMA CAR T-cell therapy.
Article
Microbiology
Jiajia Zeng, Shuaini Yang, Yuqing Tuo, Xiaoyu Zha, Ruoyuan Sun, Tingsha Lu, Hong Zhang, Lu Tan, Sai Qiao, Hong Bai
Summary: IL-27/IL-27R signaling plays a protective role in Chlamydia trachomatis infection by promoting Th1 response and suppressing neutrophilic inflammation. IL-27 expression was observed in dendritic cells (DCs), and its signaling in DCs restricted the production of IL-10, thus supporting the Th1 response against chlamydial infection.
Article
Immunology
Christopher Sie, Ravi Kant, Christian Peter, Andreas Muschaweckh, Monika Pfaller, Lucy Nirschl, Helena Dominguez Moreno, Tereza Chadimova, Gildas Lepennetier, Tanja Kuhlmann, Rupert Ollinger, Thomas Engleitner, Roland Rad, Thomas Korn
Summary: Th17 cells have an intrinsic feedback mechanism to control their pathogenicity, involving the production of IL-24 and secretion of IL-10. IL-24 interacts with Grim19 on the inner mitochondrial membrane to promote STAT3 accumulation in the mitochondrial compartment, which serves as a rheostat to regulate nuclear STAT3 activity. This mechanism plays an important role in restricting immunopathology associated with Th17 cells.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Immunology
Zhian Chen, Yanfang Cui, Yin Yao, Bo Liu, Joseph Yunis, Xin Gao, Naiqi Wang, Pablo F. Canete, Zewen Kelvin Tuong, Hongjian Sun, Hao Wang, Siling Yang, Runli Wang, Yew Ann Leong, David Simon Davis, Jiahuan Qin, Kaili Liang, Jun Deng, Conan K. Wang, Yen-Hua Huang, Jonathan A. Roco, Sam Nettelfield, Huaming Zhu, Huajun Xu, Zhijia Yu, David Craik, Zheng Liu, Hai Qi, Christopher Parish, Di Yu
Summary: In antibody responses, mutated germinal center B (BGc) cells are positively selected for reentry or differentiation, with the support of TFH cell-derived signals including CD40 and IL-21. The binding and signaling of IL-21 in BGc cells is reduced compared to non-BGc cells, due to low cellular heparan sulfate (HS) sulfation. Ndst1-mediated N-sulfation of HS in B cells promotes IL-21 binding and signal strength, and selective desensitization to IL-21 occurs in BGc cells. Therefore, the biochemical regulation of IL-21 availability and signal strength plays a crucial role in GC selection.
SCIENCE IMMUNOLOGY
(2023)
Article
Immunology
Rodolfo Soria-Castro, Angel R. Alfaro-Doblado, Gloria Rodriguez-Lopez, Marcia Campillo-Navarro, Yatsiri G. Meneses-Preza, Adrian Galan-Salinas, Violeta Alvarez-Jimenez, Juan C. Yam-Puc, Rosario Munguia-Fuentes, Adriana Dominguez-Flores, Sergio Estrada-Parra, Sonia M. Perez-Tapia, Alma D. Chavez-Blanco, Rommel Chacon-Salinas
Summary: The study found that MC infected with L.m were able to clear the bacterial load and responded by degranulating and producing various cytokines. TLR2 was shown to mediate some MC activation pathways during L.m infection, particularly those related to IL-6 and IL-13 production. Interestingly, p38 activation depended on TLR2, but not ERK or NF-kappa B activation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Fei Mo, Zhiya Yu, Peng Li, Jangsuk Oh, Rosanne Spolski, Liang Zhao, Caleb R. Glassman, Tori N. Yamamoto, Yun Chen, Filip M. Golebiowski, Dalton Hermans, Sonia Majri-Morrison, Lora K. Picton, Wei Liao, Min Ren, Xiaoxuan Zhuang, Suman Mitra, Jian-Xin Lin, Luca Gattinoni, Jonathan D. Powell, Nicholas P. Restifo, K. Christopher Garcia, Warren J. Leonard
Summary: Adoptive transfer of antigen-specific T cells is a significant advancement in cancer immunotherapy, and maintaining a stem-cell-like state before transfer is beneficial for therapeutic efficacy.
Article
Immunology
Jhalak Singhal, Evanka Madan, Ayushi Chaurasiya, Pallavi Srivastava, Niharika Singh, Shikha Kaushik, Amandeep Kaur Kahlon, Mukesh Kumar Maurya, Manisha Marothia, Prerna Joshi, Anand Ranganathan, Shailja Singh
Summary: SUMOylation is involved in the infection process of Leishmania donovani by hijacking the host immune responses and facilitating host autophagy. Targeting the SUMOylation pathway may provide a potential therapeutic intervention for leishmaniasis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Qianwen Hu, Tingting Xu, Wenqian Zhang, Chuanxin Huang
Summary: The transcription factor Bach2 plays a crucial role in regulating the germinal center (GC) reaction and is involved in the survival and maintenance of GC B cells and memory B cell formation. Bach2 controls GC programs by repressing pro-apoptotic gene Bim and genes related to cell stress response and metabolic processes.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Dennis Das Gupta, Christoph Paul, Nadine Samel, Maria Bieringer, Daniel Staudenraus, Federico Marini, Hartmann Raifer, Lisa Menke, Lea Hansal, Baerbel Camara, Edith Roth, Patrick Daum, Michael Wanzel, Marco Mernberger, Andrea Nist, Uta-Maria Bauer, Frederik Helmprobst, Malte Buchholz, Katrin Roth, Lorenz Bastian, Alina M. Hartmann, Claudia Baldus, Koichi Ikuta, Andreas Neubauer, Andreas Burchert, Hans-Martin Jaeck, Matthias Klein, Tobias Bopp, Thorsten Stiewe, Axel Pagenstecher, Michael Lohoff
Summary: This study finds that Irf4(-/-) mice are prone to developing BCP-ALL, and further investigates the impaired differentiation but enhanced proliferation of Irf4(-/-) preB-I cells, possibly due to Jak3 mutations.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Immunology
Jingwei Wang, Tianbao Li, Hong Zan, Carlos E. Rivera, Hui Yan, Zhenming Xu
Summary: The study showed that LUBAC controls cFLIP expression, inhibits the effects of caspase 8 and IL-21-activated caspase 9, thereby suppressing apoptosis of CD40 and IL-21-activated B cells, promoting GC B cell survival.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Isaraphorn Pratumchai, Jaroslav Zak, Zhe Huang, Booki Min, Michael B. A. Oldstone, John R. Teijaro
Summary: Recent studies have shown that B cells play a critical role in regulating immune responses through the production of cytokines, particularly interleukin-27 (IL-27). B cell-derived IL-27 promotes the survival and function of virus-specific CD4 T cells, as well as supporting the functions of T follicular helper (Tfh) cells. IL-27 signaling on T cells is essential for controlling viral infection and promoting optimal CD4 T cell responses and antibody class switch during persistent LCMV infection.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
D. Alejandro Canaria, Maia G. Clare, Bingyu Yan, Charlotte B. Campbell, Zachariah A. Ismaio, Nicole L. Anderson, Sungtae Park, Alexander L. Dent, Majid Kazemian, Matthew R. Olson
Summary: This study reveals the importance of IL-2 in the differentiation of Th9 cells, as IL-2 signaling is required for optimal NF-kB activation and IL-9 production. The addition of the NF-kB-activating cytokine IL-1 beta can rescue Th9 differentiation under IL-2 limiting conditions by enhancing the sensitivity of Th9 cells to limited IL-2 resources.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Pavan Vedula, Satoshi Kurosaka, Brittany MacTaggart, Qin Ni, Garegin Papoian, Yi Jiang, Dawei W. Dong, Anna Kashina
Summary: The study investigates the role of coding sequence in beta- and gamma-cytoplasmic actins' intracellular functions, revealing that differences in translation rates between the two actins affect their dynamics at focal adhesions, actin bundle formation, and cell migration. This coding sequence-mediated difference in actin translation plays a key role in cell migration.
Article
Multidisciplinary Sciences
Marianne Boeni-Schnetzler, Helene Mereau, Leila Rachid, Sophia J. Wiedemann, Friederike Schulze, Kelly Trimigliozzi, Daniel T. Meier, Marc Y. Donath
Summary: The study found that the expression level of IL-1β can affect insulin secretion as age increases, while specific knockout of IL-1β may help preserve insulin secretion levels and enhance islet function.
Article
Immunology
Caroline Fraga Nunes, Jeane S. Nogueira, Pedro Henrique Oliveira Vianna, Bianca Torres Ciambarella, Patricia Machado Rodrigues, Karla Rodrigues Miranda, Leandro Araujo Lobo, Regina Maria Cavalcanti Pillotto Domingues, Mileane Busch, Georgia Correa Atella, Andre Macedo Vale, Maria Bellio, Alberto Nobrega, Fabio B. Canto, Rita Fucs
INTERNATIONAL IMMUNOLOGY
(2018)
Article
Immunology
Joao F. Gomes-Neto, Rossella Sartorius, Fabio B. Canto, Thamyres S. Almeida, Andre A. Dias, Carlos-Henrique D. Barbosa, Guilherme A. Melo, Ana Carolina Oliveira, Pedro-Henrique N. Aguiar, Carlos R. Machado, Herbert L. de Matos Guedes, Marcelo F. Santiago, Alberto Nobrega, Piergiuseppe De Berardinis, Maria Bellio
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Immunology
Cassio Luiz Coutinho Almeida-da-Silva, Erivan S. Ramos-Junior, Ana Carolina Morandini, Gabrielle da Costa Rocha, Ygor Marinho, Augusto Shuiti Tamura, Klvia Queiroz de Andrade, Maria Bellio, Luiz Eduardo Baggio Savio, Julio Scharfstein, David M. Ojcius, Robson Coutinho-Silva
Article
Immunology
Barbara Jose Antunes Baptista, Alessandra Granato, Fabio B. Canto, Fabricio Montalvao, Lucas Tostes, Herbert L. de Matos Guedes, Antonio Coutinho, Maria Bellio, Andre M. Vale, Alberto Nobrega
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Microbiology
Mariana M. Chaves, Debora A. Sinflorio, Maria Luiza Thorstenberg, Monique Daiane Andrade Martins, Aline Cristina Abreu Moreira-Souza, Thuany Prado Rangel, Claudia L. M. Silva, Maria Bellio, Claudio Canetti, Robson Coutinho-Silva
Article
Microbiology
Camila Menezes Figueiredo, Romulo Leao da Silva Neris, Daniel Gavino-Leopoldino, Mariana Oliveira Lopes da Silva, Juliana Silva Almeida, Julio Souza dos-Santos, Claudia Pinto Figueiredo, Maria Bellio, Marcelo Torres Bozza, Iranaia Assuncao-Miranda
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Multidisciplinary Sciences
Claudia P. Figueiredo, Fernanda G. Q. Barros-Aragao, Romulo L. S. Neris, Paula S. Frost, Carolina Soares, Isis N. O. Souza, Julianna D. Zeidler, Daniele C. Zamberlan, Virginia L. de Sousa, Amanda S. Souza, Andre Luis A. Guimaraes, Maria Bellio, Jorge Marcondes de Souza, Soniza V. Alves-Leon, Gilda A. Neves, Heitor A. Paula-Neto, Newton G. Castro, Fernanda G. De Felice, Iranaia Assuncao-Miranda, Julia R. Clarke, Andrea T. Da Poian, Sergio T. Ferreira
NATURE COMMUNICATIONS
(2019)
Article
Multidisciplinary Sciences
J. Barbeito-Andres, P. Pezzuto, L. M. Higa, A. A. Dias, J. M. Vasconcelos, T. M. P. Santos, J. C. C. G. Ferreira, R. O. Ferreira, F. F. Dutra, A. D. Rossi, R. Barbosa, C. K. N. Amorim, M. P. C. De Souza, L. Chimelli, R. S. Aguiar, P. N. Gonzalez, F. A. Lara, M. C. Castro, Z. Molnar, R. T. Lopes, M. T. Bozza, J. L. S. G. Vianez, C. G. Barbeito, P. Cuervo, M. Bellio, A. Tanuri, P. P. Garcez
Article
Cell Biology
Julia Barbalho da Mota, Juliana Echevarria-Lima, Fernanda Kyle-Cezar, Matheus Melo, Maria Bellio, Julio Scharfstein, Ana Carolina Oliveira
JOURNAL OF LEUKOCYTE BIOLOGY
(2020)
Article
Infectious Diseases
Carolina da S. G. Pedrosa, Leticia R. Q. Souza, Tiago A. Gomes, Caroline V. F. de Lima, Pitia F. Ledur, Karina Karmirian, Jimena Barbeito-Andres, Marcelo do N. Costa, Luiza M. Higa, Atila D. Rossi, Maria Bellio, Amilcar Tanuri, Arnaldo Prata-Barbosa, Fernanda Tovar-Moll, Patricia P. Garcez, Flavio A. Lara, Renato J. R. Molica, Stevens K. Rehen
PLOS NEGLECTED TROPICAL DISEASES
(2020)
Article
Immunology
Andre F. Batista, Tayna Rody, Leticia Forny-Germano, Suzana Cerdeiro, Maria Bellio, Sergio T. Ferreira, Douglas P. Munoz, Fernanda G. De Felice
Summary: The study found that IL-1 beta mediates the impact of A beta Os on proteins involved in mitochondrial dynamics, and suggests that strategies aimed at preventing pathological alterations in these proteins may counteract synapse loss and cognitive impairment in Alzheimer's disease (AD).
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Immunology
Bruno Jennings-Almeida, Juliana P. Castelpoggi, Erivan S. Ramos-Junior, Eliane de Oliveira Ferreira, Regina M. C. P. Domingues, Juliana Echevarria-Lima, Robson Coutinho-Silva, Aline C. A. Moreira-Souza, Eliana Marino, Charles R. Mackay, Dario S. Zamboni, Maria Bellio, Julio Scharfstein, Leandro A. Lobo, Ana Carolina Oliveira
Summary: The intestinal barrier is crucial for gut homeostasis, and a breach can lead to severe inflammatory responses, where IL-1 beta plays a significant role in peritonitis and sepsis.
JOURNAL OF IMMUNOLOGY
(2021)
Meeting Abstract
Immunology
Romulo Neris, Camila Figueiredo, Daniel Leopoldino, Mariana da Silva, Juliana Almeida, Julio dos-Santos, Claudia Figueiredo, Maria Bellio, Marcelo Bozza, Iranaia Miranda
JOURNAL OF IMMUNOLOGY
(2020)