Article
Immunology
Chia-Hao Lin, Mei-Chi Chen, Ling-Li Lin, David A. Christian, Booki Min, Christopher A. Hunter, Li-Fan Lu
Summary: IL-27 produced by intestinal epithelial cells plays a crucial role in promoting a specific subset of intraepithelial lymphocytes, contributing to barrier immunity in the gut. Loss of IL-27 in IECs leads to a selective defect in certain IEL populations, resulting in elevated pathogen burden during parasitic infection. This suggests that IL-27 from different cell types plays distinct roles in maintaining intestinal homeostasis.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Engineering, Multidisciplinary
Yali Tao, Yutong Chen, Sicheng Wang, Weikai Chen, Dongyang Zhou, Dagui Chen, Chenxi Zhang, Ziqing Wu, Jing Yan, Hao Zhang, Yan Wei, Jiacan Su
Summary: This study systematically investigated the effects of modification density of acid oligopeptides on the bone-targeting activity of liposomes. The results showed that a higher modification density promoted the binding of liposomes to hydroxyapatite, but also increased macrophage-mediated phagocytosis and decreased blood retention. The liposomes with the highest modification density exhibited the strongest bone-targeting activity.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Polymer Science
Pratyusa Das, Ankita Hore, Aritri Ghosh, Pallab Datta
Summary: Cell electrospinning has been utilized to fabricate bone tissue engineering constructs with homogenous cell distribution. The method demonstrated the ability to maintain cell morphology and functionality, with enhanced cell viability and proliferation. Additionally, the technique showed potential for global DNA hypomethylation in cells subjected to electrical fields during electrospinning.
JOURNAL OF POLYMER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Shreya Kumar, Grace E. Mulia, Marxa L. Figueiredo
Summary: Combination therapy of chemotherapy and immunotherapy shows potential as a novel therapeutic strategy for treating bone-metastatic prostate cancer, with reduced chemotherapy-associated toxicity, enhanced sensitivity to immunotherapy, and improved bone quality.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Engineering, Multidisciplinary
Wenzhao Wang, Boqing Zhang, Mingxin Li, Jun Li, Chengyun Zhang, Yanlong Han, Li Wang, Kefeng Wang, Changchun Zhou, Lei Liu, Yujiang Fan, Xingdong Zhang
Summary: This study utilized 3D printing technology to fabricate composite scaffolds of PLA and n-HA, and demonstrated their potential for large bone defect repair through biocompatibility and in vivo implantation tests.
COMPOSITES PART B-ENGINEERING
(2021)
Article
Materials Science, Ceramics
Atchara Khamkongkaeo, Thanachai Boonchuduang, Wantana Klysubun, Penphitcha Amonpattaratkit, H-thaichnok Chunate, Nutth Tuchinda, Adulphan Pimsawat, Sujittra Daengsakul, Pitphichaya Suksangrat, Wutthigrai Sailuam, Drusawin Vongpramate, Atipong Bootchanont, Boonrat Lohwongwatana
Summary: In this study, hydroxyapatite powder was prepared by calcining Nile tilapia bone, and its structure and properties were investigated. The addition of magnesium was found to stabilize the β-TCP phase and improve the mechanical properties of the material, but it could also lead to the partial decomposition of the HAp phase.
CERAMICS INTERNATIONAL
(2021)
Article
Chemistry, Applied
Zi-Zi Hu, Xiao-Mei Sha, Tao Huang, Lu Zhang, Guang-Yao Wang, Zong-Cai Tu
Summary: By combining gamma-PGA and MTGase for modification of FG, its gelling properties can be improved, viscosity increased, and formation of the triple helix hindered, resulting in a slower gelation rate.
Article
Food Science & Technology
Sheng Shu, Xiao-Mei Sha, Zi-Zi Hu, Qing-Ling Ma, Juan-Juan Qiao, Ting Fang, Wen-Li Jiang, Zong-Cai Tu
Summary: This work investigated the effects of four different molecular weights of gamma-polyglutamic acid (gamma-PGA) on the gelling properties and structural characteristics of fish gelatin (FG). The results showed that the gelation-melting transition temperature and gel strength increased with the increase of molecular weight in gamma-PGA, with the highest gelling properties observed in FG modified by 3000 kDa gamma-PGA.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Applied
Danfeng Li, Miao Hu, Lizhen Hou, Yaxin Gao, Zhiliang Tian, Wei Wen, Bei Fan, Shuying Li, Fengzhong Wang
Summary: In this study, targeted modified W/O/W emulsions were fabricated from complexes of soybean isolate protein (SPI) and polyglutamic acid (PGA) to protect the vulnerable biological activity of Nattokinase (NK). The SPI-PGA complex formed a tighter internal structure through non-covalent bonds, resulting in improved emulsification and stability. The emulsions coated by complexes formed a stronger network structure and achieved higher bioavailability, expanding the application of NK in food formulations.
Article
Materials Science, Ceramics
Hossein Jodati, Aysen Tezcaner, Ammar Z. Alshemary, Volkan Sahin, Zafer Evis
Summary: Ion doping, specifically boron (B) doping, was used to modify the size, crystallinity, hardness, and biodegradability of hydroxyapatite (HA) nanoparticles in this study. The results showed that increasing B content led to reduced particle size, decreased crystallinity, and improved biodegradability and cell proliferation. However, high concentrations of B release did not have a positive effect on the osteogenic activity of cells.
CERAMICS INTERNATIONAL
(2022)
Article
Chemistry, Applied
Erqi Guan, Tingjing Zhang, Kun Wu, Yuling Yang, Ke Bian
Summary: The study investigates the cryoprotective functions of gamma-PGA in frozen foods. It is found that gamma-PGA can disperse free water, reduce freezable water content, and restrict water migration, leading to the formation of smaller and more uniform ice crystals. Additionally, gamma-PGA interacts with gluten proteins, transforming their conformation and enhancing protein aggregations and water-solid interplay, which improve the resilience of the dough to cope with ice growth and recrystallization.
FOOD HYDROCOLLOIDS
(2023)
Article
Materials Science, Ceramics
M. Afifi, M. K. Ahmed, Hala A. Ibrahium, Nasser S. Awwad, E. Abdel-Fattah, Mohammad Y. Alshahrani
Summary: This study investigated nanocomposites based on hydroxyapatite (HAP), which showed improved human osteoblast viability and excellent antibacterial activity when combined with CuO and GO. The results suggest that the biomaterials have great biocompatibility for biomedical applications.
CERAMICS INTERNATIONAL
(2022)
Article
Materials Science, Multidisciplinary
Amir Kahaie Khosrowshahi, Ali Baradar Khoshfetrat, Younes Beygi Khosrowshahi, Hossein Maleki-Ghaleh
Summary: The study found that a cobalt content of 1.25% in the Co-HA scaffold resulted in optimal osteogenic activity, while higher concentrations may lead to cytotoxic effects. Additionally, apatite growth was observed in the LCo-HA scaffold, and alkaline phosphatase activity and calcium deposition of osteoblastic cells cultured on the LCo-HA scaffold were in line with characterization and cytotoxicity results compared to the HA scaffold and control sample.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Materials Science, Multidisciplinary
Julia Ce de Andrade, Fernando Cabral, Frank Jorg Clemens, Jaqueline Leite Vieira, Milena B. P. Soares, Dachamir Hotza, Marcio Celso Fredel
Summary: Biocomposite filaments of polylactic acid (PLA) combined with stearic acid (SA)-coated nanohydroxyapatite (HA) were prepared and characterized. The SA coating improved the rheological properties and reduced the fragility of the PLA/HA filaments. The FDM-manufactured scaffolds showed the required mechanical, thermal, and cytotoxicity properties for bone tissue engineering.
MATERIALS TODAY COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Lili Fan, Yanmei Zhang, Jiejie Hu, Yuan Fang, Ren Hu, Wei Shi, Bin Ren, Changjian Lin, Zhong-Qun Tian
Summary: The CaP coatings prepared by electrochemical deposition exhibit a modulation on cell proliferation for different cells, with the modulation magnitude depending on cellular size and mainly attributed to the microstructure of the coatings. Crystallinity plays a significant role in the osteogenic property of OCP coatings, with high-crystalline OCP nanocrystals showing a surface rich in HPO42-.