Article
Cell Biology
Arnaud Goepfert, Carmen Barske, Sylvie Lehmann, Emmanuelle Wirth, Joschka Willemsen, Johann E. Gudjonsson, Nicole L. Ward, Mrinal K. Sarkar, Rene Hemmig, Frank Kolbinger, Jean-Michel Rondeau
Summary: Through crystallography, biophysics, and mutational studies, this research demonstrates that IL-17A, IL-17F, and IL-17A/F induce IL-17RA dimerization, leading to the formation of a 2:2:2 hexameric signaling assembly. The formation of the IL-17 signalosome potentiates IL-17-induced IL-36 gamma and CXCL1 mRNA expression in human keratinocytes compared to a dimerization-defective IL-17RA variant.
Article
Immunology
Hideaki Miyachi, Seiichiro Wakabayashi, Takashi Sugihira, Reika Aoyama, Shinobu Saijo, Hanako Koguchi-Yoshioka, Manabu Fujimoto, Gabriel Nunez, Hiroyuki Matsue, Yuumi Nakamura
Summary: The research demonstrated that Malassezia-induced IL-17-dependent skin inflammation and control of fungal infection are mediated via keratinocyte IL-36 receptor/MyD88 signaling using a new skin infection model.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Microbiology
C. N. Jondle, K. E. Johnson, C. Aurubin, P. Sylvester, G. Xin, W. Cui, A. R. Huppler, V. L. Tarakanova
Summary: Gammaherpesviruses establish lifelong infections and are associated with B cell lymphomas. This study reveals a novel proviral role of host interleukin 17A (IL-17A) in the establishment of chronic gammaherpesvirus infection and gammaherpesvirus-driven germinal center response. IL-17A signaling promotes viral infection following mucosal route, lytic replication, and reactivation from latency.
Article
Cell Biology
Flavio P. Veras, Gabriel A. Publio, Bruno M. Melo, Douglas S. Prado, Thaina Norbiato, Nerry T. Cecilio, Carlos Hiroki, Luis Eduardo A. Damasceno, Rebecca Jung, Juliana E. Toller-Kawahisa, Timna Martins, Stella F. Assuncao, Diogenes Lima, Marcia G. Alves, Gabriel V. Vieira, Lucas A. Tavares, Ana L. R. Alves-Rezende, Susanne H. Karbach, Helder I. Nakaya, Thiago M. Cunha, Cacilda S. Souza, Fernando Q. Cunha, Katiuchia U. Sales, Ari Waisman, Jose C. Alves-Filho
Summary: PKM2 mediates IL-17A signaling in keratinocytes, triggering the development of skin psoriatic inflammation. PKM2 forms a complex with Act1 and TRAF6, regulating NF-KB transcriptional signaling. Additionally, IL-17 also induces PKM2 expression in keratinocytes. These findings reveal an important signaling circuit for the development of psoriasis and suggest that PKM2 may serve as a potential therapeutic target for psoriasis.
Article
Multidisciplinary Sciences
Chenyi Shao, Yi Liu, Jiaci Li, Ziyun Liu, Yuxia Zhao, Yaqing Jing, Zhe Lv, Ting Fu, Zihan Wang, Guang Li
Summary: Osteogenesis imperfecta (OI), a congenital bone dysplasia, is mainly caused by defective production or assembly of type I collagen. Studies have found that increased osteoclasts and excessive bone resorption exist in collagen-related OI, which is associated with inflammation. Transcriptomic analysis of bone marrow cells from OI mouse models revealed dysregulated genes and pathways related to interferon response, IL17 signaling, tumor necrosis factor signaling, and osteoclast differentiation. These findings contribute to understanding the mechanism of enhanced bone absorption in OI and provide evidence for potential anti-inflammatory therapies.
Article
Biochemistry & Molecular Biology
Jixiu Wang, Qianhui Sun, Jian Zhang, Huanling Wang, Hong Liu
Summary: This study explored the biological activity of recombinant interleukin-6 (rmaIL-6) and soluble interleukin-6 receptor (rmasIL-6R) in grass carp cells and investigated their regulation of signaling pathways. The results showed that rmaIL-6 mainly activates the JAK/STAT3 pathway and not the MEK/ERK pathway. Additionally, the activation of the JAK2/STAT3 pathway was found to be essential for the generation of socs3a and socs3b induced by IL-6 trans-signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dermatology
Sonja Moos, Tommy Regen, Florian Wanke, Yizhu Tian, Lucas T. Arendholz, Judith Hauptmann, Andre P. Heinen, Lisa Bleul, Katharina Bier, Khalifa El Malki, Christoph Reinhardt, Immo Prinz, Andreas Diefenbach, Christiane Wolz, Birgit Schittek, Ari Waisman, Florian C. Kurschus
Summary: Keratinocytes (KCs) are essential for protecting the body against pathogens, and deficiencies in IL-17RA can lead to spontaneous Staphylococcus aureus skin infections. This study found an expansion of T17 cells in the skin-draining lymph nodes of mice lacking IL-17RA or both IL-17A and IL-17F. Contrary to previous suggestions, this expansion was not due to a negative feedback loop but rather depended on the microbiota and KC deficiency in IL-17RA signaling.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Review
Immunology
Lu Sun, Lufei Wang, Bethany B. Moore, Shaoping Zhang, Peng Xiao, Ann M. Decker, Hom-Lay Wang
Summary: IL-17 plays a crucial role in coordinating innate and adaptive immune responses, with both destructive and protective effects. This review highlights the canonical signaling mechanisms of IL-17 in promoting neutrophil recruitment, antimicrobial peptide production, and maintaining epithelial barrier integrity, as well as the noncanonical mechanisms involved in eliciting protective immunity.
JOURNAL OF IMMUNOLOGY RESEARCH
(2023)
Review
Immunology
Kingston H. G. Mills
Summary: IL-17 cytokines have both protective and pathological functions in the context of infection and autoimmunity. They promote protective immunity against pathogens but can also drive inflammatory pathology. Dysregulated IL-17 responses can contribute to immunopathology, and IL-17 is implicated in various inflammatory diseases.
NATURE REVIEWS IMMUNOLOGY
(2023)
Article
Immunology
Madhuparna Nandi, Mitterrand Muamba Moyo, Sakina Orkhis, Jeanne Masunga Faida Mobulakani, Marc-Andre Limoges, Fjolla Rexhepi, Marian Mayhue, Anny Armas Cayarga, Gisela Cofino Marrero, Subburaj Ilangumaran, Alfredo Menendez, Sheela Ramanathan
Summary: Interleukin-15 (IL-15) regulates immune cell activity by forming a trimeric complex with IL-15Rα, but can also signal through the IL-15Rβγ(c) dimer. IL-15 deficiency results in the inability to control bacterial infections, while mice lacking IL-15Rα are able to effectively clear pathogens.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Felix Ritzmann, Lars Peter Lunding, Robert Bals, Michael Wegmann, Christoph Beisswenger
Summary: IL-17 cytokines play an important role in chronic lung diseases, contributing to bacterial elimination but also potentially promoting disease progression.
Article
Cell Biology
Heng-Hsiung Wu, Lung-Hung Tsai, Chun-Kai Huang, Pang-Hung Hsu, Mei-Yu Chen, Yi-Ing Chen, Chun-Mei Hu, Chia-Ning Shen, Chen-Chen Lee, Ming-Chu Chang, Yu-Ting Chang, Yu-Wen Tien, Yung-Ming Jeng, Eva Y-H P. Lee, Wen-Hwa Lee
Summary: Members of the IL-17 cytokine family and their receptors have been identified for decades, with IL-17RB playing a role in tumor growth and metastasis upon stimulation with IL-17B. Research shows that IL-17RB forms a homodimer and recruits MLK4 to phosphorylate it, leading to downstream oncogenic signaling in pancreatic cancer. Inhibiting IL-17RB signaling pathway could offer a therapeutic target for pancreatic cancer treatment.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Immunology
Jingyi Tan, Anna Dai, Lai Pan, Lan Zhang, Zhongxiu Wang, Ting Ke, Weilian Sun, Yanmin Wu, Pei-Hui Ding, Lili Chen
Summary: Periodontal disease, a common age-related condition, involves inflammatory tissue loss and bone resorption. IL-17 and IFN-gamma may play significant roles in promoting osteoclastogenesis and periodontal destruction, potentially exacerbating alveolar bone loss.
JOURNAL OF IMMUNOLOGY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jie Yang, Lutian Yao, Yuxuan Li, Lin Yuan, Ruoxi Gao, Ran Huo, Hui Zhang, Liping Xia, Hui Shen, Jing Lu
Summary: IL-35 regulates differentiation and expression of pro-angiogenic molecules in IL-1 beta stimulated SW1353 cells via Th17/IL-17 related signaling pathways.
MOLECULAR IMMUNOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
J. Zhang, L. Sun, M. H. H. Withanage, S. M. Ganesan, M. A. Williamson, J. T. Marchesan, Y. Jiao, F. R. Teles, N. Yu, Y. Liu, D. Wu, K. L. Moss, A. K. Mangalam, E. Zeng, Y. L. Lei, S. Zhang
Summary: This study identified a risk locus TRAF3IP2 associated with periodontitis and investigated its underlying mechanism in the development of periodontitis. The results showed that TRAF3IP2 plays a significant role in the production of chemokines mediated by IL-17 and in host defense against periodontal pathogens.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Medicine, General & Internal
Abdul Majeed, Emad AlShwaimi
MEDICAL PRINCIPLES AND PRACTICE
(2017)
Article
Medicine, General & Internal
Wafa Alkaabi, Emad AlShwaimi, Imran Farooq, Harold E. Goodis, Sami M. A. Chogle
MEDICAL PRINCIPLES AND PRACTICE
(2017)
Article
Dentistry, Oral Surgery & Medicine
E. AlShwaimi
INTERNATIONAL ENDODONTIC JOURNAL
(2018)
Article
Dentistry, Oral Surgery & Medicine
Ava Elizabeth Carter, Emad AlShwaimi, Mark Boschen, Geoffery Carter, Roy George
AUSTRALIAN ENDODONTIC JOURNAL
(2019)
Article
Medicine, General & Internal
Emad AlShwaimi, Majdy Idrees, Zeina Berri, Haytham El-Sakka, Omar Kujan
MEDICAL PRINCIPLES AND PRACTICE
(2019)
Article
Dentistry, Oral Surgery & Medicine
Imran Farooq, Abdul Samad Khan, Imran Alam Moheet, Emad Alshwaimi
Summary: The study demonstrated that toothpaste containing theobromine and laboratory-synthesized fluoridated-bioactive glass can increase enamel micro-hardness and decrease surface roughness.
DENTAL MATERIALS JOURNAL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Amre R. Atmeh, Madi AlMadi, Emad AlShwaimi
Summary: The study found that gutta-percha stored in high alkaline pH conditions showed a significant decrease in volume, as well as structural and chemical changes on the surface compared to non-aged gutta-percha.
AUSTRALIAN ENDODONTIC JOURNAL
(2022)
Article
Medicine, General & Internal
Emad O. Alshwaimi
SAUDI JOURNAL OF MEDICINE & MEDICAL SCIENCES
(2019)
Article
Medicine, General & Internal
Abdul Majeed, Emad Alshwaimi, Muhammad Ashraf Nazir, Khalid Almas
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
(2019)
Article
Public, Environmental & Occupational Health
Imran Farooq, Abdul Majeed, Emad AlShwaimi, Khalid Almas
Article
Dentistry, Oral Surgery & Medicine
Ghassan Moustapha, Khaled Azzam, Emad AlShwaimi, Munir Silwadi, Marco Ferraris, Ziad Salameh
JOURNAL OF INVESTIGATIVE AND CLINICAL DENTISTRY
(2019)
Article
Dentistry, Oral Surgery & Medicine
Aws ArRejaie, Saleh A. Alsuliman, Mohammed O. Aljohani, Hesham A. Altamimi, Emad Alshwaimi, Ahmad M. Al-Thobity
SAUDI DENTAL JOURNAL
(2019)
Article
Medicine, General & Internal
Ahmed Rahoma, Emad AlShwaimi, Abdul Majeed
INTERNATIONAL JOURNAL OF HEALTH SCIENCES-IJHS
(2018)
Article
Dentistry, Oral Surgery & Medicine
Emad AlShwaimi
SAUDI DENTAL JOURNAL
(2018)
Article
Medicine, General & Internal
Umair Hassan, Imran Farooq, Imran Alam Moheet, Emad AlShwaimi
INTERNATIONAL JOURNAL OF HEALTH SCIENCES-IJHS
(2017)