Article
Immunology
Jessy Elst, Marcus Maurer, Vito Sabato, Margaretha A. Faber, Chris H. Bridts, Christel Mertens, Michel Van Houdt, Athina L. Van Gasse, Marie-Line M. van der Poorten, Leander P. De Puysseleyr, Margo M. Hagendorens, Viggo F. Van Tendeloo, Eva Lion, Diana Campillo-Davo, Didier G. Ebo
Summary: Research has shown that certain neuromuscular blocking agents and fluoroquinolones can cause mast cell-mediated anaphylactic reactions by activating MRGPRX2, while sugammadex can attenuate drug-induced mast cell activation. Some patients treated with rocuronium develop anaphylaxis, with reactions similar to IgE-mediated allergies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Food Science & Technology
Xiaohui Yang, Dohyeon Lee, Hyun-Woo Kim, Byung-Hyun Park, Changjin Lim, Eun Ju Bae
Summary: The study investigates the effects of cannabidiol (CBD) on mast cell degranulation and passive cutaneous anaphylaxis in mice. CBD suppresses antigen-stimulated mast cell degranulation by inhibiting downstream signaling molecules and calcium mobilization. In addition, CBD inhibits the development of mast cells and suppresses passive cutaneous anaphylaxis in mice.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Tsubasa Ashikari, Masakazu Hachisu, Kazuki Nagata, Daisuke Ando, Yuki Iizuka, Naoto Ito, Kandai Ito, Yuki Ikeda, Hiroki Matsubara, Takuya Yashiro, Kazumi Kasakura, Chiharu Nishiyama
Summary: Mast cells play a significant role in IgE-mediated immunoresponses, and salicylaldehyde, identified as an inhibitor of mast cell activation, shows potential as an antiallergic compound.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Yuejin Wang, Yuanyuan Ding, Chaomei Li, Jiapan Gao, Xiaodong Wang, Hongli An
Summary: The findings suggest that alpha-linolenic acid (ALA) could serve as a therapeutic drug candidate for preventing IgE-mediated anaphylaxis by regulating immune reactions and attenuating inflammation caused by allergies.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Cell Biology
Kasalina N. Kiwanuka, E. Motunrayo Kolawole, Jamie Josephine Avila Mcleod, Bianca Baker, Patrick A. Paez, Matthew P. Zellner, Tamara T. Haque, Anuya Paranjape, Kaitlyn Jackson, Sydney A. Kee, Jordan Dailey, Rebecca K. Martin, John J. Ryan
Summary: The lack of Stat5B in mice results in reduced responses to IgE-mediated anaphylaxis and diminished IgE-induced degranulation and cytokine secretion in mast cells. These findings suggest that the Stat5B isoform is crucial for normal mast cell function and may play a role in limiting IgE production in vivo.
CELLULAR IMMUNOLOGY
(2021)
Review
Allergy
Didier G. Ebo, Chris H. Bridts, Christel H. Mertens, Vito Sabato
Summary: The major challenge in allergy diagnosis is the development of accessible and reliable diagnostics for predicting clinical outcomes after exposure to allergens. Flow-assisted analysis and the basophil activation test (BAT) show promise in meeting this requirement for various IgE-dependent allergies, but proper execution and interpretation are essential. Other uses of BAT include therapeutic monitoring and identifying allergenic recognition sites.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Cell Biology
Bo-Gie Yang, A-Ram Kim, Dajeong Lee, Seong Beom An, Yaein Amy Shim, Myoung Ho Jang
Summary: Mast cells are important effectors of inflammation and their degranulation is induced by various cell surface receptors. These receptors have different expression patterns, contributing to varied involvement in inflammatory responses. This review focuses on mast cell receptors involved in allergic inflammation, their role in degranulation induction, tissue-specific expression, and potential new drugs for allergy-related diseases.
Article
Biochemistry & Molecular Biology
Yuka Nagasaka, Yuki Nakamura, Nguyen Quoc Vuong Tran, Yoshiaki Kobayashi, Nobuhiro Nakano, Atsuhito Nakao
Summary: This study found that Bmal1 plays a regulatory role in the expression of anti-oxidative genes in mast cells, and deficiency of Bmal1 enhances IgE-dependent mast cell degranulation associated with promotion of ROS generation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Multidisciplinary Sciences
Jeff D. Colbert, Freidrich M. Cruz, Christina E. Baer, Kenneth L. Rock
Summary: This study reveals a molecular association between Tspan5 and MHC I molecules that is critical for the formation of MHC I nanoclusters and optimal T cell responses to antigens.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Cell Biology
Joanna Baran, Anna Sobiepanek, Anna Mazurkiewicz-Pisarek, Marta Rogalska, Aleksander Gryciuk, Lukasz Kuryk, Soman N. Abraham, Monika Staniszewska
Summary: Mast cells are immune cells found in various tissues and their overactivity can lead to health hazards. They can cause allergic reactions and play a role in tumor biology. However, the mechanisms of mast cell actions are still poorly understood, making it challenging to develop therapies for their pathological condition.
Article
Gastroenterology & Hepatology
Masashi Ninomiya, Jun Inoue, Eugene W. Krueger, Jing Chen, Hong Cao, Atsushi Masamune, Mark A. McNiven
Summary: This study found that the tetraspanin protein CD63 is associated with HBV during viral infection and shedding, and may play an important role in the formation and release of infectious HBV particles.
HEPATOLOGY COMMUNICATIONS
(2021)
Article
Cell Biology
Chuda Rujitharanawong, Sunisa Yoodee, Kanyarat Sueksakit, Paleerath Peerapen, Papapit Tuchinda, Kanokvalai Kulthanan, Visith Thongboonkerd
Summary: Mast cell activation is crucial in allergic diseases and anaphylaxis. This study systematically compared different markers for mast cell activation and recommended reliable markers for in vitro studies.
CELL AND TISSUE RESEARCH
(2022)
Article
Allergy
Cyril Longe, Manuela Bratti, Mathieu Kurowska, Shamila Vibhushan, Pierre David, Valere Desmeure, Jian-Dong Huang, Alain Fischer, Genevieve de Saint Basile, Fernando E. Sepulveda, Ulrich Blank, Gael Menasche
Summary: This study demonstrates the crucial role of Rab44 in regulating secretory granule transport during degranulation in mast cells. Deficiency in Rab44 impairs granule translocation and degranulation, leading to reduced sensitivity to IgE-mediated allergic reactions. Rab44 can be considered a potential target for modulating MC degranulation and inhibiting allergic reactions.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Jia Li, Md Ashik Ullah, Hongping Jin, Yuting Liang, Lihui Lin, Juan Wang, Xia Peng, Huanjin Liao, Yanning Li, Yiqin Ge, Li Li
Summary: ORMDL3 inhibits antigen-induced mast cell activation through regulating the ERS/UPR/autophagy pathway, providing a potential therapeutic target for allergic diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Allergy
Antonella Cianferoni
Summary: Anaphylaxis is not only IgE-mediated, but also involves non-IgE pathways; mast cells and basophils can be activated by various substances, leading to reactions similar to anaphylaxis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)