Review
Microbiology
Linbo Li, Yuru Pan, Shishuang Zhang, Tianyou Yang, Zhigang Li, Baoshi Wang, Haiyan Sun, Mingxia Zhang, Xu Li
Summary: This review summarizes the research history and hotspots of quorum sensing (QS) in Saccharomyces cerevisiae, focusing on the regulatory mechanism of quorum sensing molecule (QSM) synthesis, factors influencing QSM production, and the response mechanism of QSMs. The review also highlights the applications of QS in stress adaptation, increasing fermentation products, and food preservation in S. cerevisiae.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Immunology
Liting Wu, Yanjian Yang, Along Gao, Jun Li, Jianmin Ye
Summary: The study found that tilapia anterior kidney (AK) leukocytes can be divided into two subsets of IgM(+) B cells: lymphoid (L) gate and granulocyte-monocyte/macrophage (G-M) subsets. The G-M gate IgM(+) cells resemble plasma-like cells, with high antibody-secreting, phagocytic, and antigen-presenting capacities.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell & Tissue Engineering
H. Choe, B. S. Hausman, K. M. Hujer, O. Akkus, P. N. Rather, Z. Lee, R. A. Bonomo, E. M. Greenfield
Summary: By investigating the impact of quorum sensing in Acinetobacter spp. on osseointegration, it was found that quorum sensing played a significant role in inducing interleukin 1 and inhibiting osseointegration in mice. Targeting Gram-negative acyl-homoserine lactone quorum sensing may be particularly effective for patients with Acinetobacter spp. infections.
EUROPEAN CELLS & MATERIALS
(2022)
Review
Cell Biology
Adrian A. Naoun, Itay Raphael, Thomas G. Forsthuber
Summary: Quorum sensing is not limited to bacteria, but may also play an important role in the mammalian immune system. This article explores the quorum sensing-like mechanisms in the immune system, particularly in regulating T cell behavior. It also discusses the potential therapeutic implications of modulating immune system-related quorum sensing.
Article
Immunology
Yuehua Li, Junxiang Yan, Jinghao Li, Xinke Xue, Ying Wang, Boyang Cao
Summary: This study identified a new quorum sensing regulator, LuxT, which directly inhibits hapR expression, leading to increased virulence in Vibrio cholerae. It was also found that the expression of LuxT is regulated by the two-component system ArcB/ArcA. These findings reveal a novel cell density-mediated virulence regulation pathway and contribute to a better understanding of the pathogenic mechanisms of V. cholerae.
Article
Immunology
Diana Martin, Pedro Perdiguero, Esther Morel, Irene Soleto, J. German Herranz-Jusdado, Luis A. Ramon, Beatriz Abos, Tiehui Wang, Patricia Diaz-Rosales, Carolina Tafalla
Summary: CD38 has diverse expressions in different species, with high levels in mouse B cell subsets and transient expression on early lymphocyte precursors in humans while consistently expressed on terminally differentiated plasma cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
Toshio Takahashi, Akira Shiraishi, Jun Murata, Shin Matsubara, Satsuki Nakaoka, Shinji Kirimoto, Masatake Osawa
Summary: Endogenous ACh affects the size of the intestinal stem niche through M3 signaling, impacting the growth and differentiation of intestinal epithelial cells. The EphB/ephrin-B and MAPK/ERK signaling cascade play a crucial role in maintaining the homeostasis of intestinal epithelial cell growth and differentiation.
LIFE SCIENCE ALLIANCE
(2021)
Article
Fisheries
Yorick A. van der Wal, Shiferaw Jenberie, Henriette Nordli, Linn Greiner-Tollersrud, Jaap Kool, Ingvill Jensen, Jorunn B. Jorgensen
Summary: The study showed that the intraperitoneal route is suitable for administering vaccines in Atlantic salmon, but the immune responses in the peritoneal cavity are not fully understood. Following Piscirickettsia salmonis challenge, B cell responses were found to increase significantly in the PerC, spleen, and head kidney. The serum antibody response included specific antibodies for P. salmonis, as well as non-specific antibodies for other pathogens. Additionally, adipose tissue may play a role in the PerC immune response.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Anyutoulou K. L. Davares, Mbarga M. J. Arsene, Podoprigora Viktorovna, Yashina N. Vyacheslavovna, Zhigunova A. Vladimirovna, Vasilyeva E. Aleksandrovna, Senyagin A. Nikolayevich, Sachivkina Nadezhda, Gizinger O. Anatolievna, Sharova Nikolaevna, Das M. Sergueievna
Summary: Experience-based knowledge has shown that bacteria can communicate with each other through quorum sensing (QS), which controls specific bacterial phenotypes with significant impact on food production, the economy, and health. The emergence of antibiotic resistance due to the use of conventional methods to inhibit bacterial growth necessitates research on new strategies, such as QS inhibition through quorum quenching (QQ). Multiple QS inhibitors (QSIs) have been identified from various sources and probiotics are being considered for their potential role as QSIs in food spoilage.
FERMENTATION-BASEL
(2022)
Article
Plant Sciences
Chika Takemura, Wakana Senuma, Kazusa Hayashi, Ayaka Minami, Yuki Terazawa, Chisaki Kaneoka, Megumi Sakata, Min Chen, Yong Zhang, Tatsuya Nobori, Masanao Sato, Akinori Kiba, Kouhei Ohnishi, Kenichi Tsuda, Kenji Kai, Yasufumi Hikichi
Summary: The study showed that PhcQ mainly contributes to the regulation of QS-dependent genes, while PhcR is partially involved in this process.
MOLECULAR PLANT PATHOLOGY
(2021)
Article
Engineering, Environmental
Xu Wang, Cancan Jiang, Danhua Wang, Yang Yang, Lijing Fan, Shengjun Xu, Xuliang Zhuang
Summary: Free nitrous acid (FNA) is widely used for wastewater management by altering sludge characteristic and function. This study investigated the role of collective behaviors in FNA treatment and revealed the impact of FNA on sludge morphology and composition.
Article
Chemistry, Medicinal
Andrea Muras, Ana Parga, Celia Mayer, Ana Otero
Summary: Interfering with quorum sensing systems of bacteria is a promising strategy to control biofilm formation, and the xCELLigence(R) system is proposed as an efficient method for quantifying biofilm formation.
Article
Engineering, Environmental
Jianmin Sun, Huiping Sun, Wenzhou Lv, Quandi Zhang, Pengfei Wan, Li Jiang, Yingying Zhong
Summary: Higher cell density has a strong antagonistic effect on filamentous induction, leading to better cell flocculation and settleability. Additionally, the cell density significantly influences yeast cell metabolism, affecting the utilization of phenylalanine and the production of extracellular substances and metabolites. The presence of phenethyl alcohol in metabolites suggests the involvement of quorum sensing in regulating yeast cell transformation in wastewater treatment.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Plant Sciences
Asif Iqbal, George Nwokocha, Vijay Tiwari, Inderjit K. Barphagha, Anne Grove, Jong Hyun Ham, William T. Doerrler
Summary: Bacterial panicle blight caused by Burkholderia glumae has a harmful effect on rice crops worldwide. Toxoflavin, which is synthesized and secreted by B. glumae in a quorum sensing-dependent manner, is responsible for the damage. The DedA family protein DbcA is involved in the secretion of oxalic acid, and it also plays a crucial role in the expression of quorum sensing-dependent genes.
MOLECULAR PLANT PATHOLOGY
(2023)
Article
Engineering, Environmental
Hong-Xin Shi, Xu Wang, Jin-Song Guo, Fang Fang, You-Peng Chen, Peng Yan
Summary: This study found that the proliferation of filamentous bacteria during filamentous bulking is associated with population density and AHLs concentration. The triggering of the QS-AHL system promotes the proliferation of filamentous bacteria, while the addition of the quorum sensing inhibitor vanillin effectively inhibits filamentous bulking.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Immunology
Yu Wang, Vanessa Kremer, Bruno Iannascoli, Odile Richard-Le Goff, David A. Mancardi, Leoni Ramke, Luc Chaisemartin, Pierre Bruhns, Friederike Jonsson
Summary: This study systematically assessed the binding specificities of IgG from different species to mouse and human Fcγ receptors. The results revealed specific binding patterns for each IgG subclass and identified potential issues with antibody-based immunoassays. This research provides a useful reference for the transition from animal models to preclinical mouse models or human cell-based bioassays.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Editorial Material
Medicine, Research & Experimental
Eva Conde, Vincent Serra, Pierre Bruhns, Laurent L. Reber
M S-MEDECINE SCIENCES
(2022)
Article
Immunology
Raki Sudan, Sandra Fernandes, Neetu Srivastava, Chiara Pedicone, Shea T. Meyer, John D. Chisholm, Robert W. Engelman, William G. Kerr
Summary: Humans with LRBA mutations exhibit immune-related pathologies, including inflammatory bowel disease. LRBA deficiency in mice leads to severe and lethal colitis when the colon epithelial barrier is disrupted by DSS consumption. LRBA is essential for the expression of CTLA4, IL22, and IL17 in the immune compartment. SHIP1 agonism partially attenuates the severity and lethality of DSS-mediated colitis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Chiara Pedicone, Sandra Fernandes, Alessandro Matera, Shea T. Meyer, Stewart Loh, Jeung-Hoi Ha, Denzil Bernard, John D. Chisholm, Rosa Chiara Paolicelli, William G. Kerr
Summary: In this study, artificial intelligence was used to identify novel agonists of the SH2-containing 5' inositol phosphatase 1 (SHIP1). The most potent agonist, K306, showed selectivity for SHIP1 and could suppress inflammatory responses and enhance phagolysosomal degradation in microglia.
Review
Pharmacology & Pharmacy
Marina Labella, Rocio Saenz de Santa Maria, Gador Bogas, Maria Salas, Tahia D. Fernandez, Cristobalina Mayorga, Maria Jose Torres, Inmaculada Dona
Summary: Drug hypersensitivity is increasing due to increased drug consumption, and it often presents in complex clinical settings with co-existing illnesses and polypharmacotherapy. Recent studies have improved the understanding of immediate drug hypersensitivity reactions by categorizing them based on endotypes, biomarkers, and phenotypes. This review focuses on the diagnosis and management of anaphylaxis, discussing both in vivo and in vitro diagnostic methods and highlighting the importance of clinical management, hidden allergens, and delabeling. Endophenotyping plays a crucial role in correctly identifying and treating patients with immediate drug hypersensitivity reactions, with drug desensitization being an effective approach to prevent future episodes.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Review
Anesthesiology
Alice Dejoux, Luc de Chaisemartin, Pierre Bruhns, Dan Longrois, Aurelie Gouel-Cheron
Summary: Acute hypersensitivity reactions (AHRs) during anesthesia can have severe consequences and their incidence is increasing. The most common allergens responsible for AHRs are neuromuscular blocking agents (NMBAs), followed by antibiotics, dyes, and latex. Current diagnosis of AHRs relies on the detection of mast cell degranulation products and IgE antibodies. This review provides an update on the different mechanisms involved in AHRs, including non-IgE related endotypes, and the diagnostic tools for their characterization.
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
(2023)
Article
Allergy
Jose A. Cespedes, Ruben Fernandez-Santamaria, Adriana Ariza, Gador Bogas, Inmaculada Dona, Carmen Rondon, Maria Salas, Marina Labella, Cecilia Frecha, Cristobalina Mayorga, Maria J. Torres, Tahia D. Fernandez
Summary: This study evaluated the use of BAT with CD63 and CD203c as activation markers for diagnosing immediate reactions to amoxicillin and amoxicillin-clavulanic acid. The results showed that CD203c had higher sensitivity and specificity in amoxicillin allergic patients. Using BAT as a first step in the diagnostic procedure can reduce the need for a complete allergological work-up in a significant percentage of patients, reducing the risk of reinducing allergic reactions.
Article
Multidisciplinary Sciences
Jennifer Cable, Erica Ollmann Saphire, Adrian C. Hayday, Timothy D. Wiltshire, Jarrod J. Mousa, David P. Humphreys, Esther C. W. Breij, Pierre Bruhns, Matteo Broketa, Genta Furuya, Blake M. Hauser, Matthieu Mahevas, Andrea Carfi, Tineke Cantaert, Peter D. Kwong, Prabhanshu Tripathi, Jonathan H. Davis, Neil Brewis, Bruce A. Keyt, Felix L. Fennemann, Vincent Dussupt, Arvind Sivasubramanian, Philip M. Kim, Reda Rawi, Eve Richardson, Daniel Leventhal, Rachael M. Wolters, Cecile A. W. Geuijen, Matthew A. Sleeman, Niccolo Pengo, Francesca Rose Donnellan
Summary: Therapeutic antibodies have a wide range of applications in various diseases, including oncology, autoimmune diseases, and infectious diseases. Ongoing research aims to discover antibodies with therapeutic potential and to improve existing antibodies or design new ones. The Keystone symposium Antibodies as Drugs, held from April 27-30, 2022, brought together experts in antibody research from academia and industry to discuss the latest advancements in antibody therapeutics, repertoires and deep learning, bispecific antibodies, and engineering.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sandra Fernandes, Shea T. Meyer, Jigisha P. Shah, Arijit A. Adhikari, William G. Kerr, John D. Chisholm
Summary: Inhibition of phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP) with small molecule inhibitors can lead to apoptosis in tumor cells. Pan-SHIP1/2 inhibitors that target both SHIP1 and SHIP2 may have benefits in cancer treatment, as paralog compensation is not possible when both SHIP paralogs are being inhibited. Tryptamine-based pan-SHIP1/2 inhibitors have been synthesized and evaluated for their ability to inhibit the SHIP paralogs, with the most active compounds also evaluated for their effects on cancer cell lines.
Article
Multidisciplinary Sciences
Amelie Bonaud, Laetitia Gargowitsch, Simon M. Gilbert, Elanchezhian Rajan, Pablo Canales-Herrerias, Daniel Stockholm, Nabila F. Rahman, Mark O. Collins, Hakan Taskiran, Danika L. Hill, Andres Alloatti, Nagham Alouche, Stephanie Balor, Vanessa Soldan, Daniel Gillet, Julien Barbier, Francoise Bachelerie, Kenneth G. C. Smith, Julia Jellusova, Pierre Bruhns, Sebastian Amigorena, Karl Balabanian, Michelle A. Linterman, Andrew A. Peden, Marion Espeli
Summary: We identified SNARE Sec22b as a critical regulator of plasma cell maintenance and function. In the absence of Sec22b, plasma cells were hardly detectable and serum antibody titers were dramatically reduced, leading to a failure in mounting a protective immune response. Mechanistically, Sec22b contributes to efficient antibody secretion and is involved in regulating plasma cell transcriptional identity, as well as the morphology of the endoplasmic reticulum and mitochondria.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Sandra Fernandes, Neetu Srivastava, Chiara Pedicone, Raki Sudan, Elizabeth A. Luke, Otto M. Dungan, Angela Pacherille, Shea T. Meyer, Shawn Dormann, Stephane Schurmans, Benedict J. Chambers, John D. Chisholm, William G. Kerr
Summary: By comparing different types of SHIP inhibitors, it was found that only pan-SHIP1/2 inhibitors can prevent obesity caused by excessive caloric intake. The study also discovered that the mechanism of action of pan-SHIPi is through the immune system, and it can also reduce hyperglycemia.
Letter
Allergy
Emma Lamanna, Eva Conde, Aurelie Mougel, Jonathan Bonnefoy, Fabien Colaone, Ophelie Godon, Samir Hamdi, Jasper B. J. Kamphuis, Beatrice Drouet, Vincent Serra, Pierre Bruhns, Laurent L. Reber
Letter
Allergy
Julien Stackowicz, Caitlin M. Gillis, Ophelie Godon, Bruno Iannascoli, Eva Conde, Edouard Leveque, William P. M. Worrall, Stephen J. Galli, Pierre Bruhns, Laurent L. Reber, Friederike Jonsson
Article
Immunology
Ather Adnan, Shree Acharya, Leila A. Alenazy, Leticia de las Vecillas, Pedro Giavina Bianchi, Matthieu Picard, Lucia Calbache-Gil, Salvador Romero-Pinedo, Ana Clara Abadia-Molina, William Kerr, Chiara Pedicone, Jun Nagai, Eleanor Hollers, Daniel Dwyer, Mariana Castells
Summary: Multistep mast cell desensitization inhibits the release of mediators following IgE crosslinking. This process has been successfully used in vivo to safely reintroduce drugs and foods to IgE-sensitized patients. However, the mechanisms behind this inhibitory process are not well understood.
JOURNAL OF IMMUNOLOGY
(2023)
Article
Engineering, Biomedical
Juan L. Paris, Cristina Monio, Ana M. Perez-Moreno, Raquel Jurado-Escobar, Gador Bogas, Tahia D. Fernandez, Maria I. Montanez, Cristobalina Mayorga, Maria J. Torres
Summary: This study explores the application of mesoporous silica nanoparticles in allergy diagnosis. By grafting IgG-binding protein G' onto nanoparticles with specific pore sizes, the capture capacity of IgG is greatly enhanced. The researchers find that the material with the optimal pore size efficiently captures human IgG in a selective manner, highlighting its potential in in vitro allergy diagnosis.
ADVANCED HEALTHCARE MATERIALS
(2023)
