Article
Biochemistry & Molecular Biology
Maria Clara Barbosa-de-Oliveira, Paolo Oliveira-Melo, Marcos Henrique Goncalves da Silva, Flavio Santos da Silva, Felipe Andrade Carvalho da Silva, Bruno Vinicios Silva de Araujo, Moacir Franco de Oliveira, Aristides Tadeu Correia, Sidnei Miyoshi Sakamoto, Samuel Santos Valenca, Manuella Lanzetti, Martina Schmidt, Emanuel Kennedy-Feitosa
Summary: This study investigates the role of eugenol (EUG) in cigarette smoke-induced acute lung injury (ALI) and how it modulates macrophage activity. The results show that EUG reduces inflammatory response and oxidative stress markers in vivo, and balances oxidative stress and cytokine release in vitro, indicating that it acts as a modulator of macrophage activity.
Article
Medicine, Research & Experimental
Tingting Wu, Keye Xu, Chaobo Liu, Yan Li, Mingcai Li
Summary: This study aimed to investigate the effect of interleukin-37 (IL-37) on cigarette smoke-induced lung inflammation. By administering IL-37-expressing lentivirus to mice, it was found that IL-37 can alleviate weight loss and pulmonary inflammation induced by cigarette smoke. IL-37 also significantly inhibited inflammatory cell recruitment, reduced inflammatory cell increase, and suppressed the production of pro-inflammatory cytokines.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Siddhi Jain, Sneha Durugkar, Pritam Saha, Sharad B. Gokhale, V. G. M. Naidu, Pawan Sharma
Summary: This study examined the efficacy of azithromycin alone and in combination with dexamethasone in treating cigarette smoke-induced acute lung inflammation. The results showed that azithromycin inhibited airway fibrosis, inflammation, and cell toxicity caused by cigarette smoke, and improved lung function. Further research is needed to validate the therapeutic efficacy of azithromycin as a treatment for COPD.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Alexsandro Tavares Figueiredo-Junior, Samuel Santos Valenca, Priscilla Vanessa Finotelli, Francisca de Fatima dos Anjos, Lycia de Brito-Gitirana, Christina Maeda Takiya, Manuella Lanzetti
Summary: The therapeutic use of annatto pigments has been evaluated in animal models, with beneficial effects attributed to the inhibition of oxidative stress. Bixin nanoparticles were prepared and found to prevent pulmonary inflammation and oxidative stress induced by cigarette smoke.
Article
Immunology
Tiantian Cen, Yifeng Mai, Jie Jin, Minxuan Huang, Mingcai Li, Shanshan Wang, Hongying Ma
Summary: Our study aimed to investigate the ability of IL-41 to protect against CS-induced lung inflammation in vivo. The results showed that IL-41 pre-treatment alleviated pulmonary inflammatory infiltration and lung tissue lesions, limited CS-induced weight loss, and promoted the polarization of M2 macrophages. IL-41 also increased the levels of IL-10 and reduced the production of TNF-α, IL-6, and IL-1β.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Lan Wu, Yan Cheng, Shunxiang Peng, Wensheng Zhang, Chaoxiong Zhang
Summary: The study found that atorvastatin has anti-inflammatory effects in acute lung injury, with Sphingosine kinase 1 playing a crucial role in this process. By inhibiting MAPK activity and maintaining endothelial cell junction integrity, SphK1 plays a critical role in atorvastatin-mediated anti-inflammatory effects.
MEDIATORS OF INFLAMMATION
(2021)
Review
Physiology
Marta Schiliro, Elizabeth R. Vogel, Lucia Paolini, Christina M. Pabelick
Summary: The detrimental effects of tobacco exposure on children's health are well known, and the prevalence of secondhand or direct cigarette smoke exposure in the pediatric population has not significantly decreased over time. Additionally, the rapid increase in e-cigarette use among adolescents has raised public health concerns.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Hsin-Kuo Ko, Yi-Han Hsiao, Mei-Jy Jeng, De-Ming Yang, Pei-Ku Chen, Kang-Cheng Su, Kun-Ta Chou, Diahn-Warng Perng
Summary: This study found that TGF-beta 2 reduced CSE-induced IL-8 production through the Smad3 signaling pathway in PBECs, and alleviated lung inflammation and injury caused by cigarette smoke. TGF-beta 2 has an anti-inflammatory effect on cigarette smoke-induced lung inflammation.
Article
Cell Biology
Chao Cao, Baoping Tian, Xinwei Geng, Hongbin Zhou, Zhiwei Xu, Tianwen Lai, Yanping Wu, Zhengqiang Bao, Zhihua Chen, Wen Li, Huahao Shen, Songmin Ying
Summary: Chronic inflammation has been identified as a risk factor for human cancer, and this study showed that cigarette smoke-induced genomic instability may be partially attributed to IL-17-mediated inflammation. Higher levels of IL-17 and DDR were observed in smokers' lung tissues compared to non-smokers, as well as in mice exposed to cigarette smoke. These findings suggest that IL-17 could play a crucial role in the development of lung cancer.
Article
Biochemistry & Molecular Biology
Tiziana Genovese, Andrea Duranti, Ramona D'Amico, Roberta Fusco, Daniela Impellizzeri, Alessio Filippo Peritore, Rosalia Crupi, Enrico Gugliandolo, Salvatore Cuzzocrea, Rosanna Di Paola, Rosalba Siracusa, Marika Cordaro
Summary: Acute lung injury (ALI) is a lung disease characterized by severe inflammation without treatment. This study investigated the role of fatty acid amide hydrolase (FAAH) inhibition in an ALI mouse model and found that it could counteract the inflammatory response and histological changes caused by the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Huan Xu, Feng Xu, Hongyu Lu, Jiexin Chen, Xiaoling Huang, Yongsong Chen, Ling Lin
Summary: This study aimed to investigate the role of S1PR2 in cigarette smoke extract-induced inflammation and pyroptosis in human bronchial epithelial cells. The results revealed that the S1PR2 signaling pathway may be involved in the pathogenesis of cigarette smoke-induced inflammation and injury, suggesting that S1PR2 inhibitors could be an effective treatment for cigarette smoke-induced airway inflammation and injury.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Article
Immunology
Angela Rico de Souza, Hussein Traboulsi, Xinyu Wang, Jorg H. Fritz, David H. Eidelman, Carolyn J. Baglole
Summary: Research suggests that inhibiting AhR will enhance cigarette smoke-induced pulmonary neutrophilia, but the mechanism of AhR's anti-inflammatory function remains unclear. Through the use of AhR antagonists and genetically modified mice, the study shows that features such as nuclear translocation and binding of response elements are not necessary for AhR to suppress pulmonary neutrophilia.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Carmen A. Ochoa, Claire G. Nissen, Deanna D. Mosley, Christopher D. Bauer, Destiny L. Jordan, Kristina L. Bailey, Todd A. Wyatt
Summary: Most individuals with alcohol use disorders also smoke cigarettes. Exposure to cigarette smoke and alcohol can cause lung injury, but aldehyde-trapping compounds like ADX-102 may offer protection against this damage.
Article
Environmental Sciences
Ryeo-Eun Go, Sung-Moo Lee, Young-Jun Shin, Min-Seok Kim, Chul-Min Park, Eul-Bee Ko, Soochong Kim, Kyung-Chul Choi
Summary: Cigarette smoke substances can cause various diseases, but evaluating their toxicity is challenging. This study compared the sensitivity of two animal models to cigarette smoke and identified the optimal exposure time in the lung injury rat model.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Urology & Nephrology
Ruolin Wang, Siheng Shen, Luyong Jian, Shuhua Liu, Qi Yuan, Huahui Guo, Jiasheng Huang, Penghui Chen, Renfa Huang
Summary: This study investigated the role of autophagy in AKI-induced ALI and found that autophagy can effectively ameliorate the injury by suppressing inflammation and oxidative stress.
Article
Medicine, Research & Experimental
Qin Zhang, Xiaotian Du, Qiangqiang He, Wei Shi, Liu Mei, Meiyu Qv, Dan Tan, Junsong Wu, Ling-Hui Zeng, Ximei Wu
Summary: The study reveals that the T851I mutation in the LATS1 gene reduces its tumor-suppressor functions in colorectal cancer by attenuating Hippo signaling. This mutation destabilizes the phosphorylation of LATS1 and decreases its binding to downstream effectors, YAP and TAZ, thereby controlling colorectal tumorigenesis through a previously uncharacterized mechanism.
Article
Biochemistry & Molecular Biology
Haibin Zhu, Qianlei Ren, Ziyi Yan, Shouying Xu, Jiahao Luo, Ximei Wu, Chao Tang
Summary: This study uncovers a previously unknown role of the transcription factor HAND1 in the regulation of cholesterol metabolism and steroid synthesis in human trophoblasts. HAND1 inhibits the expression of steroidogenic enzymes and decreases the levels of progesterone and estradiol in trophoblasts. The mechanisms involve direct binding to gene promoters, regulation of promoter methylation status, and destabilization of RNA.
JOURNAL OF GENETICS AND GENOMICS
(2022)
Article
Biochemistry & Molecular Biology
Liu Mei, Meiyu Qv, Hangyang Bao, Qiangqiang He, Yana Xu, Qin Zhang, Wei Shi, Qianlei Ren, Ziyi Yan, Chengyun Xu, Chao Tang, Musaddique Hussain, Ling-Hui Zeng, Ximei Wu
Summary: The study reveals that SUMOylation can activate LATS1 but not Lats2, playing a critical role in maintaining tissue homeostasis.
Article
Allergy
Xiangzhi Wang, Chengyun Xu, Yuqing Cai, Xinyi Zou, Yunqi Chao, Ziyi Yan, Chaochun Zou, Ximei Wu, Lanfang Tang
Summary: This study revealed the high expression of circZNF652 in bronchoalveolar lavage fluid of allergic asthma patients and its role in promoting pathological goblet cell metaplasia through activation of the miR-452-5p/JAK2/STAT6 signaling pathway. These findings provide new strategies for the therapeutic intervention of epithelial remodeling in allergic airway inflammation.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Chao Tang, Ximei Wu, Qianlei Ren, Minli Yao, Shouying Xu, Ziyi Yan
Summary: This study uncovers a novel mechanism controlling Hh signaling through the activation of Rac1 and subsequent translocation of Gli. Rac1 activation affects KIF3A phosphorylation and IFT88 stability, thereby disrupting SuFu-Gli complex formation and releasing Gli for nuclear translocation.
Review
Cell Biology
Ling-Hui Zeng, Muhammad Qasim Barkat, Shahzada Khurram Syed, Shahid Shah, Ghulam Abbas, Chengyun Xu, Amina Mahdy, Nadia Hussain, Liaqat Hussain, Abdul Majeed, Kashif-ur-Rehman Khan, Ximei Wu, Musaddique Hussain
Summary: The development of the embryonic lung requires complex interactions, regulated by various signaling proteins. Hedgehog (Hh) signaling plays a vital role in lung development and its controlled regulation is crucial for maintaining healthy lung function. Aberrant Hh signaling is associated with several airway lung diseases, including bronchial or tissue fibrosis, lung cancer, and pulmonary arterial hypertension. The Hh signaling pathway is also linked to lung organogenesis and asthmatic airway remodeling.
Article
Oncology
Qiangqiang He, Meiyu Qu, Tingyu Shen, Yana Xu, Jiahao Luo, Dan Tan, Chengyun Xu, Muhammad Qasim Barkat, Ling-Hui Zeng, Ximei Wu
Summary: Low-expression of VEGFD is positively correlated with LUAD development, and excessive S-nitrosylation can suppress VEGFD expression and promote angiogenesis in LUAD.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Cell Biology
Yan Guan, Liucheng Li, Liandi Kan, Qiangmin Xie
Summary: This study demonstrates the protective effects of salvianolic acid B (SalB) inhalation against PM2.5-induced airway inflammation and oxidative stress. SalB treatment reduces inflammatory cell infiltration and damage, and decreases the expression levels of pro-inflammatory proteins and genes. Additionally, SalB reduces oxidative stress levels by inhibiting specific signaling pathways.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Biochemistry & Molecular Biology
Yingying Shu, Chaochun Zou, Yuqing Cai, Qiangqiang He, Xiaowei Wu, Haibin Zhu, Meiyu Qv, Yunqi Chao, Chengyun Xu, Lanfang Tang, Ximei Wu
Summary: Vitamin C deficiency can lead to hypoglycemia and cognitive impairment, especially in female pups. The study identifies S-nitrosylation and activation of GSK3 beta as a previously unknown mechanism controlling glucose homeostasis in response to Vitamin C deprivation. Vitamin C supplementation can reverse these issues.
Review
Biochemistry & Molecular Biology
Meiyu Qu, Qiangqiang He, Jiahao Luo, Tingyu Shen, Ruibo Gao, Yana Xu, Chengyun Xu, Muhammad Qasim Barkat, Ling-Hui Zeng, Ximei Wu
Summary: This article investigates the role of alternative splicing (AS) in normal development and tumorigenesis. High-throughput sequencing-based studies have revealed the correlation between AS and diseases, including cancer. The focus of this article is the relationship between AS and medulloblastoma (MB), including the mechanisms of MB development, the regulatory roles of AS in canonical and non-canonical hedgehog signaling pathways, and the therapeutic applications of targeted AS.
Article
Cell & Tissue Engineering
Chao Tang, Jirong Wang, Minli Yao, Xing Ji, Wei Shi, Chengyun Xu, Ling-Hui Zeng, Ximei Wu
Summary: The overlapping roles of Hippo and Hedgehog signaling in biological functions and diseases prompt us to investigate their potential interactions. We found that activation of Hippo signaling enhances the transcriptional output of Hedgehog signaling, and this regulation relies on the key effector Taz. Taz phosphorylates Gli3 through PKA activation, resulting in the processing of Gli3 into its repressor form and attenuation of Hedgehog signaling.
Review
Cell Biology
Qiangqiang He, Meiyu Qu, Tingyu Shen, Jiakun Su, Yana Xu, Chengyun Xu, Muhammad Qasim Barkat, Jibao Cai, Haibin Zhu, Ling -Hui Zeng, Ximei Wu
Summary: Mitochondria-associated endoplasmic reticulum membranes (MAMs) are dynamic coupling structures between mitochondria and the endoplasmic reticulum (ER), playing important roles in calcium homeostasis, autophagy, ER stress, lipid metabolism, and various diseases. The formation and function of MAMs rely on specific proteins, including the IP3R-Grp75-VDAC complex. S-palmitoylation, a reversible protein post-translational modification, is closely related to the localization of proteins in MAMs. This article provides an overview of the composition and function of MAMs, focusing on the role of S-palmitoylated proteins in calcium flux, lipid rafts, and discusses their implication in diseases, particularly neurodegenerative diseases (NDs). Potential drug compounds targeting S-palmitoylation are also proposed.
AGEING RESEARCH REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Qiangqiang He, Meiyu Qu, Hangyang Bao, Yana Xu, Tingyu Shen, Dan Tan, Muhammad Qasim Barkat, Chengyun Xu, Ling-Hui Zeng, Ximei Wu
Summary: EGFR mutation is the most common driver mutation in non-small cell lung cancer (NSCLC). EGFR tyrosine kinase inhibitors (EGFR-TKIs) are the first-line therapy for NSCLC patients with EGFR-sensitive mutation. However, resistance mutations often develop in EGFR-TKI therapy.
CYTOKINE & GROWTH FACTOR REVIEWS
(2023)
Article
Multidisciplinary Sciences
Dan Tan, Meiping Lu, Yuqing Cai, Weibo Qi, Fugen Wu, Hangyang Bao, Meiyu Qv, Qiangqiang He, Yana Xu, Xiangzhi Wang, Tingyu Shen, Jiahao Luo, Yangxun He, Junsong Wu, Lanfang Tang, Muhammad Qasim Barkat, Chengyun Xu, Ximei Wu
Summary: Allergic asthma is characterized by goblet cell metaplasia. Here, the authors show protein SUMOylation contributes to goblet cell metaplasia and SUMOylation-mediated ROCK2 activation is an integral component of Rho/ROCK signaling pathway in controlling the airway goblet cell metaplasia.
NATURE COMMUNICATIONS
(2023)
Correction
Respiratory System
Ya-nan Liu, Yan Guan, Jian Shen, Yong-liang Jia, Jian-cang Zhou, Yun Sun, Jun-xia Jiang, Hui-juan Shen, Qiang Shu, Qiang-min Xie, Yicheng Xie
RESPIRATORY RESEARCH
(2022)
