Review
Cell Biology
Tianmiao Ma, Bernhard W. Renz, Matthias Ilmer, Dominik Koch, Yuhui Yang, Jens Werner, Alexandr V. Bazhin
Summary: Myeloid-derived suppressor cells (MDSCs) play a crucial role in the tumor microenvironment (TME) and have been linked to poor prognosis and drug resistance in cancer. Further research is needed to fully understand the definition and phenotypes of MDSCs in humans.
Article
Oncology
Jiawen Han, Minjie Wan, Zhanchuan Ma, Huanfa Yi
Summary: This study found that the DNA-PK inhibitor NU7441 alone significantly increased tumor growth in 4 T1 tumor-bearing mice. Bioinformatics analysis showed that DNA-PK and functional markers of MDSCs tended to coexist in breast cancer patients. NU7441 decreased the percentage of MDSCs in PBMCs, spleen, and tumor, but enhanced the immunosuppressive function of splenic MDSCs. The combination of NU7441 and gemcitabine reduced tumor volume by eliminating the remaining MDSCs with enhanced immunosuppressive ability.
Article
Immunology
Ge Song, Yue Zhang, Jie Tian, Jie Ma, Kai Yin, Huaxi Xu, Shengjun Wang
Summary: Myeloid-derived suppressor cells (MDSCs) are a major component of tumor-induced immunosuppressive environment, and TRAF6 plays a critical role in modulating the immunosuppressive function of MDSCs by mediating K63-linked polyubiquitination and phosphorylation of STAT3. The abnormal accumulation of MDSCs in the peripheral blood of lung cancer patients, with highly expressed TRAF6 and arginase 1, suggests a potential target for antitumor immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Jiaojiao Huang, Yue Zhao, Kexin Zhao, Kai Yin, Shengjun Wang
Summary: This review focuses on how MDSCs survive and function in high levels of ROS, and summarizes immunotherapy targeting ROS in MDSCs. The distinctive role of ROS in MDSCs will inspire us to widely apply the blocked oxidative stress strategy in targeting MDSC therapy to future clinical therapeutics.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Natalia Di Ianni, Silvia Musio, Serena Pellegatta
Summary: Glioblastoma metabolism is flexible and adaptable to adverse conditions, with altered lipid metabolism also playing a role in tumor progression. Immunosuppressive microenvironment of GBM involves MDSCs as allies of tumor cells, and there is increasing evidence of interconnection between GBM and MDSC metabolic pathways. Understanding the metabolic programs of GBM and MDSCs is important for improving treatment modalities, including immunotherapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yun Liu, Xi Chen, Wenwu Luo, Yufei Zhao, Bjoern Nashan, Lei Huang, Xiaodong Yuan
Summary: Activation of the cell cycle program in hepatocellular carcinoma (HCC) hinders immunotherapy. Cell cycle gene-based classification can predict the prognosis of HCC patients and is associated with MDSC infiltration.
Review
Cell Biology
Mithunah Krishnamoorthy, Lara Gerhardt, Saman Maleki Vareki
Summary: Myeloid cells can transform into myeloid-derived suppressor cells during cancer progression or chronic inflammation, inhibiting anti-tumor immunity. Overcoming the suppression caused by MDSCs is a major obstacle in cancer immunotherapy, highlighting the importance of understanding the mechanisms behind how MDSCs promote tumor growth for improving and developing new therapies.
Article
Oncology
Aram Lee, Haesun Park, Soyoung Lim, Jihyun Lim, Jaemoon Koh, Yoon Kyung Jeon, Young Yang, Myeong-Sok Lee, Jong-Seok Lim
Summary: This study investigated the role of MITF in immunosuppressive myeloid cells, including MDSCs. The results showed that MITF plays an important regulatory role in tumor development through its impact on the differentiation and function of MDSCs. This finding provides a basis for the development of novel therapeutic targets for modulating MDSC activity.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Ash Lee Manley, Jichun Chen, Wendy Fitzgerald, Xingmin Feng, Neal S. Young
Summary: This study demonstrates that G-MDSC-exos attenuate immune bone marrow failure by modulating the delivery of immunosuppressive miRNAs into activated T lymphocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Shifen Wang, Xingyun Zhao, Siwen Wu, Dawei Cui, Zhenshu Xu
Summary: In this review, the biological functions, phenotypic characteristics, suppressive mechanisms, and expansion of MDSC populations in various types of hematological malignancies are summarized. The clinical correlation between MDSCs and the diagnosis of malignant hematological diseases, as well as the drugs targeting MDSCs, are discussed. Furthermore, the therapeutic strategies combining MDSCs targeting with other immunotherapies, such as immune checkpoint inhibitors, are highlighted.
BIOMARKER RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Zhiguo Ling, Chuan Yang, Jiulin Tan, Ce Dou, Yueqi Chen
Summary: MDSCs, a heterogeneous population of immature myeloid cells with immunosuppressive functions, play crucial roles in cancer-related bone metastasis and bone repair. They interact closely with stromal cells within the bone microenvironment and have promising value in the treatment of bone-related diseases.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Oncology
Ihor Arkhypov, Feyza Gul Ozbay Kurt, Rebekka Bitsch, Daniel Novak, Vera Petrova, Samantha Lasser, Thomas Hielscher, Christopher Groth, Alisa Lepper, Xiaoying Hu, Wei Li, Jochen Utikal, Peter Altevogt, Viktor Umansky
Summary: Soluble HSP90 alpha can convert monocytes into MDSC, which inhibits the antitumor function of T and NK cells. Higher levels of HSP90 alpha in plasma of patients with melanoma are associated with increased PD-L1 expression on MDSC and shorter PFS after ICI therapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Immunology
Estefania Prochetto, Eliana Borgna, Carlos Jimenez-Cortegana, Victor Sanchez-Margalet, Gabriel Cabrera
Summary: Myeloid-derived suppressor cells (MDSCs) play a role in both pathological and non-pathological conditions, including cancer, infections, pregnancy, aging, and vaccination. Vaccination is a crucial public health measure, but the presence of MDSCs may impact vaccine efficacy.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Pathology
Lingfei Li, Mingyang Li, Qingge Jia
Summary: Myeloid-derived suppressor cell (MDSC) mainly exists in tumor microenvironment (TME) and interferes with normal immune response of the body. These immature differentiated cells cooperate with tumor cells for immune escape and proliferation. The subtypes of MDSC are different in different organisms, and STAT become a high priority for the signaling pathway mediating the regulation of MDSC.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Cell Biology
Jie Chen, Fengdong Cheng, Eva Sahakian, John Powers, Zi Wang, Jianguo Tao, Edward Seto, Javier Pinilla-Ibarz, Eduardo M. Sotomayor
Summary: MDSCs lacking HDAC11 exhibit increased arginase activity and NO production in granulocytic MDSCs, and elevated iNOS expression and NO production in monocytic MDSCs. Additionally, the absence of HDAC11 is associated with up-regulation of C/EBP beta, which influences the expression of immunosuppressive molecules in MDSCs.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)