Article
Multidisciplinary Sciences
Mark Almond, Hugo A. Farne, Millie M. Jackson, Akhilesh Jha, Orestis Katsoulis, Oliver Pitts, Tanushree Tunstall, Eteri Regis, Jake Dunning, Adam J. Byrne, Patrick Mallia, Onn Min Kon, Ken A. Saunders, Karen D. Simpson, Robert J. Snelgrove, Peter J. M. Openshaw, Michael R. Edwards, Wendy S. Barclay, Liam M. Heaney, Sebastian L. Johnston, Aran Singanayagam
Summary: Obese individuals have deficient pulmonary antiviral immune responses in bronchoalveolar lavage cells, due to increased airway concentrations of leptin, which impair interferon responses and facilitate severe influenza infection.
NATURE COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Kim Thomsen, Niels Hoiby, Peter Ostrup Jensen, Oana Ciofu, Claus Moser
Summary: Biofilm infections are resistant to host responses and antibiotics. The host immune response plays a crucial role in the outcome and exacerbation of chronic infections. In chronic Pseudomonas aeruginosa lung infections, antibody response and Th1/Th2 imbalance have been associated with a worse outcome.
Review
Cell Biology
Nazli Alizadeh-Tabrizi, Stefan Hall, Christian Lehmann
Summary: Intravital microscopy is a unique imaging method that provides real-time insights into cellular functions without the need for tissue extraction. Despite specific challenges in lung imaging, advancements in surgical and optical techniques have enabled researchers to uncover mechanisms of leukocyte recruitment and function in models of pulmonary inflammation and infection.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Fisheries
Junrong Li, Liqun Wang, Xinyue Zhang, Xiaozhi Wen, Xinyan Wei, Qiwei Qin, Shaowen Wang
Summary: This study identified and characterized AnxA2 (EcAnxA2) in Epinephelus coioides and investigated its role in RGNNV infection. EcAnxA2 was widely expressed in different tissues and its expression was significantly increased after RGNNV infection. Overexpression of EcAnxA2 enhanced RGNNV infection, while knockdown of EcAnxA2 reduced infection. EcAnxA2 also modulated the host immune response by regulating the transcription of interferon-related and inflammatory factors. These findings provide new insights into the role of AnxA2 in fish during virus infection.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Immunology
Garrison Cox, Andres J. Gonzalez, Emmanuel C. Ijezie, Andres Rodriguez, Craig R. Miller, James T. Van Leuven, Tanya A. Miura
Summary: Rhinoviruses (RV) can inhibit pulmonary coronavirus infection, reduce inflammation and tissue damage, and prevent mortality. These findings are important for understanding the interaction between respiratory viruses and the host, and their impact on disease pathogenesis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Maria Teresa Herrera, Silvia Guzman-Beltran, Karen Bobadilla, Teresa Santos-Mendoza, Mario Alberto Flores-Valdez, Luis Horacio Gutierrez-Gonzalez, Yolanda Gonzalez
Summary: This review focuses on the local immune response induced by Mycobacterium tuberculosis in the lungs of patients with active tuberculosis. The cellular response is characterized by inflammation and oxidative stress, mainly produced by macrophages and T lymphocytes. Cytokine levels are increased in the alveolar microenvironment. Despite the presence of chronic infection, adaptive immune response is induced, indicated by the production of specific immunoglobulins.
Article
Oncology
Feng Wang, Ayse Ece Cali Daylan, Lei Deng, Jihua Yang, Janaki Sharma, Christopher Su, Shenduo Li, Xingxing Zang, Balazs Halmos, Alain Borczuk, Haiying Cheng
Summary: Pulmonary sarcomatoid carcinoma (PSC) is an aggressive subtype of non-small-cell lung cancer (NSCLC) that doesn't respond well to standard chemotherapy and PD-1/PD-L1 inhibitors. This study found that PD-L1 expression was higher in the epithelial component compared to the sarcomatoid component, and most PSC patients had at least one immune checkpoint expression in both components. Combination immune checkpoint inhibition based on expression profiles may be a personalized and effective treatment strategy.
Article
Fisheries
Xiumei Chen, Jiasong Zhang, Muyang Li, Jiaxin Tian, Xiaotian Niu, Xiaofeng Shan, Sha Luo, Guiqin Wang, Aidong Qian
Summary: This study provides transcriptomic data on the immune response of Channa argus to pathogen infection, revealing differentially expressed genes related to disease resistance. The findings shed light on the defense mechanisms of C. argus and the interrelationships between immune pathways.
AQUACULTURE INTERNATIONAL
(2023)
Article
Entomology
Yongfeng Wang, Meijuan Shi, Jiameng Yang, Lu Ma, Xuedong Chen, Meng Xu, Ruji Peng, Guang Wang, Zhonghua Pan, Yanghu Sima, Shiqing Xu
Summary: Studies have shown that introducing the recombinant Ser3 gene into the posterior silk gland of silkworms affects hemolymph melanization and metabolism. Hemolymph melanin content and phenoloxidase activity are significantly reduced in transgenic silkworms, leading to slower blood melanization and weaker sterilization ability. Additionally, the redox metabolic capacity of hemolymph is enhanced. These findings have positive implications for the safe assessment and development of genetically modified organisms.
Article
Immunology
Akhila Balachander, Bernett Lee, Subhra K. Biswas, David C. Lye, Raymond T. P. Lin, Yee-Sin Leo, Paul Chui, Lisa F. P. Ng, Laurent Renia
Summary: In young adults without comorbidities, SARS-CoV-2 infection can lead to imbalanced immune cell populations and organ-specific dysfunction. Lung and ileal tissue show altered architecture with loss of tissue integrity, while lung and heart tissue exhibit severe hyperinflammation.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2022)
Review
Cell Biology
Matthew Burgess, Franklin Valdera, David Varon, Esko Kankuri, Kristo Nuutila
Summary: Burns are diverse and complex injuries that have local and systemic effects. Improvements in burn care have been made over the past decades. Severity of burns depends on size, depth, location, age, and underlying diseases.
Article
Environmental Sciences
Lisa Buchenauer, Kristin M. Junge, Sven-Bastiaan Haange, Jan C. Simon, Martin von Bergen, Anna-Lena Hoh, Gabriela Aust, Ana C. Zenclussen, Gabriele I. Stangl, Tobias Polte
Summary: Exposure to low-dose glyphosate in mothers has an immunosuppressive effect on their female offspring, which is not observed in the second generation. The altered microbiota composition might mediate this immune response modulation.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Agriculture, Dairy & Animal Science
Yufei Tian, Yang Liu, Qiuyuan Wang, Jie Wen, Yiru Wu, Jianwei Han, Chaolai Man
Summary: This study investigated the impact of stress-induced immunosuppression on the immune response to the Newcastle disease virus (NDV) vaccine by analyzing the changes in circulating microRNAs (miRNAs). The results showed that stress-induced immunosuppression led to differential expressions of candidate circulating miRNAs, particularly at specific timepoints post immunization. Furthermore, stress-induced immunosuppression significantly affected the immune response to the NDV vaccine by altering the expressions of candidate circulating miRNAs. These findings suggest that candidate circulating miRNAs may serve as potential biomarkers in immunity and immunosuppression.
Article
Biology
Wei Zhou, Dongying Xuan, Ting Yu, Jincai Zhang
Summary: This study investigates the pulmonary immune response to periodontal infection in diet-induced obese (DIO) mice, and finds that periodontitis aggravates the pulmonary immune response and leads to a decrease in alveolar macrophage infiltration.
OPEN LIFE SCIENCES
(2022)
Article
Oncology
Nam Q. Bui, Neda Nemat-Gorgani, Ajay Subramanian, Ileana A. Torres, Marta Lohman, Timothy J. Sears, Matt van de Rijn, Gregory W. Charville, Hans-Christoph Becker, David S. Wang, Gloria L. Hwang, Kristen N. Ganjoo, Everett J. Moding
Summary: This study evaluated the role of circulating tumor DNA (ctDNA) as a biomarker in monitoring treatment response in patients with advanced soft tissue sarcomas (STS). The results showed that ctDNA was associated with treatment response, progression-free survival, and overall survival. This suggests that ctDNA may serve as a promising biomarker in STS patients.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Patrick P. C. Boor, Kostandinos Sideras, Katharina Biermann, M. Hosein Aziz, Iris J. M. Levink, Shanta Mancham, Nicole S. Erler, Xudong Tang, Casper H. van Eijck, Marco J. Bruno, Dave Sprengers, Xingxing Zang, Jaap Kwekkeboom
BRITISH JOURNAL OF CANCER
(2020)
Article
Cell Biology
Zhen Zhang, Jinyan Liu, Chaoqi Zhang, Feng Li, Lifeng Li, Dan Wang, Damini Chand, Fangxia Guan, Xingxing Zang, Yi Zhang
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Cell Biology
Yuxin Li, Yao Liu, Na Zhao, Xiaojun Yang, Yaqing Li, Fangzheng Zhai, Xingxing Zang, Wei Cui
CELL DEATH & DISEASE
(2020)
Article
Oncology
Ziqiang Yuan, Juliet C. Gardiner, Elaine C. Maggi, Shuyu Huang, Asha Adem, Svetlana Bagdasarov, Guiying Li, Sylvia Lee, Daniel Slegowski, Alyssa Exarchakis, James R. Howe, Edmund C. Lattime, Xingxing Zang, Steven K. Libutti
Summary: The study found that HHLA2 and B7x are highly expressed in GINETs and PNETs, and correlate with malignancy and spread. The overexpression of HIF-1 alpha is associated with the upregulation of B7x, and Men1/B7x double knockout mice show increased T-cell infiltration. Targeting B7x may offer a promising strategy for immunotherapy in patients with NETs.
ENDOCRINE-RELATED CANCER
(2021)
Article
Oncology
Phillip M. Galbo, Xingxing Zang, Deyou Zheng
Summary: This study conducted a comprehensive analysis of CAFs from multiple cancer types, identified shared molecular characteristics in CAF subtypes, and revealed the association of different CAF subtypes with clinical outcomes and immunotherapy resistance.
CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Wei Zhang, Ana Acuna-Villaorduna, Kevin Kuan, Sorab Gupta, Shaomin Hu, Kim Ohaegbulam, Joseph Albanese, Meghan Kaumaya, Rachel Levy, Richard R. Hwang, Xingxing Zang, Juan Lin, Qiang Liu, Radhashree Maitra, Sanjay Goel
Summary: Low expression of both PD-L1 and B7-H3 in colorectal cancer is associated with better survival outcomes, without significant variation among different racial groups in terms of relevant protein markers for CRC.
CLINICAL COLORECTAL CANCER
(2021)
Review
Biochemistry & Molecular Biology
Christopher D. Nishimura, Marc C. Pulanco, Wei Cui, Liming Lu, Xingxing Zang
Summary: This article discusses the ligand-ligand cis-interaction between PD-L1 and B7-1 and its impact on immune checkpoint pathways, suggesting significant crosstalk between these pathways and providing new insights for immunotherapies and treatments.
TRENDS IN MOLECULAR MEDICINE
(2021)
Article
Oncology
Qianghua Zhou, Kaiwen Li, Yiming Lai, Kai Yao, Qiong Wang, Xiangyu Zhan, Shirong Peng, Wenli Cai, Wei Yao, Xingxing Zang, Kewei Xu, Jian Huang, Hai Huang
Summary: Both B7-H3 and HHLA2 have a critical impact on the immunosuppressive microenvironment in PCa. The B7 score, combined with CD8(+) TILs, can be used as a new immune classification to stratify the risk of death, especially cancer-related death, for patients with PCa.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Immunology
Yao Wei, Xiaoxin Ren, Phillip M. Galbo, Scott Moerdler, Hao Wang, R. Alejandro Sica, Bijan Etemad-Gilbertson, Lei Shi, Liqiang Zhu, Xudong Tang, Qi Lin, Mou Peng, Fangxia Guan, Deyou Zheng, Jordan M. Chinai, Xingxing Zang
Summary: HHLA2 is a promising target for cancer immunotherapy due to its coinhibitory function and overexpression in human cancers. The KIR3DL3-HHLA2 pathway may be a potential immunotherapeutic target for cancer.
SCIENCE IMMUNOLOGY
(2021)
Article
Hematology
Ilseyar Akhmetzyanova, Tonya Aaron, Phillip Galbo, Anastasia Tikhonova, Igor Dolgalev, Masato Tanaka, Iannis Aifantis, Deyou Zheng, Xingxing Zang, David Fooksman
Summary: The dissemination and progression of multiple myeloma is associated with an increased inflammatory signature in bone marrow MPs, with CD169(+) MPs playing a critical role in the early spread of myeloma.
Article
Multidisciplinary Sciences
Peter John, Marc C. Pulanco, Phillip M. Galbo, Yao Wei, Kim C. Ohaegbulam, Deyou Zheng, Xingxing Zang
Summary: B7x, an immune checkpoint molecule, promotes the conversion of CD4+ T cells into regulatory T cells within the tumor microenvironment. It induces transcriptomic changes in regulatory T cells, altering their phenotype to an activated and suppressive state. B7x-mediated regulation reduces the efficacy of anti-CTLA-4 treatment, but combination therapy with anti-B7x and anti-CTLA-4 overcomes this resistance and shows synergistic therapeutic efficacy.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Elodie Picarda, Phillip M. Galbo, Haihong Zong, Meenu Rohini Rajan, Ville Wallenius, Deyou Zheng, Emma Borgeson, Rajat Singh, Jeffrey Pessin, Xingxing Zang
Summary: The immune checkpoint B7-H3 has been studied in the tumor microenvironment and immunotherapy, but its potential role in metabolism remains largely unknown. This study reveals that B7-H3 is highly expressed in adipose tissue, particularly in adipocyte progenitor cells, and it regulates the glycolytic and mitochondrial activity of these cells. Loss of B7-H3 leads to impaired oxidative metabolism and increased lipid accumulation in derived adipocytes. Knockout of B7-H3 in mice results in spontaneous obesity, metabolic dysfunction, and adipose tissue inflammation.
Review
Immunology
Marc C. Pulanco, Anne T. Madsen, Ankit Tanwar, Devin T. Corrigan, Xingxing Zang
Summary: The B7/CD28 families of immune checkpoints play important roles in regulating immune cells and are closely related to various diseases. Recent studies have discovered new pathways and therapeutics for cancer therapy in this field. This review covers the newly discovered KIR3DL3/TMIGD2/HHLA2 pathways, metabolic regulation by PD-1/PD-L1 and B7-H3, the glycobiology of PD-1/PD-L1, B7x, and B7-H3, as well as the interaction between PD-L1 and B7-1. The article also discusses the resistance mechanisms to current immunotherapies targeting PD-1/PD-L1 and CTLA-4 in clinical settings, and reviews new immunotherapies targeting B7-H3, B7x, PD-1/PD-L1, and CTLA-4 in ongoing clinical trials.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Xiaoxin Ren, Yixian Li, Christopher Nishimura, Xingxing Zang
Summary: Somatic activating mutations in EGFR are common in various cancers. Targeted therapies against EGFR have shown clinical efficacy, but acquired resistance is a challenge. PD-1/PD-L1 immune checkpoint inhibitors are effective in some cancers, but limited in EGFR mutated cancers. Up-regulation of new B7/CD28 family members related to EGFR signaling may contribute to immunosuppressive tumor microenvironment and resistance to EGFR-targeted therapies. Understanding these interactions could inform combination therapeutic strategies.
Article
Oncology
Scott Moerdler, Michelle Ewart, Debra L. Friedman, Kara Kelly, Qinglin Pei, Mou Peng, XingXing Zang, Peter D. Cole
Summary: In pediatric Hodgkin lymphoma, LAG-3 expression is found to be positively correlated with PD-L1 expression, serving as an innovative immune checkpoint target with unclear association to patient outcomes.
LEUKEMIA & LYMPHOMA
(2021)