Article
Pharmacology & Pharmacy
Zhiwei Xu, Xianli Yuan, Qiaoyan Gao, Yan Li, Mingcai Li
Summary: The overexpression of IL-38 in mice with bleomycin-induced pulmonary fibrosis reduced body weight loss and inflammation, while increasing the release of anti-inflammatory cytokines, suggesting that IL-38 may be a new strategy for the treatment of pulmonary fibrosis by regulating the balance of inflammatory cytokines.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Takahiro Yamazaki, Sayuri Yamada, Konomi Ohshio, Miho Sugamata, Yuji Morita
Summary: Lactobacillus paracasei KW3110 has anti-inflammatory effects and prevents inflammatory stress-induced mitochondrial damage by promoting IL-10 production in mouse macrophages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Haohai Zhang, Lili Feng, Paola de Andrade Mello, Changchuin Mao, Richard Near, Eva Csizmadia, Leo Li-Ying Chan, Keiichi Enjyoji, Wenda Gao, Haitao Zhao, Simon C. Robson
Summary: Accumulation of immunosuppressive cells in the tumor microenvironment is a barrier to current immunotherapeutic approaches. Elevated expression of ectonucleotidase CD39 is a common feature of tumor-associated immune and vascular endothelial cells. The use of afucosylated anti-CD39 antibody can deplete immunosuppressive cells and block tumor angiogenesis through enhanced ADCC.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Gastroenterology & Hepatology
Na Wu, Yu-Qing Feng, Na Lyu, Di Wang, Wei-Dong Yu, Yong-Fei Hu
Summary: In this study, it was demonstrated that F. nucleatum infection altered the colon mucosal microbiota by enriching pathogens related to the development of CRC, providing new insights into the role of F. nucleatum in the oncogenic microbial environment of the colon.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Cell Biology
Andrew Higham, James M. Baker, Natalie Jackson, Rajesh Shah, Simon Lea, Dave Singh
Summary: This study found that pulmonary iron levels are increased in chronic obstructive pulmonary disease (COPD) patients, which may play an important role in the pathophysiology of COPD. The dysregulation of the CD163-haptoglobulin axis in COPD was examined, and it was found that soluble CD163 levels were lower in COPD patients compared to controls, with a significant correlation to forced expiratory volume in 1 s (FEV1)% predicted. The study also revealed a correlation between macrophage CD163 expression and haptoglobin levels, supporting the role of CD163 in the cellular uptake of haptoglobin.
Article
Chemistry, Multidisciplinary
Pia A. S. Kinaret, Joseph Ndika, Marit Ilves, Henrik Wolff, Gerard Vales, Hannu Norppa, Kai Savolainen, Tiina Skoog, Juha Kere, Sergio Moya, Richard D. Handy, Piia Karisola, Bengt Fadeel, Dario Greco, Harri Alenius
Summary: Toxicogenomics utilizes computational methods to map molecular events and biological processes, and in this study, the transcriptomic and immunopathological changes associated with airway exposure to a variety of engineered nanomaterials (ENM) were investigated. The results show that surface modification and core chemistry of ENM can have varying effects on airway toxicity, and a subset of shared differentially expressed genes can help cluster these ENM according to their toxicity levels. This study provides valuable information for developing predictive models for ENM toxicity.
Article
Biotechnology & Applied Microbiology
Ainize Pena-Cearra, Deguang Song, Janire Castelo, Ainhoa Palacios, Jose Luis Lavin, Mikel Azkargorta, Felix Elortza, Miguel Fuertes, Miguel Angel Pascual-Itoiz, Diego Barriales, Itziar Martin-Ruiz, Asier Fullaondo, Ana M. Aransay, Hector Rodriguez, Noah W. Palm, Juan Anguita, Leticia Abecia
Summary: There is potential association between mitochondrial dysfunction and inflammatory bowel diseases (IBD). The bidirectional interaction between the intestinal microbiota and host mitochondria may affect intestinal inflammation. The study shows that fecal microbiota transplantation (FMT) from MCJ-deficient mice to germ-free mice increases susceptibility to colitis. Furthermore, the study identifies potential microbial signatures associated with complex I deficiency and disease progression.
NPJ BIOFILMS AND MICROBIOMES
(2023)
Article
Geriatrics & Gerontology
Xuemeng Miao, Qian Wu, Siyu Du, Ludan Xiang, Siyao Zhou, Junzhe Zhu, Zirun Chen, Hui Wang, Xuyi Pan, Yiren Fan, Lihan Zhang, Jingkang Qian, Yuxuan Xing, Yiyang Xie, Lixin Hu, Haiyun Xu, Wei Wang, Ying Wang, Zhihui Huang
Summary: Neuroinflammation is crucial in the development and progression of Alzheimer's disease (AD), and SARM1 is known to promote axonal degeneration and be involved in neuroinflammation. This study showed that SARM1 was reduced in hippocampal neurons of AD model mice. Conditional knockout of SARM1 in the central nervous system delayed cognitive decline, reduced A beta deposition and inflammatory infiltration, and inhibited neurodegeneration in AD model mice. Further investigation revealed the downregulation of the TNF-alpha pathway in the hippocampus of SARM1 knockout mice, which alleviated cognitive decline, A beta deposition, and inflammatory infiltration.
Article
Immunology
Qianwen Wen, Yunfeng Wang, Qi Pan, Ruimin Tian, Dunke Zhang, Guangcheng Qin, Jiying Zhou, Lixue Chen
Summary: The study found that the upregulation of miR-155-5p in patients with chronic migraine, and inhibiting miR-155-5p can alleviate neuroinflammation by activating SIRT1 in the TNC.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Oncology
Marta Correia de Sousa, Nicolas Calo, Cyril Sobolewski, Monika Gjorgjieva, Sophie Clement, Christine Maeder, Dobrochna Dolicka, Margot Fournier, Laurent Vinet, Xavier Montet, Jean-Francois Dufour, Bostjan Humar, Francesco Negro, Christine Sempoux, Michelangelo Foti
Summary: Despite being considered a potent oncomiR in human cancers, genetic deletion of miR-21 in mouse models surprisingly promotes hepatocellular carcinoma (HCC) development by affecting various signaling pathways and immune responses. These results challenge the current belief in miR-21 as an oncogene and raise caution regarding using miR-21 inhibition as a therapeutic approach for HCC.
Article
Oncology
Wenjie Zhu, Xu Chen, Xiangyu Guo, Haiting Liu, Ranran Ma, Yawen Wang, Yahang Liang, Ying Sun, Mengqi Wang, Ruinan Zhao, Peng Gao
Summary: Breast cancer is the most common malignancy in women globally, and understanding its energy metabolism and progression mechanisms is still lacking. The study reveals that the activated long noncoding RNA (lncRNA), HOXC-AS3, plays a critical role in triggering energy metabolism reprogramming in breast cancer cells under glucose deprivation, enabling them to adapt to nutrient stress.
Article
Immunology
Ester Sala, Celia Vived, Julia Luna, Noemi Alejandra Saavedra-Avila, Upasana Sengupta, A. Raul Castano, Sabrina Villar-Pazos, Laura Haba, Joan Verdaguer, Ana B. Ropero, Thomas Stratmann, Javier Pizarro, Manuel Vazquez-Carrera, Angel Nadal, Jill M. Lahti, Conchi Mora
Summary: CDK11 downregulation in T1D acts as a protective mechanism against inflammation-induced apoptosis, and it may regulate Cyclin D3 signaling.
CDK11 hemideficiency protects against T1D progression and affects pancreatic islet sensitivity to cytokine-induced apoptosis.
CDK11/Cyclin D3 tandem could be a potential new intervention target in T1D.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Kathryn W. Juchem, Anshu P. Gounder, Jian Ping Gao, Elise Seccareccia, Narayana Yeddula, Nicholas J. Huffmaster, Alexandra Cote-Martin, Steven E. Fogal, Donald Souza, Sarah Sirui Wang, Elizabeth R. A. Glynn, Ivy Yung, Julie Ritchie, Li Li, Jie Zheng, M. Lamine Mbow, Jun Li, Sumit K. Chanda
Summary: NFAT activating protein with ITAM motif 1 (NFAM1) is significantly induced in intestinal biopsies from Crohn's disease (CD) and ulcerative colitis (UC) patients, mainly expressed in monocytes and neutrophils; NFAM1 promotes monocyte activation, amplifying the response to diverse stimuli; NFAM1 promotes cytokine production in inflammatory bowel disease (IBD).
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Guojian Fang, Yingze Li, Jiali Yuan, Wei Cao, Shuai Song, Long Chen, Yuepeng Wang, Qunshan Wang
Summary: Heart failure is a severe and life-threatening disease worldwide. Cadherin-11 (Cad-11) is highly expressed in the heart and associated with inflammation. The study found that Cad-11 is increased in heart failure patients and plays a role in ventricular remodeling. Cad-11 deficiency improved pressure overload-induced structural and electrical remodeling in mice. Furthermore, Cad-11 induces IL-6 secretion from cardiac fibroblasts, which modulates the pathophysiology of neighboring cardiomyocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Simona Laurino, Pellegrino Mazzone, Vitalba Ruggieri, Pietro Zoppoli, Giovanni Calice, Antonella Lapenta, Mario Ciuffi, Orazio Ignomirelli, Giulia Vita, Alessandro Sgambato, Sabino Russi, Geppino Falco
Summary: The expression of calcium regulator gene TRPV2 in gastric cancer is associated with resistance to cisplatin, affecting cell death by modulating intracellular calcium levels. Overexpression of TRPV2 leads to drug resistance, but its inhibition can restore sensitivity to cisplatin in cancer cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Letter
Cardiac & Cardiovascular Systems
Laurent Davin, Alain Nchimi, Federica Ilardi, Raluca Dulgheru, Stella Marchetta, Olivier Gach, Patrick Marechal, Sara Cimino, Pierre-Julien Bruyere, Andreas Georgiopoulos, John Epoh Dibato, Gessica d'Amico, Maurizio Galderisi, Valentina Parisi, Cecile Oury, Patrizio Lancellotti
JACC-CARDIOVASCULAR IMAGING
(2019)
Editorial Material
Respiratory System
Christophe Martinez, Tadafumi Sugimoto, Toshimitsu Tsugu, Cecile Oury, Patrizio Lancellotti
JOURNAL OF THORACIC DISEASE
(2019)
Letter
Cardiac & Cardiovascular Systems
Patrizio Lancellotti, Lucia Musumeci, Nicolas Jacques, Laurence Servais, Eric Goffin, Bernard Pirotte, Cecile Oury
Article
Hematology
Odile Wera, Christelle Lecut, Laurence Servais, Alexandre Hego, Celine Delierneux, Zheshen Jiang, Aurore Keutgens, Richard J. Evans, Philippe Delvenne, Patrizio Lancellotti, Cecile Oury
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2020)
Article
Cardiac & Cardiovascular Systems
Federica Ilardi, Stella Marchetta, Christophe Martinez, Muriel Sprynger, Arnaud Ancion, Roberta Manganaro, Tadafumi Sugimoto, Toshimitsu Tsugu, Adriana Postolache, Caroline Piette, Marianna Cicenia, Giovanni Esposito, Maurizo Galderisi, Cecile Oury, Raluca Dulgheru, Patrizio Lancellottit
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2020)
Article
Cardiac & Cardiovascular Systems
Cecile Oury, Nancy Cote, Marie-Annick Clavel
CARDIOLOGY CLINICS
(2020)
Editorial Material
Cardiac & Cardiovascular Systems
Cecile Oury, Nathalie Donis, Patrick Marechal
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2020)
Review
Cell Biology
Celine Delierneux, Sana Kouba, Santhanam Shanmughapriya, Marie Potier-Cartereau, Mohamed Trebak, Nadine Hempel
Article
Cardiac & Cardiovascular Systems
Arnaud Ancion, Julien Tridetti, Mai-Linh Nguyen Trung, Cecile Oury, Patrizio Lancellotti
Editorial Material
Cardiac & Cardiovascular Systems
Patrizio Lancellotti, Nicolas Jacques, Cecile Oury
Article
Medicine, General & Internal
Patrick Marechal, Julien Tridetti, Mai-Linh Nguyen, Odile Wera, Zheshen Jiang, Maxime Gustin, Anne-Francoise Donneau, Cecile Oury, Patrizio Lancellotti
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Cecile Oury, Patrick Marechal, Nathalie Donis, Alexia Hulin, Alexandre Hego, Julien Tridetti, Mai-Linh Nguyen, Raluca Dulgheru, Marianne Fillet, Alain Nchimi, Patrizio Lancellotti
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Editorial Material
Cardiac & Cardiovascular Systems
Lucia Musumeci, Cecile Oury, Patrizio Lancellotti
REVISTA ESPANOLA DE CARDIOLOGIA
(2020)
Letter
Cardiac & Cardiovascular Systems
Christophe Martinez, Marianna Cicenia, Muriel Sprynger, Adriana Postolache, Federica Ilardi, Raluca Dulgheru, Marc Radermecker, Giovanni Esposito, Patrick Marechal, Victoria Marechal, Nathalie Donis, Julien Tridetti, Mai-Linh Nguyen, Tadafumi Sugimoto, Toshimitsu Tsugu, Yun Yun Go, Augustin Coisne, David Montaigne, Khalil Fattouch, Alain Nchimi, Cecile Oury, Patrizio Lancellotti
JACC-CARDIOVASCULAR IMAGING
(2020)
Article
Cell Biology
Jean-Francois Kaux, Vincent Libertiaux, Laura Dupont, Alain Colige, Vincent Denoel, Christelle Lecut, Alexandre Hego, Maxime Gustin, Luc Duwez, Cecile Oury, Andre Gothot, Laura Greimers, Pierre Drion