Journal
JOURNAL OF IMMUNOLOGY
Volume 189, Issue 11, Pages 5178-5184Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1201983
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Funding
- Norwegian Cancer Society
- Research Council of Norway
- Anders Jahre Fund
- Oddrun Mjaland's Fund for Cancer Research
- Marie Curie Intra-European Fellowship from the European Union [MEIF-CT-2003-501330]
- European Union [MRTN-CT-2004-512253]
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Natural killer cells are able to recognize and kill target cells according to differences in MHC class I expression. In rodents, the Ly49 receptors are primarily responsible for this MHC differentiation. We previously described the cloning of a novel C-type lectin-like receptor, KLRH1, encoded in the NK complex adjacent to the Ly49 genes and expressed by subsets of NK and NKT cells. MHC influence on selection of KLRH1(+) NK cells in congenic strains suggested that KLRH1 may have an MHC ligand, although we were unable to identify any such ligand. In this study, we have used a sensitive reporter system and Fc fusion protein to demonstrate that KLRH1 binds specifically to the classical MHC class I molecule RT1-A2 of the RT1(n) haplotype. Cytolytic activity of KLRH1-transfected RNK-16 cells was also inhibited by target cells expressing RT1-A2(n). Thus, KLRH1 represents a novel family of MHC allele-specific inhibitory receptors expressed by NK cells. The Journal of Immunology, 2012, 189: 5178-5184.
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