Journal
JOURNAL OF IMMUNOLOGY
Volume 187, Issue 9, Pages 4695-4704Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1101776
Keywords
-
Categories
Funding
- National Institutes of Health
- Alliance for Lupus Research
- Arthritis Foundation
- National Institutes of Health, National Institute of Allergy and Infectious Diseases
Ask authors/readers for more resources
Dysregulation of the T cell-dependent Ab response can lead to numerous immunological disorders, ranging from systemic lupus erythematosus to B cell lymphomas. Cellular processes governed by MHC class II proteins play a major role in this response and its dysregulation. The extent to which processes controlled by the diverse family of MHC class I proteins impact such autoimmune and neoplastic disorders, however, is less clear. In this study, we genetically dissect the contributions of individual MHC class I family members and the pathological processes under their control in the systemic lupus erythematosus-like disease of BXSB.Yaa mice and B cell lymphomagenesis of SJL mice. This study reveals a powerful repressive regulatory axis comprised of MHC class I-dependent CD8(+) T cells and NK cells. These results indicate that the predominant role of the MHC class I protein family in such immunological disorders is to protect from more aggressive diseases. The Journal of Immunology, 2011, 187: 4695-4704.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available