Review
Allergy
David I. Pritchard, Franco H. Falcone, Piers D. Mitchell
Summary: This article discusses the evolutionary origin and immunological role of the allergic phenotype, suggesting that allergies may have evolved for a purpose and emphasizing the positive impact of allergies on mammals.
Article
Immunology
Yasmeen S. El Ansari, Cynthia Kanagaratham, Oliver T. Burton, Jenna V. Santos, Brianna-Marie A. Hollister, Owen L. Lewis, Harald Renz, Hans C. Oettgen
Summary: Mast cells and basophils play important roles in IgE-mediated hypersensitivity reactions. IgG and IgA antibodies can regulate the activation of these cells by activating or inhibiting receptors. This study found that IgA antibodies can bind to mast cells and basophils, and inhibit their activation to maintain immune homeostasis at mucosal sites.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Daiki Matsubara, Yuhki Yanase, Kaori Ishii, Shunsuke Takahagi, Akio Tanaka, Koichiro Ozawa, Michihiro Hide
Summary: This article discusses the role of basophils in the pathogenesis of chronic spontaneous urticaria (CSU), as well as the critical role of the complement system in its activation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Allergy
Jun-ichi Kashiwakura, Mari Yoshihara, Kodai Saitoh, Kota Kagohashi, Yuto Sasaki, Fuki Kobayashi, Iori Inagaki, Yuichi Kitai, Ryuta Muromoto, Tadashi Matsuda
Summary: Propolis can inhibit IgE-dependent basophil activation and basophil-mediated allergic inflammation, potentially offering protection against food allergic reactions in sensitive individuals.
ALLERGOLOGY INTERNATIONAL
(2021)
Article
Immunology
Anette T. Hansen Selno, Vadim V. V. Sumbayev, Bernhard F. F. Gibbs
Summary: Basophils play a crucial role in allergies and Th2-driven diseases by releasing inflammatory and immunomodulatory mediators. The responsiveness of basophils to IgE-mediated activation may be regulated by the expression of SERCA2, a calcium-regulating protein. This study found an inverse correlation between SERCA2 expression and basophil responsiveness, suggesting that SERCA2 may be an additional regulator of basophil reactivity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Ryota Sakai, Minako Ito, Kyoko Komai, Mana Iizuka-Koga, Kazuhiko Matsuo, Takashi Nakayama, Osamu Yoshie, Koichi Amano, Hiroshi Nishimasu, Osamu Nureki, Masato Kubo, Akihiko Yoshimura
Summary: Tregs accumulation in the kidney is crucial for disease control, with GATA3 playing an important role in recruiting Tregs to the kidney. The experimental data suggest that PPAR gamma agonist enhances the accumulation of GATA3(+) Tregs in the kidney.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Allergy
Sarbjit S. Saini
Summary: Chronic spontaneous urticaria (CSU) is a common skin disease with unknown etiology in most cases and involves the activation of mast cell IgE receptors and blood basophils. Blood basopenia and altered degranulation patterns in blood basophils are observed in active CSU, and changes in IgE receptor signaling molecule expression levels accompany these alterations. The use of IgE-targeted therapies in CSU patients suggests that blood basophil phenotypes and enumeration have potential as disease biomarkers.
ALLERGOLOGY INTERNATIONAL
(2023)
Article
Immunology
Izumi Kishimoto, Ni Ma, Riko Takimoto-Ito, Chisa Nakashima, Atsushi Otsuka, Andrew F. Walls, Hideaki Tanizaki, Naotomo Kambe
Summary: Chronic spontaneous urticaria may lead to a decrease in basophil counts in the peripheral blood, possibly due to the migration of basophils from circulation to the skin. To investigate this phenomenon, a mouse model was utilized for research purposes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dermatology
Emma Treco, Eunice Huan, Afshin Varzavand, Janet A. Fairley, Kelly N. Messingham
Summary: The study found that sCD48 is elevated in Bullous pemphigoid (BP) patients and that patients with mild-moderate disease have higher levels of sCD48 than those with severe disease. Furthermore, there is an inverse relationship between sCD48 and disease activity, serum BP180 IgE, and peripheral eosinophil numbers.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Allergy
Marlon Munera, Dalgys Martinez, Judith Wortmann, Josefina Zakzuk, Walter Keller, Luis Caraballo, Leonardo Puerta
Summary: The study identified LvFABP as a shrimp allergen that cross-reacts with the house dust mite allergen Blo t 13, and has allergenic activity in shrimp allergic patients. The structure of LvFABP was characterized, showing a beta-barrel fold with two alpha-helices and ten beta-strands. Epitope mapping revealed two IgE-binding antigenic regions and inhibition assays demonstrated high cross-reactivity between LvFABP and Blo t 13.
Article
Medical Laboratory Technology
Didier G. Ebo, Kevin Heremans, Michiel Beyens, Marie-Line M. van der Poorten, Athina L. Van Gasse, Christel Mertens, Michel Van Houdt, Vito Sabato, Jessy Elst
Summary: The basophil activation test (BAT) is a reliable complementary diagnostic for IgE-dependent allergies, but it has limitations. In contrast, the mast cell activation test (MAT) using passively sensitized mast cells (MCs) has advantages such as using frozen serum samples and studying IgE-independent mechanisms.
CLINICA CHIMICA ACTA
(2022)
Review
Pharmacology & Pharmacy
Didier G. Ebo, Michiel Beyens, Kevin Heremans, Marie-Line M. van der Poorten, Athina L. Van Gasse, Christel Mertens, Michel Van Houdt, Vito Sabato, Jessy Elst
Summary: Immediate hypersensitivity reactions are challenging to diagnose due to their wide range of clinical presentations and uncertain mechanisms. These reactions can be caused by activation and degranulation of specific and nonspecific mast cells and basophils. Degranulation of these cells leads to the release of inflammatory mediators, which can vary depending on the trigger.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Article
Biochemistry & Molecular Biology
Szonja Gal, Erzsebet Gajdocsi, Esam Khanfar, Katalin Olasz, Diana Simon, Peter Balogh, Timea Berki, Peter Nemeth, Ferenc Boldizsar
Summary: The natural autoantibody (natAAb) network plays a role in immune regulation by reacting with evolutionary conserved antigens without causing tissue destruction. The relation between natAAbs and pathAAbs is not completely understood. In this study, the levels of nat- and pathAAb against three conserved antigens were measured in NZB mice, a spontaneous autoimmune disease model. The levels of natAAbs increased until 6-9 months of age and then decreased, while pathAAbs appeared after six months of age, corresponding with the onset of autoimmune disease. The changes in nat/pathAAb levels were associated with alterations in B1 cells, plasma cells, and memory B cells, suggesting a switch from natAAbs towards pathAAbs in aged NZB mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Allergy
Mikhail Volkov, Mariateresa Coppola, Ruth Huizinga, Filip Eftimov, Tom W. J. Huizinga, Anneke J. van der Kooi, Liesbeth E. M. Oosten, Joost Raaphorst, Theo Rispens, Rocco Sciarrillo, Maarten J. Titulaer, Luuk Wieske, Rene E. M. Toes, Maartje G. M. Huijbers, Karin A. van Schie, Diane van der Woude
Summary: The presence of autoreactive antibodies is a characteristic of autoimmune diseases. This study examines the isotype/subclass distribution of these antibodies, revealing shared patterns among different diseases. Most autoimmune responses are dominated by IgG, but specific diseases show a predominance of IgG4 or IgE. Understanding isotype/subclass profiles is important for understanding disease pathogenesis and treatment response.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Pediatrics
Ling-Sai Chang, Ying-Hsien Huang, Hsin-Yu Chang, Zon-Min Lee, Wei-Ling Feng, Ho-Chang Kuo
Summary: This study analyzed the specific IgE levels against food and inhalant allergens in patients with Kawasaki disease (KD). The results suggested a correlation between specific IgE and the age at KD diagnosis and the basophils in KD patients. Further prospective studies are needed to clarify the unique profile of specific IgE in KD patients.
Article
Rheumatology
Gerardo Quintana-Lopez, Ignasi Rodriguez-Pinto, Kevin Maldonado-Canon, Gerard Espinosa, Jorge Diaz-Rojas, Ricard Cervera
Summary: This study evaluated the effectiveness and cost-effectiveness of different treatment schemes for CAPS. The results showed that scheme 2 was the most cost-effective strategy in the Colombian healthcare system.
Article
Rheumatology
G. Pires da Rosa, E. Ferreira, B. Sousa-Pinto, P. Bettencourt, G. Espinosa, R. Cervera
Summary: This study analyzed a cohort of patients with laboratory criteria for anti-phospholipid syndrome (APS) but only presenting "non-criteria" clinical manifestations. The patients were compared with definite APS patients. The results showed that these "clinical non-criteria" patients had mainly hematological and neurological involvements, with significant treatment use. Some patients may progress to future systemic lupus erythematosus (SLE).
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Article
Rheumatology
Giuseppe Barilaro, Carlo Della Rocca, Alexandra Esteves, Ricard Cervera, Gerard Espinosa
Summary: This study analyzed the association between the average 'adjusted' Global APS Score (aGAPSS) and the change in Damage Index for APS (DIAPS) in patients with thrombotic and non-thrombotic APS. The results showed that a higher average aGAPSS value was associated with an increase in DIAPS during follow-up, suggesting that the average aGAPSS score can predict the increase in DIAPS.
Article
Genetics & Heredity
Martin Kerick, Marialbert Acosta-Herrera, Carmen Pilar Simeon-Aznar, Jose Luis Callejas, Shervin Assassi, Susanna M. Proudman, Mandana Nikpour, Nicolas Hunzelmann, Gianluca Moroncini, Jeska K. de Vries-Bouwstra, Gisela Orozco, Anne Barton, Ariane L. Herrick, Chikashi Terao, Yannick Allanore, Carmen Fonseca, Marta Eugenia Alarcon-Riquelme, Timothy R. D. J. Radstake, Lorenzo Beretta, Christopher P. Denton, Maureen D. Mayes, Javier Martin
Summary: This study investigated the association of C4 CN with systemic sclerosis risk, finding that higher C4 CN provides protection to SSc, while deviations from CN parity of C4A and C4B increase risk. Gender differences were observed in the protection conferred by C4A and C4B.
NPJ GENOMIC MEDICINE
(2022)
Review
Immunology
Maria Velasco-de Andres, Guillermo Munoz-Sanchez, Laura Carrillo-Serradell, Maria del Mar Gutierrez-Hernandez, Cristina Catala, Marcos Isamat, Francisco Lozano
Summary: Adoptive cell transfer (ACT) therapies, especially those based on chimeric antigen receptor (CAR) technology, have gained significant attention in the field of immunotherapy. CAR-based ACT has shown successful results in treating hematological malignancies and has the potential to be effective in other tumors as well as immune-mediated disorders. This review discusses the results and limitations of preclinical and clinical studies in areas such as infection, allergy, autoimmunity, transplantation, and fibrotic repair.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Rheumatology
Laura Pelegrin, Montse Morato, Olga Araujo, Marc Figueras-Roca, Javier Zarranz-Ventura, Alfredo Adan, Ricard Cervera, Ricardo P. Casaroli-Marano, Vanesa Budi, Lucia Barrera-Lopez, Jose Rios, Jose Hernandez-Rodriguez, Gerard Espinosa
Summary: This study detected preclinical changes in retinal microvascularization and retinal and optical nerve structure in SLE patients using optical coherence tomography. The results showed that structural and perifoveal vascular parameters were decreased in SLE patients, especially in those with longer disease duration and higher disease damage. APS was associated with preclinical damage to the optic nerve and impairment of the perifoveal microvasculature.
Article
Pharmacology & Pharmacy
Joaquin Bonelli, Maria Velasco-de Andres, Neus Isidro, Cristina Bayo, Sergi Chumillas, Laura Carrillo-Serradell, Sergi Casado-Llombart, Cheryl Mok, Daniel Benitez-Ribas, Francisco Lozano, Josep Rocas, Vicente Marchan
Summary: This study reports a technology that encapsulates water-soluble bioactive compounds in double-walled polyurethane-polyurea hybrid nanocapsules (NCs) loaded with indocyanine green (ICG). The NCs demonstrate specific accumulation in tumor tissues while avoiding premature clearance in the bloodstream, making them promising for cancer theragnosis.
Editorial Material
Medicine, General & Internal
Giuseppe Barilaro, Ricard Cervera
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Medicine, General & Internal
Isaac Pons, Joana Louro, Marta Sitges, Barbara Vidal, Ricard Cervera, Gerard Espinosa
Summary: This study describes the prevalence, clinical and laboratory features, and evolution of heart valve involvement in patients with APS. The results showed that 50% of APS patients had valve involvement, with most of them being female and having arterial hypertension and arterial thrombosis. The valve involvement group had a higher mortality rate.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Albert Perez-Isidro, Marc Xipell, Arturo Llobell, Noemi De Moner, Gema M. Lledo, Ricard Cervera, Sergio Prieto-Gonzalez, Luis F. Quintana, Gerard Espinosa, Mila Garcia-Ormaechea, Estibaliz Ruiz-Ortiz, Odette Vinas
Summary: This study investigated whether dsDNA antibody-secreting B-cells could be a complementary biomarker for monitoring disease activity and prognosis in SLE patients. The results showed that SLE-ELISpot had the best performance in identifying active patients. High SLE-ELISpot results were associated with haematological involvement and increased risk of disease flare-up, especially renal flare. Combining hypocomplementemia and high SLE-ELISpot results further increased these risks. Therefore, adding SLE-ELISpot to the current follow-up protocol can improve clinicians' personalized care decisions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Pilar Brito-Zeron, Elyse E. Lower, Manuel Ramos-Casals, Robert P. Baughman
Summary: This article provides an updated overview of the hematological involvement associated with sarcoidosis, including the management approach for cytopenias and the association with hematological malignancies. The etiology of cytopenias in sarcoidosis can be attributed to infiltration of hematopoietic organs and autoimmune-mediated cytopenias. The association between sarcoidosis and hematologic involvement is best understood as a pathogenic continuum, where cytopenias and hematologic neoplasms are intertwined due to various etiopathogenic mechanisms.
EXPERT REVIEW OF CLINICAL IMMUNOLOGY
(2023)
Editorial Material
Rheumatology
Gerard Espinosa, Ricard Cervera
Article
Rheumatology
Teresa Oton, Loreto Carmona, Jose Luis Andreu
Summary: This study assessed the experience and needs of patients receiving MTX treatment through an online survey. The results showed that patients were not satisfied with the quality of information provided by clinics and had a demand for more and better-quality written or web-based information.
RHEUMATOLOGY INTERNATIONAL
(2023)
Meeting Abstract
Rheumatology
Marina Pavia Pascual, Isidro Jarque Canalias, Jose Luis Morell, Jesus Loarce Martos, Lorena Montano Tapia, Olga Rusinovich, Natalia de la Torre-Rubio, Maria Machattou, Pablo Navarro Palomo, Maria Carmen Barbadillo Mateos, Monica Fernandez Castro, Blanca Garcia-Magallon, Maria Hildegarda Godoy Tundidor, Carolina Merino, Jesus Sanz Sanz, Jose Luis Andreu, Jose Campos
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Rheumatology
Gilberto Pires da Rosa, Bernardo Sousa-Pinto, Ester Ferreira, Olga Araujo, Giuseppe Barilaro, Paulo Bettencourt, Ricard Cervera, Gerard Espinosa
Summary: Compared with the control group, the SN-APS group showed more thrombosis recurrence, indefinite anticoagulation, and use of VKA. The presence of these features may negatively impact the clinical course of patients with thrombosis and negative aPL.
ARTHRITIS RESEARCH & THERAPY
(2022)
