Article
Multidisciplinary Sciences
Elena Cesaro, Andrea Patrizia Falanga, Rosa Catapano, Francesca Greco, Simona Romano, Nicola Borbone, Arianna Pastore, Maria Marzano, Federico Chiurazzi, Stefano D'Errico, Gennaro Piccialli, Giorgia Oliviero, Paola Costanzo, Michela Grosso
Summary: In this study, we successfully downregulated the expression of CD5 in chronic lymphocytic leukemia using an innovative antisense approach based on Peptide Nucleic Acids. The results suggest that anti-CD5 PNAs could be potential therapeutics for CLL.
Article
Biochemistry & Molecular Biology
Walker D. Short, Emily Steen, Aditya Kaul, Xinyi Wang, Oluyinka O. Olutoye, Hima V. Vangapandu, Natalie Templeman, Alexander J. Blum, Chad M. Moles, Daria A. Narmoneva, Timothy M. Crombleholme, Manish J. Butte, Paul L. Bollyky, Sundeep G. Keswani, Swathi Balaji
Summary: This study found that overexpression of IL-10 in dermal wounds recruits EPCs, increases vascular structures, and accelerates re-epithelialization.
Article
Immunology
Hye-Soo Park, Yong Woo Back, In-Taek Jang, Kang-In Lee, Yeo-Jin Son, Han-Gyu Choi, Thi Binh Dang, Hwa-Jung Kim
Summary: Rv2145c protein stimulates production of IL-10 and other cytokines in macrophages, enhancing bacterial growth and delaying clearance in the lungs and spleens of mice through modulation of host signals. Antibody treatment against IL-10 receptor restores the clearance of Rv2145c-expressing bacteria, suggesting a role for Rv2145c in creating a favorable environment for bacterial survival.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Bandik Foeh, Jana Sophia Buhre, Hanna B. Lunding, Maria E. Moreno-Fernandez, Peter Koenig, Christian Sina, Senad Divanovic, Marc Ehlers
Summary: The microbial metabolite butyrate promotes the differentiation of IgM(+) plasma cells and their expression of IL-10. HDAC3 inhibition may be involved in the underlying pathway for both plasma cell differentiation and IL-10 expression, while reduced mitochondrial superoxide levels are crucial only for plasma cell differentiation.
Article
Cell Biology
Ben Wang, Jin Zhang, Guo Li, Chenzhong Xu, Langmei Yang, Jie Zhang, Yalan Wu, Ye Liu, Zuojun Liu, Ming Wang, Ji Li, Xiaolong Tang, Baohua Liu
Summary: In this study, NAT10 was found to play an important role in cutaneous wound repair by promoting NF-κB/p65-IL-6/8-STAT3 signaling pathway. Depletion of NAT10 resulted in delayed wound repair and inhibited keratinocyte migration. Targeting NAT10 could be a potential strategy for the treatment of skin wound dysfunctions and related diseases.
CELL DEATH DISCOVERY
(2023)
Article
Oncology
Domenico Maisano, Enrico Iaccino, Alessandro D'Ambrosio, Federico Chiurazzi, Vincenzo Dattilo, Mariangela Scalise, Massimo Gentile, Eleonora Vecchio, Nancy Nistico, Annamaria Aloisio, Erika De Sensi, Giuseppe Fiume, Ileana Quinto, Selena Mimmi
Summary: The study highlights the crucial role of IgBCR in tumorigenesis of CLL B cells and proposes a phage display screening method for identifying small peptide molecules mimicking tumor IgBCR antigens. It reveals the coexistence of multiple CLL clones and suggests a potential role of CD5 receptor in autoimmunity and cell survival.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Oleksi Petrenko, Jinyu Li, Velasco Cimica, Patricio Mena-Taboada, Ha Youn Shin, Stephen D'Amico, Nancy C. Reich
Summary: IL-6 is a critical tumor promoter in early stages of B cell lymphomagenesis, inhibiting tumor suppressors BIM and PTEN to advance MYC-driven B cell tumorigenesis.
Article
Multidisciplinary Sciences
Satomi Miki, Jun-ichiro Suzuki, Miyuki Takashima, Mari Ishida, Hiroki Kokubo, Masao Yoshizumi
Summary: Overall, our study demonstrates that S1PC, a sulfur compound found in AGE, can enhance anti-inflammatory effects and promote M2c macrophage polarization, thus showing potential in improving atherosclerosis.
SCIENTIFIC REPORTS
(2021)
Article
Hematology
Delphine Tardivon, Mateusz Antoszewski, Nadine Zangger, Marianne Nkosi, Jessica Sordet-Dessimoz, Rudi Hendriks, Ute Koch, Freddy Radtke
Summary: NOTCH1 gain-of-function mutations are common in B-cell chronic lymphocytic leukemia, and play a role in disease progression and chemotherapy resistance. In an in vivo mouse model of CLL, activation of Notch signaling facilitated disease initiation and promoted CLL cell proliferation and disease progression, while inhibition of Notch signaling delayed disease induction.
Article
Immunology
Magalie Michee-Cospolite, Marina Boudigou, Alexis Grasseau, Quentin Simon, Olivier Mignen, Jacques-Olivier Pers, Divi Cornec, Laetitia Le Pottier, Sophie Hillion
Summary: Regulatory B cells (Bregs) play important roles in various pathological conditions by producing IL-10 and utilizing multiple suppressing mechanisms to modulate immune response. The molecular regulation of Bregs is not fully understood, and this manuscript provides detailed insights into the role of transcription factors STAT3 and c-MAF in controlling IL-10 production in B cells and their significance in the Breg response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Dino Gobelli, Pablo Serrano-Lorenzo, Maria J. Esteban-Amo, Julia Serna, M. Teresa Perez-Garcia, Antonio Orduna, Alexis A. Jourdain, Miguel A. Martin-Casanueva, Miguel A. . de la Fuente, Maria Simarro
Summary: The subunits Sdha and Sdhb of the mitochondrial electron transport chain play important roles in the respiration and effector responses of macrophages. Their absence impairs the stabilization of HIF-1 alpha and the production of the pro-inflammatory cytokine IL-1 beta in response to LPS stimulation, and also inhibits the production of IL-10. This is due to the excessive accumulation of mitochondrial reactive oxygen species (mitoROS) and the inhibition of Stat3 tyrosine phosphorylation caused by the absence of Sdha and Sdhb.
Article
Oncology
David Allard, Pavel Chrobak, Yacine Bareche, Bertrand Allard, Priscilla Tessier, Marjorie A. Bergeron, Nathalie A. Johnson, John Stagg
Summary: Our study identified CD73 as a pro-leukemic immune checkpoint in CLL and uncovered a previously unknown sex bias for the CD73-adenosine pathway. The therapeutic potential of targeting CD73 in CLL was investigated using genetically engineered mice, revealing a pro-leukemic role for CD73 in an autochthonous mouse model of CLL. Our findings suggest that targeting CD73 in CLL in combination with anti-PD-1/PD-L1 immunotherapies may be beneficial, with sex potentially contributing to responses to adenosine-targeting agents.
Article
Multidisciplinary Sciences
Teng Huang, Jia Song, Jia Gao, Jia Cheng, Hao Xie, Lu Zhang, Yu-Han Wang, Zhichao Gao, Yi Wang, Xiaohui Wang, Jinhan He, Shiwei Liu, Qilin Yu, Shu Zhang, Fei Xiong, Qing Zhou, Cong-Yi Wang
Summary: Aberrant amino acid metabolism, particularly the excessive plasma kynurenine (Kyn), is common in obesity. This study demonstrates that overexpressed indoleamine 2,3-dioxygenase 1 (IDO1) in adipocytes is the primary source of excessive Kyn, highlighting the central role of adipocytes in Kyn metabolism. Depletion of Ido1 in adipocytes eliminates Kyn accumulation, protecting mice against obesity.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Laura Berneking, Indra Bekere, Soeren Rob, Marie Schnapp, Jiabin Huang, Klaus Ruckdeschel, Martin Aepfelbacher
Summary: The multifunctional Yersinia effector YopM enhances IL-10 gene expression and suppresses host immune response by increasing phosphorylation of RSK1 and promoting nuclear translocation of Stat3.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2023)
Article
Oncology
Natasha Malik, Jodie Hay, Hassan N. B. Almuhanna, Karen M. Dunn, Jamie Lees, Jennifer Cassels, Jiatian Li, Rinako Nakagawa, Owen J. Sansom, Alison M. Michie
Summary: This study reveals the essential role of mTORC1 in the initiation/maintenance of leukemia in a CLL model and identifies the inactivation of eEF2 activity as a novel therapeutic target for blocking CLL progression.
Review
Cell Biology
Cristina Bagacean, Cristina Adela Iuga, Anne Bordron, Adrian Tempescul, Ioana-Ecaterina Pralea, Delphine Bernard, Melanie Cornen, Tiffany Bergot, Christelle Le Dantec, Wesley Brooks, Hussam Saad, Jean-Christophe Ianotto, Jacques-Olivier Pers, Mihnea Zdrenghea, Christian Berthou, Yves Renaudineau
Summary: Chronic lymphocytic leukemia (CLL) is characterized by significant biologic and clinical heterogeneity. This study investigated the proteomic profiles of CLL B-cells, showing differences between stable and progressive disease groups at an early stage, with RNA splicing dysregulation underlying CLL evolution and impacting B-cell survival and migration.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Immunology
Caroline Carle, Francoise Fortenfant, Marie Tauber, Emilie Tournier, Carle Paul, Chloe Bost, Yves Renaudineau
Summary: The lupus band test is debated for its ability to distinguish between cutaneous lupus erythematosus (CLE) and systemic lupus erythematosus (SLE), and its association with antinuclear antibodies (ANA) and complement reduction. Certain clinical, histopathologic, and serological parameters can effectively differentiate lupus from other skin disorders and distinguish between SLE and CLE.
CLINICAL IMMUNOLOGY
(2022)
Article
Respiratory System
Laurent Meijer, Genevieve Hery-Arnaud, Cyril Leven, Emmanuel Nowak, Sophie Hillion, Yves Renaudineau, Isabelle Durieu, Raphael Chiron, Anne Prevotat, Isabelle Fajac, Dominique Hubert, Marlene Murris-Espin, Sandrine Huge, Isabelle Danner-Boucher, Bruno Ravoninjatovo, Sylvie Leroy, Julie Macey, Thierry Urban, Gilles Rault, Dominique Mottier, Rozenn Le Berre
Summary: A study was conducted to evaluate the safety and effects of roscovitine in patients with Cushing disease. The results showed that roscovitine was relatively safe and well-tolerated, but did not show significant efficacy in treating the disease. The variability in pharmacokinetics of roscovitine may have contributed to the lack of effectiveness.
JOURNAL OF CYSTIC FIBROSIS
(2022)
Article
Gastroenterology & Hepatology
Kalliopi Zachou, Pinelopi Arvaniti, Aggeliki Lyberopoulou, Eirini Sevdali, Matthaios Speletas, Maria Ioannou, George K. Koukoulis, Yves Renaudineau, George N. Dalekos
Summary: This study investigated the alterations of DNA methylation in peripheral lymphocytes of patients with autoimmune hepatitis (AIH) at diagnosis and remission. The results showed abnormal expressions of TET1 and DNMT3A in AIH patients' lymphocytes, which were associated with disease activity and may affect immunological pathways.
LIVER INTERNATIONAL
(2022)
Article
Oncology
Julia Katharina Schwarze, Soizic Garaud, Yanina J. L. Jansen, Gil Awada, Valerie Vandersleyen, Jens Tijtgat, Alexandre de Wind, Paulus Kristanto, Teofila Seremet, Karen Willard-Gallo, Bart Neyns
Summary: Low-dose regimens of PD-1 immune checkpoint inhibitors may serve as effective and cost-efficient alternatives to standard dosing in melanoma patients. Immunohistochemical tumor profiling shows promise as a potential biomarker.
Article
Immunology
Yves Renaudineau, Laurent Sailler, Florence Abravanel, Jacques Izopet, Adrien Delourme, Damien Biotti, Jonathan Ciron, Emmanuel Treiner, Nicolas Congy-Jolivet, Chloe Bost, Antoine Blancher
Summary: Disease modifying therapies can compromise the immune response to the SARS-Cov2 virus and its vaccine in patients with immune system diseases. A retrospective study evaluated the impact of COVID-19 immunization on immune system disease patients and found that certain treatments and patient characteristics were associated with negative cellular and humoral responses.
JOURNAL OF AUTOIMMUNITY
(2022)
Article
Immunology
Stanislas Faguer, Matthieu Groh, Francois Vergez, Mathilde Hunault-Berger, Nicolas Duployez, Yves Renaudineau, Carle Paul, Guillaume Lefevre, Jean-Emmanuel Kahn
Summary: Alternatives are required for CD3(-) CD4(+) lymphocytic-variant hypereosinophilic syndrome patients who do not respond well to high-dose steroids or conventional therapies. This study reports successful treatment of five L-HES patients with cutaneous involvement and persistent eosinophilia by using JAK inhibitors. Complete clinical remission was achieved in all patients within three months, and adverse events were not observed during follow-up. Prospective clinical trials are needed to further investigate the use of JAK inhibitors in L-HES.
CLINICAL IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Caroline Carle, Yannick Degboe, Adeline Ruyssen-Witrand, Marina I. Arleevskaya, Cyril Clavel, Yves Renaudineau
Summary: T cells play a crucial role in the development of rheumatoid arthritis (RA). A comprehensive review based on the analysis of the Immune Epitope Database (IEDB) was conducted to better understand the contribution of T cells to RA. It was found that an immune CD8+ T cell senescence response is present in RA and inflammatory diseases, driven by viral antigens and self-apoptotic peptides. Additionally, pro-inflammatory CD4+ T cells in RA are selected by MHC class II and immunodominant peptides derived from molecular chaperones, host peptides, and bacterial cross-reactive peptides.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Yves Renaudineau, Wesley Brooks, Julie Belliere
Summary: Lupus nephritis is the most severe organ manifestation of systemic lupus erythematosus. Efforts have been made to characterize the different steps of the disease and develop biomarkers for early diagnosis, disease monitoring, and preventing complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Yves Renaudineau, Sylviane Muller, Christian M. Hedrich, Dominique Chauveau, Julie Belliere, Sebastien De Almeida, Jan Damoiseaux, Marc Scherlinger, Jean Charles Guery, Laurent Sailler, Chloe Bost
Summary: The first LBMR-Tim symposium, held on December 16, 2022 in Toulouse, France, focused on addressing challenging questions in systemic lupus erythematosus (SLE). The symposium discussed the role of genes, sex, TLR7, and platelets in SLE pathophysiology, as well as the contributions of autoantibodies, urinary proteins, and thrombocytopenia at the time of diagnosis and during follow-up. It also explored topics such as neuropsychiatric involvement, vaccine response in the COVID-19 era, lupus nephritis management, and therapeutic perspectives for patients with lupus nephritis.
JOURNAL OF TRANSLATIONAL AUTOIMMUNITY
(2023)
Article
Immunology
Yves Renaudineau, Chloe Bost, Florence Abravanel, Jacques Izopet, Antoine Blancher, Nicolas Congy, Emmanuel Treiner, Laurent Sailler
Summary: The immune response to vaccines and pathogens in patients with systemic lupus erythematosus (SLE) is not well understood. A retrospective study of 47 SLE patients vaccinated against COVID-19 showed that SLE patients had reduced post-vaccine response against the Spike protein compared to controls. This reduction was observed in both memory T-cell response and IgG anti-Spike antibody response. The defective response was associated with low serum albumin levels, the use of glucocorticoids, and lower levels of specific antibodies.
JOURNAL OF TRANSLATIONAL AUTOIMMUNITY
(2023)
Article
Immunology
Guillaume Dorcet, Marie Benaiteau, Jeremie Pariente, Fabienne Ory-Magne, Emmanuel Cheuret, Marie Rafiq, Wesley Brooks, Benedicte Puissant-Lubrano, Francoise Fortenfant, Yves Renaudineau, Chloe Bost
Summary: This study aimed to explore the correlation between several biomarkers and the clinical course of autoimmune encephalitis (AIE). The results showed that the decrease in YKL-40 and MMP-9A at the protein level was associated with AIE remission, and the decrease in NfL and NfH levels in the serum was also associated with AIE remission. The study suggests that YKL-40 can be used as a biomarker to evaluate disease activity and therapeutic response in AIE.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2023)
Article
Immunology
Silvia Martinez-Rivera, Helene Guet-Revillet, Fabrice Herin, Guillaume Martin-Blondel, Marcel Miedouge, Laura Billon, Emmanuel Treiner, Yves Renaudineau
Summary: The study evaluated the use of QTF-TB and mycobacterial infection testing to differentiate MTC exposure from active disease. QTF-TB had limited ability to distinguish between LTBI and active MTC disease, but a cut-off value of 4.4 IFN-gamma IU/mL showed the best diagnostic performance for MTC detection. Antibodies were detected in active MTC disease cases using the humoral assay, but not in LTBI or negative QTF-TB cases.
Review
Rheumatology
Alice Tison, Soizic Garaud, Laurent Chiche, Divi Cornec, Marie Kostine
Summary: Immune-checkpoint inhibitors have changed the management of advanced cancers, but can also cause immune-related adverse events. Evidence is accumulating regarding the use of these inhibitors in patients with pre-existing autoimmune disease, suggesting acceptable safety but a risk of disease flare or other adverse events. Proper management of immunosuppressive drugs is important to balance autoimmunity protection and tumor response, and there is emerging research on the potential synergy of TNF or IL-6 inhibitors with immune-checkpoint inhibitors.
NATURE REVIEWS RHEUMATOLOGY
(2022)
Article
Immunology
Regina Larionova, K. Byvaltsev, Olga Kravtsova, Elena Takha, Sergei Petrov, Gevorg Kazarian, Anna Valeeva, Eduard Shuralev, Malik Mukminov, Yves Renaudineau, Marina Arleevskaya
Summary: The clinical and immunological spectrum of acute and post-active COVID-19 syndrome overlaps with criteria used to characterize autoimmune diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The immune response after SARS-Cov2 infection is altered with delayed production of IFN-I and activation of NF-kappa B and inflammasome pathways. An alternative immune response against SARS-Cov2 occurs in the lungs and digestive tissues, leading to breakdown of tolerance and the emergence of autoantibodies. The risk of severe COVID-19 in SLE and RA patients is similar to the general population, unless they have pre-existing neutralizing autoantibodies against IFN-I. Discontinuation of treatment increases the risk of flares. There have been a few case reports of individuals developing SLE or RA following COVID-19 infection/vaccination. Overall, the SARS-Cov2 pandemic provides a unique opportunity to study the dangerous interplay between immune response and autoimmunity, and understand the role of infection as a triggering factor in autoimmune and chronic inflammatory disease development.
JOURNAL OF TRANSLATIONAL AUTOIMMUNITY
(2022)