Journal
ORGANIC LETTERS
Volume 17, Issue 24, Pages 6134-6137Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b03148
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Funding
- National Natural Science Foundation of China [21372220, 21532006]
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A streamlined method for the enantioselective synthesis of 2-amino-4H-chromenes from readily available 2-alkyl-substituted phenols and active methylene compounds bearing a cyano group with up to 97% ee is presented. This reaction is a cascade procedure including manganese dioxide mediated CH oxidation for the generation of o-quinone methides and bifunctional squaramide-catalyzed Michael addition/cyclization.
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