Article
Immunology
Zhen Wang, Deng Liu, Qi Yan, Fang Liu, Mengting Zhan, Shunli Qi, Qi Fang, Lei Yao, Weizhi Wang, Ruixin Zhang, Jian Du, Lijian Chen
Summary: This study found that activation of AXL can alleviate liver inflammation and liver cell apoptosis in hepatic ischemia-reperfusion (I/R) injury. It acts by upregulating SOCS-1 and inhibiting the Toll-like receptor 4/myeloid differentiation factor-88/nuclear factor kappa-B signaling axis.
Article
Oncology
Li Li, Fengyang Li, Xiuhong Hu, Zengshuai Wu, Wenbo Ren, Tingting Wang, Zhengchao Ji, Na Li, Jingmin Gu, Changjiang Sun, Xin Feng, Wenyu Han, Jing Huang, Liancheng Lei
Summary: This study reveals that IFN-γ induces arginine depletion in bovine mammary epithelial cells (BMECs) through the regulation of leucine aminopeptidase 3 (LAP3), leading to malignant transformation. The findings also suggest that LAP3 could serve as a potential therapeutic target for breast cancer in both humans and dairy cows.
Article
Virology
Chen Li, Jiabao Shi, Haiwei Wang, Efrain E. Rivera-Serrano, Decheng Yang, Guohui Zhou, Chao Sun, Craig E. Cameron, Li Yu
Summary: This study demonstrates the importance of FMDV genetic diversity in viral virulence and transmissibility in susceptible animals. The generation of a high-fidelity FMDV variant with a single amino acid substitution in polymerase highlights the impact of viral population diversity on interhost viral spread. Furthermore, the high genetic diversity of type O FMDV may contribute to its dominance in the global epidemic by increasing both virulence and transmissibility.
JOURNAL OF VIROLOGY
(2021)
Review
Cell Biology
David J. De George, Tingting Ge, Balasubramaniam Krishnamurthy, Thomas W. H. Kay, Helen E. Thomas
Summary: Type 1 diabetes is an autoimmune disease that affects children. It is challenging to study in humans due to the difficulty in biopsy and early stage activity. The NOD mouse model provides an opportunity to understand the molecular mechanisms of the disease. IFN-γ plays a role in inflammation and autoreactive T cell proliferation, but inhibiting it may not be an effective therapeutic target.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Lu Bai, Margaux Vienne, Ling Tang, Yann Kerdiles, Marion Etiennot, Bertrand Escaliere, Justine Galluso, Haiming Wei, Rui Sun, Eric Vivier, Hui Peng, Zhigang Tian
Summary: Research indicates that the adult mouse liver contains lineage-CD122(+)CD49a(+) progenitor cells for liver ILC1s derived from fetal liver. The production of IFN-gamma by liver ILC1s themselves promotes their development in situ, emphasizing the role of extramedullary hematopoiesis in liver immune composition.
Article
Plant Sciences
Manman Guo, Zhongda Wang, Jinya Dai, Haizhen Fan, Ningning Yuan, Liming Gao, Huiping Peng, Xiaolan Cheng
Summary: This study found that glycyrrhizic acid (GA) attenuated liver fibrosis by promoting CUGBP1-mediated IFN-gamma/STAT1/Smad7 signaling pathway, thereby reducing liver damage. GA may be a potential candidate compound for preventing or relieving liver fibrosis.
Article
Plant Sciences
Kamal Tyagi, Anusha Sunkum, Prateek Gupta, Himabindu Vasuki Kilambi, Yellamaraju Sreelakshmi, Rameshwar Sharma
Summary: Tomato cultivars exhibit significant variations in folate levels in ripe fruits, and the loci regulating these levels remain unknown. We compared two tomato cultivars with contrasting folate levels and found that PKM-1 fruits had lower ethylene emission and phytohormone levels. PKM-1 fruits also exhibited upregulation of amino acids, sugars, and carotenoids, especially lycopene and beta-carotene.
HORTICULTURE RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Brigitte Bauvois, Elodie Pramil, Ludovic Jondreville, Claire Quiney, Florence Nguyen-Khac, Santos A. Susin
Summary: The study reveals that both type I and II interferons promote survival of chronic lymphocytic leukemia cells by activating the STAT3/Mcl-1 signaling pathway, inhibiting intrinsic apoptosis. Inhibitors against STAT3, TYK2 (for type I IFN), JAK2 (for type II IFN), and Src family kinase PP2 can effectively reduce interferon-mediated cell survival. Combining conventional treatments with inhibitors targeting STAT3 and Mcl-1 may offer a new therapeutic strategy for CLL.
Article
Genetics & Heredity
Wen-Na Liu, Kai-Xuan Wu, Xiao-Tong Wang, Li-Rong Lin, Man-Li Tong, Li-Li Liu
Summary: This study elucidated the role of lncRNA-ENST00000421645 in the pathogenic mechanism of neurosyphilis by mediating IFN-gamma production through interaction with PCM1 protein after PMA stimulation.
Article
Biochemistry & Molecular Biology
Shuzhao Zhuang, Aaron Russell, Yifan Guo, Yingying Xu, Weihua Xiao
Summary: Blocking IFN-γ in PD-1 knockout mice may exacerbate skeletal muscle damage and fibrosis, inhibit muscle regeneration, and affect the quantity and phenotype transition of macrophages as well as the infiltration of neutrophils.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2023)
Article
Pediatrics
Xuangjie Guo, Yiping Xu, Wei Luo, Rongli Fang, Li Cai, Ping Wang, Yuxia Zhang, Zhe Wen, Yanhui Xu
Summary: In patients with biliary atresia, PD-1 was significantly upregulated in CD4(+) and CD8(+) T cells. The expression of PD-1 in T cells was negatively associated with IFN-gamma concentration in the liver. Blockade of PD-1 increased IFN-gamma expression in T cells, suppressed bilirubin production, and exacerbated liver immunopathology.
Article
Biochemistry & Molecular Biology
Jing Li, Qian Chen, Jing Yi, Xi Lan, Kaikai Lu, Xiaojuan Du, Zizhen Guo, Yuanxu Guo, Manman Geng, Dongmin Li, Shemin Lu
Summary: Research suggests that IFN-γ promotes TLR2 transcription and target gene expression through STAT1 beta, leading to a vicious cycle of hepatic inflammation in NASH.
MOLECULAR IMMUNOLOGY
(2021)
Article
Cell Biology
Qi Li, Simeng Wei, Yue Li, Fengjiao Wu, Xiaoling Qin, Zhongsha Li, Jingyu Li, Chang Chen
Summary: Blocking of PD-L1 promotes CD8+IFN-gamma+ T cell-mediated immune responses, exacerbating inflammation and increasing the burden of atherosclerosis under high-cholesterol diet. However, further studies are needed to explore whether PD-L1 activation could be a novel immunotherapy strategy for atherosclerosis.
INFLAMMATION RESEARCH
(2023)
Article
Chemistry, Medicinal
Srijita Paul Chowdhuri, Shiv Dhiman, Subhendu K. Das, Neha Meena, Sonali Das, Anil Kumar, Benu Brata Das
Summary: This study reports a novel antileishmanial agent C17, which can poison topoisomerase 1-DNA covalent complexes (LdTop1cc) inside parasites and inhibit its religation activity. C17 is effective against both drug sensitive and antimony-resistant L. donovani isolates without affecting human Top1. It overcomes the chemical instability of camptothecin (CPT) and shows promising results in clearing Leishmania parasites in infected mice.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Qiuyun Fu, Xingchi Liu, Houfu Xia, Yicun Li, Zili Yu, Bing Liu, Xuepeng Xiong, Gang Chen
Summary: This study reveals that in salivary adenoid cystic carcinoma (SACC), a type of cancer with few infiltrated immune cells, a high levels of interferon-gamma (IFN-gamma) is found. Unlike other immunologically hot cancers, SACC cells are less sensitive to the growth-inhibitory effect of IFN-gamma, and IFN-gamma treatment enhances their migration and invasion abilities. Additionally, IFN-gamma exposure up-regulates programmed death ligand 1 (PD-L1) on SACC cell-derived small extracellular vesicles (sEVs), leading to the apoptosis of CD8(+) T cells through PD-1 antagonism. Interestingly, SACC patients with higher levels of plasma IFN-gamma also have higher levels of circulating sEVs carrying PD-L1.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2022)
Review
Immunology
Kyohei Nakamura, Mark J. Smyth
CELLULAR & MOLECULAR IMMUNOLOGY
(2020)
Article
Multidisciplinary Sciences
Marc Rigau, Simone Ostrouska, Thomas S. Fulford, Darryl N. Johnson, Katherine Woods, Zheng Ruan, Hamish E. G. McWilliam, Christopher Hudson, Candani Tutuka, Adam K. Wheatley, Stephen J. Kent, Jose A. Villadangos, Bhupinder Pal, Christian Kurts, Jason Simmonds, Matthias Pelzing, Andrew D. Nash, Andrew Hammet, Anne M. Verhagen, Gino Vairo, Eugene Maraskovsky, Con Panousis, Nicholas A. Gherardin, Jonathan Cebon, Dale I. Godfrey, Andreas Behren, Adam P. Uldrich
Editorial Material
Dermatology
Tobias Bald, Mark J. Smyth
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2020)
Review
Hematology
Kyohei Nakamura, Mark J. Smyth, Ludovic Martinet
Editorial Material
Cell Biology
Kyohei Nakamura, Tobias Bald, Mark J. Smyth
IMMUNOLOGY AND CELL BIOLOGY
(2020)
Review
Oncology
Basit Salik, Mark J. Smyth, Kyohei Nakamura
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2020)
Review
Immunology
Tobias Bald, Matthew F. Krummel, Mark J. Smyth, Kevin C. Barry
Review
Immunology
Adam P. Uldrich, Marc Rigau, Dale I. Godfrey
IMMUNOLOGICAL REVIEWS
(2020)
Article
Multidisciplinary Sciences
Catarina F. Almeida, Dylan G. M. Smith, Tan-Yun Cheng, Chris M. Harpur, Elena Batleska, Catriona V. Nguyen-Robertson, Tram Nguyen, Tamara Thelemann, Scott J. J. Reddiex, Shihan Li, Sidonia B. G. Eckle, Ildiko Van Rhijn, Jamie Rossjohn, Adam P. Uldrich, D. Branch Moody, Spencer J. Williams, Daniel G. Pellicci, Dale Godfrey
Summary: A study found that nonlipidic small molecules activate a polyclonal population of type II NKT cells in a CD1d-restricted manner in human donors, with the combination of PPBF and short-chain sphingomyelin enhancing CD1d tetramer staining.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Immunology
Marc Rigau, Adam P. Uldrich, Andreas Behren
Summary: V gamma 9V52+ T cells are part of the innate immune system and can be activated by phosphorylated antigens produced by bacteria and tumors. Recent discoveries have provided insights into the activation mechanism of V gamma 9V52+ T cells. The presence of live bacteria in the tumor microbiome may offer a potential source of high affinity bacterial phosphoantigens for enhancing anti-tumor immune responses.
TRENDS IN IMMUNOLOGY
(2021)
Article
Immunology
Nicholas A. Gherardin, Samuel J. Redmond, Hamish E. G. McWilliam, Catarina F. Almeida, Katherine H. A. Gourley, Rebecca Seneviratna, Shihan Li, Robert De Rose, Fiona J. Ross, Catriona Nguyen-Robertson, Shian Su, Matthew E. Ritchie, Jose A. Villadangos, D. Branch Moody, Daniel G. Pellicci, Adam P. Uldrich, Dale Godfrey
Summary: This study identified members of the CD36 family as ligands for CD1c, CD1b, and CD1d proteins, with CD36 being responsible for non-TCR-mediated CD1c tetramer staining of blood cells. Blocking CD36 clarified the identification of CD1c-restricted T cells and enhanced the detection of CD1b- and CD1d-restricted T cells. The technique developed in this study allowed for the characterization of diverse phenotypic features, TCR repertoire, and antigen-specific subsets of CD1c-restricted T cells, facilitating further research in the biology of CD1 and human CD1-restricted T cells.
SCIENCE IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Darryl N. Johnson, Zheng Ruan, Emma Petley, Sapna Devi, Lauren E. Holz, Adam P. Uldrich, Jeffrey Y. W. Mak, Jyh Liang Hor, Scott N. Mueller, James McCluskey, David P. Fairlie, Phillip K. Darcy, Paul A. Beavis, William R. Heath, Dale Godfrey
Summary: NKT cells are concentrated in the thymus, spleen, and lymph nodes within T cell zones, while MAIT cells are more closely associated with the B cell zone and red pulp of the spleen. Their precise intra-organ locations differ.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Roeland Lameris, Adam Shahine, Daniel G. Pellicci, Adam P. Uldrich, Stephanie Gras, Jerome Le Nours, Richard W. J. Groen, Jana Vree, Scott J. J. Reddiex, Sergio M. Quinones-Parra, Stewart K. Richardson, Amy R. Howell, Sonja Zweegman, Dale I. Godfrey, Tanja D. de Gruijl, Jamie Rossjohn, Hans J. van der Vliet
Review
Immunology
Achim K. Moesta, Xian-Yang Li, Mark J. Smyth
NATURE REVIEWS IMMUNOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Satvika Burugupalli, Catarina F. Almeida, Dylan G. M. Smith, Sayali Shah, Onisha Patel, Jamie Rossjohn, Adam P. Uldrich, Dale I. Godfrey, Spencer J. Williams