Article
Multidisciplinary Sciences
Xuanzhong Chen, Daigo Hashimoto, Ko Ebata, Shuichiro Takahashi, Yu Shimizu, Ryuga Shinozaki, Yuta Hasegawa, Ryo Kikuchi, Hajime Senjo, Kazuki Yoneda, Zixuan Zhang, Shinpei Harada, Eiko Hayase, Takahide Ara, Hiroyuki Ohigashi, Yoichiro Iwakura, Kiminori Nakamura, Tokiyoshi Ayabe, Takanori Teshima
Summary: This study reveals an interaction between gut microbiota and neutropenia after syngeneic hematopoietic stem cell transplantation and chemotherapy, suggesting their potential in stimulating reactive granulopoiesis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Rafael A. Paiva, Camila V. Ramos, Goncalo Leiria, Vera C. Martins
Summary: IL-7/IL-7R is necessary for T lymphocyte differentiation by promoting proliferation and survival of the most immature thymocytes, leading to a significant decrease in the number of early T lineage progenitor cells.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Sarah C. Edwards, Ann Hedley, Wilma H. M. Hoevenaar, Robert Wiesheu, Teresa Glauner, Anna Kilbey, Robin Shaw, Katerina Boufea, Nizar Batada, Shinya Hatano, Yasunobu Yoshikai, Karen Blyth, Crispin Miller, Kristina Kirschner, Seth B. Coffelt
Summary: This study reveals that different subsets of IL-17A-producing gamma delta T cells in the lung of mice are controlled by PD-1 and TIM-3 in steady-state and cancer. Vγ6(+) cells express high levels of PD-1, while Vγ4(+) cells upregulate TIM-3 in response to tumor-related stimulation. Inhibition of PD-1 or TIM-3 increases the numbers of Vγ6(+) and Vγ4(+) cells respectively. Moreover, genetic deletion of gamma delta T cells enhances responsiveness to anti-PD-1 and anti-TIM-3 immunotherapy in a mammary tumor model, indicating that IL-17A-producing gamma delta T cells contribute to immunotherapy resistance.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Immunology
Anastasia O. Smirnova, Anna M. Miroshnichenkova, Laima D. Belyaeva, Ilya V. Kelmanson, Yuri B. Lebedev, Ilgar Z. Mamedov, Dmitriy M. Chudakov, Alexander Y. Komkov
Summary: Diversity of T-cell receptor (TR) variable domains is generated through recombination of alpha (TRA) and beta (TRB) chains. We analyzed poorly explored partial TRBD1-TRBD2 rearrangements in T-cell genomic DNA and detected a bimodal distribution of D-D junctions indicating two active recombination sites. These rearrangements contribute to TRB V-(D)-J combinatorial diversity and are present in human antigen-experienced memory T cells, showing their role in antigen recognition and immune response.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Li Xiao, Wan-Hua Zhang, Yin Huang, Peng Huang
Summary: This study found that the release of IL-17A regulates cell viability, inflammation, apoptosis, and barrier damage in intestinal ischemia-reperfusion injury. The TAK1/MAPK signaling pathway plays an important role in IL-17A regulation.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Immunology
In-Ho Seo, Seung-Jun Lee, Tae Wook Noh, Jung-Hwan Kim, Hyun-Chel Joo, Eui-Cheol Shin, Su-Hyung Park, Young-Guk Ko
Summary: The research found that V delta 2(+) T cells are presented at a higher frequency in aortic aneurysmal tissue compared to normal aortic tissue. In addition, these V delta 2(+) T cells in AAA tissue display immunophenotypes indicative of CCR5(+) non-exhausted effector memory cells, with a decreased proportion of CD16(+) cells. Furthermore, the study suggests that increased V delta 2(+) T cells producing IL-17A in aortic aneurysmal tissue may play a role in AAA pathogenesis and progression.
Article
Cell Biology
Gideon Obasanmi, Noemi Lois, David Armstrong, Jose M. Romero Hombrebueno, Aisling Lynch, Mei Chen, Heping Xu
Summary: This study investigated alterations in inflammatory cytokines in peripheral blood mononuclear cells (PBMCs) in people with type 1 diabetes (T1D) and different stages of diabetic retinopathy (DR). The results showed that in mild non-proliferative DR (mNPDR), IL-10 secretion was increased, while IL-6 and IFN-gamma expression were reduced. In active and inactive proliferative DR (aPDR), IL-6 and IL-10 secretion decreased, and IL-6 expression in CD11b(+) PBMCs increased. These findings suggest that IL-10, especially myeloid-produced IL-17A, may be involved in early stages of DR, and IL-6-producing myeloid cells may play a role in PDR development.
Article
Dentistry, Oral Surgery & Medicine
Tao Yu, Qinchao Tang, Xueru Chen, Wan Fan, Zhuoqian Zhou, Wanqian Huang, Feixin Liang
Summary: This study investigated the role of TGF-beta 1 and IL-17A in modulating neutrophil function in oral squamous cell carcinoma (OSCC). The findings suggest that the cooperative effect of these two factors promotes a protumorigenic phenotype in neutrophils, leading to enhanced progression of OSCC cells. Additionally, specific neutrophil-associated markers in peripheral blood of OSCC patients may serve as predictive indicators for disease progression.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2021)
Article
Hematology
Patrick R. Hagner, Hon-Wah Man, Celia Fontanillo, Maria Wang, Suzana Couto, Mike Breider, Chad Bjorklund, Courtney G. Havens, Gang Lu, Emily Rychak, Heather Raymon, Rama Krishna Narla, Leo Barnes, Gody Khambatta, Hsiling Chiu, Jolanta Kosek, Jian Kang, Michael D. Amantangelo, Michelle Waldman, Antonia Lopez-Girona, Ti Cai, Michael Pourdehnad, Matthew Trotter, Thomas O. Daniel, Peter H. Schafer, Anke Klippel, Anjan Thakurta, Rajesh Chopra, Anita K. Gandhi
Article
Hematology
Emily Rychak, Derek Mendy, Tao Shi, Yuhong Ning, Jim Leisten, Ling Lu, Karen Miller, Rama K. Narla, Robert Z. Orlowski, Heather K. Raymon, Chad C. Bjorklund, Anjan Thakurta, Anita K. Gandhi, Brian E. Cathers, Rajesh Chopra, Thomas O. Daniel, Antonia Lopez-Girona
BRITISH JOURNAL OF HAEMATOLOGY
(2016)
Article
Hematology
Matthew Harrison, Emily Smith, Ewan Ross, Robert Krams, Dolf Segers, Christopher D. Buckley, Gerard B. Nash, G. Ed Rainger
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2013)
Article
Hematology
Anita K. Gandhi, Derek Mendy, Michelle Waldman, Gengxin Chen, Emily Rychak, Karen Miller, Svetlana Gaidarova, Yan Ren, Maria Wang, Michael Breider, Gilles Carmel, Afshin Mahmoudi, Pilgrim Jackson, Mahan Abbasian, Brian E. Cathers, Peter H. Schafer, Tom O. Daniel, Antonia Lopez-Girona, Anjan Thakurta, Rajesh Chopra
BRITISH JOURNAL OF HAEMATOLOGY
(2014)
Article
Cardiac & Cardiovascular Systems
Emily Smith, Konkal-Matt R. Prasad, Matthew Butcher, Anca Dobrian, Jay K. Kolls, Klaus Ley, Elena Galkina
Article
Immunology
Helen M. McGettrick, Emily Smith, Andrew Filer, Stephen Kissane, Michael Salmon, Christopher D. Buckley, G. Ed Rainger, Gerard B. Nash
EUROPEAN JOURNAL OF IMMUNOLOGY
(2009)
Article
Immunology
Emily Smith, Matthew A. Stark, Alexander Zarbock, Tracy L. Burcin, Anthony C. Bruce, Devin Vaswani, Patricia Foley, Klaus Ley
JOURNAL OF IMMUNOLOGY
(2008)
Article
Immunology
Alexander Zarbock, Matthew R. DiStasi, Emily Smith, John M. Sanders, Gerhard Kronke, Brian L. Harry, Sibylle von Vietinghoff, Konrad Buscher, Jerry L. Nadler, Klaus Ley
JOURNAL OF IMMUNOLOGY
(2009)
Article
Oncology
A. Lopez-Girona, D. Mendy, T. Ito, K. Miller, A. K. Gandhi, J. Kang, S. Karasawa, G. Carmel, P. Jackson, M. Abbasian, A. Mahmoudi, B. Cathers, E. Rychak, S. Gaidarova, R. Chen, P. H. Schafer, H. Handa, T. O. Daniel, J. F. Evans, R. Chopra
Article
Biochemistry & Molecular Biology
Philip P. Chamberlain, Antonia Lopez-Girona, Karen Miller, Gilles Carmel, Barbra Pagarigan, Barbara Chie-Leon, Emily Rychak, Laura G. Corral, Yan J. Ren, Maria Wang, Mariko Riley, Silvia L. Delker, Takumi Ito, Hideki Ando, Tomoyuki Mori, Yoshinori Hirano, Hiroshi Handa, Toshio Hakoshima, Thomas O. Daniel, Brian E. Cathers
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2014)
Article
Immunology
Emily Smith, Alexander Zarbock, Matthew A. Stark, Tracy L. Burcin, Anthony C. Bruce, Patricia Foley, Klaus Ley
JOURNAL OF IMMUNOLOGY
(2007)
Article
Rheumatology
Andrew Filer, Greg Parsonage, Emily Smith, Chloe Osborne, Andrew M. C. Thomas, S. John Curnow, G. Ed. Rainger, Karim Raza, Gerard B. Nash, Janet Lord, Mike Salmon, Christopher D. Buckley
ARTHRITIS AND RHEUMATISM
(2006)
Article
Rheumatology
F Lally, E Smith, A Filer, MA Stone, JS Shaw, GB Nash, CD Buckley, GE Rainger
ARTHRITIS AND RHEUMATISM
(2005)
Article
Immunology
Klaus Ley, Emily Smith, Matthew A. Stark
IMMUNOLOGIC RESEARCH
(2006)