Article
Biochemistry & Molecular Biology
Alena Hofrova, Petr Lousa, Monika Kubickova, Jozef Hritz, Tomas Otasevic, Martin Repko, Andrea Knight, Martin Piskacek
Summary: The 9aaTAD interacts with KIX through two hydrophobic regions, forming the KIX-L12-G2 region and enhancing binding. Both hydrophobic regions of 9aaTAD provide cooperative and universal binding with KIX.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Zhiming Wang, Yaye Bian, Chang Liu, Song He, Liancheng Zhao, Xianshun Zeng
Summary: An activatable mitochondria-targeted fluorescent probe Hcy-OPD was synthesized for the detection of methylglyoxal (MGO). The probe showed high selectivity and sensitivity for monitoring MGO (0.22 μM) and could be successfully applied in the imaging of exogenous and endogenous MGO in living cells.
CHEMICAL COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Yang Li, Hanying Huang, Ziang Zhu, Shuzhao Chen, Yang Liang, Lingling Shu
Summary: In this study, the correlation between TSC22D3 expression, immunoinfiltration, and prognostic significance in AML was evaluated. The results showed that knockdown of TSC22D3 significantly attenuated cell proliferation and increased sensitivity to Ara-c drugs. Furthermore, TSC22D3 inhibited the NF-kB/NLRP3 signaling pathway and reduced IL-1b release, thereby inhibiting macrophage polarization and attenuating the pro-inflammatory tumor microenvironment.
Review
Biochemistry & Molecular Biology
Jose Cesar Rosa Neto, Philip C. Calder, Rui Curi, Philip Newsholme, Jaswinder K. Sethi, Loreana S. Silveira
Summary: Macrophages and lymphocytes exhibit metabolic plasticity, influenced by their activation state and the availability of energy substrates. Fatty acids play a crucial role in governing the phenotype, activation, and functional status of these cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Laura Vitiello, Lucia Gatta, Sara Ilari, Stefano Bonassi, Mario Cristina, Filippo Ciatti, Massimo Fini, Stefania Proietti, Patrizia Russo, Carlo Tomino, Dolores Limongi
Summary: This study evaluated the durability of specific immune response induced by the BNT162b2 mRNA COVID-19 vaccine and found that a majority of individuals still had Spike-specific B and T lymphocytes 7 months after the second dose, suggesting the potential for long-lasting protection and aiding in the development of future vaccination strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Chao Zhang, Jiesheng Li, Yongqian Cheng, Fanping Meng, Jin-Wen Song, Xing Fan, Hongtao Fan, Jing Li, Yu-Long Fu, Ming-Ju Zhou, Wei Hu, Si-Yu Wang, Yuan-Jie Fu, Ji-Yuan Zhang, Ruo-Nan Xu, Ming Shi, Xueda Hu, Zemin Zhang, Xianwen Ren, Fu-Sheng Wang
Summary: In this study, the comprehensive immune responses in different phases of HBV infection were analyzed using single-cell RNA sequencing. The results showed that both immune active and acute recovery phases were characterized by high levels of exhausted CD8+ T cells in the liver. Significant cell-cell interactions were observed between these exhausted T cells and regulatory CD4+ T cells, as well as between T cells and macrophages. Specific subsets of CD8+ T cells were expanded during the acute recovery phase, providing a potential marker for viral resolution. This study provides important insights into the immunopathogenesis of HBV and the development of effective therapeutic strategies.
Review
Chemistry, Multidisciplinary
Xiaohan Liu, Limeng Pan, Kaiye Wang, Wei Pan, Na Li, Bo Tang
Summary: This review summarizes and discusses the importance of real-time monitoring of the immune response to evaluate immune status and guide immunotherapy. It also explores various imaging methods, immune-related imaging probes, and current challenges and opportunities.
Article
Cell Biology
Andrey Elchaninov, Polina Vishnyakova, Maria Kuznetsova, Elena Gantsova, Viktoria Kiseleva, Anastasiya Lokhonina, Maria Antonova, Aiaz Mamedov, Anna Soboleva, Dmitry Trofimov, Timur Fatkhudinov, Gennady Sukhikh
Summary: The role of the immune system and spleen in liver repair was investigated in this study. The loss and regeneration of liver volume significantly affected the cytological architecture and gene expression profiles of the spleen. The study found a decrease in Ki-67+ cells, CD115+ macrophages, Ly6C+ cells, and CD3+CD8+ cytotoxic lymphocytes during the recovery phase.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Allergy
Hui Li, Huaqi Wang, Leon Sokulsky, Shaoxia Liu, Rui Yang, Xiaojie Liu, Lujia Zhou, Juan Li, Chun Huang, Fangfang Li, Xu Lei, Hongxia Jia, Jiuling Cheng, Fuguang Li, Ming Yang, Guojun Zhang
Summary: This study identified significantly elevated levels of monocytes, CD8(+) T cells, and macrophages in the bronchoalveolar lavage fluid of patients with asthma exacerbation. Additionally, a complicated molecular framework involving a set of cytokines and intracellular transduction regulators shared across multiple cell clusters was discovered. Moreover, core exacerbation-associated modules activated included pathways such as eukaryotic initiation factor 2 signaling and C-X-C chemokine receptor type 4 signaling in specific cell populations associated with infection.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Biology
Liang Zhao, Mingxin Shi, Sarayut Winuthayanon, James A. MacLean, Kanako Hayashi
Summary: In a mouse model of endometriosis, niclosamide is found to have potential therapeutic value through its fine regulations of the dynamic progression of macrophages.
COMMUNICATIONS BIOLOGY
(2022)
Review
Oncology
James Harber, Tamihiro Kamata, Catrin Pritchard, Dean Fennell
Summary: Malignant pleural mesothelioma (MPM) is a difficult-to-treat cancer, but recent trials on immune checkpoint blockade (ICB) have shown promising results. While TMB and PD-L1 may not predict ICB response in MPM, understanding the tumor immune microenvironment can lead to improved therapy outcomes.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Madoka Koyanagi, Satoshi Imai, Mayuna Matsumoto, Yoko Iguma, Nobuko Kawaguchi-Sakita, Takeshi Kotake, Yuki Iwamitsu, Mpumelelo Ntogwa, Ren Hiraiwa, Kazuki Nagayasu, Mamiko Saigo, Takashi Ogihara, Atsushi Yonezawa, Tomohiro Omura, Shunsaku Nakagawa, Takayuki Nakagawa, Kazuo Matsubara
Summary: The elevated plasma galectin-3 level is a common pathologic change in both humans and mice with CIPN, and targeting galectin-3 is a proposed therapeutic option to delay CIPN progression. Schwann cell-derived galectin-3 plays a pronociceptive role via macrophage infiltration in the pathogenesis of taxane-induced peripheral neuropathy.
Review
Gastroenterology & Hepatology
Bai Li, Li Fang
Summary: This review synthesizes the progress in research on acupuncture in the context of NAFLD treatment, highlighting the mechanisms including inhibiting inflammatory responses, regulating lipid metabolism disorder, treating insulin resistance, antagonizing oxidative stress injury, and interfering with endoplasmic reticulum stress. Acupuncture shows potential applications and ongoing challenges in the treatment of NAFLD.
GASTROENTEROLOGY RESEARCH AND PRACTICE
(2022)
Review
Gastroenterology & Hepatology
Bai Li, Li Fang
Summary: This review examines the progress of acupuncture in the treatment of nonalcoholic fatty liver disease (NAFLD), focusing on its effects in inhibiting inflammatory responses, regulating lipid metabolism disorder, treating insulin resistance, antagonizing oxidative stress injury, and interfering with endoplasmic reticulum stress.
GASTROENTEROLOGY RESEARCH AND PRACTICE
(2022)
Article
Ophthalmology
Wenna Gao, Xuemin Jin, Pengyi Zhou, Haiyan Zhu, Kunpeng Xie, Bo Jin, Liping Du
Summary: Uveitis, a group of complex ocular inflammatory diseases, is influenced by various factors such as infection, autoimmunity, and genetics. However, there is a lack of safe and effective treatments for uveitis, which hinders its appropriate treatment. Microglia, as innate immune cells in the retina, play a significant role in retinal homeostasis. Research has shown that targeting microglial reactivity can mitigate uveitis. This paper aims to enhance the understanding of microglial versatility and accelerate the exploration of potential visual protection strategies.
OPHTHALMIC RESEARCH
(2023)