Journal
ORGANIC LETTERS
Volume 17, Issue 15, Pages 3922-3925Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b01972
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Funding
- NSFC [21272002, 21472150]
- Fundamental Research Funds for the Central Universities [XDJK2013B028]
- Program for New Century Excellent Talents in Universities [NCET-12-0929]
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The highly efficient, regioselective, and enantioselective transfer hydrogenation of alpha-keto ketimines and reductive amination of diketones by Bronsted acid catalysis is described. A series of chiral a-amino ketones is prepared in high yields (up to >99%), excellent regioselectivities (up to >99:1), and enantioselectivities (up to 98% ee). This method has broad substrate scope.
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