Article
Chemistry, Analytical
S. Guerrero, E. Sanchez-Tirado, L. Agui, A. Gonzalez-Cortes, P. Yanez-Sedeno, J. M. Pingarron
Summary: This work presents an amperometric bioplatform for detecting anti-MBP, a relevant biomarker for multiple sclerosis. The method shows competitive analytical performance and provides results consistent with ELISA in serum samples of healthy individuals and MS patients.
Review
Biochemistry & Molecular Biology
Vebjorn Martinsen, Petri Kursula
Summary: MBP is an abundant protein in CNS myelin and is studied in relation to the pathogenesis of MS. While its direct role as a primary antigen in human MS is unclear, MBP and its functions in myelin formation and maintenance are linked to the disease. This molecule demonstrates the complex relationship between normal nervous system development and neurodegenerative disease.
Article
Biochemistry & Molecular Biology
Daria A. Kamaeva, Liudmila P. Smirnova, Svetlana N. Vasilieva, Daria Kazantseva, Alisa R. Vasilieva, Svetlana A. Ivanova
Summary: This article investigates the hydrolytic activity of serum IgG on MBP in bipolar disorder and provides a detailed characterization of its catalytic properties. The study shows that IgG from bipolar patients exhibits significantly higher MBP-hydrolyzing activity compared to healthy individuals. This finding may reveal an additional link between myelin damage and inflammation in bipolar disorder.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Klaus Berek, Angelika Bauer, Dagmar Rudzki, Michael Auer, Robert Barket, Anne Zinganell, Magdalena Lerch, Livia Hofer, Astrid Grams, Paulina Poskaite, Sebastian Wurth, Thomas Berger, Franziska Di Pauli, Florian Deisenhammer, Harald Hegen, Markus Reindl
Summary: This study investigated the distribution of 65 different cytokines, chemokines, and related molecules in the cerebrospinal fluid (CSF) and serum of newly diagnosed people with multiple sclerosis (pwMS). The results showed that 29 cytokines and chemokines were significantly elevated in the CSF, while 15 were elevated in the serum. Additionally, associations were found between 34 analytes and sex, age, CSF, MRI parameters, and disease progression. These findings contribute to a better understanding of the pathophysiology of multiple sclerosis and its association with disease progression.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Christopher Khayeka-Wandabwa, Xiaoshuang Ma, Yingjie Jia, Matthias Bureik
Summary: In this study, anti-CYP autoantibodies were monitored in lung cancer patients and healthy controls, with most sera showing low signals and no significant differences between test groups. However, unexpectedly, multiple anti-CYP autoantibodies were detected in two female lung cancer patients and four healthy controls, suggesting the importance of considering the simultaneous presence of different anti-CYP autoantibodies as potential biomarkers.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Maria Teresa Martin Monreal, Bjarke E. Hansen, Pernille F. Iversen, Christian Enevold, Niels Odum, Finn Sellebjerg, Peter Hojrup, Marina Rode von Essen, Claus H. Nielsen
Summary: The research suggests that citrullination, a post-translational modification, may play a role in the development of multiple sclerosis (MS). The autoimmune response to myelin basic protein (MBP) is enhanced when it is hypercitrullinated in MS patients. In addition, citMBP binds more effectively to HLA-DR15, which is associated with MS, compared to native MBP. These findings point to the importance of citrullination in breaching tolerance to MBP and maintaining the autoimmune response in MS patients.
JOURNAL OF AUTOIMMUNITY
(2023)
Article
Clinical Neurology
Lida Zoupi, Sam A. Booker, Dimitri Eigel, Carsten Werner, Peter C. Kind, Tara L. Spires-Jones, Ben Newland, Anna C. Williams
Summary: Neurodegeneration in multiple sclerosis may affect specific neuronal components early on, and could be a result of demyelination.
ACTA NEUROPATHOLOGICA
(2021)
Article
Clinical Neurology
Marja Niiranen, Aleksi Kontkanen, Olli Jaaskelainen, Hanna-Mari Tertsunen, Tuomas Selander, Paivi Hartikainen, Nadine Huber, Eino Solje, Annakaisa Haapasalo, Tarja Kokkola, Tarja Lohioja, Sanna-Kaisa Herukka, Sakari Simula, Anne M. Remes
Summary: The study found significantly elevated serum GFAP levels in both BRRMS and ARRMS patients compared to healthy controls, with no significant differences between BRRMS and ARRMS. There were also no significant differences in serum NfL levels among the groups.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Letter
Medicine, General & Internal
Arie R. Gafson, Xiaotong Jiang, Changyu Shen, Raj Kapoor, Henrik Zetterberg, Robert J. Fox, Shibeshih Belachew
Summary: This cohort study examines the serum neurofilament light concentration as a biomarker in relation to disability progression in multiple sclerosis, without considering the presence of acute inflammation.
Review
Clinical Neurology
Alexandru-Stefan Niculae, Lucia-Elena Niculae, Cristiana Vacaras, Vitalie Vacaras
Summary: This study aims to evaluate the levels of serum neurofilament light chains in pediatric patients with multiple sclerosis under the age of 18. The study found that pediatric patients had higher levels of serum neurofilament light chains at their first clinical demyelinating attack compared to the normal control group.
JOURNAL OF NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Hsiuying Wang
Summary: Multiple sclerosis (MS) is a chronic disease affecting the central nervous system, with up to 50% of patients experiencing depressive disorders. Major depression (MD) is a serious comorbidity of MS, potentially involving various dysfunctions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Jan Hendrik Schaefer, Martin A. Schaller-Paule, Katharina Wenger, Christoph Mayer, Ulrike Mann, Alexander Bickert, Falk Steffen, Stefan Bittner, Yavor Yalachkov, Christian Foerch
Summary: This study aimed to determine whether established serum markers are predictive of contrast-enhancing (CE) lesions in multiple sclerosis (MS) patients. The results showed that only higher NfL values were correlated with the number and diameter of CE lesions, and NfL Z-scores improved diagnostic accuracy.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Cell Biology
Evgeniya V. V. Smirnova, Tatiana V. V. Rakitina, Rustam H. H. Ziganshin, George A. A. Saratov, Georgij P. P. Arapidi, Alexey A. A. Belogurov Jr, Anna A. A. Kudriaeva
Summary: Myelin basic protein (MBP) is a key structural element of the myelin sheath in multiple sclerosis (MS) and has autoantigenic properties. By using a fusion protein called TurboID, we identified the interaction network of MBP. We found that MBP potentially interacts with proteins involved in Fe2+ and lipid metabolism, suggesting a more comprehensive role of MBP in the integrity of the myelin sheath.
Article
Biochemistry & Molecular Biology
Hiroyuki Watanabe, Rinka Maekawa, Shimpei Iikuni, Masashi Kakae, Nagisa Matsuo, Hisashi Shirakawa, Shuji Kaneko, Masahiro Ono
Summary: This study characterized four diaryl oxadiazole derivatives as potential myelin-imaging probes for single photon emission computed tomography (SPECT) in multiple sclerosis (MS). The results showed that one of the derivatives, [123I]1,3,4-PODP-DM, could potentially be used as a SPECT probe for imaging myelin in MS.
ACS CHEMICAL NEUROSCIENCE
(2022)
Review
Neurosciences
Michel Maitre, Helene Jeltsch-David, Nwife Getrude Okechukwu, Christian Klein, Christine Patte-Mensah, Ayikoe-Guy Mensah-Nyagan
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the accumulation of toxic A beta peptide oligomers, plaques, and tangles containing tau protein, resulting in neuronal and synaptic losses. Sporadic AD, the more common form, is believed to be caused by chronic neuroinflammation and mitochondriopathies, leading to the accumulation of free radicals. Mutations in DNA and unfolded proteins in aging brains contribute to chronic amyloidosis, which affects myelin sheath and axons and ultimately leads to cognitive deficits and dementia. This study explores the potential role of early myelin alterations in the development of neuronal alterations and symptom onset, suggesting that structural and metabolic disorders in myelination/demyelination processes may play a crucial role in certain pathophysiological and clinical forms of the disease.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
A. A. Kudriaeva, A. V. Sokolov, A. A. Belogurov
Article
Multidisciplinary Sciences
Tatiana N. Sharapova, Elena A. Romanova, Natalia V. Soshnikova, Alexey A. Belogurov, Yakov A. Lomakin, Lidia P. Sashchenko, Denis V. Yashin
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Stanislav S. Terekhov, Yuliana A. Mokrushina, Anton S. Nazarov, Alexander Zlobin, Arthur Zalevsky, Gleb Bourenkov, Andrey Golovin, Alexey Belogurov, Ilya A. Osterman, Alexandra A. Kulikova, Vladimir A. Mitkevich, Hua Jane Lou, Benjamin E. Turk, Matthias Wilmanns, Ivan Smirnov, Sidney Altman, Alexander G. Gabibov
Article
Biochemistry & Molecular Biology
A. A. Kudriaeva, V. M. Lipkin, A. A. Belogurov
DOKLADY BIOCHEMISTRY AND BIOPHYSICS
(2020)
Article
Biochemistry & Molecular Biology
Irina A. Ishina, Ioanna N. Filimonova, Maria Y. Zakharova, Leyla A. Ovchinnikova, Azad E. Mamedov, Yakov A. Lomakin, Alexey A. Belogurov
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Multidisciplinary Sciences
Yuliana A. Mokrushina, Andrey Golovin, Ivan Smirnov, Spyros D. Chatziefthimiou, Anastasia Stepanova, Tatyana Bobik, Arthur O. Zalevsky, Alexander S. Zlobin, Kirill A. Konovalov, Stanislav S. Terekhov, Alexey Stepanov, Sofiya O. Pipiya, Olga G. Shamborant, Ekaterina Round, Alexey A. Belogurov, Gleb Bourenkov, Alexander A. Makarov, Matthias Wilmanns, Jia Xie, G. Michael Blackburn, Alexander G. Gabibov, Richard A. Lerner
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Multidisciplinary Sciences
Stanislav S. Terekhov, Igor E. Eliseev, Leyla A. Ovchinnikova, Marsel R. Kabilov, Andrey D. Prjibelski, Alexey E. Tupikin, Ivan Smirnov, Alexey A. Belogurov, Konstantin Severinov, Yakov A. Lomakin, Sidney Altman, Alexander G. Gabibov
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Biochemistry & Molecular Biology
A. E. Mamedov, I. N. Filimonova, I. Smirnov, A. A. Belogurov
Summary: Predisposition to multiple sclerosis is influenced by various factors, with genetics playing a significant role, especially HLA class II genes. The HLA-DRB1*01 allele group has been found to provide protection against MS in the Russian population. Research showed that the myelin peptide binds to protective HLA-DR1 and predisposing HLA-DR15 at a lower rate compared to viral peptides.
Article
Microbiology
Irina P. Balmasova, Evgenii I. Olekhnovich, Ksenia M. Klimina, Anna A. Korenkova, Maria T. Vakhitova, Elmar A. Babaev, Leyla A. Ovchinnikova, Yakov A. Lomakin, Ivan V. Smirnov, Victor N. Tsarev, Ashot M. Mkrtumyan, Alexey A. Belogurov, Alexander G. Gabibov, Elena N. Ilina, Sergey D. Arutyunov
Summary: In this study, the subgingival periodontal microbiome of patients with chronic periodontitis associated with type 2 diabetes mellitus was analyzed, revealing specific microbiome features within this group.
Article
Surgery
Georgii B. Telegin, Alexey N. Minakov, Aleksandr S. Chernov, Vitaly A. Kazakov, Elena A. Kalabina, Vasily N. Manskikh, Dmitry S. Asyutin, Alexey A. Belogurov, Alexander G. Gabibov, Nikolay A. Konovalov, Aldo Spallone
Summary: A novel model of post-traumatic spinal cord glial scarring in rats has been developed through cryoapplication, resulting in a highly standardized transmural lesion. Compared to other experimental methods, this technique is minimally invasive, precise, and reproducible, showing minimal variation in histological findings and postoperative clinical course among different animals. The study aims to better understand self-recovery processes in damaged spinal cord and potentially lead to innovative approaches for SCI treatment.
FRONTIERS IN SURGERY
(2021)
Article
Biochemistry & Molecular Biology
Tatiana N. Sharapova, Elena A. Romanova, Aleksandr S. Chernov, Alexey N. Minakov, Vitaly A. Kazakov, Anna A. Kudriaeva, Alexey A. Belogurov, Olga K. Ivanova, Alexander G. Gabibov, Georgii B. Telegin, Denis V. Yashin, Lidia P. Sashchenko
Summary: In severe cases of COVID-19, infection by SARS-CoV-2 can lead to a cytokine storm with excessive production of proinflammatory cytokines. Peptides derived from innate immunity protein Tag7 have been found to inhibit the activation of certain receptors, reducing the production of proinflammatory cytokines and potentially benefiting the therapy or prevention of acute lung injury, particularly in COVID-19 patients with severe pulmonary lesions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Grazia R. Tundo, Diego Sbardella, Francesco Oddone, Anna A. Kudriaeva, Pedro M. Lacal, Alexey A. Belogurov, Grazia Graziani, Stefano Marini
Summary: The immunoproteasome plays a crucial role in antigen presentation and its modulation presents promising research opportunities. Immunotherapy has shown significant advancements, however, a broader understanding of cancer cell antigen processing dynamics is still required for further improvements.
Article
Biochemistry & Molecular Biology
Evgeniya V. Smirnova, Tatiana V. Rakitina, Rustam H. Ziganshin, Georgij P. Arapidi, George A. Saratov, Anna A. Kudriaeva, Alexey A. Belogurov
Summary: The study revealed the interaction network of MBP in mammalian cells, showing its connections with proteins involved in the protein translation machinery and RNA biogenesis.
Article
Biochemistry & Molecular Biology
Anna A. Kudriaeva, Ido Livneh, Mikhail S. Baranov, Rustam H. Ziganshin, Alexey E. Tupikin, Snizhana O. Zaitseva, Marsel R. Kabilov, Aaron Ciechanover, Alexey A. Belogurov
Summary: Utilizing fluorescent tracking, this study revealed the short half-life of ubiquitin, the dynamic equilibrium between Ub ligases and DUBs, the loss of Ub molecules during engagement with proteasomes, the correlation between Ub chain types and half-life, and the critical influence of the lysine residue K27 on Ub stability. These findings provide a comprehensive understanding of the dynamics of the ubiquitin-proteasome system.
CELL CHEMICAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Anna Bacheva, Nataliya N. Gotmanova, Alexey A. Belogurov, Anna A. Kudriaeva
Summary: Covalent attachment of ubiquitin residue is not only a proteasomal degradation signal, but also a widespread posttranslational modification in eukaryotic cells. Histones are one of the key targets of regulatory ubiquitination, and depending on their type and the specific lysine residue being modified, histone ubiquitination can affect transcription activation, gene repression, and contribute to DNA repair through various mechanisms. The structural diversity of RING E3 ubiquitin ligases catalyzing histone ubiquitination provides high specificity in modification of initial targets.
BIOCHEMISTRY-MOSCOW
(2021)