4.8 Article

Chiral Phosphoric Acid Catalyzed Asymmetric Synthesis of 2-Substituted 2,3-Dihydro-4-quinolones by a Protecting-Group-Free Approach

Journal

ORGANIC LETTERS
Volume 17, Issue 13, Pages 3202-3205

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b01654

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Funding

  1. Ministry of Education, Culture, Sports, Science and Technology, Japan

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Chiral 2-substituted 2,3-dihydro-4-quinolones were synthesized based on the chiral phosphoric acid catalyzed intramolecular aza-Michael addition reaction using N-unprotected 2-aminophenyl vinyl ketones as substrates in good yields with high enantioselectivities.

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