Palladium-Catalyzed Oxidative Arylation of Tertiary Benzamides: Para-Selectivity of Monosuhstituted Arenes

A mild and efficient protocol for the high para-selective arylation of monosubstituted arenes with tertiary benzamides has been developed via palladium-catalyzed oxidative coupling reactions. Due to the mild conditions and the easy availability of substrates and oxidant, this method could potentially provide a practical approach for the synthesis of para-substituted biaryl compounds.