Article
Cardiac & Cardiovascular Systems
Sadiya S. Khan, Lucia C. Petito, Xiaoning Huang, Katharine Harrington, Rebecca B. McNeil, Natalie A. Bello, C. Noel Bairey Merz, Eliza C. Miller, Rupa Ravi, Christina Scifres, Janet M. Catov, Victoria L. Pemberton, Jasmina Varagic, Phyllis C. Zee, Lynn M. Yee, Mitali Ray, Jin Kyung Kim, Abbi D. Lane-Cordova, Jennifer Lewey, Lauren H. Theilen, George R. Saade, Philip Greenland, William A. Grobman
Summary: This study found a significant association between early pregnancy obesity and postpartum hypertension, hyperlipidemia, and diabetes risk. Adverse pregnancy outcomes were related to increased incidence of postpartum hypertension and hyperlipidemia. However, these adverse pregnancy outcomes only partially mediated the association between early pregnancy obesity and postpartum hypertension.
CIRCULATION RESEARCH
(2023)
Article
Peripheral Vascular Disease
Antonietta Gigante, Adolfo Marco Perrotta, Oriana De Marco, Edoardo Rosato, Silvia Lai, Rosario Cianci
Summary: This study evaluated intrarenal ultrasound parameters in hypertensive patients with normal renal function, finding that the atrophic index (AI) is correlated with renal function reduction and, in combination with the renal resistive index (RI), can serve as an additional marker for renal damage progression in hypertensive patients.
JOURNAL OF CLINICAL HYPERTENSION
(2022)
Review
Medicine, General & Internal
Roxana Darabont, Diana Mihalcea, Dragos Vinereanu
Summary: Initially aimed at improving diagnosis in kidney diseases, the investigation of renal resistive index (RRI) did not meet this goal. However, recent research has highlighted the prognostic significance of RRI in chronic kidney disease, renal transplantation, and acute kidney injury in critically ill patients. The correlation of RRI with parameters of systemic circulation and its implications for cardiovascular risk beyond its prognostic relevance for kidney disease have also been explored. This review provides an overview of the clinical research on the implications of RRI in renal and cardiovascular disease.
Article
Cardiac & Cardiovascular Systems
Felix Mahfoud, Giuseppe Mancia, Roland E. Schmieder, Luis Ruilope, Krzysztof Narkiewicz, Markus Schlaich, Bryan Williams, Flavio Ribichini, Joachim Weil, Hsien-Li Kao, Oriol Rodriguez-Leor, Elias Noory, Tiong Kiam Ong, Thierry Unterseeh, Pedro de Araujo Goncalves, Andreas Zirlik, Khaled Almerri, Faisal Sharif, Lucas Lauder, Marianne Wanten, Martin Fahy, Michael Bohm
Summary: This study aimed to evaluate the impact of radiofrequency renal denervation (RDN) on time in therapeutic range (TTR) and its association with cardiovascular outcomes. The results showed sustained blood pressure reductions and higher TTR through 36 months after RDN. A 10% increase in TTR through 6 months was associated with significant risk reductions in major cardiovascular events from 6 to 36 months.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Peripheral Vascular Disease
Jean-Michel Halimi, Louis-Marie Vernier, Juliette Gueguen, Nicolas Goin, Philippe Gatault, Benedicte Sautenet, Christelle Barbet, Helene Longuet, Jerome Roumy, Matthias Buchler, Jacques Blacher, Jean-Baptiste de Freminville
Summary: A retrospective analysis of 2362 kidney transplant patients found that renal resistive index is associated with the risk of death, but the mechanism underlying this association is unclear. Renal resistive index is derived from end-diastolic velocity (EDV) and peak systolic velocity (PSV). The predictive value of EDV or PSV alone is unknown.
JOURNAL OF HYPERTENSION
(2023)
Article
Peripheral Vascular Disease
Yang Wang, Jie Wang, Xiao-Wei Zheng, Ming-Fei Du, Xi Zhang, Chao Chu, Dan Wang, Yue-Yuan Liao, Qiong Ma, Hao Jia, Gui-Lin Hu, Yu Yan, Yue Sun, Chen Chen, Xiao-Yu Zhang, Hao Li, Ting Zou, Ze-Jiaxin Niu, Zi-Yue Man, Lan Wang, Wen-Jing Luo, Guan-Ji Wu, Yu-Ming Kang, John Chang, Christian Delles, Yao Lu, Jian-Jun Mu
Summary: This study found that the accumulation of individual cardiovascular risk factors from childhood to midlife was associated with vascular aging in midlife. Persistent increase and accumulation of cardiovascular risk factors were associated with arterial stiffness and thickening of arterial walls in midlife.
Article
Cell Biology
Jing Hu, Huilin Xu, Jingjing Zhu, Jinling Zhang, Jun Li, Linli Chen, Xiaohua Liu, Guoyou Qin
Summary: The study revealed a U-shaped relationship between BMI and CVD-specific mortality among hypertensive Chinese adults, with overweight and obesity potentially reducing the risk of CVD death in older individuals.
Article
Acoustics
Betul Banu Karasu, Emre Emekli
Summary: This study aimed to investigate the presence of cardiorenal interaction at subclinical level in patients with hypertension. The researchers used renal Doppler ultrasonographic parameter-augmented velocity index (Avi) and an echocardiographic measure-ventriculoarterial coupling to examine the relationship between the heart and kidney. They found that renal Avi was a more reliable and promising index for measuring subclinical changes in the cardiorenal circulation compared to renal resistive index (RI).
JOURNAL OF ULTRASOUND IN MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Anastasia V. Poznyak, Nikolay K. Sadykhov, Andrey G. Kartuesov, Evgeny E. Borisov, Alexandra A. Melnichenko, Andrey V. Grechko, Alexander N. Orekhov
Summary: Atherosclerosis, a predecessor of cardiovascular diseases, has a high morbidity and mortality rate. However, the trigger mechanism is not well understood. Hypertension, among the various modifiable risk factors, is considered the most widespread and extensively researched factor for atherosclerosis development.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Abdulrahman Altheaby, Nuha Alajlan, Mohammed F. Shaheen, Ghaleb Abosamah, Basma Ghallab, Basayl Aldawsari, Awatif Rashidi, Mohammed Gafar, Ziad Arabi
Summary: The study investigated the incidence of weight gain postrenal transplantation and identified potential risk factors, showing that patients with lower dialysis duration, a living kidney donor, and baseline obesity were more likely to gain weight. Close monitoring of weight changes in kidney transplant patients is necessary, and further research is needed to determine risk factors and appropriate interventions.
Article
Peripheral Vascular Disease
Huanhuan Miao, Zhanyang Zhou, Shijie Yang, Yuqing Zhang
Summary: This study found significant associations between the triglyceride-glucose index and related parameters with hypertension and cardiovascular risk. TyG-WC showed the highest diagnostic efficacy for hypertension, while TyG-WHR performed best in distinguishing participants with high cardiovascular risk.
HYPERTENSION RESEARCH
(2023)
Review
Peripheral Vascular Disease
Rohan Samson, Pierre Vladimir Ennezat, Thierry H. Le Jemtel, Suzanne Oparil
Summary: Anti-hypertensive and lipid lowering therapy only addresses half of the cardiovascular disease risk in obese patients. This review examines newer aspects of obesity pathobiology that explain the partial effectiveness of these therapies in reducing cardiovascular disease risk in obesity.
CURRENT HYPERTENSION REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Yingshan Liu, Xiaocong Liu, Haixia Guan, Shuting Zhang, Qibo Zhu, Xiaoying Fu, Hongmei Chen, Songtao Tang, Yingqing Feng, Jian Kuang
Summary: In hypertensive patients, weight, waist circumference, waist-to-hip ratio, waist-to-height ratio, body adiposity index, body roundness index, and waist-hip-height ratio were identified as independent risk factors for diabetes, with the body roundness index being the most superior predictor among the anthropometric indices.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Peripheral Vascular Disease
Rosario Cianci, Antonietta Gigante, Domenico Bagordo, Giovanni Pintus, Antonello Giovannetti, Silvia Lai, Sandro Mazzaferro, Edoardo Rosato
Summary: This retrospective observational study found that IgA nephropathy patients have lower RRI values compared to patients with renal scleroderma vasculopathy. Additionally, IgA nephropathy patients showed a higher prevalence of hypertension and were younger in age compared to the renal scleroderma vasculopathy patients.
MICROVASCULAR RESEARCH
(2021)
Article
Urology & Nephrology
Jingping Wu, Jian Liu, Guanghan Li, Weiliang Sun, Jiang Liu, Wenge Li, Hao Wang, Min Zheng
Summary: This study revealed that there was no correlation between renal resistive index (RRI) and renal microvessel density (RMD) or between RRI and fibrosis in patients with chronic kidney disease (CKD). However, in CKD stages 2 to 5, RRI was negatively correlated with CD34 positive area in the glomerulus, but no correlation was found with CD34 positive area overall, CD34 positive area in the peritubular capillary, or kidney fibrosis. Furthermore, estimated glomerular filtration rate (eGFR) showed a positive correlation with RMD.
Editorial Material
Medicine, General & Internal
Elisa Russo, Francesca Viazzi
INTERNAL AND EMERGENCY MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Giovanna Leoncini, Elisa Russo, Elisabetta Bussalino, Cecilia Barnini, Francesca Viazzi, Roberto Pontremoli
Summary: This review discusses the biological mechanisms of kidney protection with SGLT2is and provides an overview of their current uses and future therapeutic potential through data from cardiovascular and renal outcome trials conducted mostly in diabetic patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Urology & Nephrology
Elisa Russo, Francesca Viazzi, Roberto Pontremoli, Carlo Maria Barbagallo, Michele Bombelli, Edoardo Casiglia, Arrigo Francesco Giuseppe Cicero, Massimo Cirillo, Pietro Cirillo, Giovambattista Desideri, Lanfranco D'Elia, Claudio Ferri, Ferruccio Galletti, Loreto Gesualdo, Cristina Giannattasio, Guido Iaccarino, Giovanna Leoncini, Francesca Mallamaci, Alessandro Maloberti, Stefano Masi, Alessandro Mengozzi, Alberto Mazza, Maria Lorenza Muiesan, Pietro Nazzaro, Paolo Palatini, Gianfranco Parati, Marcello Rattazzi, Giulia Rivasi, Massimo Salvetti, Valerie Tikhonoff, Giuliano Tocci, Andrea Ungar, Paolo Verdecchia, Agostino Virdis, Massimo Volpe, Guido Grassi, Claudio Borghi
Summary: The study analyzed clinical data of 26,971 individuals and found that serum uric acid levels were positively correlated with kidney disease measures (eGFR and albuminuria), especially in cases of renal function decline.
JOURNAL OF NEPHROLOGY
(2022)
Article
Medicine, General & Internal
Pasquale Esposito, Leda Cipriani, Daniela Verzola, Maria Antonietta Grignano, Mara De Amici, Giorgia Testa, Fabrizio Grosjean, Elisa Russo, Giacomo Garibotto, Teresa Rampino, Francesca Viazzi
Summary: Uncontrolled inflammation is important in COVID-19 pathogenesis. In HD patients, levels of inflammatory markers were elevated but not sustained. Modulation of inflammation may not be a suitable therapeutic target in this specific population.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cell Biology
Pasquale Esposito, Daniela Verzola, Daniela Picciotto, Leda Cipriani, Francesca Viazzi, Giacomo Garibotto
Summary: The hypothesis suggests that myostatin and activin-A are involved in vascular damage in atherosclerosis and CKD, binding to different activin receptors and activating distinct signaling pathways. Myostatin promotes vascular inflammation and premature aging, while activin-A is implicated in vascular calcification and CKD-related mineral bone disorders. Understanding their roles in vascular disease and bone metabolism could lead to novel therapeutic opportunities.
Review
Urology & Nephrology
Giovanna Leoncini, Cecilia Barnini, Luca Manco, Giulia Nobili, Daniele Dotta, Martina Penso, Elisa Russo, Francesca Cappadona, Francesca Viazzi, Roberto Pontremoli
Summary: Hyperuricemia is associated with cardiovascular risk factors and is a predictor of kidney disease. Urate-lowering treatment has been proposed to improve kidney outcomes, but recent randomized controlled trials have failed to show its beneficial effect on renal disease.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Medicine, General & Internal
Pasquale Esposito, Elisa Russo, Daniela Picciotto, Francesca Cappadona, Yuri Battaglia, Giovanni Battista Traverso, Francesca Viazzi
Summary: This study evaluated the impact of the COVID-19 pandemic on the epidemiology of AKI in hospitalized patients. The results showed that the incidence of AKI during the COVID-19 period was significantly higher compared to the pre-COVID-19 period, and it was independently associated with SARS-CoV-2 infection and admission period. Additionally, patients admitted during the COVID-19 period had worse clinical outcomes and higher mortality rates.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Environmental Sciences
Pasquale Esposito, Daniela Picciotto, Francesca Cappadona, Elisa Russo, Valeria Falqui, Novella Evelina Conti, Angelica Parodi, Laura Mallia, Sara Cavagnaro, Yuri Battaglia, Francesca Viazzi
Summary: This study retrospectively compared hemodialysis patients affected by COVID-19 during the first pandemic waves of 2020 with patients from September 2021 to February 2022 after vaccination. The findings showed that patients in the later group had milder symptoms, lower hospitalization rates, shorter illness duration, and lower mortality rates. Responders to the vaccine also had reduced infection duration and hospitalization compared to nonresponders.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biology
Pasquale Esposito, Sara Garbarino, Daniela Fenoglio, Isabella Cama, Leda Cipriani, Cristina Campi, Alessia Parodi, Tiziana Vigo, Diego Franciotta, Tiziana Altosole, Fabrizio Grosjean, Francesca Viazzi, Gilberto Filaci, Michele Piana
Summary: This study used a combination of linear mixed effect modeling and cluster analysis on longitudinal data to stratify hemodialysis patients with COVID-19. The results identified high-risk patients and could contribute to improving COVID-19 management in different clinical settings.
Article
Biochemistry & Molecular Biology
Elisa Russo, Maria Bertolotto, Valentina Zanetti, Daniela Picciotto, Pasquale Esposito, Federico Carbone, Fabrizio Montecucco, Roberto Pontremoli, Giacomo Garibotto, Francesca Viazzi, Daniela Verzola
Summary: This study demonstrates that uric acid (UA) can induce changes in VSMC cytoskeleton, leading to increased cell migration and activation of specific signaling pathways. These findings suggest that UA may play a critical role in vascular remodeling, emphasizing the importance of interventions to prevent the development of cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Elisa Russo, Alberto Stefano Tagliafico, Lorenzo Derchi, Bianca Bignotti, Simona Tosto, Carlo Martinoli, Alessio Signori, Francesca Brigati, Francesca Viazzi
Summary: The study aimed to investigate the role of opportunistic kidney assessment on non-enhanced chest CT in COVID-19 patients. The results showed that low RPA values and the presence of PFS independently predicted the occurrence of AKI and increased risk for mortality, respectively.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Francesca Cappadona, Elisa Costa, Laura Mallia, Filippo Sangregorio, Lorenzo Nescis, Valentina Zanetti, Elisa Russo, Stefania Bianzina, Francesca Viazzi, Pasquale Esposito
Summary: Lung-protective ventilation with low tidal volumes can increase survival in ARDS patients. However, there are concerns about the risk of hypercapnia and respiratory acidosis. ECCO2R techniques and devices have been developed to address these concerns and have shown effectiveness in controlling PaCO2 levels, allowing for the application of lung-protective ventilation in ARDS patients.
Review
Biochemistry & Molecular Biology
Elisa Russo, Elisabetta Bussalino, Lucia Maccio, Daniela Verzola, Michela Saio, Pasquale Esposito, Giovanna Leoncini, Roberto Pontremoli, Francesca Viazzi
Summary: Arterial hypertension is a global challenge that greatly impacts cardiovascular morbidity and mortality worldwide. It is a major risk factor for the development and progression of kidney disease. Despite the availability of antihypertensive treatments, the kidney damage associated with arterial hypertension is still unresolved. Recent studies have identified novel potential therapeutic targets for hypertensive nephropathy management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Pasquale Esposito, Daniela Verzola, Michela Saio, Daniela Picciotto, Marco Frascio, Alessandro Laudon, Valentina Zanetti, Giuliano Brunori, Giacomo Garibotto, Francesca Viazzi
Summary: Protein energy wasting (PEW) is a common complication in chronic kidney disease (CKD) and end-stage kidney disease (ESKD), and it is strongly associated with morbidity and mortality in these patient populations. The pathogenesis of PEW involves various mechanisms such as anorexia, insulin resistance, acidosis, low-grade inflammation, and sterile muscle inflammation at advanced CKD stages. Immune and resident muscle cells play critical roles in triggering sterile tissue inflammation through innate immunity pathways, including toll-like receptor 4 (TLR4) activation and NLRP3 inflammasome signaling. Targeting these innate immune pathways could potentially lead to novel therapies for CKD-related PEW.
Review
Biochemistry & Molecular Biology
Edoardo La Porta, Ottavia Exacoustos, Francesca Lugani, Andrea Angeletti, Decimo Silvio Chiarenza, Carolina Bigatti, Sonia Spinelli, Xhuliana Kajana, Andrea Garbarino, Maurizio Bruschi, Giovanni Candiano, Gianluca Caridi, Nicoletta Mancianti, Marta Calatroni, Daniela Verzola, Pasquale Esposito, Francesca Viazzi, Enrico Verrina, Gian Marco Ghiggeri
Summary: Plastic pollution has become a major challenge for humans, with microplastics being found ubiquitously in human tissues and fluids. Limited evidence suggests potential harmful effects of microplastics on human cells, mediated by oxidative stress, inflammation, and fibrosis. Studies on the impact of microplastics on kidneys are insufficient, but animal models have shown histological and functional alterations, as well as cytotoxicity, in kidney cells. Urgent further research is needed to analyze the potential correlation between kidney disease and exposure to microplastics in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
