Article
Cardiac & Cardiovascular Systems
Maria M. Pereira, Juan Torrado, Joshua Bock, Claudio Sosa, Alejandro Diaz, Daniel Bia, Yanina Zocalo
Summary: This study compared the changes in pressure wave components between pregnancy-associated hypertension (PAH) patients and non-pregnant women and women with normal pregnancies (HP) using Wave Separation Analysis (WSA) and Pulse Wave Analysis (PWA). The results showed that PAH was associated with higher forward wave component (Pf), but not higher backward wave component (Pb), compared to NP and HP. PAH also showed lower reflection magnitude (RM) and index (RIx) compared to NP and HP.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Physiology
Yanina Zocalo, Daniel Bia
Summary: Aortic blood pressure waveform-derived indexes provide valuable information beyond cardiovascular risk factors, but there are differences between techniques, recording sites, and analysis methods. Gender, body height, and age also affect these indexes. Therefore, specific reference intervals for gender, body height, and age are needed to accurately evaluate waveform-derived indexes.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Peripheral Vascular Disease
Dora Batta, Beata Korosi, Helga Gyongyosi, Zsofia Nemcsik-Bencze, Andrea Laszlo, Andras Tisler, Orsolya Cseprekal, Janos Nemcsik
Summary: This study compared office and ambulatory measurements of PWV and observed the changes in PWV after lifestyle modifications or initiation of antihypertensive medication. The results showed significant differences between office and ambulatory measurements, suggesting that the two methods are not interchangeable.
JOURNAL OF HYPERTENSION
(2022)
Article
Computer Science, Interdisciplinary Applications
Liam Murphy, J. Geoffrey Chase
Summary: This study proposes a novel method for accurately estimating central blood pressure using only a single peripheral pressure measurement, without the need for additional clinical measurements. The method allows for the individualization of transfer functions to better capture changes in patient condition during disease progression and treatment.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Jing Liu, Niema M. Pahlevan
Summary: The study proposes a novel dicrotic wave decomposition model to explain the intersite discrepancies in ejection time measurement from arterial waveforms, aiming to enhance the accuracy of both classical physics-based and contemporary artificial intelligence-based pulse wave analysis methods in clinical and wearable radial blood pressure monitoring applications.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Peripheral Vascular Disease
Frederik Trinkmann, Urs Benck, Julian Halder, Alexandra Semmelweis, Joachim Saur, Martin Borggrefe, Ibrahim Akin, Jens J. Kaden
Summary: The study evaluated the accuracy of the novel VascAssist 2 in estimating central blood pressure, showing that it is at least as accurate as existing techniques and can even be used in diabetic patients. Automated measurement significantly simplifies the application process without the need for operator training and can be reliably applied even in patients with arrhythmias.
AMERICAN JOURNAL OF HYPERTENSION
(2021)
Article
Biochemistry & Molecular Biology
Alessandro Scalia, Chadi Ghafari, Wivine Navarre, Philippe Delmotte, Rob Phillips, Stephane Carlier
Summary: This study demonstrates the advantages of non-invasive central blood pressure monitoring and validates the accuracy of different devices through comparison with invasive measurements. It also provides a novel method of validation using recognized gold standard transducers and highlights the potential for easily measuring pulse wave velocity during coronary angiography.
Article
Geriatrics & Gerontology
Catarina de Andrade Barboza, Eliezer Guimaraes Moura, Gabriela Ministro, Javier Bedoya Castano, Gabriela C. Silva Santos, Gilmar Dias Junior, Heitor Moreno Junior, Bruno Rodrigues
Summary: The study found that self-reported long-term water exercise training did not improve central hemodynamic variables in postmenopausal hypertensive women compared to sedentary ones. However, it is worth emphasizing that diastolic blood pressure levels were reduced in the trained group, potentially reducing cardiovascular outcomes.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Cansu Sivrikaya Yildirim, Pelin Kosger, Tugcem Akin, Birsen Ucar
Summary: Children with a family history of hypertension show higher blood pressure and early signs of hypertensive vascular changes before clinical symptoms appear. This study found that arterial stiffness, pulse wave velocity, and central blood pressure values were higher in normotensive children with hypertensive parents compared to the control group, suggesting potential early markers for hypertensive disease.
CARDIOLOGY IN THE YOUNG
(2022)
Article
Cardiac & Cardiovascular Systems
Takanobu Okamoto, Yuto Hashimoto, Madoka Ogawa
Summary: Increased arterial stiffness, as indicated by AI@75, is associated with lower pulmonary function in postmenopausal women, as measured by FVC, FEV1, and FEV1/FVC ratio.
HEART LUNG AND CIRCULATION
(2021)
Article
Multidisciplinary Sciences
Jacopo Belfiore, Etrusca Brogi, Niccolo Nicolini, Davide Deffenu, Francesco Forfori, Carlo Palombo
Summary: This study investigated the hemodynamic variations associated with the application of positive end-expiratory pressure (PEEP) in healthy subjects. The results showed that low levels of PEEP prolong diastolic phase and reduce systolic work of the heart.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Faniya Maganova, Mikhail Voevoda, Vladimir Popov, Alexey Moskalev
Summary: A prospective randomized comparative placebo-controlled double-blind study was conducted to investigate the effects of a dietary supplement containing Siberian fir terpenes, limonene, alpha-linolenic acid, and vitamin E on arterial health. The study found that the supplement significantly reduced the biological age of the arteries.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Gilberto Campos Guimaraes Filho, Priscila Valverde de Oliveira Vitorino, Sayuri Inuzuka, Adriana Sebba Barroso, Robson Pierre Pacifico Alves Filho, Victoria Alves Melo, Luiz Fernando de Oliveira Urzeda, Ana Luiza Lima Sousa, Antonio Coca, Paulo Cesar Brandao Veiga Jardim, Weimar Kunz Sebba Barroso
Summary: This study compared the parameters, arterial stiffness, target organ damage, and renal profile between central blood pressure (CBP) and peripheral blood pressure (PBP) guided hypertension treatments. The intervention guided by CBP resulted in reductions in central diastolic blood pressure and augmentation index (AIx) compared to the peripheral group (PG). Additionally, the frequency of changed pulse wave velocity (PWV) and left ventricular mass index (LVMI) was lower in the CBP group.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Ophthalmology
Younhea Jung, Hyun Suh, Jung Il Moon
Summary: The study showed that in patients using prostaglandin analogues, there were significant differences in IOP measurements between GAT and NCT, with RBT overestimating and NCT underestimating IOP compared to GAT.
Article
Chemistry, Analytical
Yosuke Osawa, Tetsuji Dohi
Summary: In this paper, a new discriminant index is proposed to evaluate the wearing condition of a blood pressure pulse wave measurement device with small variability. The index is based on the ratio of the blood pressure pulse wave component to the noise component. The correlation coefficient between the index and the amplitude of the blood pressure pulse wave is 0.879, and the index reduces the coefficient of variation by 12.8%.
Article
Geriatrics & Gerontology
Jilles M. Fermont, Divya Mohan, Marie Fisk, Charlotte E. Bolton, William Macnee, John R. Cockcroft, Carmel McEniery, Jonathan Fuld, Joseph Cheriyan, Ruth Tal-Singer, Hana Mullerova, Angela M. Wood, Ian B. Wilkinson, Michael Polkey
Summary: The study found that using the SPPB and its components as an alternative to the 6MWT in the BODE Index maintained a similar predictive ability for mortality in COPD patients.
Article
Biophysics
Ye Li, Alessandro Giudici, Ian B. Wilkinson, Ashraf W. Khir
Summary: Arterial function and wall mechanical properties play crucial roles in circulation hemodynamics. A novel non-invasive method for determining vessel distensibility and elastic modulus was proposed and validated, showing comparable results to invasive techniques. This new approach holds potential for clinical applications.
JOURNAL OF BIOMECHANICS
(2021)
Article
Cardiac & Cardiovascular Systems
Jillian N. Simon, Besarte Vrellaku, Stefania Monterisi, Sandy M. Chu, Nadiia Rawlings, Oliver Lomas, Gerard A. Marchal, Dominic Waithe, Fahima Syeda, Parag R. Gajendragadkar, Raja Jayaram, Rana Sayeed, Keith M. Channon, Larissa Fabritz, Pawel Swietach, Manuela Zaccolo, Philip Eaton, Barbara Casadei
Summary: The study revealed that PKARI alpha disulfide formation is significantly increased in response to I/R in both humans and mice, leading to enhanced AKAP binding and preferential localization to the lysosome. This redox-dependent regulation of lysosomal channels by PKARI alpha plays a critical role in protecting the heart from extensive injury and could serve as a novel target for cardioprotective therapeutics.
Editorial Material
Rheumatology
Tania Gudu, Carmel Stober, Andrew P. Cope, Joseph Cheriyan, James Galloway, Ian B. Wilkinson, Michalis Kostapanos, David Jayne, Frances Hall
Article
Peripheral Vascular Disease
Kaisa M. Maki-Petaja, Adam McGeoch, Lucy L. Yang, Annette Hubsch, Carmel M. McEniery, Paul A. R. Meyer, Fraz Mir, Parag Gajendragadkar, Nicola Ramenatte, Gayathri Anandappa, Sara Santos Franco, Simon J. Bond, Carola-Bibiane Schonlieb, Yoeri Boink, Christoph Brune, Ian B. Wilkinson, Duncan Jodrell, Joseph Cheriyan
Summary: The study found that in patients receiving the VEGF inhibitor pazopanib, the drug led to hypertension, possibly through increasing peripheral vascular resistance and reducing microvascular density and diameter.
Article
Medicine, General & Internal
Parag Ravindra Gajendragadkar, Adam Von Ende, Maysson Ibrahim, Elsa Valdes-Marquez, Christian Fielder Camm, Federico Murgia, Alexander Stiby, Barbara Casadei, Jemma C. Hopewell
Summary: Using a mendelian randomisation approach, this study found evidence supporting a causal association between lifelong differences in ECG parameters representing longer atrial conduction times within the normal range and a lower risk of AF. These findings suggest the need for more individualised treatment strategies for AF.
Article
Cardiac & Cardiovascular Systems
Faye Forsyth, James Brimicombe, Joseph Cheriyan, Duncan Edwards, F. D. Richard Hobbs, Navazh Jalaludeen, Jonathan Mant, Mark Pilling, Rebekah Schiff, Clare J. Taylor, M. Justin Zaman, Christi Deaton
Summary: Identification of HFpEF patients in primary care is challenging, requiring increased awareness and establishment of clear diagnostic pathways. The use of diagnostic algorithms and scores can provide systematic approaches to diagnosis, but may be challenging to apply in older multi-morbid patients.
Article
Cardiac & Cardiovascular Systems
Ashutosh Wechalekar, Gunnar Antoni, Wasfi Al Azzam, Mats Bergstrom, Swethajit Biswas, Chao Chen, Joseph Cheriyan, Matthew Cleveland, Louise Cookson, Paul Galette, Robert L. Janiczek, Raymond Y. Kwong, Mary Ann Lukas, Helen Millns, Duncan Richards, Ian Schneider, Scott D. Solomon, Jens Sorensen, James Storey, Douglas Thompson, Guus van Dongen, Danielle J. Vugts, Anders Wall, Gerhard Wikstrom, Rodney H. Falk
Summary: This study reports the results of a Phase 2 trial using the SAP depleter miridesap and dezamizumab in the treatment of cardiac amyloidosis. The results showed that dezamizumab had no significant effect on improving cardiac function or removing cardiac amyloid deposits. Furthermore, treatment-associated rash and vasculitis were observed in the study.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Public, Environmental & Occupational Health
C. Fielder Camm, Ben Lacey, M. Sofia Massa, Adam Von Ende, Parag Gajendragadkar, Alexander Stiby, Elsa Valdes-Marquez, Sarah Lewington, Rohan Wijesurendra, Sarah Parish, Barbara Casadei, Jemma C. Hopewell
Summary: The study found that weight, measures of adiposity, waist circumference, and lean mass (LM) are associated with the risk of atrial fibrillation (AF). LM was the strongest predictor, but its effect was weaker in men compared to women.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Shivani Singh, Anne Weiss, James Goodman, Marie Fisk, Spoorthy Kulkarni, Ing Lu, Joanna Gray, Rona Smith, Morten Sommer, Joseph Cheriyan
Summary: This article reviews the pharmacology and scientific rationale for repurposing niclosamide, an anti-helminth drug, for the treatment of COVID-19. It highlights the drug's potent antiviral activity and its pleiotropic effects in preclinical and early clinical studies. The advantages and rationale for nebulized and intranasal formulations of niclosamide are also discussed, along with an overview of ongoing clinical trials.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Faye Forsyth, James Brimicombe, Joseph Cheriyan, Duncan Edwards, F. D. Richard Hobbs, Navazh Jalaludeen, Jonathan Mant, Mark Pilling, Rebekah Schiff, Clare J. Taylor, M. Justin Zaman, Christi Deaton
Summary: The study found that identifying HFpEF patients in primary care is challenging and greater awareness of the condition and specialist support are needed. The use of diagnostic algorithms and scores can provide systematic approaches to diagnosis, but may be challenging to apply in older, multi-morbid patients, requiring pragmatic decisions.
